[Semen parameters in secondary infertile couples]. / Analiza parametrów nasienia we wtórnej nieplodnosci malzenskiej.

OBJECTIVE: The aim of this study was to evaluate sperm values in the group of secondary infertile couples. MATERIAL AND METHODS: The material of the study included 35 couples with abortion in anamnesis, 12 couples with delivery in past and 11 couples conceive and deliver during studies. Sperm analysis was performed according to the WHO guidelines. RESULTS: Men from couples with abortion in past had significantly higher sperm concentration compare to couples with delivery in past. In other parameters there was no significant differences observed. CONCLUSION: Sperm concentration can be important factor in secondary infertility.

[Effects of oral administration of estrogen replacement therapy in surgical menopause]. / Wczesna pooperacyjna doustna estrogenoterapia zastepcza u pacjentek po usunieciu macicy z przydatkami.

OBJECTIVE: The aim of this study was to analyze effects of oral administration of conjugated estrogens in women after surgical menopause. MATERIAL AND METHODS: A prospective study that included 41 women after hysterectomy with bilateral oophorectomy, was performed. All patients received conjugated estrogens (Premarin) 0.625 mg daily from second or third days after surgery. Plasma level of estradiol, FSH and several homeostatic parameters were evaluated before and after 2, 5 days and 6 weeks of hormone therapy. The symptoms of climacteric syndrome were estimated based on the scale of Kuppermann. RESULTS: A decrease in plasma estradiol levels in early postoperative days and an increase up to 100 pg/ml in estradiol concentration after 6 weeks of estrogen therapy were observed. Changes in platelet number, plasma concentration of coagulation factors were transient and there were no significant thrombophilic effects after 6 weeks of Premarin administration. CONCLUSIONS: The postoperative oral administration of conjugated estrogens did not cause thromboembolic complications among women after surgical menopause. Early beginning of estrogen replacement therapy after hysterectomy may prevent symptoms of climacteric syndrome occurrence.

[The effectiveness of prenatal steroid and ambroxol therapy for the prevention of respiratory distress syndrome in newborns of diabetic mothers]. / Profilaktyka zaburzen oddychania noworodków u ciezarnych z przedciazowa cukrzyca insulinozalezna.

The aim of the study was to determine the effectiveness of antenatal steroids and ambroxol in reduction of respiratory distress syndrome (RDS) in newborns of diabetic mothers. A retrospective chart review was done on 101 diabetic gravidas who were hospitalised at 1st Department of Obstetrics and Gynaecology Medical University in Warsaw between January 1989 and December 1999. We studied the neonatal outcomes for women with diabetes mellitus who delivered before 37 gestational weeks depend on exposition to antenatal steroids or ambroxol. Both groups were compared with unexposed neonates for respiratory distress syndrome. Frequency of occurrence and severity of RDS were similar in all study subgroups. We did not found reduction of respiratory distress syndrome in newborns of diabetic mothers exposed to antenatal steroids or ambroxol.

[The influence of prenatal glucocorticoids on glycemic control among pregnant women with type I diabetes]. / Wplyw sterydoterapii stosowanej w profilaktyce zaburzen oddychania na gospodarke weglowodanowa ciezarnych z cukrzyca przedciazowa insulinozalezna.

The purpose of this study was to determine the impact of glucocorticoids treatment, administered for a severe risk of premature delivery. The study material consisted of 30 diabetic mothers treated with intensive insulin therapy. The effects of steroid treatment on glucose level two days prior, one day prior, during 1-, or 2-, or 3-days therapy and the first 2 days following treatment were determined. No case of ketoacidosis was reported.