Accounting for radiation exposure from previous CT exams while deciding on the next exam: What do referring clinicians think?

PURPOSE: To obtain clinicians' views of the need to account for radiation exposure from previous CT scans and the advisability of a regulatory mechanism to control the number of CT scans for an individual patient. METHODS: A convenience survey was conducted by emailing a link to a three-question electronic survey to clinicians in many countries, mostly through radiology and radiation protection contacts. RESULTS: 505 responses were received from 24 countries. 293 respondents (58%) understand that current regulations do not limit the number of CT scans that can be prescribed for a single patient in a year. When asked whether there should be a regulation to limit the number of CT scans that can be prescribed for a single patient in one year, only a small fraction (143, 28%) answered 'No', 182 (36%) answered 'Maybe' and 166 (33%) answered 'Yes'. Most respondents (337; 67%) think that radiation risk should form part of the consideration when deciding whether to request a CT exam. A minority (138; 27%) think the decision should be based only on the medical indication for the CT exam. Comparison among the 4 countries (South Korea, Hungary, USA and Canada) with the largest number of respondents indicated wide variations in responses. CONCLUSIONS: A majority of the surveyed clinicians consider radiation risk, in addition to clinical factors, when prescribing CT exams. Most respondents are in favor of, or would consider, regulation to control the number of CT scans that could be performed on a patient annually.

Bisphosphonate therapy associated with bilateral atypical femoral fracture and delayed union.

OBJECTIVES: The aim of this study was to identify the risk factors for developing atypical femoral fractures (AFF) and to examine the effect of bisphosphonate (BP) therapy on delayed bone union and bilateral fractures. PATIENTS AND METHODS: Between January 1st, 2012 and December 31st, 2020, a total of 74 AFF patients (8 males, 66 females; mean age: 75.4±7.2 years; range, 51 to 94 years) were recorded in two centers and retrospectively analyzed. A control fragility fracture group (n=143) was compared to the AFF group according to fracture characteristics, surgical fixation methods, comorbidities, and medications. The AFF patients were selected and subdivided according to their BP therapy: Group 1 (without BP) and Group 2 (with BP). Group 2 was further classified into Group 2a (<5 years of BP) and Group 2b (<5 years of BP). RESULTS: The multivariate logistic regression model showed that, BP drug use was the most significant risk factor in development of AFF (p<0.001, odds ratio= 10.749, 95% confidence interval: 3.886-29.733). The patients on BP showed longer bone union (Group 2 - 8.3±3.5 vs. Group 1 - 6.4±3.1 months, p=0.02; Group 2b - 9±3.8 vs. Group 2a - 7.3 ±3.9 months, p=0.09). Of all 19 cases of bilateral fractures, 14 were in Group 2 with BP use (p=0.11). Of 74 cases, 26 (35%) contralateral femoral X-rays were taken on admission and 24 (92%) showed AFF minor criteria signs. Of these 24 patients, 10 (42%) developed contralateral AFF. CONCLUSION: The most significant risk factor in development of AFF was BP drug use. Longer BP therapy (>5 years) showed longer delayed bone union, which was not significant. There was a relatively high risk of developing AFFs and bilateral fractures on BP therapy. In case of an AFF, a contralateral femoral X-ray must be always performed for signs of an impending fracture.

Two- plane point of care ultrasonography helps in the differential diagnosis of pulled elbow.

INTRODUCTION: Pulled elbow (PE) is one of the most common injury in children under the age of five years. Diagnosis of PE is usually based on the typical anamnesis and clinical symptoms. A simple reduction maneuver without the need of any imaging modality can eliminate the problem. Certain fractures however can mimic the physical findings of PE and in this cases reduction should not be attempted. The aim of our prospective diagnostic study was to evaluate the accuracy of a sonographic testing method in the differential diagnosis of PE. METHODS: 205 children aged 0-5 with clinical suspicion for PE were enrolled in our study. Inclusion criteria were the typical clinical sign of PE: painful, motionless, extended or slightly flexed and pronated arm following a traumatic event under the age of five. We excluded older children and patients with pronounced elbow swelling and initially flexed and supinated upper arm position. A two plane point of care sonographic examination was carried out at each patient immediately after history taking and primary physical survey. Presence of the elevated dorsal sonographic fat pad sign(FPS) and the synovial fringe enlargement (SFE) were examined from dorsal and ventral longitudinal planes. Children with FPS positivity and/or unsuccessful reduction were x-rayed. Suspected occult fractures with persistent complains were also x-rayed on the 3rd week. Sonographic pictures and x-rays were analyzed and compared to clinical findings. RESULTS: The diagnosis of PE was confirmed in 196 cases. (95.6%). 9 children had type I. supracondylar humerus fractures. (4.39%) Out of these 2 proved to be occult fractures.(0.97%). SFE positivity was detected only in the PE group (156 cases, 76%) fractures have not shown this sign. Elevated FPS was negative in all but one PE cases, while all fractures showed FPS positivity without exception. Evaluating the two parameters together both sensitivity, specificity, negative and positive predictive value were 100%. CONCLUSIONS: The two plane sonographic point of care method is an effective tool for confirming the diagnosis of PE and excluding the presence of fractures. It is an easy, standard and objective procedure which can be used as a fast diagnostic test before reduction attempts.

Standardized sonographic examination of pediatric elbow injuries is an effective screening method and improves diagnostic efficiency.

INTRODUCTION: Positive role of ultrasound in the diagnosis of pediatric elbow injuries were confirmed by many papers but no comprehensive, standardized method has been developed for daily clinical practice. The aim of our prospective diagnostic study was to prove the efficacy of a five point sonographic point of care method for detecting different pediatric elbow fractures or dislocations. METHODS: Between 2016 January and 2017 March 365 children (age 1-14) with suspected closed elbow injury were enrolled in our study. Sonographic point of care examination was carried out by a properly trained resident and two orthopedic surgeons immediately after physical survey. We used a standardized five point sonographic examination. Two plane x-rays were made following sonography according to protocol. Utility of sonographic pictures were analyzed by a radiologist. Cases with images which have not met with standard requirements were excluded. In those cases when primary x-rays were negative and/or any of the ultrasound planes showed positive findings, radiography was repeated after 4 weeks of injury. If we detected callus formation the fracture was considered occult. Cases with images which have not met with standard requirements were excluded. Ultrasonic pictures, evaluation sheets and x-ray results were compared. RESULTS: Out of the 365 cases we identified 165 with positive findings (45, 2%) by primary x-rays. Distribution of the different injuries were the following: Radial condylar fractures, (n = 29) supracondylar humeral fractures (n = 84 proximal radial fractures, (n = 19) proximal ulnar fractures, (n = 7) fractures with joint dislocations (n = 3) joint dislocations without fractures, n = 2 medial epicondyle fractures (n = 14) fracture combinations (n = 7) We did not find injuries in this series that we could not categorize into these groups. Evaluating the abnormal sonographic dorsal fat pad sign (FPS) as a sole parameter for fracture detection we found sensitivity: 0, 97, specificity: 0,97, positive predictive value: 0,97, negative predictive value: 0,97 Evaluating the effectivity of the four cortical planes we calculated sensitivity 0, 85 specificity 0.96 positive predictive value: 0. 95 negative predictive value 0.87. The overall values of the five planes were the following: specificity0.97 sensitivity 1, positive predictive value 0.97 negative predictive value: 1 Interrater agreements on the cortical plane abnormality were considered good at two examiners and very good at one examiner. (Kappa = 0.79, 0, 81, 0, 79) Agreements on differentiation of elevated, normal fat pad) or lipohaemarthrosis in sonographic pictures were very good in all cases. (Kappa = 0,83, 0,86,0,82) While identification of any displacement or dislocation was possible in 96%, of all cases(n = 59)the exact determination of the type of the injury was possible in only 70,3% (n = 116) CONCLUSIONS: Using the five point ultrasonic examination provides enough information for excluding or confirming the presence of any pediatric elbow fractures or dislocations. The method is quick, simple and can help in the immediate differentiation of the severity of injuries. Sonographic lipohaemarthrosis seems to be more sensitive than elevated fat pad sign for the detection of potential occult fractures. Positive cases should be cleared by x-rays because the exact nature of the fractures are not identifiable only by ultrasound.

Hybrid solution combining osteosynthesis and endoprosthesis for double column acetabular fractures in the elderly provide more stability with finite element model.

OBJECTIVES: This study aims to compare mechanical stability of osteosynthesis (plate and screw fixation) alone versus the same method supplemented with hip arthroplasty (hybrid solution) for double column fractures in elderly. PATIENTS AND METHODS: Mechanical investigations were performed on an advanced finite element pelvis model developed for double column fractures. The following simulated implant combinations were analyzed: modular acetabular basket with a ring with polyaxial screws and U-plate; plates with polyaxial screws placed on the medial-horizontal (linea terminalis) and quadrilateral bone surfaces; modular acetabular cup with U-plates; and polyaxial screws in sizes optimized based on a finite element model (FEM). Using the models, the possible shifts in peak load positions arising in different movement patterns caused by load and tension and implant deformation were measured. RESULTS: Hybrid systems resulted in minimal deformation of the implants already available on the market. We observed less possible shifts and greater stability in the acetabular fracture zones, compared to conventional osteosynthesis alone. Optimization with available and compatible implant sizes led to a further significant increase in stability. CONCLUSION: Hybrid method combining osteosynthesis and prosthesis implantation provide more stability in biomechanical models in the treatment of double column fractures in elderly.

Comparison of different fixation methods of bicolumnar acetabular fractures.

OBJECTIVES: This study aims to investigate if the stabilization of iliac wing fractures influences the stability of the acetabular osteosynthesis, if surgical fixation is the choice of treatment, and which technique to be used. MATERIALS AND METHODS: In the study, measurements were performed with an improved finite element model. Tension and displacement values were measured in bicolumnar acetabular fractures in the following cases: combination of cranial and medial plate fixation through the linea terminalis, or combination of cranial plate and quadrilateral surface plates. The iliac wing fracture was either not fixed, or fixed with screws or with a plate. RESULTS: In cases where osteosynthesis was performed through the linea terminalis, 0.01 mm fracture gap displacement was observed with the use of a combination of cranial and quadrilateral surface plate fixations. In the combination of cranial and medial positioned plates, the displacement in the fracture gap was 0.088 mm. The fixation of the iliac wing fracture did not improve the stability of the osteosynthesis of the linea terminalis. Plate fixation of the iliac wing fracture was more stable than screw fixation alone. CONCLUSION: In double column fractures, if the reduction does not require an anterior approach, it is not necessary to fix the iliac wing fracture only to improve the stability of the fixation. If the reduction does require an anterior approach, it is worth fixing the iliac wing fracture with the technically less demanding screw fixation.

Delayed Spinal Cord-Brachial Plexus Reconnection after C7 Ventral Root Avulsion: The Effect of Reinnervating Motoneurons Rescued by Riluzole Treatment.

Ventral root avulsion induces dramatic loss of the affected spinal cord motoneurons. The neuroprotective effect of riluzole has been previously proven on the injured motoneurons: the vast majority of them can be rescued even when they have no possibility to regenerate their axons. In this study the number of injured motoneurons rescued by riluzole treatment and their capacity to reinnervate the denervated forelimb muscles was investigated. Surgical reconnection with a peripheral nerve graft between the affected spinal cord segment and the C7 spinal nerve was established immediately or with 1- and 3-week delay after avulsion. Avulsion and immediate reconnection of the motoneuron pool to the spinal nerve resulted in moderate reinnervation of the spinal nerve (281 ± 23 standard error of mean [SEM] retrogradely labeled motoneurons), whereas treatment of the injured motoneurons with riluzole yielded considerably higher numbers of reinnervating motoneurons (548 ± 18 SEM). Reconnection of the motor pool with the C7 spinal nerve with 1-week delay allowed fewer motor axons to reinnervate their targets in control and riluzole-treated animals (159 ± 21 vs. 395 ± 16 SEM). A clinically relevant 3-week delay in reconnection further reduced the number of reinnervating motoneurons (76 ± 22 SEM), but riluzole pre-treatment still enabled a significant number of rescued motoneurons (396 ± 17 SEM) to regenerate their axons into the C7 spinal nerve. These results show that those injured adult motoneurons that are rescued by riluzole treatment started immediately after the avulsion injury are able to reinnervate their targets even if they are provided with a conduit several weeks after the primary injury. This finding suggests that partial rescue of injured motoneurons with riluzole in patients who suffered a brachial plexus avulsion injury may provide an available pool of surviving motoneurons for late reconnection/reimplantation surgeries.

Intrapelvic acetabulum surgery: does the positioning of the plate fixation play a role in the stability of the osteosynthesis?

OBJECTIVES: This study aims to investigate whether positioning of the plate fixation plays a role in the stability of the osteosynthesis. MATERIALS AND METHODS: We used finite element modelling to model an anterior pillar fracture and a T-type fracture of the acetabulum. Fracture fixation was carried out in three different variations: cranially positioned plate, medially positioned plate, and a combination of the two methods. In all cases, 3-3 screws were inserted on both ends of the plate to fix the fracture. RESULTS: In both fractures, nearly the same amount of displacement was detected in the fracture gap using a cranially positioned or medially positioned plate, and the amount of displacement was not less when using both plates simultaneously. CONCLUSION: The position of the plate fixation does not affect the stability of the osteosynthesis and in cases of simple fracture patterns, fixation using two plates does not provide more stability than one plate alone.

Does surgically fixation of pubic fracture increase the stability of the operated posterior pelvis?

OBJECTIVES: This study aims to investigate whether surgical treatment of pubic rami fractures increases the stability of the posterior pelvis. PATIENTS AND METHODS: A finite element pelvic model with improved geometric and material characteristics was analyzed. By imitating a standing position, a type I Denis sacrum fracture and a unilateral pubis fracture, we measured the differences in tension and displacement. The posterior injury was treated with a direct plate synthesis or transsacral plate synthesis, while the pubis fracture was left without fixation or fixed with either a retrograde pubic screw or plate synthesis. RESULTS: The operative fixation of pubic rami fractures decreased the movement in the fracture gap not only at the site of the pubis fracture, but also at the site of the fixed sacrum fracture. The plate synthesis provided greater stability of the anterior fracture than the retrograde screw. The tensions in the implants were below the allowed values. CONCLUSION: We concluded that surgically fixation of pubic fracture increases the stability of the operated posterior pelvis.

Further development of our finite element pelvic model to compare fixation methods for pelvic fractures.

OBJECTIVES: In this study, we aimed to create a realistic model which is suitable for computerized simulation of any kind of fractures and provides reliable results. PATIENTS AND METHODS: We used a plastic pelvic model to construct advanced specimens. The data were retrieved from the computed tomography scans of a healthy pelvis. A geometrically exact model by the means of three-dimensional scanning of the plastic pelvis was obtained. The material properties of the bony parts based on the data retrieved from the computed tomography scans were modified. The pelvis was divided into distinct segments and the proportion of the cortical and cancellous bone substance in each segment were determined to make the material properties accurate. In the validation of the pelvic model, a type C pelvic injury was simulated and the fracture of the sacrum and the symphyseolysis were stabilized with plates. These data were compared with those of previously performed cadaver experiments. RESULTS: Based on the simulation performed on the new model, the shift values between the fragments of the broken sacrum approximated the reported values of our cadaver experiments and also arising strains remained in the tolerable interval. CONCLUSION: Our new finite element pelvic model represents the pelvis more accurately than the former one. As the validation of the model was successful, it is suitable for computerized simulation of any kind of fractures offering reliable results.

Short-term results of total hip replacement due to acetabular fractures.

OBJECTIVES: This study aims to evaluate short-term results of total hip replacement performed for post-traumatic osteoarthritis and/or femoral head necrosis caused by acetabular fractures. PATIENTS AND METHODS: We performed 39 arthroplasties due to acetabular fractures on 25 male and 14 female patients during the course of a five-year period. The mean age of the patients was 45 years (range 25 to 73 years) at the time of surgery. Cemented cup was implanted in 29 patients and uncemented cup in 10 patients. Bone replacement was indicated in eight patients for different degrees of acetabular deformities. Implantation of an acetabular socket was indicated in six patients. RESULTS: The evaluation was based on the Harris hip score (HHS). The mean HHS score was 42 prior to arthroplasty and 81 after arthroplasty. Repeated surgery was required for infection in two patients. Dislocation of the prosthesis occurred in three patients, deep venous thrombosis in one patient and the lesion of the sciatic nerve in one patient after surgery. CONCLUSION: Our study results suggest that the selection of the cup type depends on the condition and bone deformity secondary to acetabular fracture. Surgical interventions are technically more difficult, and take longer with a high rate of the postoperative complications and prolonged rehabilitation period, compared to arthroplasties for degenerative hip diseases.

Biomechanical comparison of two stabilization techniques for unstable sacral fractures.

AIM: The purpose of the study was to assess the stability provided by an ilio-iliac dorsal plate fixation technique using an AO narrow DCP on the pelvic brim in vertically and rotationally unstable type-C pelvic ring injuries. MATERIALS AND METHODS: We examined 12 fresh cadaver pelvises in a single limb stance load. A type-C pelvic ring injury (a type I lateral sacral fracture in the classification of Denis with symphysis pubis rupture) was performed on the cadaver specimen and fixed with a four-hole narrow dynamic compression plate to stabilize the symphysis pubis rupture; the sacrum fracture was stabilized either anteriorly with two 3-hole reconstruction plates ("anterior plate osteosynthesis") or with a posterior fixation using a 12-hole narrow DCP. A cyclic load of between 100 and 250 N was applied to the fifth lumbar vertebra of the specimen. An extensometer was attached to both sides of the sacrum fracture to detect movements at the fracture site. RESULTS: We were able to achieve usable measurements in nine specimens. Three measurements were performed on each specimen, and the movements recorded at the fracture gap in trans-sacral plate fixation were higher than or similar to those observed for anterior plate synthesis in 23 out of 27 cases. CONCLUSION: Dorsal ilio-iliac bridge plate fixation provides somewhat reduced stability compared to anterior plate fixation, but the difference is not significant.

Comparison of stability in the operative treatment of pelvic injuries in a finite element model.

PURPOSE OF THE STUDY: The comparison of the stability of four surgical methods for the treatment of vertically and rotationally unstable type C pelvic ring injuries. METHODS: We produced a type C pelvic ring injury (type Denis II fracture of the sacrum and symphysiolysis) on a finite element model, in the case of standing on both feet. We stabilized the symphysiolysis with a five-hole reconstruction plate; the sacrum fracture was fixed in the first experiment with two, two-hole reconstruction plates on the ventral surface, in the second one we applied dorsally the transsacral, narrow DC plate, in the third one with KFI-H plate, and in the last one with iliosacral screw. Finite element modeling was performed by the use of the ALGOR software. Not only bones and joints, but joints and mechanically important ligaments were modeled as well. We measured the shift between the two surfaces of the fracture gap, compared to the results of measurements accomplished on cadaver models. RESULTS: Larger shift could be elicited after transsacral plating than after direct plating. These results correspond to those of the parallel investigation of the bony ligamentous cadaver pelvis specimens. The shift values after KFI-H plating and iliosacral screw fixation are larger than after direct plating, but smaller than after transsacral plating. The tension created in the implants is less than the allowed values; therefore, the choice of operation should depend on the type of injury. CONCLUSIONS: The finite element model may be utilized for the comparison of different methods of osteosynthesis for the treatment of injuries described above. Due to several difficulties in investigations performed on cadaver specimens, this model has undoubted utility.