[Clinical value of determining serum levels of glycocholic acid in alcoholic lesions of the liver]. / Klinicheskoe znachenie opredeleniia kontsentratsii glikokholevoi kisloty v syvorotke krovi pri alkogol'nom porazhenii pecheni.

To assess the diagnostic value of radioimmunoassay determination of serum levels of glycocholic acid in alcohol-induced chronic diffuse hepatic lesions, this technique was compared by sensitivity and informative content with conventional hepatic tests. Hepatocytic function was measured in combined examination of 83 patients and 30 controls. It is shown that serum glycocholic acid concentration permits detection of early alcohol defects of the liver, excretory dysfunction in particular, control of cholestatic changes, of transformation of hepatic steatosis into hepatitis or cirrhosis, evaluation of cholestasis. The above radioimmunoassay is a useful prognostic tool in decompensated alcohol cirrhosis of the liver.

[Lipid metabolism in cholelithiasis]. / Lipidnyi obmen pri zhelchnokamennoi bolezni.

The results of studies of the blood and bile lipid metabolism in normal subjects and cholelithiasis patients and the findings of guinea pig experiments indicate that lipid levels decrease with age. The time course of the blood and bile lipids and the relationship thereof reflect the depression of cholesterol hydroxylation processes and reduction with age of cholic and deoxycholic acids synthesis and conjugation intensities in the patients with cholelithiasis, as well as a reduction of deoxycholic acid synthesis in normal subjects.

[The content of cholylglycine in the blood serum in cholelithiasis during treatment with litholytic preparations of bile acids]. / Soderzhanie kholilglitsina v syvorotke krovi pri zhelchnokamennoi bolezni v protsesse lecheniia kamnerastvoriaiushchimi preparatami zhelchnykh kislot.

Liver function has been assessed on the basis of radioimmunoassays of the primary conjugated cholic acid, cholylglycine, in the blood sera of cholelithiasis patients treated with cheno- and ursodeoxycholic acid drugs for a long time. The findings indicate that the blood serum cholylglycine levels may be regarded, among other things, as a prognostic criterion of the efficacy of cholelithiasis therapy with bile acid preparations for litholysis.