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1.
Pediatr Transplant ; 28(1): e14537, 2024 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-37550267

RESUMO

BACKGROUND: Endovascular management of portal vein thrombosis (PVT) is challenging. Transsplenic access (TSA) is growing as an access option to the portal system but with higher rates of bleeding complications. The aim of this article is to evaluate the efficacy and safety of transsplenic portal vein recanalization (PVR) using a metallic stent after pediatric liver transplantation. MATERIALS AND METHODS: This is a retrospective review of 15 patients with chronic PVT who underwent PVR via TSA between February 2016 and December 2020. Two children who had undergone catheterization of a mesenteric vein tributary by minilaparotomy were excluded from the patency analysis but included in the splenic access analysis. The technical and clinical success of PVR and complications related to the procedure via TSA were evaluated. RESULTS: Thirteen children with PVT were treated primarily using the TSA. The mean age was 4.1 years (range, 1.5-13.7 years), and the most common clinical presentation was hypersplenism (60%). Technically successful PVR was performed in 11/13 (84.6%) children, and clinical success was achieved in 9/11 (81.8%) children. No major complications were observed, and one child presented moderate pain in the TSA (from a total of 17 TSA). The median follow-up was 48.2 months. The median primary patency was 9.9 months. Primary patency in the first 4 years was 75%, and primary assisted patency was 100% in the follow-up period. CONCLUSIONS: Transsplenic PVR is a safe and effective method for the treatment of PVT after pediatric liver transplantation.


Assuntos
Hepatopatias , Transplante de Fígado , Trombose Venosa , Humanos , Criança , Pré-Escolar , Transplante de Fígado/efeitos adversos , Veia Porta/cirurgia , Resultado do Tratamento , Hepatopatias/complicações , Trombose Venosa/etiologia , Trombose Venosa/cirurgia , Estudos Retrospectivos
2.
Microorganisms ; 10(5)2022 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-35630472

RESUMO

Background: The COVID-19 infection has received the attention of the scientific community due to its respiratory manifestations and association with evolution to severe acute respiratory syndrome (SARS-CoV-2). There are few studies characterizing SARS-CoV-2 in pediatric immunocompromised patients, such as liver transplanted patients. The aim of this study was to analyze the outcomes of the largest cohort of pediatric liver transplant recipients (PLTR) from a single center in Brazil who were infected with COVID-19 during the pandemic. Methods: Cross-sectional study. Primary outcomes: COVID-19 severity. The Cox regression method was used to determine independent predictors associated with the outcomes. Patients were divided into two groups according to the severity of COVID-19 disease: moderate−severe COVID and asymptomatic−mild COVID. Results: Patients categorized as having moderate−severe COVID-19 were younger (12.6 months vs. 82.1 months, p = 0.03), had a higher prevalence of transplantation from a deceased donor (50% vs. 4.3%, p = 0.02), and had a higher prevalence of COVID infection within 6 months after liver transplantation (LT) (75% vs. 5.7%, p = 0.002). The independent predictor of COVID-19 severity identified in the multivariate analysis was COVID-19 infection <6 months after LT (HR = 0.001, 95% CI = 0.001−0.67, p = 0.03). Conclusion: The time interval of less than 6 months between COVID-19 infection and LT was the only predictor of disease severity in pediatric patients who underwent liver transplantation.

3.
J Pediatr Gastroenterol Nutr ; 72(5): 674-676, 2021 05 01.
Artigo em Inglês | MEDLINE | ID: mdl-33661244

RESUMO

ABSTRACT: A case of low-γ-glutamyltranspetidase cholestasis associated with ubiquitin-specific peptidase 53 (USP53) gene mutation in a Brazilian child is described. Transient jaundice and hypocholia started at the age of 10 days. Liver enzymes, total bilirubin, and total bile acids were elevated at presentation. During follow-up, he developed cholelithiasis treated with cholecystectomy, and an intracranial hemorrhage resolved with full recovery. At last, evaluation at the age of 18 months, he was not jaundiced and had normal liver tests, but experienced from moderate pruritus despite treatment with rifampicin and ursodeoxycholic acid. A genetic study revealed novel homozygous mutations c.1687_1688delinsC p.Ser563Profs∗25 in the USP53 gene. His parents carried the same heterozygous mutation in the USP53 gene.


Assuntos
Colestase Intra-Hepática , Colestase , Brasil , Criança , Colestase/genética , Humanos , Lactente , Masculino , Mutação , Proteases Específicas de Ubiquitina/genética
4.
Rev Bras Ortop (Sao Paulo) ; 55(5): 605-611, 2020 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-33093725

RESUMO

Objective The present paper aims to present results from radiographic evaluations of patients with extra-articular distal radius fractures submitted to percutaneous fixation with a 3.5 mm solid screw. Methods Analytical, descriptive and retrospective case series of 16 patients with evaluation of the radiographic parameters. Results The average age of the study population was 46.5 years old (25-60 years old); 81.25% of the sample was female. The average time until surgery was 8.8 days (4-14 days). The mean preprocedural volar tilt was - 7.41° (-23.48°-5.29°, standard deviation [SD] ± 6.59°). The mean volar tilt immediately after surgery was 5.93° (SD ± 6.23°, p < 0.001). There was no statistical difference in volar tilt values after 6 months of follow-up. The mean preprocedural radial height was 4.13 mm (-7.8 mm-9.5 mm, SD ± 5.06 mm). There was a statistically significant increase at the immediate postoperative period to 10.04 mm ( p = 0.002), and a significant reduction at 6 months to 9.55 mm ( p = 0.012). The consolidation rate was 100% with the technique used, with a minimal complication rate. No patient had infection or required a reoperation. Conclusion The technique was effective for the treatment of distal radial extra-articular fractures at 6 months, with a low complication rate; radiographic parameters values were acceptable and close to the anatomical ones.

5.
Rev. bras. ortop ; 55(5): 605-611, Sept.-Oct. 2020. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1144212

RESUMO

Abstract Objective The present paper aims to present results from radiographic evaluations of patients with extra-articular distal radius fractures submitted to percutaneous fixation with a 3.5 mm solid screw. Methods Analytical, descriptive and retrospective case series of 16 patients with evaluation of the radiographic parameters. Results The average age of the study population was 46.5 years old (25-60 years old); 81.25% of the sample was female. The average time until surgery was 8.8 days (4-14 days). The mean preprocedural volar tilt was - 7.41° (−23.48°-5.29°, standard deviation [SD] ± 6.59°). The mean volar tilt immediately after surgery was 5.93° (SD ± 6.23°, p< 0.001). There was no statistical difference in volar tilt values after 6 months of follow-up. The mean preprocedural radial height was 4.13 mm (−7.8 mm-9.5 mm, SD ± 5.06 mm). There was a statistically significant increase at the immediate postoperative period to 10.04 mm (p= 0.002), and a significant reduction at 6 months to 9.55 mm (p= 0.012). The consolidation rate was 100% with the technique used, with a minimal complication rate. No patient had infection or required a reoperation. Conclusion The technique was effective for the treatment of distal radial extra-articular fractures at 6 months, with a low complication rate; radiographic parameters values were acceptable and close to the anatomical ones.


Resumo Objetivo Apresentar o resultado das avaliações radiográficas dos pacientes com fraturas extra-articulares do rádio distal submetidos a fixação percutânea com parafuso maciço de 3.5mm. Métodos Série de casos, analítica, descritiva e retrospectiva de 16 pacientes com avaliação dos parâmetros radiográficos da técnica utilizada. Resultados A média de idade da população estudada foi de 46,5 anos (25-60 anos), sendo 81,25% do sexo feminino. O tempo de espera até a cirurgia foi de 8,8 dias (4-14 dias). O tilt volar médio pré-procedimento foi - 7,41° (−23,48°-5,29°, desvio padrão [DP] ± 6,59°). O tilt volar imediatamente após o procedimento cirúrgico foi de 5,93° (DP ± 6,23°, p< 0,001). Sem diferença estatística nos valores de tilt volar ao final de 6 meses de evolução. A altura radial pré-procedimento foi de 4,13 mm (−7,8°-9,5°, DP ± 5,06°). Aumento estatisticamente significativo no pós-operatório imediato para 10,04 mm (p= 0,002). Redução significativa ao final de 6 meses para 9,55 mm (p= 0,012). Atingimos 100% de consolidação com a técnica utilizada, com índice mínimo de complicações. Nenhum paciente apresentou infecção ou precisou ser reoperado. Conclusão A técnica mostrou-se eficaz para o tratamento de fraturas extra-articulares da extremidade distal do rádio ao final de 6 meses, com baixo índice de complicações e parâmetros radiográficos aceitáveis e próximos dos valores anatômicos.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Fraturas do Rádio/cirurgia , Fraturas do Rádio/diagnóstico por imagem , Parafusos Ósseos , Fixação Interna de Fraturas/métodos , Rádio (Anatomia)/anatomia & histologia , Estudos Retrospectivos , Amplitude de Movimento Articular , Procedimentos Cirúrgicos Minimamente Invasivos
6.
Orthop Clin North Am ; 51(1): 65-76, 2020 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-31739880

RESUMO

Surgical strategies for scaphoid nonunions become more complex based on time from injury to treatment. The decision-making process, however, can follow a logical sequence. Scaphoid nonunions less than 1 year after trauma and no carpal malalignment can be treated with percutaneous screw fixation under fluoroscopic and/or arthroscopic guidance. Reinterventions or patients with avascular proximal poles that do not need substantial grafts are reliably treated with pedicle vascularized bone grafts. Resection of the distal pole of the scaphoid is a good option in old nonunions or after a failed scaphoid procedures. When there are radioscaphoid degenerative changes, salvage procedures such as proximal row carpectomy (PRC) should be considered.


Assuntos
Fixação Interna de Fraturas/métodos , Fraturas não Consolidadas/cirurgia , Osteonecrose/cirurgia , Osso Escafoide/lesões , Artroscopia/métodos , Transplante Ósseo/métodos , Consolidação da Fratura/fisiologia , Fraturas não Consolidadas/classificação , Fraturas não Consolidadas/diagnóstico por imagem , Humanos , Osteonecrose/epidemiologia , Osteonecrose/patologia , Ensaios Clínicos Controlados Aleatórios como Assunto , Recuperação de Função Fisiológica , Estudos Retrospectivos , Osso Escafoide/irrigação sanguínea , Osso Escafoide/diagnóstico por imagem , Osso Escafoide/patologia , Resultado do Tratamento , Traumatismos do Punho/complicações , Traumatismos do Punho/diagnóstico por imagem , Traumatismos do Punho/epidemiologia , Traumatismos do Punho/cirurgia , Articulação do Punho/diagnóstico por imagem
7.
J. pediatr. (Rio J.) ; 95(4): 419-427, July-Aug. 2019. tab, graf
Artigo em Inglês | LILACS | ID: biblio-1040348

RESUMO

Abstract Objective: This large study with a long-term follow-up aimed to evaluate the clinical presentation, laboratory findings, histological profile, treatments, and outcomes of children and adolescents with autoimmune hepatitis. Methods: The medical records of 828 children and adolescents with autoimmune hepatitis were reviewed. A questionnaire was used to collect anonymous data on clinical presentation, biochemical and histological findings, and treatments. Results: Of all patients, 89.6% had autoimmune hepatitis-1 and 10.4% had autoimmune hepatitis-2. The female sex was predominant in both groups. The median age at symptom onset was 111.5 (6; 210) and 53.5 (8; 165) months in the patients with autoimmune hepatitis 1 and autoimmune hepatitis-2, respectively. Acute clinical onset was observed in 56.1% and 58.8% and insidious symptoms in 43.9% and 41.2% of the patients with autoimmune hepatitis-1 and autoimmune hepatitis-2, respectively. The risk of hepatic failure was 1.6-fold higher for autoimmune hepatitis-2. Fulminant hepatic failure occurred in 3.6% and 10.6% of the patients with autoimmune hepatitis-1 and autoimmune hepatitis-2, respectively; the risk was 3.1-fold higher for autoimmune hepatitis-2. The gamma globulin and immunoglobulin G levels were significantly higher in autoimmune hepatitis-1, while the immunoglobulin A and C3 levels were lower in autoimmune hepatitis-2. Cirrhosis was observed in 22.4% of the patients; biochemical remission was achieved in 76.2%. The actuarial survival rate was 93.0%. A total of 4.6% underwent liver transplantation, and 6.9% died (autoimmune hepatitis-1: 7.5%; autoimmune hepatitis-2: 2.4%). Conclusions: In this large clinical series of Brazilian children and adolescents, autoimmune hepatitis-1 was more frequent, and patients with autoimmune hepatitis-2 exhibited higher disease remission rates with earlier response to treatment. Patients with autoimmune hepatitis-1 had a higher risk of death.


Resumo Objetivo: Este estudo com acompanhamento de longo prazo visou a avaliar o quadro clínico, os achados laboratoriais, o perfil histológico, os tratamentos e os resultados de crianças e adolescentes com hepatite autoimune. Métodos: Foram analisados os prontuários médicos de 828 crianças e adolescentes com HAI. Foi usado um questionário para coletar os dados anônimos sobre o quadro clínico, os achados bioquímicos e histológicos e os tratamentos. Resultados: De todos os pacientes, 89,6% tinham hepatite autoimune-1 e 10,4% hepatite autoimune-2. O sexo feminino foi predominante nos dois grupos. A idade média no início dos sintomas foi 111,5 (6; 210) e 53,5 (8; 165) meses nos pacientes com hepatite autoimune-1 e hepatite autoimune-2, respectivamente. Foi observado início clínico agudo em 56,1% e 58,8% e sintomas insidiosos em 43,9% e 41,2% dos pacientes com hepatite autoimune-1 e hepatite autoimune-2, respectivamente. A probabilidade de insuficiência hepática foi 1,6 vezes maior para hepatite autoimune-2; 3,6% e 10,6% dos pacientes com hepatite autoimune-1 e hepatite autoimune-2, respectivamente, apresentaram insuficiência hepática fulminante; o risco foi 3,1 vezes maior para hepatite autoimune-2. Os níveis de gamaglobulina e imunoglobulina G foram significativamente maiores nos pacientes com hepatite autoimune-1, ao passo que os níveis de imunoglobulina A e C3 foram menores em pacientes com hepatite autoimune-2; 22,4% dos pacientes apresentaram cirrose e a remissão bioquímica foi atingida em 76,2%. A taxa de sobrevida atuarial foi de 93,0%. Um total de 4,6% pacientes foram submetidos a transplante de fígado e 6,9% morreram (hepatite autoimune-1: 7,5%; hepatite autoimune-2: 2,4%). Conclusões: Nesta grande série clínica de crianças e adolescentes brasileiros, a hepatite autoimune-1 foi mais frequente e os pacientes com hepatite autoimune-2 mostraram maiores taxas de remissão da doença com respostas mais rápidas aos tratamentos. Os pacientes com hepatite autoimune-1 apresentaram maior risco de óbito.


Assuntos
Humanos , Masculino , Feminino , Criança , Adolescente , Azatioprina/uso terapêutico , Prednisona/uso terapêutico , Hepatite Autoimune/patologia , Imunossupressores/uso terapêutico , Autoanticorpos/análise , Biópsia por Agulha , Brasil , Imunoglobulinas/análise , Imageamento por Ressonância Magnética , Análise de Sobrevida , Anticorpos Antinucleares/sangue , Estudos Retrospectivos , Terapia de Imunossupressão , Resultado do Tratamento , Hepatite Autoimune/imunologia , Hepatite Autoimune/tratamento farmacológico , Fígado/patologia
8.
J Pediatr (Rio J) ; 95(4): 419-427, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-29856944

RESUMO

OBJECTIVE: This large study with a long-term follow-up aimed to evaluate the clinical presentation, laboratory findings, histological profile, treatments, and outcomes of children and adolescents with autoimmune hepatitis. METHODS: The medical records of 828 children and adolescents with autoimmune hepatitis were reviewed. A questionnaire was used to collect anonymous data on clinical presentation, biochemical and histological findings, and treatments. RESULTS: Of all patients, 89.6% had autoimmune hepatitis-1 and 10.4% had autoimmune hepatitis-2. The female sex was predominant in both groups. The median age at symptom onset was 111.5 (6; 210) and 53.5 (8; 165) months in the patients with autoimmune hepatitis 1 and autoimmune hepatitis-2, respectively. Acute clinical onset was observed in 56.1% and 58.8% and insidious symptoms in 43.9% and 41.2% of the patients with autoimmune hepatitis-1 and autoimmune hepatitis-2, respectively. The risk of hepatic failure was 1.6-fold higher for autoimmune hepatitis-2. Fulminant hepatic failure occurred in 3.6% and 10.6% of the patients with autoimmune hepatitis-1 and autoimmune hepatitis-2, respectively; the risk was 3.1-fold higher for autoimmune hepatitis-2. The gamma globulin and immunoglobulin G levels were significantly higher in autoimmune hepatitis-1, while the immunoglobulin A and C3 levels were lower in autoimmune hepatitis-2. Cirrhosis was observed in 22.4% of the patients; biochemical remission was achieved in 76.2%. The actuarial survival rate was 93.0%. A total of 4.6% underwent liver transplantation, and 6.9% died (autoimmune hepatitis-1: 7.5%; autoimmune hepatitis-2: 2.4%). CONCLUSIONS: In this large clinical series of Brazilian children and adolescents, autoimmune hepatitis-1 was more frequent, and patients with autoimmune hepatitis-2 exhibited higher disease remission rates with earlier response to treatment. Patients with autoimmune hepatitis-1 had a higher risk of death.


Assuntos
Azatioprina/uso terapêutico , Hepatite Autoimune/patologia , Imunossupressores/uso terapêutico , Prednisona/uso terapêutico , Adolescente , Anticorpos Antinucleares/sangue , Autoanticorpos/análise , Biópsia por Agulha , Brasil , Criança , Feminino , Hepatite Autoimune/tratamento farmacológico , Hepatite Autoimune/imunologia , Humanos , Imunoglobulinas/análise , Terapia de Imunossupressão , Fígado/patologia , Imageamento por Ressonância Magnética , Masculino , Estudos Retrospectivos , Análise de Sobrevida , Resultado do Tratamento
9.
Pediatr Transplant ; 22(1)2018 02.
Artigo em Inglês | MEDLINE | ID: mdl-29131462

RESUMO

LT exerts considerable stress on the heart perioperatively. Limited data exist on impact of cardiovascular diseases on LT children. This study evaluated the outcomes of children with CVD who underwent LT and compared with pretransplant findings. From 518 LT recipients, 82 (15.8%) had CVD. Sixty patients were classified as low-risk adjustment for congenital heart surgery 1 (RACHS 1 and 2). Five patients were classified as RACHS ≥3. The most common echocardiographic finding in the CVD patients (25/82) was ASD. CVD patients had more abnormal EKG (32.4% vs 14.5%, P < .001), abnormal chest X-ray (11.8% vs 1.4%, P < .001), and altered echocardiography (89.7% vs 15.4%, P < .001) findings compared with the No-CVD group pretransplant. Post-transplant, significant differences between groups were observed related to abnormal EKG (14.7% vs 7.0%, P = .03) and echocardiography (48.5% vs 3.2%, P < .01) findings. Pretransplant ASD spontaneously closed in 22 patients. At 1 and 5 years post-transplant, there was no difference in the survival rate between groups (P = .96). The prevalence of CVD in recipients of LT was high, and its presence was associated with significantly higher cardiac decompensation before and after LT. Minor and moderate cardiovascular disease did not impact the long-term survival.


Assuntos
Doenças Cardiovasculares/complicações , Doença Hepática Terminal/cirurgia , Transplante de Fígado , Adolescente , Doenças Cardiovasculares/diagnóstico por imagem , Doenças Cardiovasculares/mortalidade , Criança , Pré-Escolar , Ecocardiografia , Doença Hepática Terminal/complicações , Doença Hepática Terminal/mortalidade , Feminino , Seguimentos , Humanos , Lactente , Recém-Nascido , Estimativa de Kaplan-Meier , Transplante de Fígado/mortalidade , Masculino , Estudos Retrospectivos , Taxa de Sobrevida , Resultado do Tratamento
10.
Liver Transpl ; 20(10): 1157-67, 2014 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-24954288

RESUMO

The technique of vascular reconstruction plays a major role in the outcome of living donor liver transplantation (LDLT). An increased use of vascular grafts (VGs) as replacements for sclerotic portal veins has become a standard technique for our group. The aim of this study was to analyze the factors associated with portal vein thrombosis (PVT) in pediatric LDLT. We performed a retrospective analysis of 486 primary pediatric LDLT procedures performed between October 1995 and May 2013. VGs used for portal reconstruction included living donor inferior mesenteric veins, living donor ovarian veins, recipient internal jugular veins, deceased donor iliac arteries, and deceased donor iliac veins. Thirty-four patients (7.0%) developed PVT. The incidence of PVT dropped from 10.1% to 2%; the overall utilization of VGs increased from 3.5% to 37.1%. In a multivariate analysis, only the use of VGs remained an independent risk factor for the occurrence of PVT (hazard ratio = 7.2, 95% confidence interval = 2.8-18.7, P < 0.001). There was no difference in survival rates between patients with PVT and patients without PVT. No patient with PVT underwent retransplantation. In conclusion, the use of VGs was independently associated with the development of PVT. Over time, there was a reduction in the incidence of early PVT in this cohort, and there was a trend toward a reduction in total PVT. The occurrence of isolated PVT in this study was not associated with decreased patient or graft survival.


Assuntos
Transplante de Fígado/efeitos adversos , Doadores Vivos , Veia Porta , Transplantados , Trombose Venosa/etiologia , Brasil/epidemiologia , Pré-Escolar , Feminino , Seguimentos , Humanos , Incidência , Lactente , Transplante de Fígado/métodos , Masculino , Complicações Pós-Operatórias , Prognóstico , Estudos Retrospectivos , Fatores de Risco , Taxa de Sobrevida/tendências , Trombose Venosa/epidemiologia
11.
Hepatology ; 59(5): 1964-71, 2014 May.
Artigo em Inglês | MEDLINE | ID: mdl-24122953

RESUMO

UNLABELLED: Ascites is the most common complication of cirrhosis and in adults it is associated with 50% mortality at 5 years if patients do not receive a liver transplant. The occurrence of hyponatremia in these patients has been associated with increased mortality on the waiting list. The importance of serum sodium levels and the presence of ascites in the pediatric setting remain to be clarified. A retrospective analysis of pediatric patients with cirrhosis on the transplant list was carried out between October 2000 and February 2012. The primary objective of this study was to evaluate the association of pretransplant variables with mortality within 90 days following the inclusion of patients on the waiting list. In all, 522 patients were included in the study; 345 (66%) patients were under 1 year of age; 208 (40%) of the children presented ascites. A multivariate Cox proportional hazards analysis was conducted and total bilirubin (P < 0.001, hazard ratio [HR] = 2.09, 95% confidence interval [CI] = 1.35-3.21), international normalized ratio (INR) (P < 0.001, HR = 9.83, 95% CI = 4.51-21.45), serum sodium levels (P = 0.03, HR = 0.96, 95% CI = 0.92-0.99), ascites (P = 0.001, HR = 2.59, 95% CI = 1.44-4.64), and categorized age (0-1 versus ≥ 1 year old) (P = 0.025, HR = 2.33, 95% CI = 1.11-4.86) were independently associated with risk of death in 90 days. Malnutrition (Z score height/age, weight/age) and serum albumin (pediatric endstage liver disease [PELD] formula) were not included in the final model. CONCLUSION: The presence of ascites and serum sodium levels are important variables associated with decreased patient survival while candidates wait for a liver graft. Multicenter studies are necessary to validate these findings in order to improve current allocation policies based on the PELD score.


Assuntos
Ascite/mortalidade , Doença Hepática Terminal/mortalidade , Transplante de Fígado , Sódio/sangue , Listas de Espera , Adolescente , Ascite/etiologia , Biomarcadores/sangue , Criança , Pré-Escolar , Doença Hepática Terminal/complicações , Doença Hepática Terminal/cirurgia , Feminino , Humanos , Lactente , Doadores Vivos , Masculino , Modelos de Riscos Proporcionais , Estudos Retrospectivos
12.
Liver Transpl ; 19(4): 431-6, 2013 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-23447137

RESUMO

The vascular anomalies encountered in patients with biliary atresia associated with polysplenia syndrome and situs inversus (SI) demand technical refinements when liver transplantation is being performed. The available data describing the technique used in living donor liver transplantation (LDLT) in this population are limited; the short vascular stumps of the donor's liver can impart additional technical difficulties during vascular reconstruction. Here we describe our experience with 9 children with biliary atresia and SI who underwent LDLT. In our series, the retrohepatic vena cava was absent for 7 patients, 7 had a preduodenal portal vein (PV), and 4 had a variant arterial anatomy. The donor's left hepatic vein was anastomosed to the confluence of the recipient's 3 hepatic veins in 7 patients. Vascular grafts were used for PV reconstruction in 3 cases. A left lateral segment graft was used in all but 1 patient who needed a graft reduction. All grafts were placed in the upper left abdomen. There were no vascular complications after transplantation. All patients were alive and well at a median follow-up of 55 months. In conclusion, LDLT can be successfully performed in pediatric patients with SI. Complex vascular anomalies associated with the use of partial liver grafts obtained from living donors are not associated with an increased occurrence of vascular complications.


Assuntos
Atresia Biliar/cirurgia , Transplante de Fígado/métodos , Doadores Vivos , Situs Inversus/cirurgia , Enxerto Vascular , Malformações Vasculares/cirurgia , Fatores Etários , Atresia Biliar/complicações , Feminino , Artéria Hepática/anormalidades , Artéria Hepática/cirurgia , Humanos , Lactente , Transplante de Fígado/efeitos adversos , Masculino , Veia Porta/anormalidades , Veia Porta/cirurgia , Estudos Retrospectivos , Situs Inversus/complicações , Resultado do Tratamento , Enxerto Vascular/efeitos adversos , Malformações Vasculares/complicações , Veia Cava Inferior/anormalidades , Veia Cava Inferior/cirurgia
13.
Rev Bras Ortop ; 47(4): 488-92, 2012.
Artigo em Inglês | MEDLINE | ID: mdl-27047856

RESUMO

OBJECTIVE: Describe the results from arthroscopic surgical treatment on a group of patients who developed symptoms after repetitive physical activity of moving their hips in a position of hyperflexion, as in leg presses and squats. METHODS: The study group comprised 47 individuals (48 hips) who developed the onset of painful symptoms associated with hip hyperflexion exercises (leg presses or squats) and underwent arthroscopic treatment. The patients were evaluated radiographically and clinically according to the "Harris Hip Score", as modified by Byrd (MHHS), pre and postoperatively, and were asked about their return to sports activities and the surgical findings. RESULTS: The mean preoperative and postoperative MHHS, respectively, were 60 points (SD 11.0, range 38.5 to 92.4) and 95.9 points (SD 7.7, range 63.8 to 100), with an increase of 35.9 points (P < 0.001). Regarding physical activity, 30 individuals (71.5%) resumed sports activities after surgery, and 25 of them (83.4%) at the previous level. Six patients (12.8%) did not resume activities because of persistent pain. During arthroscopy, 48 hips (100%) presented lesions of the acetabular labrum, and 41 hips (85.4%) had acetabular chondral lesions. CONCLUSION: The patients with painful symptoms after hip hyperflexion exercises associated with femoroacetabular impingement presented improvements after arthroscopic treatment.

14.
Rev. bras. ortop ; 47(4): 488-492, 2012. ilus
Artigo em Português | LILACS | ID: lil-656132

RESUMO

OBJETIVO: Relatar os resultados do tratamento cirúrgico artroscópico de um grupo de pacientes que desenvolveram sintomas após atividades físicas repetitivas, movimentando o quadril em uma posição de hiperflexão, como leg press e agachamento. MÉTODOS: O grupo do estudo compreendeu 47 indivíduos (48 quadris) que desenvolveram o início dos sintomas dolorosos associados a exercícios de hiperflexão de quadril (leg press ou agachamento) e submetidos a tratamento artroscópico. Os pacientes foram avaliados radiográfica e clinicamente segundo o Harris Hip Score modificado por Byrd (MHHS), nos períodos pré e pós-operatório, questionados sobre seu retorno às atividades esportivas e os achados cirúrgicos. RESULTADOS: A média do MHHS nos períodos pré e pós-operatório foi, respectivamente, 60 pontos (DP 11,0, faixa 38,5-92,4) e 95,9 pontos (DP 7,7, faixa 63,8-100), aumento de 35,9 pontos (P < 0,001). Em relação à atividade física, 30 indivíduos (71,5%) retomaram as atividades esportivas após a cirurgia, 25 (83,4%) destes com o mesmo nível anterior, seis indivíduos (12,8%) não retornaram devido à dor persistente. Na artroscopia, 48 quadris (100%) apresentaram lesões do lábio acetabular e 41 quadris (85,4%), lesões condrais acetabulares. CONCLUSÃO: Os pacientes com sintomas dolorosos após os exercícios de hiperflexão do quadril associados ao impacto femoroacetabular apresentaram melhora após o tratamento artroscópico.


OBJECTIVE: Describe the results from arthroscopic surgical treatment on a group of patients who developed symptoms after repetitive physical activity of moving their hips in a position of hyperflexion, as in leg presses and squats. METHODS: The study group comprised 47 individuals (48 hips) who developed the onset of painful symptoms associated with hip hyperflexion exercises (leg presses or squats) and underwent arthroscopic treatment. The patients were evaluated radiographically and clinically according to the "Harris Hip Score", as modified by Byrd (MHHS), pre and postoperatively, and were asked about their return to sports activities and the surgical findings. RESULTS: The mean preoperative and postoperative MHHS, respectively, were 60 points (SD 11.0, range 38.5 to 92.4) and 95.9 points (SD 7.7, range 63.8 to 100), with an increase of 35.9 points (P < 0.001). Regarding physical activity, 30 individuals (71.5%) resumed sports activities after surgery, and 25 of them (83.4%) at the previous level. Six patients (12.8%) did not resume activities because of persistent pain. During arthroscopy, 48 hips (100%) presented lesions of the acetabular labrum, and 41 hips (85.4%) had acetabular chondral lesions. CONCLUSION: The patients with painful symptoms after hip hyperflexion exercises associated with femoroacetabular impingement presented improvements after arthroscopic treatment.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto Jovem , Pessoa de Meia-Idade , Acetábulo , Artroscopia , Articulação do Quadril/patologia , Seguimentos , Lesões do Quadril
15.
Tech Hand Up Extrem Surg ; 15(3): 135-7, 2011 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-21869642

RESUMO

Serratus anterior palsy can be a very disabling condition. However, not much has been written about many other upper limb palsies and the surgical approaches for them. In contrast, not much has been published about this particular muscle palsy. Most investigators engaged in the treatment of peripheral nerve palsies are focused on the restoration of elbow flexion/extension and shoulder abduction/external rotation. Nevertheless, scapulothoracic stability is of utmost importance for shoulder function inasmuch as it offers a stable base for arm motion--mostly forward flexion. As a result, serratus anterior palsy leads to loss of strength, range of motion, and pain due to fatigue of synergistic muscles--an issue disabling enough to warrant surgical intervention. Many investigators have suggested a variety of techniques including muscle transfers, fascial slings, or scapulothoracic fusion. The last option leads to obvious limitations in the final range of motion and should be avoided in young high-demand patients. Fascial slings have a tendency to attenuate over time.


Assuntos
Fascia Lata/transplante , Músculo Esquelético/inervação , Paralisia/cirurgia , Escápula/cirurgia , Transferência Tendinosa/métodos , Humanos , Instabilidade Articular/cirurgia , Músculos Peitorais/cirurgia , Cuidados Pós-Operatórios , Amplitude de Movimento Articular , Articulação do Ombro/inervação
16.
Rev. bras. ortop ; 42(1/2): 17-23, jan.-fev. 2007. ilus
Artigo em Português | LILACS | ID: lil-453307

RESUMO

Objetivo: Avaliar os resultados radiológicos e funcionais no tratamento das fraturas instáveis do rádio distal com a utilização de uma placa volar de ângulo fixo tipo DVR (distal volar radius). Métodos: Fraturas deslocadas instáveis intra ou extra-articulares do rádio distal em 57 pacientes, 23 homens e 34 mulheres com média de idade de 48,2 anos, foram fixadas através de acesso volar com placa volar de ângulo fixo e avaliadas com seguimento mínimo de um ano. Resultados: Todos os casos evoluíram com consolidação óssea. Não houve casos de falência do material de síntese ou perda da redução e três pacientes apresentaram distrofia simpático-reflexa. O resultado funcional de 57 pacientes foi considerado excelente em 38, bom em 16 e ruim em três. A avaliação radiológica demonstrou 47 casos excelentes e 10 bons. Conclusão: A placa volar de ângulo fixo, tipo DVR, quando utilizada nas fraturas instáveis, intra ou extra-articulares do rádio distal, com deslocamento dorsal, apresenta excelentes resultados, podendo ser usada rotineiramente no tratamento dessas fraturas


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso de 80 Anos ou mais , Fixação de Fratura/métodos , Fraturas do Rádio/cirurgia
17.
Rev. bras. ortop ; 41(10): 432-437, out. 2006. ilus, tab
Artigo em Português | LILACS | ID: lil-453257

RESUMO

Objetivo: Relatar a experiência obtida no trato de uma rara lesão traumática: a da síndrome escafocapitato (SEC), descrevendo seus tratamento e desfecho. Métodos: Cinco pacientes foram tratados cirurgicamente no período de 1995 a 1999. Todos eram do sexo masculino, com média de idade de 29 anos. O seguimento pós-operatório médio foi de 38 meses. Resultados: O tempo médio para consolidação foi de dois meses. A avaliação radiográfica final não revelou sinais de osteoartrose pós-traumática, instabilidade cárpica ou osteonecrose. Os resultados foram analisados segundo o escore da Clínica Mayo para lesães traumáticas do punho, que demonstrou um paciente com evolução excelente, três com evolução boa e um, ruim. Conclusães: A SEC é uma entidade de rara ocorrência. O diagnóstico deve ser no primeiro atendimento, pois, se tardio, o resultado clínico e radiográfico será pior. A estabilidade obtida pela fixação rígida evita o aparecimento de artrose, consolidação viciosa e instabilidade do carpo.


Assuntos
Humanos , Masculino , Adulto , Fixação de Fratura , Ossos do Carpo/cirurgia , Ossos do Carpo/lesões , Traumatismos do Punho/cirurgia , Estudos Retrospectivos
18.
Rev. bras. ortop ; 41(7): 259-263, jul. 2006. ilus, tab, graf
Artigo em Português | LILACS | ID: lil-438282

RESUMO

Objetivo: Os autores avaliam os resultados do tratamento cirúrgico em oito pacientes com lesão crônica do ligamento colateral ulnar (LCU) da articulação metacarpofalângica do polegar. Métodos: Os casos foram tratados utilizando enxerto tendinoso com a técnica de Littler modificada e avaliados retrospectivamente em relação ao resultado clínico, com 12 meses de pós-operatório, avaliando-se os critérios de mobilidade, força de pinça, dor e satisfação pessoal. Resultados: Todos os pacientes evoluíram com melhora clínica evidente. Conclusão: Nossa avaliação, baseada na escala de Glickel, reforça a indicação do tratamento cirúrgico pela técnica de Littler modificada, nas lesões crônicas do ligamento colateral ulnar do polegar.


Assuntos
Humanos , Masculino , Feminino , Adulto , Pessoa de Meia-Idade , Articulação Metacarpofalângica/cirurgia , Ligamentos Colaterais , Ligamentos Colaterais/cirurgia , Polegar/cirurgia , Transplantes , Traumatismos dos Dedos/cirurgia , Resultado do Tratamento
19.
RGO (Porto Alegre) ; 52(4): 301-304, out. 2004. ilus, tab
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-397062

RESUMO

Sendo a deglutição de grande importância para o desenvolvimento normal da oclusão, pretende-se neste trabalho, por meio de exame clínico e anamnese, verificar a incidência deste distúrbio miofuncional em 150 estudantes de uma escola municipal de Passo Fundo RS na faixa etária entre 6 e 8 anos de idade, fazendo um paralelo com as pesquisas existentes relacionadas ao tema proposto


Assuntos
Humanos , Masculino , Feminino , Criança , Língua , Transtornos de Deglutição/epidemiologia
20.
Ortodontia ; 34(3): 74-79, set.-dez. 2001. ilus
Artigo em Português | LILACS, BBO - Odontologia | ID: lil-308200

RESUMO

Sendo a deglutiçäo de grande importância para o desenvolvimento normal da oclusäo, pretende-se neste trabalho, por meio de revisäo bibliográfica, apresentar as opiniöes de diversos autores sobre a deglutiçäo atípica com pressionamento anormal da língua, os problemas ortodônticos que acarretam e as diversas abordagens terapêuticas


Assuntos
Humanos , Masculino , Feminino , Deglutição , Ortodontia , Língua
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