[Training of residents in obstetrics and gynecology: Assessment of an educational program including formal lectures and practical sessions using simulators]. / Formation des internes de gynécologie obstétrique : évaluation d'un programme pédagogique intégrant cours théoriques et sessions pratiques sur simulateurs.

OBJECTIVES: Evaluate an educational program in the training of residents in gynecology-obstetrics (GO) with a theory session and a practical session on simulators and analyze their learning curve. METHODS: Single-center prospective study, at the university hospital (CHU). Two-day sessions were leaded in April and July 2013. An evaluation on obstetric and gynecological surgery simulator was available to all residents. Theoretical knowledge principles of obstetrics were evaluated early in the session and after formal lectures was taught to them. At the end of the first session, a satisfaction questionnaire was distributed to all participants. RESULTS: Twenty residents agreed to participate to the training sessions. Evaluation of theoretical knowledge: at the end of the session, the residents obtained a significant improvement in their score on 20 testing knowledge. Obstetrical simulator: a statistically significant improvement in scores on assessments simulator vaginal delivery between the first and second session. Subjectively, a larger increase feeling was seen after breech delivery simulation than for the cephalic vaginal delivery. However, the confidence level of the resident after breech delivery simulation has not been improved at the end of the second session. Simulation in gynecological surgery: a trend towards improvement in the time realized on the peg-transfer between the two sessions was noted. In the virtual simulation, no statistically significant differences showed, no improvement for in salpingectomy's time. Subjectively, the residents felt an increase in the precision of their gesture. Satisfaction: All residents have tried the whole program. They considered the pursuit of these sessions on simulators was necessary and even mandatory. CONCLUSION: The approach chosen by this structured educational program allowed a progression for the residents, both objectively and subjectively. This simulation program type for the resident's training would use this tool in assessing their skills and develop learning curves.

Recombinant human FVIIa for reducing the need for invasive second-line therapies in severe refractory postpartum hemorrhage: a multicenter, randomized, open controlled trial.

BACKGROUND: Case reports on recombinant human factor VIIa (rhuFVIIa) use in women with severe postpartum hemorrhage (PPH) showed encouraging results, but no randomized controlled trial (RCT) is available. PATIENTS AND METHODS: Eighty-four women with severe PPH unresponsive to uterotonics were randomized to receive one early single rhuFVIIa infusion (n = 42) or standard care (no rhuFVIIa; n = 42). The primary efficacy outcome measure was the reduction of the need for specific second-line therapies, such as interventional hemostatic procedures, for blood loss and transfusions. The primary safety outcome measure was the number of deaths and thrombotic events during the 5 days following rhuFVIIa infusion. RESULTS: rhuFVIIa was associated with a reduction in the number of patients who needed second-line therapies compared with controls (standard care). Specifically, 39/42 (93%) patients in the standard care arm received second-line therapies and 22/42 (52%) patients in the rhuFVIIa arm (absolute difference, 41%; range, 18-63%; relative risk RR, 0.56 [0.42-0.76]). The delivery mode (vaginal or Cesarean section) did not affect the primary outcome. No death occurred. Two venous thrombotic events were recorded in the rhuFVIIa arm: one ovarian vein thrombosis and one deep vein thrombosis with a non-severe pulmonary embolism. CONCLUSION: This open RCT in women with severe PPH refractory to uterotonics shows that rhuFVIIa reduces the need for specific second-line therapies in about one in three patients, with the occurrence of non-fatal venous thrombotic events in one in 20 patients.

[Role of imaging in cases of bleeding after spontaneous or induced abortion]. / Rôle de l'imagerie en cas de métrorragies après fausse couche spontanée ou interruption volontaire de grossesse.

Post-abortum hemorrhage is a common clinical situation and etiological diagnosis has to be made early to avoid further complications such as persistent bleeding, infection or adhesions that may compromise fertility. Retained products of conception are the most common cause of bleeding. The diagnosis is based on endovaginal color doppler ultrasound showing a thickened and hypervascular endometrial echo-complex extending partly to the myometrium. The main differential diagnosis is uterine arteriovenous malformation, mostly iatrogenic. Diagnosis is based on the presence of myometrial confluent cystic lesions filled with turbulent and high velocity arterial flow on endovaginal color doppler ultrasound. The distinction between these two etiologies of post-abortion bleeding is mandatory because of totally different treatment: typically medical and/or surgical in case of retained products of conception and by selective arterial embolization in case of vascular malformation.

[Diagnosis of postpartum abdominal pain: about a rare case of portal vein thrombosis]. / Orientation diagnostique devant des douleurs abdominales du post-partum: à propos d'un cas rare de thrombose portale.

We report the management of patient with acute abdominal pain in the immediate post-partum caesarean section performed in the context of preeclampsia. Acute portal vein thrombosis is diagnosed, in a patient with no personal or family history of venous thrombosis. Blood tests showed a protein C and S deficiencies. Portal vein thrombosis is an extremely rare occurrence in pregnancy and postpartum.

[Instrumental extractions using Thierry's spatulas: evaluation of the learning curve]. / Évaluation de la courbe d'apprentissage des extractions par spatules de Thierry.

OBJECTIVES: To determine the learning curve of fetal extractions with Thierry's spatulas. PATIENTS AND METHODS: Single-center prospective study following the progress of six residents in obstetrics and gynecology in learning fetal extractions by Thierry's spatulas. The instrumental extractions procedures performed by the residents were evaluated by the senior obstetrician on call according to a validated scoring rubric. In parallel, the residents would fill out a questionnaire on their own perception of their abilities at the time of the procedure. RESULTS: The six residents participated in 160 extractions using Thierry's spatulas between November and May 2011. Sixty-three (39.6%) were evaluated, i.e. an average number of 12±6 extractions per resident. After validating respectively 0, 1, 2 or 3 semesters, the mean global assessment scores (graded out of 5) obtained by the residents were 3.54, 3.18, 4.43 and 4.61. The overall average score was significantly higher when the resident participated in more than 20 extractions before the studied extraction (4.0 vs. 3.7, P<0.001). After attending more than 20 extractions, no resident had obtained the maximum evaluation score of 5/5 nor was deemed capable of performing extractions without supervision. DISCUSSION AND CONCLUSIONS: Learning extractions with Thierry's spatulas, including an objective assessment by senior doctors and a self-assessment by the residents, is a constant process over the first six months of training. Specific training simulator should be developed to enable students to achieve a threshold number of extractions, ensuring the safety of the procedure in the birthing rooms.

Evaluation of single incision laparoscopic surgery "low-fidelity" simulation training.

GOAL: Evaluate the learning curve of SILS (Single Incision Laparoscopic Surgery) on a simulator, based on two tests of the Fundamentals of Laparoscopic Surgery certification program (FLS(®)), in a population of novice medical students, and compare their performance to those of senior surgeons practicing both "conventional" laparoscopic surgery and SILS. MATERIALS AND METHODS: Monocentric prospective study with four groups: two groups of novice medical students, and two groups of senior surgeons. The two FLS(®) tests used for evaluation were the peg transfer and the precision cutting tasks. RESULTS: No statistically significant differences were found between the novice groups, whether they started their first session directly, or immediately after watching a video presentation of the exercises. For the novice medical students, the average completion time of both tests improved significantly between the first and the sixth sessions with a short learning curve. The group of experienced seniors performed fastest in both tests. For the peg transfer task, the skills of the novice medical students were comparable to those of non-experienced seniors after the 4th session and improved after 6 sessions (P=0.017). For the precision cutting task, the average timing of the novice group became better than that of the non-experienced seniors, starting from the third session. CONCLUSIONS: FLS(®) "low fidelity" simulator training is effective for the training of novice medical students. To minimize the risk of technical errors, novice medical students should practice a minimum of six simulator-training sessions before starting their practical learning of SILS in the operating room.

[Vaginal metastasis revealing an adenocarcinoma of the transverse colon]. / Métastase vaginale révélatrice d'un adénocarcinome du côlon transverse.

Secondary localization to vagina had a severe prognosis, suggesting a disseminated metatastic disease. We report the case of prevalent vaginal metastasis of adenocarcinoma of the transverse colon. A 65 years old patient has consulted for vaginal mass. After delayed diagnosis, she presented with disseminated metastatic disease with peritoneal carcinomatosis. After neoadjuvant chemotherapy, the following treatment consisted of complete cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy and vaginal adjuvant radiotherapy. No recurrence occurred after one year. Vaginal metastasis of colon cancer are rare. The dark prognosis might justify a systematic gynecological examination of women presenting colorectal neoplasy.

[Umbilical vein varix thrombosis]. / Thrombose d'un anévrysme de la veine ombilicale.

Umbilical vein varix is a rare entity, which can lead to in utero fetal death. We report the case of a women diagnosed with umbilical vein varix on the 31st week of amenorrhea. A close follow-up and the early diagnosis of umbilical vein thrombosis have allowed the patient to give birth to a healthy newborn on the 34th week of amenorrhea. Improved ultrasound imaging as well as systematic study of fetal annexes lead to an early diagnosis of umbilical vein abnormalities. This allows a close follow-up and an early diagnosis of fetal life-threatening complications.

[Conservative treatment of a compressive adenomyosis: report of a case]. / Traitement conservateur d'une adénomyose compressive: à propos d'un cas.

Adenomyosis is frequent, mostly asymptomatic. A hypertrophy of the smooth muscular cells around ectopic endometrial glands might induce a compressive syndrome. We report the case of an embolization of a voluminous adenomyosic uterus which has triggered venous iliac's compression in patient refusing surgery. This treatment was efficient in reduction of uterin volume, without recurrence after three years. MR imaging is the exam of choice particularly when diagnosis is still uncertain and allows a non-invasive and good evaluation, and follow-up. Embolization is not actually recommended. But, it appears to be efficient, relatively safe and contributes to the conservation of fertility.

[Prolactinoma: from quest of pregnancy to delivery]. / Adénome à prolactine : du désir de grossesse à l'accouchement.

Prolactinoma is the most frequent hormone-secreting pituitary tumor (100 for million patients) and a major cause of both female and male reproductive function disorders. Physician, gynecologist, urologist and sexologist can face this situation during their career. As part of the fertility restoration, treatment gives very satisfactory results. With adequate management, most women are expected to achieve successful pregnancies. The natural history of these tumors during pregnancy depends on their size with a risk of a clinically relevant estimate between 5 to 30 %. Their management is complex, requiring finding balance between effects of pregnancy on tumor growth and potential risks of overtreatment on fetal development. The aim of this study is to discuss the management of prolactinoma on woman before, during and after pregnancy, and to evaluate the medical and surgical alternatives regarding the actual literature.

First case report of an acute genotype 3 hepatitis E infected pregnant woman living in South-Eastern France.

In European countries, epidemiology of hepatitis E virus (HEV) infection is not well known. Although, seroprevalence of HEV Immunoglobulin G reached a few percent in European women, no acute hepatitis E during pregnancy has been described so far. Here, we report a case of an autochthonous HEV genotype 3 infection in a 41-years-old pregnant woman living in a non-endemic country. The acute hepatitis had a spontaneous good outcome for the mother and the child. In non-endemic areas where Hepatitis E infections are emerging, unexplained cytolysis, whatever its level, in a pregnant woman could be investigated for HEV, using biological molecular and serology tools.

[A recurrent cutaneous fistula secondary to the migration of a clip: report of a complication of tubal sterilization]. / Fistule cutanée récidivante secondaire à la migration d'un clip de Filshie : une complication de stérilisation tubaire.

The tubal sterilization is a safe and recognized sterilization method. The complications of this intervention are rare and mainly concern failure of surgical procedure or clip migrations. We report the first case of spontaneous migration of a clip behind the psoas followed by a chronic osteitis.

Gran quemado experiencia en una unidad de cuidados intensivos pediatricos: evolución de la morbimortalidad / Great burned pediatric patient: experience in a pediatric intensive care unit

Introducción: En 1974 Garcés y Artigas, publican un score de índice de gravedad (IG) predictivo de evolución y mortalidad. Este índice, modificado por edad, es recomendado en las guías clínicas del Ministerio de Salud de Chile. Objetivos: Relacionar la mortalidad esperada y real según IG e identificar factores asociados entre IG elevado y mayor gravedad o evolución. Materiales y Métodos: Análisis retrospectivo de fichas clínicas de pacientes quemados ingresados a la Unidad de Paciente Crítico (UPC) del Hospital Roberto del Río entre julio de 2005 a noviembre de 2007. Resultados: En el período estudiado egresaron 1.161 pacientes, 30 eran quemados, 22 (73 por ciento) tenían IG sobre 70. El porcentaje de superficie corporal total quemada (SQC) promedio fue 32 (14-75). El IG osciló entre 71 y 205. Un total de 13 pacientes presentaron IG 70-100, 8 entre 101 y 150, 1 (4,5 por ciento) paciente ingresó con IG >150. Los pacientes con IG 100-150 presentaron más complicaciones y mayor estadía en UPC, que aquellos pacientes con IG <100 (p<0,02). Letalidad global fue de 4,5 por ciento. Conclusiones: El IG en pacientes críticos (IG 101-150) sobrestimó la mortalidad real en esta serie (p <0,05), aunque el número de casos es pequeño. La mayor gravedad según IG se asoció a estadías más prolongadas y mayor incidencia de complicaciones.

Introduction: In 1974, Garcés and Artigas published a severity index (SI), predictor of mortality trends. This index, modified by age, is recommended till now by the clinical guidelines of the Chilean Ministry of Health. Objectives: Link the real and expected mortality based on the calculated SI score in great burned pediatric patients. Identify a relation between higher SI score and outcome. Materials and Methods: Retrospective analysis of medical records of burned patients admitted to the Pediatric Intensive Care Unit(PICU) Roberto del Río Hospital between July 2005 to November2007. Results: Among 1161 PICU admissions, 30 were burned patients. The ranged total burned surface area (TBSA) was 14 to 75. 22 (73 percent) had a SI above 70. The SI averaged 115 (71-205), 13 (59 percent) between 70 and 100, 8 (36.3 percent) between 101 and 150, 1 (4.5 percent) patient was admitted with SI > 150. Patients with SI between100-150 had a higher incidence of complications and length of stay in the PICU, compared with patients with SI less than100. One patient died. Conclusions: The SI in patients categorized as critical (SI 101-150) overestimated the real mortality in this series (p <0.05), although the number of cases is small. SI associated severity was related to a higher incidence of complications and longer PICU stay.

[Management of delivery after previous caesarean section in France]. / État des lieux en France de la prise en charge des utérus cicatriciels.

UNLABELLED: Since many years, caesarean section rate has increased in France. The purpose of the study was to compare the different French obstetrical attitudes after a prior caesarean section. METHODS: This retrospective study was performed between March 2008 and February 2010. We collected the answers of a majority of maternity centres contacted with an anonymous questionnaire sent by postal, electronic, fax mails. RESULTS: Of the 194 maternity centres which have responded, there were 37 university hospitals and 312 obstetricians: 75.6% of them worked in public sector and 19.2% in private one. The use of a protocol is registered for 29.6% of questioned obstetricians (only 14% in private sector, P=0.002). Pelvimetry is consistently proposed by 44.4% of them. A trial of labour in case of breech presentation is proposed by 20% of questioned obstetricians, with twin pregnancies by 23.7%, with two prior low-transverse caesarean delivery by 12%, most in university hospitals, level III, with more than 1500 births per year. Induction of labour is allowed by 73.9% of questioned obstetricians, by ocytocics as a majority. Induction by Prostine(®) is underwent by 14.5% of them (24.6% in academic centres, P=0.01), by Propess(®) by 19.2% of them (30% in university hospitals, P=0.008). CONCLUSION: These findings showed that the management of delivery after caesarean section is associated with statistically significant differences in France. These informations are relevant for counselling French obstetrical practices.

Normal serum concentrations of anti-Mullerian hormone in a population of fertile women in their first trimester of pregnancy.

BACKGROUND: Anti-Müllerian hormone (AMH) levels are used to evaluate the ovarian reserve. AMH serum concentrations have recently been studied among women attending fertility centers, and among women with regular menstrual cycles but normative values have not been established among fertile women: the objective of this study was to establish those values. METHODS: This prospective cross-sectional study included 340 healthy fertile women attending a single centre, aged between 15 and 50 years. The women were all in the first trimester of pregnancy, had no serious medical history and attended the abortion service of the University Hospital of Nice, France. Serum AMH was measured using a second-generation AMH enzyme-linked immunosorbent assay. RESULTS: Median AMH concentration was 2.42 ng/ml (25-75 percentiles 1.19-4.12). The relationship between AMH concentration and age was best fitted by a polynomial function. Serum AMH values rose until age 29 years and then showed a significant decline (R(2)= 0.289, P < 0.001). Normative values for serum AMH were established in different age groups between 15 and 50 years. CONCLUSIONS: We established the normative values for serum AMH in a population of French fertile women in their first trimester of pregnancy.

[Is there a real place for robotics in proximal tubal surgery?]. / Y a-t-il une réelle place à la robotique pour la chirurgie tubaire proximale ?

Tubal surgery requires a fine gesture. Its complexity, the difficulty of learning, the low recognition at the time of T2A and the success of Assisted Reproductive Technology (ART) could have announced the obituary of this surgery. However, in well-trained hands, tubal surgery avoids unnecessary ARTs and even allows pregnancies when medical technology fails. In this context, it is legitimate to ask whether the contribution of new technologies in the operating theatre, such as robotic surgery, can lead to an easy realization of microsurgery on a particularly complex portion of Fallopian tubes: the proximal segment.

Prospective study on the prevalence and associated risk factors of cryptorchidism in 6246 newborn boys from Nice area, France.

To assess the incidence and risk factors of cryptorchidism in Nice area. A 3-year prospective study was conducted at two maternity wards involving neonatal screening of boys born ≥34weeks of amenorrhoea. Methodology was strict with examination at birth, 3 and 12months by the same paediatrician. Two strictly matched controls were included for each case. Information on child and parents (medical history, pregnancy, lifestyle) was recorded using medical chart and self-administered questionnaires. A total of 102 of 6246 boys were born with cryptorchidism (prevalence 1.6%, 95 included). Half of them were still cryptorchid at three and 12months with, however, 10% of secondary re-ascent (recurrent cryptorchidism) at 12months, justifying long-term follow-up. Cryptorchidism at birth was associated with instrumental delivery, inguinal hernia and urogenital malformations, particularly micropenis and paternal history of cryptorchidism. Our results suggest that maternal exposure to anti-rust or phthalates could be a risk factor, whereas eating fruits daily seemed somewhat protective. Prevalence of cryptorchidism in our area is on the lower bracket compared with other countries, and is associated with both familial and environmental risk factors.

[Rate of cervical intraepithelial neoplasia before HPV vaccination, Alpes-Maritimes 2006]. / Taux observés des CIN en 2006 avant la vaccination anti-HPV parmi les résidentes des Alpes-Maritimes.

OBJECTIVE: The incidence rate of uterix cervical cancer in 2006 in the Alpes-Maritime was 6.2 per 100,000 women. The existence of curable precancerous lesions and an effective vaccine make it a target cancer in public health. The objective of this study was to establish prevalence of cervical intraepithelial neoplasia in 2006 before the campaign of vaccination against HPV. PATIENTS AND METHODS: Retrospective study including all histological samples (smears excluded) of the cervix, performed in 2006 with a diagnosis of intraepithelial Neoplasia among residents of the Alpes-Maritimes. Extraction codes' corresponding was carried out by all pathology laboratories located in the Alpes-Maritimes and around. A comparison of codes with pathology reports was performed for 11.4% of random samples. RESULTS: This study included 2066 patients aged 16 to 88 years. The average age was 37.3 years (±12.3). Among these patients, most pejorative intraepithelial neoplasia lesion was CIN 1, CIN 2, CIN 3, respectively for 941, 380 and 375 patients. Prevalence of CIN 2 among women 20 to 25 years old was similar to rates seen in 35 to 39 years old (166.5 per 100,000) and the rate of CIN 3 was similar to that seen in 45 to 49 years (78.1 per 100,000). DISCUSSION AND CONCLUSION: Rates of CIN for the entire female population of the Alpes-Maritimes in 2006 has been established. The results observed in women aged less than 25 years old will be useful for comparison after the campaign of vaccination against HPV.