Comparison of tolerability and adverse symptoms in oxcarbazepine and carbamazepine in the treatment of trigeminal neuralgia and neuralgiform headaches using the Liverpool Adverse Events Profile (AEP).

BACKGROUND: Adverse effects of drugs are poorly reported in the literature . The aim of this study was to examine the frequency of the adverse events of antiepileptic drugs (AEDs), in particular carbamazepine (CBZ) and oxcarbazepine (OXC) in patients with neuralgiform pain using the psychometrically tested Liverpool Adverse Events Profile (AEP) and provide clinicians with guidance as to when to change management. METHODS: The study was conducted as a clinical prospective observational exploratory survey of 161 patients with idiopathic trigeminal neuralgia and its variants of whom 79 were on montherapy who attended a specialist clinic in a London teaching hospital over a period of 2 years. At each consultation they completed the AEP questionnaire which provides scores of 19-76 with toxic levels being considered as scores >45. RESULTS: The most common significant side effects were: tiredness 31.3 %, sleepiness 18.2 %, memory problems 22.7 %, disturbed sleep 14.1 %, difficulty concentrating and unsteadiness 11.6 %. Females reported significantly more side effects than males. Potential toxic dose for females is approximately 1200 mg of OXC and 800 mg of CBZ and1800mg of OXC and 1200 mg of CBZ for males. CONCLUSIONS: CBZ and OXC are associated with cognitive impairment. Pharmacokinetic and pharmacodynamic differences are likely to be the reason for gender differences in reporting side effects. Potentially, females need to be prescribed lower dosages in view of their tendency to reach toxic levels at lower dosages. Side effects associated with AED could be a major reason for changing drugs or to consider a referral for surgical management.

Dietary fats and 16-year coronary heart disease mortality in a cohort of men and women in Great Britain.

OBJECTIVE: The paper aims to investigate the relationships of dietary fats to subsequent coronary heart disease (CHD) mortality in men and women while taking account of other CHD-related behaviours. DESIGN: A cohort of randomly selected men and women were interviewed in 1984-85 and monitored subsequently for 16 y for deaths. The interview covered health, health-related behaviours, physical measurements, socio-demographic details and a dietary questionnaire. Appropriate exclusions left 1225 men and 1451 women aged 40-75 with 98 and 57 CHD deaths, respectively. Saturated, polyunsaturated and total fat intakes were estimated. SETTING: The sample was randomly selected from households in Great Britain. The interviews took place in participants' own homes. RESULTS: Not consuming alcohol, smoking, not exercising and being socially disadvantaged were related to high saturated fat intake and CHD death. Cox survival analyses adjusting for these factors found that a level of saturated fat 100 g per week higher corresponded to a relative risk for CHD death for men of 1.00 (0.86-1.18) and 1.40 (1.09-1.79) for women. This difference between the effects of saturated fat in men and women was statistically significant (P=0.019). Results are also reported for total fat and the relative effects of polyunsaturated and saturated fats. CONCLUSIONS: Strong evidence was found for the within cohort relationship of dietary fat and CHD death in women while no evidence was found for a relationship in men. Possible explanations for this are discussed.

Social and demographic factors predictive of change over seven years in CHD-related behaviours in men aged 18-49 years.

It is possible that the relationship of social status to coronary heart disease is partly mediated through health-related behaviours that have been found to relate to both social status and CHD. Changes in certain health-related behaviours are known to lead to changes in CHD incidence. What are the characteristics of men who change or do not change these behaviours and their subsequent chances of CHD? This study aims to relate changes in men's CHD-related behaviours over a seven-year period to their social and demographic characteristics.A survey was carried out on a random sample of adults in Great Britain in 1984-85 and the equivalent information was obtained again on those participants who were re-interviewed seven years later in 1991-92. Results are presented for the 582 men aged 18-34 and the 584 men aged 35-49 at the first interview who were re-interviewed seven years later. Changes over the seven years in smoking, saturated fat intake, alcohol consumption and exercise were related to social and demographic factors. The two age groups showed broadly similar patterns of behaviour. In both age groups, those who continued with or took up a low fat diet and/or exercise were more likely to be in a higher social class, in employment, to live in private housing and to have more educational qualifications. For the younger men only, those in private housing were more likely to reduce the amount they smoked. Other findings are also reported. The findings suggest that those people who are in less advantageous social and economic situations are less likely to change to a more healthy lifestyle and so should be a focus for health education.

Investigation of validity of closed questions in a survey of British South Asian and white populations.

OBJECTIVES: The paper concerns the validity of closed-format questions in an interview-based population survey and focuses on a comparison of South Asian and white respondents. METHOD: A two-part interview consisting of open, respondent-centred questions followed by closed questions taken from a large-scale interview-based health survey was carried out with 15 persons from white and 14 from South Asian communities resident in the UK. Interviewees' views of their stays in hospital was the focus. RESULTS: The two-part interview was found to provide a broadly satisfactory method for the investigation of validity although a limitation was recognised. Twenty-nine per cent of the variation in response to a closed question on 'overall satisfaction' was predictable from views expressed in the open interview. The views of both groups, as expressed in the open interview, were inadequately represented by the closed questions. This appeared to be especially true for the South Asian sample. The validity of the closed question appeared greater for white than for South Asian interviewees. CONCLUSIONS: It is concluded that when designing and piloting health surveys consideration should be given to members of all communities to be included in the survey.

Estimating food and nutrient intake from food frequency questionnaire data by reference to a standard weighed diet survey.

INTRODUCTION: The food frequency questionnaire is widely regarded as more appropriate for ranking and grouping individuals according to levels of nutrient intake than for estimating absolute nutrient amounts. AIMS: To develop a method for estimation of amount of nutrient intake from food frequency questionnaires by reference to an independent weighed dietary survey. METHOD: Six stages of the method are described and illustrated in the estimation of total dietary fat from the 1984-85 Health and Lifestyle Survey using the 1986-87 Dietary and Nutritional Survey of British Adults as the reference standard. RESULTS: Several points support the validity of the approach although limitations are identified.

The effects of time delay and temperature on capillary blood gas measurements.

Monitoring of blood gas measurements is an important part of the assessment of patients with chronic lung disease. Increasingly, this is being done in the patients' homes by specialist nurses. This makes it important to know the effect of time delay and storage temperature on the reliability of capillary blood gas analysis results. In this study, the effect of a delay of 1 and 2 h and of storage at both room temperature and in ice, on blood stored in glass capillary tubes was investigated. Samples, initially taken from the earlobes, were transferred to glass capillary tubes and used to provide duplicate initial samples for immediate analysis, and then single samples at 1 and 2 h stored at room temperature or in ice. The duplicate baseline measurements showed good reproducibility. There was a small, but statistically significant, increase in PCO2 when samples were stored in capillaries at room temperature, or in ice, both at 1 and 2 h. Small changes in PO2 were not statistically significant, either in ice or at room temperature. None of the changes was considered to be sufficient to be of clinical significance, thus supporting the use of capillary blood sampling even when there might be a delay of 1-2 h and transport is at room temperature, as might be the case when taking domiciliary samples.

Antenatal perineal massage and subsequent perineal outcomes: a randomised controlled trial.

OBJECTIVE: To study the effects of antenatal perineal massage on subsequent perineal outcomes at delivery. DESIGN: A randomised, single-blind prospective study. SETTING: Department of Obstetrics and Gynaecology, Watford General Hospital. PARTICIPANTS: Eight hundred and sixty-one nulliparous women with singleton pregnancy and fulfilling criteria for entry to the trial between June 1994 and October 1995. RESULTS: Comparison of the group assigned to massage with the group assigned to no massage showed a reduction of 6.1% in second or third degree tears or episiotomies. This corresponded to tear rates of 75.1% in the no-massage group and 69.0% in the massage group (P = 0.073). There was a corresponding reduction in instrumental deliveries from 40.9% to 34.6% (P = 0.094). After adjustment for mother's age and infant's birthweight these reductions achieved statistical significance (P = 0.024 and P = 0.034, respectively). Analysis by mother's age showed a much larger benefit due to massage in those aged 30 and over and a smaller benefit in those under 30. CONCLUSION: Antenatal perineal massage appears to have some benefit in reducing second or third degree tears or episiotomies and instrumental deliveries. This effect was stronger in the age group 30 years and above.