Hierarchical syntax model of music predicts theta power during music listening.

Linguistic research showed that the depth of syntactic embedding is reflected in brain theta power. Here, we test whether this also extends to non-linguistic stimuli, specifically music. We used a hierarchical model of musical syntax to continuously quantify two types of expert-annotated harmonic dependencies throughout a piece of Western classical music: prolongation and preparation. Prolongations can roughly be understood as a musical analogue to linguistic coordination between constituents that share the same function (e.g., 'pizza' and 'pasta' in 'I ate pizza and pasta'). Preparation refers to the dependency between two harmonies whereby the first implies a resolution towards the second (e.g., dominant towards tonic; similar to how the adjective implies the presence of a noun in 'I like spicy … '). Source reconstructed MEG data of sixty-five participants listening to the musical piece was then analysed. We used Bayesian Mixed Effects models to predict theta envelope in the brain, using the number of open prolongation and preparation dependencies as predictors whilst controlling for audio envelope. We observed that prolongation and preparation both carry independent and distinguishable predictive value for theta band fluctuation in key linguistic areas such as the Angular, Superior Temporal, and Heschl's Gyri, or their right-lateralised homologues, with preparation showing additional predictive value for areas associated with the reward system and prediction. Musical expertise further mediated these effects in language-related brain areas. Results show that predictions of precisely formalised music-theoretical models are reflected in the brain activity of listeners which furthers our understanding of the perception and cognition of musical structure.

Decoding reveals the neural representation of held and manipulated musical thoughts.

Imagine a song you know by heart. With little effort you could sing it or play it vividly in your mind. However, we are only beginning to understand how the brain represents, holds, and manipulates these musical "thoughts". Here, we decoded listened and imagined melodies from MEG brain data (N = 71) to show that auditory regions represent the sensory properties of individual sounds, whereas cognitive control (prefrontal cortex, basal nuclei, thalamus) and episodic memory areas (inferior and medial temporal lobe, posterior cingulate, precuneus) hold and manipulate the melody as an abstract unit. Furthermore, the mental manipulation of a melody systematically changes its neural representation, reflecting the volitional control of auditory images. Our work sheds light on the nature and dynamics of auditory representations and paves the way for future work on neural decoding of auditory imagination.

High-fidelity transmission of auditory symbolic material is associated with reduced right-left neuroanatomical asymmetry between primary auditory regions.

The intergenerational stability of auditory symbolic systems, such as music, is thought to rely on brain processes that allow the faithful transmission of complex sounds. Little is known about the functional and structural aspects of the human brain which support this ability, with a few studies pointing to the bilateral organization of auditory networks as a putative neural substrate. Here, we further tested this hypothesis by examining the role of left-right neuroanatomical asymmetries between auditory cortices. We collected neuroanatomical images from a large sample of participants (nonmusicians) and analyzed them with Freesurfer's surface-based morphometry method. Weeks after scanning, the same individuals participated in a laboratory experiment that simulated music transmission: the signaling games. We found that high accuracy in the intergenerational transmission of an artificial tone system was associated with reduced rightward asymmetry of cortical thickness in Heschl's sulcus. Our study suggests that the high-fidelity copying of melodic material may rely on the extent to which computational neuronal resources are distributed across hemispheres. Our data further support the role of interhemispheric brain organization in the cultural transmission and evolution of auditory symbolic systems.

Magnetoencephalography recordings reveal the spatiotemporal dynamics of recognition memory for complex versus simple auditory sequences.

Auditory recognition is a crucial cognitive process that relies on the organization of single elements over time. However, little is known about the spatiotemporal dynamics underlying the conscious recognition of auditory sequences varying in complexity. To study this, we asked 71 participants to learn and recognize simple tonal musical sequences and matched complex atonal sequences while their brain activity was recorded using magnetoencephalography (MEG). Results reveal qualitative changes in neural activity dependent on stimulus complexity: recognition of tonal sequences engages hippocampal and cingulate areas, whereas recognition of atonal sequences mainly activates the auditory processing network. Our findings reveal the involvement of a cortico-subcortical brain network for auditory recognition and support the idea that stimulus complexity qualitatively alters the neural pathways of recognition memory.

An ALE meta-analytic review of musical expertise.

Through long-term training, music experts acquire complex and specialized sensorimotor skills, which are paralleled by continuous neuro-anatomical and -functional adaptations. The underlying neuroplasticity mechanisms have been extensively explored in decades of research in music, cognitive, and translational neuroscience. However, the absence of a comprehensive review and quantitative meta-analysis prevents the plethora of variegated findings to ultimately converge into a unified picture of the neuroanatomy of musical expertise. Here, we performed a comprehensive neuroimaging meta-analysis of publications investigating neuro-anatomical and -functional differences between musicians (M) and non-musicians (NM). Eighty-four studies were included in the qualitative synthesis. From these, 58 publications were included in coordinate-based meta-analyses using the anatomic/activation likelihood estimation (ALE) method. This comprehensive approach delivers a coherent cortico-subcortical network encompassing sensorimotor and limbic regions bilaterally. Particularly, M exhibited higher volume/activity in auditory, sensorimotor, interoceptive, and limbic brain areas and lower volume/activity in parietal areas as opposed to NM. Notably, we reveal topographical (dis-)similarities between the identified functional and anatomical networks and characterize their link to various cognitive functions by means of meta-analytic connectivity modelling. Overall, we effectively synthesized decades of research in the field and provide a consistent and controversies-free picture of the neuroanatomy of musical expertise.

Associations between abstract working memory abilities and brain activity underlying long-term recognition of auditory sequences.

Memory is a complex cognitive process composed of several subsystems, namely short- and long-term memory and working memory (WM). Previous research has shown that adequate interaction between subsystems is crucial for successful memory processes such as encoding, storage, and manipulation of information. However, few studies have investigated the relationship between different subsystems at the behavioral and neural levels. Thus, here we assessed the relationship between individual WM abilities and brain activity underlying the recognition of previously memorized auditory sequences. First, recognition of previously memorized versus novel auditory sequences was associated with a widespread network of brain areas comprising the cingulate gyrus, hippocampus, insula, inferior temporal cortex, frontal operculum, and orbitofrontal cortex. Second, we observed positive correlations between brain activity underlying auditory sequence recognition and WM. We showed a sustained positive correlation in the medial cingulate gyrus, a brain area that was widely involved in the auditory sequence recognition. Remarkably, we also observed positive correlations in the inferior temporal, temporal-fusiform, and postcentral gyri, brain areas that were not strongly associated with auditory sequence recognition. In conclusion, we discovered positive correlations between WM abilities and brain activity underlying long-term recognition of auditory sequences, providing new evidence on the relationship between memory subsystems. Furthermore, we showed that high WM performers recruited a larger brain network including areas associated with visual processing (i.e., inferior temporal, temporal-fusiform, and postcentral gyri) for successful auditory memory recognition.

An ALE meta-analytic review of top-down and bottom-up processing of music in the brain.

A remarkable feature of the human brain is its ability to integrate information from the environment with internally generated content. The integration of top-down and bottom-up processes during complex multi-modal human activities, however, is yet to be fully understood. Music provides an excellent model for understanding this since music listening leads to the urge to move, and music making entails both playing and listening at the same time (i.e., audio-motor coupling). Here, we conducted activation likelihood estimation (ALE) meta-analyses of 130 neuroimaging studies of music perception, production and imagery, with 2660 foci, 139 experiments, and 2516 participants. We found that music perception and production rely on auditory cortices and sensorimotor cortices, while music imagery recruits distinct parietal regions. This indicates that the brain requires different structures to process similar information which is made available either by an interaction with the environment (i.e., bottom-up) or by internally generated content (i.e., top-down).

Putting Cells in Motion: Advantages of Endogenous Boosting of BDNF Production.

Motor exercise, such as sport or musical activities, helps with a plethora of diseases by modulating brain functions in neocortical and subcortical regions, resulting in behavioural changes related to mood regulation, well-being, memory, and even cognitive preservation in aging and neurodegenerative diseases. Although evidence is accumulating on the systemic neural mechanisms mediating these brain effects, the specific mechanisms by which exercise acts upon the cellular level are still under investigation. This is particularly the case for music training, a much less studied instance of motor exercise than sport. With regards to sport, consistent neurobiological research has focused on the brain-derived neurotrophic factor (BDNF), an essential player in the central nervous system. BDNF stimulates the growth and differentiation of neurons and synapses. It thrives in the hippocampus, the cortex, and the basal forebrain, which are the areas vital for memory, learning, and higher cognitive functions. Animal models and neurocognitive experiments on human athletes converge in demonstrating that physical exercise reliably boosts BDNF levels. In this review, we highlight comparable early findings obtained with animal models and elderly humans exposed to musical stimulation, showing how perceptual exposure to music might affect BDNF release, similar to what has been observed for sport. We subsequently propose a novel hypothesis that relates the neuroplastic changes in the human brains after musical training to genetically- and exercise-driven BDNF levels.

On the Association Between Musical Training, Intelligence and Executive Functions in Adulthood.

Converging evidence has demonstrated that musical training is associated with improved perceptual and cognitive skills, including executive functions and general intelligence, particularly in childhood. In contrast, in adults the relationship between cognitive performance and musicianship is less clear and seems to be modulated by a number of background factors, such as personality and socio-economic status. Aiming to shed new light on this topic, we administered the Wechsler Adult Intelligence Scale III (WAIS-III), the Wechsler Memory Scale III (WMS-III), and the Stroop Test to 101 Finnish healthy adults grouped according to their musical expertise (non-musicians, amateurs, and musicians). After being matched for socio-economic status, personality traits and other demographic variables, adult musicians exhibited higher cognitive performance than non-musicians in all the mentioned measures. Moreover, linear regression models showed significant positive relationships between executive functions (working memory and attention) and the duration of musical practice, even after controlling for intelligence and background variables, such as personality traits. Hence, our study offers further support for the association between cognitive abilities and musical training, even in adulthood. HIGHLIGHTS: - Musicians show higher general intelligence (FSIQ), verbal intelligence (VIQ), working memory (WMI) and attention skills than non-musicians. Amateurs score in between.- Significant positive correlations between years of musical playing and cognitive abilities support the hypothesis that long-term musical practice is associated with intelligence and executive functions.

Driver's visual attention to different categories of roadside advertising signs.

Roadside advertising signs are a salient potential source of driver's distraction. Previous research has mainly investigated driver's visual attention to billboards, which represents only one category of advertising signs. In this study, driver's visual attention was assessed in a naturalistic driving setting for six categories of roadside advertising signs: vendor signs, billboards, movable display boards, single and multiple commercial directional signs, and gas price LED displays. Fixation rate, fixation duration, fixation distance and driving speed were assessed in a sample of 15 drivers along a 30-km route including a total of 154 advertising signs belonging to the six categories described above. The role of clearance from the road, elevation, height, width, surface, number and size of characters, total number of characters, side of the road (driving side, opposite side), context (rural, urban), were also considered. Overall 24% of the roadside advertising signs were fixated. Fixation rate was significantly influenced by sign category, clearance from the road and number of characters. Median value for fixation duration was 297 ms. Fixation duration was significantly influenced by speed, elevation from road level, number of medium size characters, and was higher in the rural context. Median value for fixation distance was 58.10 m, and was significantly influenced by advertising sign category, character count and speed.

The role of peripheral vision in vertical road sign identification and discrimination.

The role of peripheral vision in road sign identification and discrimination was investigated in two studies. Peripheral vision plays an important role in road signs perception due to their lateral positioning. In the first study 20 participants identified road signs presented at five levels of horizontal eccentricity (1.1°-12.4°), and two levels of vertical eccentricity (0°-2.5°). In the second study road sign discrimination was tested in a same-different discrimination task. The first study showed that a vertical offset of 2.5° degraded proportion correct rate by 9%. Proportion correct rate decreased from 79% to 41% in the transition from 1.1° to 12.4° of horizontal offset. The second study showed an accurate discrimination for road signs presented within a horizontal offset of 6.4°. Road signs with angular shapes and prominent vertexes as triangular or cross signs were better identified in peripheral vision than signs with more compact shapes (circular signs). Practitioner summary: Vertical road signs, due to their lateral positioning, are often perceived in peripheral vision. Horizontal and vertical eccentricity negatively impacts the driver's ability to correctly identify and discriminate traffic signs. The use of singular shapes and a design with simple pictograms and large contrasting areas strongly facilitate road sign perception in peripheral vision.

Linear Perspective and Framing in the Vista Paradox.

The vista paradox is the illusion in which an object seen through an aperture appears to shrink in apparent size as the observer approaches the aperture. In four studies, we tested the effect of framing and fixating on the target object. The first two studies assessed the vista paradox in a large scale naturalistic setting in which a 162.26 -m long corridor was aligned to a 97.2 -m high tower (1,407 m away). In the first study, the results showed, for each 16 m section, a mean 9.95% tower enlargement in the moving backward condition, and a mean 11.62% shrinking in the moving forward condition. In the second study, participants had to compensate perceived width change adjusting the focal length of a photographic zoom lens. The results showed, for each 16 m section, a mean change in optical size of 26.37% in the experimental condition, and of 53.08% in the control condition. In the third study, we presented an identical vertical rectangle inserted within five frames differing in size. In the fourth study, linear perspective was added to the images. The results showed that both frame size and linear perspective cues were critical factors for the vista paradox illusion.

Reflective Tape Applied to Bicycle Frame and Conspicuity Enhancement at Night.

OBJECTIVE: Four studies were conducted to assess bicyclist conspicuity enhancement at night by the application of reflective tape (ECE/ONU 104) to the bicycle rear frame and to pedal cranks. BACKGROUND: Previous studies have tested the benefits of reflective markings applied to bicyclist clothing. Reflective jackets however need to be available and worn while reflective markings enhance conspicuity without any active behavior by the bicyclist. METHOD: In the first study, reflective tape was applied to the rear frame. Detection distance was compared in four conditions: control, rear red reflector, high visibility jacket, and reflective tape. In the second study, the same conditions were studied with night street lighting on and off. In the third study, detection and recognition distances were evaluated in rainy conditions. In the fourth study, visibility was assessed with the reflective tape applied to pedal cranks. RESULTS: In the first study, the application of reflective markings resulted in a detection distance of 168.28 m. In the second study, the detection distance with reflective markings was 229.74 m with public street light on and 256.41 m with public street light off. In rainy conditions, detection distance using the reflective markings was 146.47 m. Reflective tape applied to pedal cracks resulted in a detection distance of 168.60 m. CONCLUSION: Reflective tape applied to the rear bicycle frame can considerably increase bicyclist conspicuity and safety at night. APPLICATION: Reflective tape is highly recommended to complement anterior and rear lights in bicycle riding at night.

Geometrical Factors in the Perception of Sacredness.

Geometrical and environmental factors in the perception of sacredness, dominance, and attractiveness were assessed by 137 participants in five tests. In the first test, a two-alternative forced-choice paradigm was used to test the perception of sacredness, dominance, and attractiveness in geometrical figures differing in shape, verticality, size, and symmetry. Verticality, symmetry, and convexity were found to be important factors in the perception of sacredness. In the second test, participants had to mark the point inside geometrical surfaces that was perceived as most sacred, dominant, and attractive. The top and the center areas were associated with sacredness, dominance, and attractiveness. In the third test, peaks and elevated regions in landscapes were evaluated as more sacred, dominant, and attractive than valley regions. In the fourth test, three figures sharing the same area but differing in horizontal and vertical orientation were evaluated on eight scales. The vertical figure was evaluated as more sacred, dominant, and attractive than the horizontal figure. The fifth test demonstrated the significant role of space seclusion and inaccessibility in the perception of sacredness. Geometrical factors in the perception of sacredness, dominance, and attractiveness were largely overlapping.