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1.
Dalton Trans ; 46(20): 6645-6653, 2017 May 23.
Artigo em Inglês | MEDLINE | ID: mdl-28474029

RESUMO

The synthesis, acid-base behavior and Pb2+ coordination chemistry of the new aza-scorpiand like ligand 5-[2-(N-2-fluorenyl)ethylamino]-2,5,8-triaza[9]-2,6-pyridinophane (L1) have been studied by potentiometry, NMR and spectrofluorimetric titrations, and the results are compared with those obtained for the related compounds L2, lacking the fluorenyl group, and L3, the macrocycle lacking the pendant arm. The crystal structures obtained for complexes [PbL1][PbL1Cl](NO3)Cl2·4H2O (1) and [PbL3](ClO4)2 (2) reveal that the metal ion is located over the plane defined by the nitrogen atoms of the macrocyclic core due to its inability to accommodate the large Pb2+ ion in the macrocyclic cavity. For L1, the secondary amino group of the pendant arm is implicated in the coordination of the metal ion, although the stereoactive lone pair of Pb2+ prevents the closed conformation associated with the coordination of metal ions in aza-scorpiand derivatives. The kinetics of the acid-promoted dissociation of the ligand from the Pb2+ complexes with the three ligands have been studied using stopped-flow with simultaneous absorbance and fluorescence detection. The results indicate that in spite of their similarity, the dissociation of the metal ion occurs with very different rates in the three complexes. During the course of the kinetic studies evidence was obtained for the occurrence of a photochemical process that leads to ligand degradation with the unexpected elimination of one CH2CH2 fragment from the macrocyclic core.

2.
Rev Calid Asist ; 28(2): 124-31, 2013.
Artigo em Espanhol | MEDLINE | ID: mdl-22999530

RESUMO

OBJECTIVE: To describe the knowledge and perceptions of patients and health professionals on the factors that influence the quality and continuity of care of diabetic patients provided in Primary Care. MATERIAL AND METHODS: A qualitative study using a phenomenological perspective. PARTICIPANTS: Medical and nursing professionals working in Primary Care Centres in the city of Zaragoza, and patients with diabetes mellitus attended in the same centres. Two group (focus group) and 6 individual interviews were carried out in February and March 2010. A predetermined script, with the variables to explore, was used. RESULTS: The patients and health professionals interviewed identified problems in assuming diabetes as a chronic disease. Among the factors related to success in changing habits and lifestyles, were gender (women showed greater difficulties to change), type of job and work situation. Health professionals identified the availability of guidelines and protocols, and personal motivation as factors that work in favour; and lack of time and current information systems as factors that hamper the provision of good quality care. There were discrepancies among health professionals as regards the role played by patient groups and associations. CONCLUSIONS: It is important to take into account the factors that make changes in habits and lifestyles difficult, such as gender and the employment situation, when designing actions aimed at modifying risk factors in diabetic patients.


Assuntos
Atitude Frente a Saúde , Diabetes Mellitus/terapia , Pessoal de Saúde/psicologia , Pacientes/psicologia , Atenção Primária à Saúde/organização & administração , Qualidade da Assistência à Saúde , Percepção Social , Adulto , Idoso , Continuidade da Assistência ao Paciente , Diabetes Mellitus/enfermagem , Diabetes Mellitus/psicologia , Feminino , Grupos Focais , Hábitos , Humanos , Estilo de Vida , Masculino , Pessoa de Meia-Idade , Motivação , Ocupações , Cooperação do Paciente , Educação de Pacientes como Assunto , Pesquisa Qualitativa , Fatores de Risco , Autocuidado , Espanha
3.
J Periodontal Res ; 47(1): 33-44, 2012 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-21906056

RESUMO

BACKGROUND AND OBJECTIVE: The periodontal regeneration of bone defects is often unsatisfactory and could be largely improved by cell therapy. Therefore, the purpose of this study was to evaluate the regenerative potential of implanting canine cementum-derived cells (CDCs) and canine periodontal ligament-derived cells (PDLDCs) in experimentally created periodontal intrabony defects in beagle dogs. MATERIAL AND METHODS: Cells were obtained from premolars extracted from four beagle dogs. Three-wall intrabony periodontal defects, 3 mm wide and 4 mm deep, were surgically created in their second and fourth premolars and plaque was allowed to accumulate. Once the defects were surgically debrided, periodontal regeneration was attempted by random implantation of collagen sponges embedded with 750,000 CDCs, 750,000 PDLDCs or culture medium. After 3 mo of healing, specimens were obtained and periodontal regenerative outcomes were assessed histologically and histometrically. RESULTS: The histological analysis showed that a minimal amount of new cementum was formed in the control group (1.56 ± 0.39 mm), whereas in both test groups, significantly higher amounts of new cementum were formed (3.98 ± 0.59 mm in the CDC group and 4.07 ± 0.97 mm in the PDLDC group). The test groups also demonstrated a larger dimension of new connective tissue, resulting in a significantly more coronal level of histological attachment. CONCLUSION: This proof-of-principle study suggests that cellular therapy, in combination with a collagen sponge, promoted periodontal regeneration in experimental intrabony periodontal defects.


Assuntos
Perda do Osso Alveolar/cirurgia , Transplante de Células , Cemento Dentário/citologia , Regeneração Tecidual Guiada Periodontal/métodos , Ligamento Periodontal/citologia , Perda do Osso Alveolar/patologia , Processo Alveolar/patologia , Animais , Dente Pré-Molar/patologia , Técnicas de Cultura de Células , Separação Celular , Sobrevivência Celular , Cementogênese/fisiologia , Colágeno , Tecido Conjuntivo/patologia , Desbridamento , Cães , Masculino , Distribuição Aleatória , Curetagem Subgengival , Engenharia Tecidual , Alicerces Teciduais , Resultado do Tratamento
4.
Artigo em Inglês | MEDLINE | ID: mdl-19162768

RESUMO

The emergent IMS (Internet Protocol Multimedia Subsystem) technology appears to improve the current communication technologies. Its characteristics, such as Quality of Service (QoS), make it an advantageous system for innovative applications. Providing integrated services to users is one of the main reasons for the existence of IMS. Operators provide the technology as an open source, to be able to use services developed by researchers. Combining and integrating them, users will receive completely new services. Our proposal of use for IMS is the development of a telemedicine platform, designed to support not only remote biological signal monitoring, but value-added services for diagnosis and medical care, both of these working in real time.


Assuntos
Diagnóstico por Computador/tendências , Internet/tendências , Multimídia/tendências , Telemedicina/métodos , Telemedicina/tendências , Terapia Assistida por Computador/tendências , Interface Usuário-Computador , Espanha
5.
Artigo em Inglês | MEDLINE | ID: mdl-19163321

RESUMO

This paper proposes an iterative procedure for the determination of parameters and working conditions of biomedical signal processing algorithms. A systematization of the process required to determine the parameters is proposed, avoiding "trial and error" tests, and considering all the specific requirements of a Telemedicine system, such as reliability and guaranteed signal reconstruction quality. An application of the method is included, also, focusing on ECG processing. Hardware platform Biolet(E) is designed for validation in an electronic implementation.


Assuntos
Eletrocardiografia/instrumentação , Eletrocardiografia/métodos , Processamento de Sinais Assistido por Computador , Algoritmos , Arritmias Cardíacas/diagnóstico , Engenharia Biomédica , Computadores , Humanos , Modelos Estatísticos , Modelos Teóricos , Controle de Qualidade , Reprodutibilidade dos Testes , Software , Telemedicina/métodos
6.
Surgeon ; 5(3): 182-5, 2007 Jun.
Artigo em Inglês | MEDLINE | ID: mdl-17575672

RESUMO

BACKGROUND: Gastrointestinal stromal tumours (GISTs) are rare. Few cases of such tumours are reported in the literature. Until recently, they were only treated surgically but, nowadays, for high grade tumours, we can consider wide excision, not only as a palliative measure, but also to enable subsequent treatment with Imatinib mesylate. METHODS: We describe the case of a patient with a high-grade GIST, who, two years after undergoing surgery and medical treatment, is still in remission. Computerised axial tomography (CT) of the abdomen detected the presence of multiple heterogeneous solid masses of various sizes but no localised retroperitoneal adenopathies. MAIN FINDINGS: Median laparotomy was performed and revealed multiple intraperitoneal tumours. The larger masses were excised and the smaller residual implants are currently being treated with Imatinib mesylate. The patient had visceral, parietal and peritoneal dissemination. One of them, located in the supramesocolic area, had a maximal diameter of 20cm. Another one, at the level of the retro-gastric space, had a diameter of 22cm. The other tumours were smaller and spread over the parietal and visceral peritoneum, mainly between the loops of the small intestine and pelvis. Two years after cytoreduction surgery, the patient is well and free of obvious disease and has shown a good tolerance to pharmacological treatment. CONCLUSIONS: Imatinib mesylate has revolutionised the treatment of GIST and offers good palliation and prolongation of overall survival.


Assuntos
Tumores do Estroma Gastrointestinal/patologia , Neoplasias Peritoneais/secundário , Antineoplásicos/uso terapêutico , Benzamidas , Biomarcadores Tumorais/sangue , Feminino , Tumores do Estroma Gastrointestinal/diagnóstico por imagem , Tumores do Estroma Gastrointestinal/cirurgia , Humanos , Mesilato de Imatinib , Pessoa de Meia-Idade , Neoplasias Peritoneais/diagnóstico por imagem , Neoplasias Peritoneais/tratamento farmacológico , Neoplasias Peritoneais/cirurgia , Piperazinas/uso terapêutico , Pirimidinas/uso terapêutico , Tomografia Computadorizada por Raios X
7.
Rev Neurol ; 41(7): 404-8, 2005.
Artigo em Espanhol | MEDLINE | ID: mdl-16193446

RESUMO

INTRODUCTION: In cancer patients, cerebrovascular accidents (CVA) are the most common complication occurring in the central nervous system after metastasis. One of its causations is non-bacterial thrombotic endocarditis (NBTE), which appears on rare occasions as the first symptom of the tumour. The clinical manifestations of NBTE are the result of multiple systemic embolism. Emboli consist of platelets and strands of fibrin that are deposited in the valves of the heart, within a context of a state of hypercoagulability secondary to the tumour. The tumours that are most frequently associated to NBTE are mucin-secreting adenocarcinomas. Cases of ovarian cancer with NBTE are rare in the different series reported in the literature. CASE REPORT: We describe the case of a 58-year-old female, previously asymptomatic, who suddenly showed a lowered level of consciousness, hemiplegia on the right-hand side and motor aphasia. A computerised axial tomography scan taken at 48 hours showed two acute ischaemic lesions in the left hemisphere. Magnetic resonance imaging of the brain with diffusion sequences revealed multiple ischaemic lesions in different arterial territories. Transthoracic echocardiography at 24 hours showed a vegetation on the posterior leaflet of the mitral valve. The patient was treated with intravenous sodium heparin and no new CVA appeared. The valve injuries disappeared after treatment. In a study conducted to search for occult neoplasia, a tumour was found in the right ovary. CONCLUSIONS: NBTE must be taken into account in cases of cerebral embolism due to unknown causes. The results of the analyses of most patients reveal chronic disseminated intravascular coagulation. The most valuable diagnostic tests are the transesophageal echocardiogram and magnetic resonance imaging of the brain with diffusion sequences. Preferred treatment is with heparin.


Assuntos
Isquemia Encefálica/etiologia , Endocardite , Neoplasias Ovarianas/complicações , Trombose , Isquemia Encefálica/diagnóstico , Isquemia Encefálica/patologia , Coagulação Intravascular Disseminada/complicações , Coagulação Intravascular Disseminada/etiologia , Coagulação Intravascular Disseminada/patologia , Ecocardiografia , Endocardite/complicações , Endocardite/diagnóstico , Endocardite/etiologia , Endocardite/patologia , Evolução Fatal , Feminino , Valvas Cardíacas/patologia , Humanos , Imageamento por Ressonância Magnética , Pessoa de Meia-Idade , Neoplasias Ovarianas/diagnóstico , Neoplasias Ovarianas/patologia , Trombose/complicações , Trombose/diagnóstico , Trombose/etiologia , Trombose/patologia
8.
Rev Esp Enferm Dig ; 97(3): 161-9, 2005 Mar.
Artigo em Inglês, Espanhol | MEDLINE | ID: mdl-15839811

RESUMO

AIM: To study a sample of patients with morbid obesity who are on the waiting list for a surgical intervention, to establish various scores of surgical risk (Possum and severity score), and to assess potential criteria for list prioritization. DESIGN: We calculated physiological and surgical Possum scores for every patient, and analysed comorbidities and other associated factors to calculate the severity score. Likewise, we calculated the predictive rates of morbimortality. Differences between associated comorbidities in body mass index (BMI) were also analyzed. The correlation between Possum score, prediction rates, and severity score were analyzed. PATIENTS: Fifty-two patients on the surgical waiting list in our institution (San Juan University Hospital, Reus) from 26/4/02 to 5/03/04. RESULTS: The mean qualitative score is significantly higher in the female sex. Invalidating arthropathy and socio-occupational and/or psychiatric criteria are significantly higher in women. There is a significant correlation between the severity score and Possum score. Age does not correlate with any of the variables studied. CONCLUSIONS: Possum scores are significantly related to BMI, particularly in terms of morbidity rates. The degree of correlation between the Possum score and the qualitative score tells how useful the latter is to cover other determinant factors in the severity of this condition. Socio-occupational and psychiatric criteria, and invalidating arthropathy are the main variables to be taken into account for postsurgical prediction, and are directly related to BMI degree.


Assuntos
Obesidade Mórbida/cirurgia , Adulto , Desvio Biliopancreático , Feminino , Derivação Gástrica , Humanos , Masculino , Pessoa de Meia-Idade , Medição de Risco , Listas de Espera
10.
Antibiot. infecc ; 6(3): 35-37, jul.-sept. 1998. tab, graf
Artigo em Espanhol | LILACS | ID: lil-327384

RESUMO

Las infecciones invasivas por candida spp son un problema serio frecuente en pacientes críticamente enfermos. Las especies de candida son un ejemplo de patógenos adquiridos en el hospital. Dentro de las áreas de alto riesgo están las Unidades de Cuidados Intensivos (UCI), donde los médicos se encuentran con frecuencia, al cuidado de pacientes con cultivos positivos para candida spp de uno o más sitios anatómicos. En la UCI del Hospital Universitario "Ruiz y Páez" no hay estudios que describan el comportamiento de esta patología y las especies involucradas. Se diseñó un estudio prospectivo, no aleatorio abierto (agosto 1996 - enero 1997), incluyendo 30 pacientes ingresados a la UCI en este período, tomándose como criterio de inclusión el haber ingresado a la UCI y criterio de exclusión que al momento del ingreso estuviese recibiendo antimicóticos. Las muestras se tomaron en los primeros 8 días del ingreso. Se recolectaron 238 muestras, 40 correspondieron a orina, 38 a exudados faríngeos, 27 a secreción traqueobronquial, 90 a hemocultivos. La frecuencia global del total de muestras recolectadas fue de 44, 11 por ciento para candida spp en los pacientes ingresados al protocolo. La especie más aislada fue C. albicans (73,3 por ciento); luego C. stellatoidea (15,23 por ciento); C. kruseii (7,61 por ciento); C. tropicalis 82,85 por ciento) y C. guillermondi (0,9 por ciento). No se encontró candidemia, durante el protocolo, sin embargo, en 2 pacientes con más de dos semanas en UCI se dectectó candidiasis sistémica. El 86,66 por ciento estaban colonizados por candida spp en al menos un sitio anatómico y el 56,66 por ciento en 3 o más sitios anatómicos. El tracto gastrointestinal fue el sitio anatómico más colonizado, el 76,66 or ciento de los pacientes presentaban entre 8 y 12 factores de riesgo para candidiasis y el 50 por ciento e ellos se clasificaron según TISS (Indice de Intervención Terapéutica) de ingreso en Clase III y el 23,33 por ciento en Clave IV. El promedio de estancia en la UCI fue de 7,06 ñ 4,7 días. Para detectar candidemia en los pacientes recluidos se necesitaría ampliar el tiempo de toma de muestra a dos semanas


Assuntos
Humanos , Masculino , Feminino , Candidíase , Medicina , Venezuela
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