Hot isostatic pressing as an alternative thermo-mechanical treatment for metallic full-arch implant-supported frameworks obtained by additive and subtractive manufacturing technology: Vertical and horizontal fit, screw removal torque, and stress analysis.

PURPOSE: To assess vertical and horizontal fit, screw removal torque, and stress analysis (considered biomechanical aspects) of full-arch implant frameworks manufactured in Ti-6Al-4V through milling, and additive manufacturing Direct Metal Laser Sintering (DMLS) and Electron Beam Melting (EBM), and the effect of the thermo-mechanical treatment Hot Isostatic Pressing (HIP) as a post-treatment after manufacturing. MATERIAL AND METHODS: Maxillary full-arch implant frameworks were made by milling, DMLS, and EBM. The biomechanical assessments were screw removal torque, strain-gauge analyses, and vertical and horizontal marginal fits. The vertical fit was assessed by the single-screw test and with all screws tightened. All frameworks were submitted to a standardized HIP cycle (920°C, 1000 bar pressure, 2 h), and the tests were repeated (α = 0.05). RESULTS: At the initial time, milled frameworks presented higher screw removal torque values, and DMLS and EBM frameworks presented lower levels of strain. Using the single-screw test, milled and DMLS frameworks presented higher vertical fit values, and with all screws tightened and horizontally, higher fit values were found for milled frameworks, followed by DMLS and EBM. After HIP, milling and EBM frameworks presented higher screw removal torque values; the lowest strain values were found for EBM. Using the single-screw test, milled and DMLS frameworks presented higher vertical fit values, and with all screws tightened and horizontally no differences were found. CONCLUSIONS: DMLS and EBM full-arch frameworks presented adequate values of screw removal torque, strain, and marginal fit, although the worst values of marginal fit were found for EBM frameworks. The HIP cycle enhanced the screw removal torque of milled and EBM frameworks and reduced the strain values of milled frameworks. The HIP represents a reliable post-treatment for Ti-6Al-4V dental prostheses produced by milling and EBM technologies.

Targeting Biomechanical Endurance of Dental-Implant Abutments Using a Diamond-Like Carbon Coating.

Abutment components (i.e., fixtures associated with oral implants) are essentially made of titanium (Ti), which is continuously exposed to the hash oral environment, resulting in scratching. Thus, such components need to be protected, and surface treatments are viable methods for overcoming long-term damage. Diamond-like carbon (DLC), an excellent protective material, is an alternative surface-treatment material for Ti abutments. Here, we demonstrate that a silicon interlayer for DLC film growth and the pulsed-direct current plasma-enhanced chemical vapor deposition (DC-PECVD) method enables the deposition of an enhanced protective DLC film. As a result, the DLC film demonstrated a smooth topography with a compact surface. Furthermore, the DLC film enhanced the mechanical (load-displacement, hardness, and elastic modulus) and tribological properties of Ti as well as increased its corrosion resistance (16-fold), which surpassed that of a bare Ti substrate. The biofilm formed (Streptococcus sanguinis) after 24 h exhibited an equal bacterial load (∼7 Log colony-forming units) for both the groups (Ti and DLC). In addition, the DLC film exhibited good cytocompatibility, owing to its noncytotoxicity toward human gingival fibroblast cells. Therefore, DLC deposition via DC-PECVD can be considered to be a promising protective and cytocompatible alternative for developing implant abutments with enhanced mechanical, tribological, and electrochemical properties.

Clinical efficacy of triclosan-containing toothpaste in peri-implant health: A systematic review and meta-analysis of randomized clinical trials.

STATEMENT OF PROBLEM: Recent evidence suggests that toothpaste containing 0.3% triclosan (TCS) is more effective than regular toothpaste in improving clinical periodontal conditions. However, a consensus on whether TCS favors a healthy peri-implant environment is limited. PURPOSE: The purpose of this systematic review and meta-analysis of randomized clinical trials was to determine the effects of TCS-containing toothpaste on dental implant health based on clinical, immunological, and microbiological parameters, as well as on reported adverse events. MATERIAL AND METHODS: Clinical studies comparing peri-implant conditions in participants by using TCS toothpaste versus conventional fluoride toothpaste (control) were extracted from 9 databases. The studies were assessed with the Cochrane risk-of-bias tool for randomized clinical trials (RoB 2). Datasets for bleeding on probing (BOP), probing depth (PD), clinical attachment level (CAL), gingival index (GI), plaque index (PI), osteo-immunoinflammatory mediators, and bacterial load were plotted, and the standard mean difference (SMD) quantitative analysis was applied by using the Rev Man 5.3 software program. Adverse effects reported by the studies were also tabulated. The certainty of evidence was assessed by using the grading of recommendations assessment, development, and evaluation approach. RESULTS: Six studies were included in the meta-analyses. BOP was higher in the control group than in the TCS toothpaste group at 3 months (SMD -0.59 [-1.11, -.07] P=.002, I2=77%) and 6 months (SMD -0.59 [-0.83, -0.34] P=.009, I2=79%). PD (SMD -0.04 [-0.08, -0.00] P=.04, I2=0%) was also deeper in the control group versus TCS toothpaste at 6 months (SMD -0.41 [-0.73, -0.10] P=.04, I2=77%). CAL, GI, and PI did not differ between groups (P>.05). Among the osteo-immunoinflammatory mediators, IL-10 levels increased, and IL-1ß and osteoprotegerin levels decreased in the TCS toothpaste group (P<.05). Microbiological findings found that TCS toothpaste prevented the growth of periodontal pathogens, specifically in up to approximately 20% of the Prevotella intermedia. Adverse effects were not reported after toothbrushing in either group. However, most studies had "some" or "high" risk of bias, and the certainty of the evidence was considered to be "very low." CONCLUSIONS: Most studies were short-term (3 and 6 months) analyses, and the results found that, although TCS-containing toothpaste had positive osteo-immunoinflammatory and microbiologic results, clinical parameters, including CAL, GI, and PI, were not influenced.

Funding assistance and global productivity in the field of implant overdentures: A bibliometric analysis of 35 years.

STATEMENT OF PROBLEM: Implant overdentures have been widely used as a treatment option for edentulous patients. However, the development of implants, aside from commercial growth, requires funding assistance to determine scientific reliability and clinical applications. Nonetheless, bibliometric studies in the implant overdenture field are lacking. PURPOSE: The purpose of this bibliometric analysis was to evaluate the prevalence of funding and its bibliometric associated parameters according to the financial assistance granted and the implant overdenture documentation over time. MATERIAL AND METHODS: Six databases were assessed, and 12 bibliometric parameters related to the economy, geographical origin, publication details, and corresponding author metrics were recorded. An incidence rate ratio was applied by using a multiple Poisson regression model (α=.05) to assess the association between funding and each bibliometric parameter. RESULTS: In total, 1369 studies published between 1986 and 2021 were assessed bibliometrically. The prevalence of funded studies was 34.8% (n=477). The parameter associated with the presence of funding was country income (P<.01), with those having a high and upper-middle income being more funded than those with a lower-middle and low income. Oceania and South America were the continents more frequently funded (P<.05), with Africa being the least frequent. Randomized and nonrandomized controlled trials, in vitro studies, and in silico studies were more funded (P<.001) than case reports and series. Stud and ball attachment systems were more funded (P<.01) than studies with more than 1 retention system. Funding increased over time (P<.01), and corresponding authors with a higher h-index had more studies funded (P<.05). CONCLUSIONS: The number of funded studies on implant overdentures increased over the years. Other bibliometric parameters such as country income, continent, study design, retention system, and corresponding author h-index were associated with the frequency of funded studies published.

Factors and clinical outcomes for standard and mini-implants retaining mandibular overdentures: A systematic review and meta-analysis.

STATEMENT OF PROBLEM: Standard-diameter dental implants are not always applicable because of anatomic limitations of the residual ridge. Thus, mini-implants have been increasingly used and offer an alternative. However, data regarding prosthetic complications, maintenance factors, and clinical outcomes are limited. PURPOSE: The purpose of this systematic review and meta-analysis was to compare prosthetic complications and maintenance events and clinical outcomes in residual ridges rehabilitated with mandibular implant overdentures (IODs) by using standard implants or mini-implants. MATERIAL AND METHODS: Nine electronic databases were searched. Quantitative analyses to measure the risk ratio (RR) and standardized mean difference (SMD) were applied. Those methods were used to assess prosthetic complications and maintenance events (abutment adjustments, replacement of retentive element, occlusal adjustment, and overdenture fracture) and clinical outcomes related to postoperative pain, probing depth (PD), plaque index (PI), marginal bone loss (MBL), and implant survival rate. RESULTS: Altogether, 7 publications were selected. Mini-implants presented reduced abutment adjustments (RR 0.23 [0.07, 0.73], P=.01), replacement of retentive element (RR 0.41 [0.31, 0.54], P<.001), occlusal adjustment (RR 0.53 [0.31, 0.91], P=.02), and overdenture fracture (RR 0.46 [0.23, 0.94], P=.03) compared with standard implants. Additionally, mini-implants presented lower values for PI at 6 months (SMD -0.27 [-0.47, -0.08], P=.006) and 12 months (SMD -0.25 [-0.46, -0.05], P=.01). No additional tangible differences were noted. CONCLUSIONS: Mini-implants might be an alternative choice based on the number of prosthetic complications and maintenance events. This was also confirmed by the comparable clinical data between standard implants and mini-implants.

Bibliometric assessment in implant-retained overdenture articles: Mapping citation and journal impact factor trends.

STATEMENT OF PROBLEM: Implant-retained overdentures are a recognized treatment option. However, a comprehensive assessment of all articles on implant-retained overdentures to identify publication standards such as mean citation and the Journal Citation Reports (JCR) impact factor is lacking. PURPOSE: The purpose of this bibliometric assessment was to evaluate the association of mean citation and JCR impact factor with bibliometric parameters in articles on implant-retained overdentures. MATERIAL AND METHODS: Articles reporting randomized controlled clinical trials (RCTs) and nonrandomized controlled clinical trials (N-RCTs); case reports and series; retrospective studies; and in silico, in vitro, or systematic reviews in 6 databases were included. Data were extracted, and 2 multiple Poisson regressions analyses were applied (α=.05). The dependent variables were mean citation and JCR impact factor, which were evaluated to identify their association with bibliometric parameters by using prevalence ratio (PR) values. RESULTS: A total of 1369 articles published from 1986 to 2021 were included. The data revealed a high mean citation and high JCR impact factor for RCT, N-RCT, retrospective, and in vitro studies (P<.05). In silico studies presented a high mean citation (P<.001). Senior researchers with a high h-index were more likely to have a high mean citation and publications with a high JCR impact factor (P<.001). Also, senior authors associated with an international network were more likely to have a high mean citation (P=.001). High-income countries had more studies with a high mean citation and JCR impact factor (P<.05). Higher JCR impact factors were associated with articles evaluating only the maxilla or mandible (P<.05). The topics "implant setting" and "macrodesign" were associated with a high mean citation (P<.05). CONCLUSIONS: The publication trends suggest a high mean citation and a high JCR impact factor for clinical designs (RCT, N-RCT, retrospective) and in vitro studies. The same pattern was also displayed for researchers with a high h-index and located in high-income countries.

Patient-reported outcome measures and clinical performance of implant-retained mandibular overdentures with stud and ball attachments: A systematic review and meta-analysis.

STATEMENT OF PROBLEM: Evidence regarding the retention system for a mandibular overdenture is important for treatment planning. However, the clinical performance of stud and ball attachments for mandibular overdenture retainers is unclear. PURPOSE: The purpose of this systematic review and meta-analysis was to compare the clinical performance and self-reported patient outcomes of ball and stud attachments as mandibular overdenture retainers. MATERIAL AND METHODS: Randomized (RCTs) and nonrandomized (N-RCTs) controlled clinical trials were selected based on the eligibility criteria. The risk of bias was assessed by using the Cochrane Collaboration Tools, and the certainty of the evidence (COE) by using the grades of recommendation, assessment, development, and evaluation (GRADE) workshop approach. Meta-analyses according to the follow-up period were performed for implant survival, prosthetic maintenance and complications, bleeding on probing (BoP), marginal bone loss (MBL), satisfaction, and oral health-related quality of life (OHRQoL). RESULTS: Thirteen RCTs and 4 N-RCTs were included. Twelve studies presented a high risk of bias. The stud demonstrated a lower risk ratio (RR) (P<.001) for maintenance and complications concerning the need for matrix activation (RR 7.12 [2.65, 19.15]) (very low COE) and new overdentures (RR 2.47 [1.02, 5.96]) (moderate COE), ranging from 1 to 5 years of follow-up. Mean difference (MD) for MBL after 1 (MD 0.40 [0.28, 0.52]; P<.001) and 5 years (MD 0.18 [0.16, 0.20]; P<.001) was higher for ball attachments than that for stud (very low COE) attachments. Stud attachments also improved satisfaction (P<.001) when compared with ball attachments (very low COE). Implant survival rate (high COE), BoP (very low COE), and OHRQoL (low COE) were similar for the attachments. CONCLUSIONS: Stud and ball attachments are clinically appropriate options as mandibular overdenture retainers and are capable of restoring OHRQoL. Nevertheless, the stud showed greater improvement in satisfaction and less prosthetic aftercare and MBL.

Additive Manufacturing of Metallic Frameworks Supported by the All-on-Six Implant Concept: Dimensional Precision After Veneer Layering and Spark Erosion.

PURPOSE: To compare frameworks manufactured by selective laser melting (SLM) and electron beam melting (EBM) with frameworks manufactured by milling, regarding dimensional precision after veneer layering and spark erosion for the all-on-six implant concept. MATERIALS AND METHODS: Frameworks (n = 5/group) were manufactured by milling, SLM, and EBM. Dimensional precision of the frameworks was evaluated by marginal fit, screw loosening torque, and strain. Marginal fit was assessed by the single screw protocol. The screw-loosening torque was measured for the evaluation of screw stability. Tension distribution was analyzed with strain gauges. All frameworks received veneer layering followed by the marginal fit, screw-loosening torque, and strain gauge tests. Subsequently, the frameworks were subjected to the spark erosion process. The analyses were repeated after each stage (baseline, veneer layering, and spark erosion). Data was explored by two-way repeated-measures analysis of variance (ANOVA) with the Bonferroni test (α = .05). RESULTS: At baseline, the highest (worst) marginal fit values were displayed by SLM frameworks (mean ± standard deviation [SD]: 186.13 ± 21.27 µm), while the milling group (83.30 ± 12.03 µm) showed the lowest (best) values (P < .05). After veneer layering, EBM presented the worst marginal fit values (222.55 ± 52.56 µm; P < .05) among the groups. Over time (from the baseline to veneer layering), the marginal fit values increased (became worse) for milling (P = .002) and EBM (P < .001), while for SLM (P = .002) the values decreased (improved). Compared with veneer layering data, spark erosion improved the marginal fit values only for EBM (P = .005). Irrespective of time, the screw-loosening torque for the milling group showed higher values. The lowest strain was found for the SLM at baseline (P < .05), but it increased after veneer layering (P = .015) and after spark erosion (P = .028). CONCLUSION: Additive technologies are promising for dental applications. In addition, all technologies demonstrated accuracy in the manufacturing of implant-supported frameworks, especially the EBM technology, which demonstrated biomechanical behavior similar to the milling technology after the intervals (baseline, veneer layering, and spark erosion) assessed in the study.

Patient-reported outcome measures and clinical assessment of implant-supported overdentures and fixed prostheses in mandibular edentulous patients: A systematic review and meta-analysis.

STATEMENT OF PROBLEM: A consensus based on patients' perceptions as to whether to use overdentures or fixed prostheses to rehabilitate mandibular edentulous arches is limited. PURPOSE: The purpose of this systematic review and meta-analysis was to compare the patient-reported outcome measures (PROMs) and clinical outcomes associated with implant-supported overdentures and fixed prostheses in edentulous mandibles. MATERIAL AND METHODS: Nine electronic databases were searched for randomized clinical trials (RCTs) and nonrandomized clinical trials (N-RCTs). The risk of bias was assessed by the revised Cochrane risk of bias tool for RCTs (RoB 2) and N-RCT (ROBINS-I). Data sets for oral health-related quality of life (OHRQoL), satisfaction, survival rate, implant probing depth, and marginal bone loss were plotted, and the appropriate analyses were applied by using the Rev Man 5.3 software program. Certainty of evidence was also evaluated by means of the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach. RESULTS: Ten eligible trials were included and evaluated quantitatively. For 3 domains of OHRQoL, fixed prostheses showed significantly higher quality of life when compared with overdentures regarding functional limitation (P<.001), physical disability (P=.001), and physical pain (P=.003). Fixed prostheses also improved satisfaction, when compared with overdentures for comfort (P=.02), ease of mastication (P<.001), retention (P<.001), and stability (P<.001). The same pattern was observed for overall OHRQoL (P=.01) and satisfaction (P=.01) in which fixed prostheses improved patient satisfaction. Only ease of cleaning presented greater satisfaction for the overdenture group. Clinical parameters did not differ statistically (P>.05) between both types of prosthesis. CONCLUSIONS: Fixed rehabilitations for mandibular edentulous patients seem to be a well-accepted treatment from the patients' oral health perspective. However, mandibular overdentures are no less efficient than fixed prostheses in terms of clinical outcomes.

Clinical efficacy of anodized dental implants for implant-supported prostheses after different loading protocols: A systematic review and meta-analysis.

OBJECTIVES: To summarize the clinical performance of anodized implants connected to different prostheses design after immediate/early (IL) or conventional loading (CL) protocols. MATERIALS AND METHODS: Seven databases were surveyed for randomized (RCTs) and non-randomized controlled clinical trials (CCTs). Studies comparing IL vs. CL protocol of anodized implants supporting single crown, fixed partial denture (FPD), full-arch fixed dental prosthesis (FDP), or overdenture were included. Risk-of-bias was evaluated using Cochrane Collaboration tools. Meta-analyses for different follow-up were analyzed, followed by heterogeneity source assessment and GRADE approach. The outcomes included implant survival rate, marginal bone loss (MBL), implant stability quotient (ISQ), probing depth (PD), plaque index (PI), and peri-implantitis prevalence. RESULTS: From 24 eligible studies, 22 were included for quantitative evaluation. Most RCTs (58%, n = 11) and all the 5 CCTs had high and serious risk-of-bias, respectively. Overall, pooling all prosthesis design, no difference between IL vs. CL protocols was observed for all outcomes (p > .05). However, according to prosthesis type subgroups, CL reduced MBL for full-arch FDP (p < .05). In a point-in-time assessment, with overdenture, although IL presented higher PI (12 months), it showed lower MBL (≥24 months), higher ISQ (3 months), and lower PD (6 and 12 months) (p < .05). Conversely, PD was higher for IL in single crown (3 and 6 months) (p < .05). Regarding MBL, IL demonstrated higher mean difference for full-arch FDP (36 months) and FPD (12 and 36 months) (p < .05). CONCLUSION: Within the limitations of this study, overall, there is no significant difference in the outcomes between IL and CL loading protocols.

Peri-implant and esthetic outcomes of cemented and screw-retained crowns using zirconia abutments in single implant-supported restorations-A systematic review and meta-analysis.

OBJECTIVES: To evaluate the peri-implant tissue changes and esthetic outcomes of cemented and screw-retained crowns of single-tooth implants in the esthetic zone using zirconia abutments. MATERIAL AND METHODS: An electronic search was performed on nine databases. The risk-of-bias was assessed by the revised Cochrane risk-of-bias tool for randomized (RoB 2) and non-randomized (ROBINS-I) clinical trials. Marginal bone level change, soft tissue thickness, bleeding on probing, probing depth, survival rates of implants and crowns, complications, plaque and papilla indexes, and pink esthetic score data were extracted and analyzed. The certainty of evidence was accessed through the GRADE approach. RESULTS: Nine records were included and 7 were used in the meta-analyses. Screw-retained crowns presented greater marginal bone level change (MD -0.04 [-0.08, -0.00] p = 0.04, I2  = 0%) compared to cemented crowns up to 1-year. At 3 and 4 years no significant differences (p > 0.05) were observed. Soft tissue thickness did not differ between groups (p > 0.05). The bleeding on probing was higher in cemented group than in screw-retained crowns at 1-year (MD 0.17 [0.08, 0.27] p = 0.0005, I2  = 0%), at medium-term periods (3 and 4 years) no statistically significant differences (p > 0.05) were observed for this outcome. Probing depth, survival rates of implants and crowns, complications, and plaque index, as well as esthetic analysis using the papilla index and pink esthetic score did not differ statistically (p > 0.05) between both retention systems at short and medium-term periods. CONCLUSION: The connection system considering zirconia abutments presented no influence on peri-implant parameters and esthetics evaluation for medium-term periods (3 and 4 years).

Is one dental mini-implant biomechanically appropriate for the retention of a mandibular overdenture? A comparison with Morse taper and external hexagon platforms.

STATEMENT OF PROBLEM: Limited information is available to clinicians on the use of dental mini-implants (MI) as opposed to standard-diameter implants (SDIs) for the stabilization of implant-retained mandibular overdentures (MOs). PURPOSE: The purpose of this in vitro and finite element analysis study was to analyze and compare the biomechanical behavior of MOs with either 1 or 2 implants with external hexagon (EH), Morse taper (MT) SDIs, and MIs. MATERIAL AND METHODS: Thirty photoelastic models (n=30) of each group (n=5) of SDIs (EH-1, EH-2, MT-1, MT-2) and MI (MI-1, MI-2) were fabricated for posterior, peri-implant, and total maximum shear stress evaluation by quantitative photoelastic analysis. One specimen of each group was further used to create the 6 computational models to be analyzed by finite element analysis. The maximum von Mises values and stress maps were plotted for each ductile component. Two types of load were applied to the overdenture: a150-N load bilaterally and simultaneously on the first molar and a 100-N load on the incisal edge of the central incisors at a 30-degree angle. The data were subjected to the 2-way ANOVA test and the Tukey honestly significant difference test (α=.05). RESULTS: The EH-2 and MT-2 showed the lowest posterior (P<.001) and total (P<.05) mean shear stress values. For peri-implant shear stress, no difference was found among all groups (P>.05). Regardless of the loading area, the MI-1 and MI-2 groups showed the lowest von Mises stress values. However, for implant housing, the MI-1 group, under incisor loading, presented greater stress, followed by MT-1, EH-1, EH-2, MI-2, and MT-2. The attachment was the most overloaded structure, with high values under incisor loading, especially for the groups with 2 implants (MT-2, EH-2) as compared with the other models. CONCLUSIONS: Biomechanically, regardless of the implant number, MI is a promising rehabilitation method with similar peri-implant shear stress and lower von Mises stress on the implant when compared with SDIs for MOs.

Can ceramic veneer spark erosion and mechanical cycling affect the accuracy of milled complete-arch frameworks supported by 6 implants?

STATEMENT OF PROBLEM: Milling is a well-established method for manufacturing prosthetic frameworks. However, information about the influence of ceramic veneer and spark erosion on the accuracy of the all-on-six complete-arch fixed frameworks manufactured from different materials is lacking. PURPOSE: The purpose of this in vitro study was to compare the accuracy of milled complete-arch fixed frameworks with zirconia, cobalt-chromium, and titanium at different steps of their manufacturing process and the influence of mechanical cycling. MATERIAL AND METHODS: Fifteen milled complete-arch fixed frameworks, supported by 6 implants, were made in zirconia, cobalt-chromium, and titanium (n=5). The fit was measured by the single-screw test protocol. Stress was measured by photoelastic analysis. The loosening torque was evaluated by tightening the screws, retightening them after 10 minutes, and then evaluating the loosening torque 24 hours later. Thereafter, all frameworks received ceramic veneer, and the previous tests were repeated. Cobalt-chromium and titanium frameworks received spark erosion after ceramic veneer, and all analyses were repeated. Before and after mechanical cycling, loosening torque was evaluated. The results were subjected to 2-way repeated-measures ANOVA and the Bonferroni test (α=.05). RESULTS: Titanium presented higher fit values than zirconia (P=.037) and similar to cobalt-chromium frameworks (P>.05) at baseline. After ceramic veneer, higher fit levels were observed for zirconia (P=.001) and cobalt-chromium (P=.008). Titanium showed higher stress values (P<.05) regardless of time. Baseline for all materials presented lower stress values (P<.05). Higher loosening torque values were found for the titanium group at baseline (P<.001) and after ceramic veneer (P<.001). Spark erosion improved fit and loosening torque values only for cobalt-chromium (P<.05). Mechanical cycling did not influence the loosening torque (P>.05). CONCLUSIONS: Titanium milled complete-arch fixed frameworks presented poorer fit values than zirconia, although the loosening torque at baseline was higher. Ceramic veneer increased the fit levels for zirconia and cobalt-chromium, decreased the loosening torque values for cobalt-chromium, and enhanced stress levels. Spark erosion can be a reliable technique to improve fit and loosening torque for cobalt-chromium frameworks. Mechanical cycling did not decrease loosening torque.

Long-term outcomes of different loading protocols for implant-supported mandibular overdentures: A systematic review and meta-analysis.

STATEMENT OF PROBLEM: Evidence provided by implant-supported mandibular overdenture research on different loading protocols is important. However, methodological inconsistency, as well as inadequate reporting of results, hampers a consistent decision in terms of clinical applicability. PURPOSE: The purpose of this systematic review and meta-analysis was to evaluate whether immediate or early loading protocols can achieve comparable clinical outcomes when compared with a conventional loading protocol in edentulous patients rehabilitated with mandibular overdentures. MATERIAL AND METHODS: In accordance with the Participant, Intervention, Comparison, Outcome strategy, prospective clinical studies without restrictions as to language or follow-up period were included. The Cochrane collaboration and ROBINS-I tools were used for quality assessment and risk-of-bias evaluation. The follow-up for the different outcomes ranged from 3 to 168 months, with the focus on implant success and survival rates, marginal bone loss, bleeding on probing, probing depth, plaque index, and the implant stability quotient. Statistical analyses in which standard mean differences were applied with a 95% confidence interval when continuous data were included were performed. For dichotomous data, risk difference was adopted. RESULTS: The search strategy resulted in 14 234 references. Twenty-three studies fulfilled the inclusion criteria. Meta-analysis showed statistically significant differences for plaque index at 12 months (standard mean difference=0.284 [0.022, 0.545], P=.033, I2=35%), probing depth at 36 months (standard mean difference=0.460 [0.098, 0.823], P=.013, I2=0%), and on pooled results for plaque index (standard mean difference=0.157 [0.031, 0.284], P=.015, I2=18%) in which the conventional loading protocol presented lower indices than those of immediate loading protocol or early loading protocol. Implant stability quotient presented a statistically significant difference only at 3 months (standard mean difference=0.602 [0.309, 0.895], P<.001, I2=0%) with higher values for the conventional loading protocol. For the other parameters, statistically significant differences (P>.05) were not found. CONCLUSIONS: Immediate loading protocol or early loading protocolfor mandibular overdentures has been determined to be a well-established treatment and worthy of consideration in clinical practice.

3D metal printing in dentistry: An in vitro biomechanical comparative study of two additive manufacturing technologies for full-arch implant-supported prostheses.

The use of 3D technologies is progressing in the dental field. However, little is known about the biomechanical behavior of the additive manufacturing of full-arch fixed dental prostheses (FAFDPs) for the establishment of clinical protocols. We investigated the influence of three CAD/CAM technologies: milling (control), Selective Laser Melting (SLM) and Electron Beam Melting (EBM) for FAFDP manufacturing. Also, the effects of ceramic veneer and spark erosion on marginal misfits of FAFDPs, the stability of prosthetic screws, strain and stress on the implant-supported system, as well as the effect of chewing simulation on screw stability were evaluated. Fifteen Ti-6Al-4V alloy FAFDPs were obtained by means of CAD/CAM systems: milling, SLM and EBM (n = 5/group). The marginal misfit was analyzed according to the single-screw test protocol. Screw stability was analyzed by screw-loosening torque. Strain-gauge analysis investigated the strain on the mini-abutment analog, and photoelastic analysis investigated the stress on the peri-implant region. Subsequently, all frameworks underwent ceramic veneer and spark erosion procedures. Marginal misfit, screw-loosening and strain and stress analyses were assessed after each evaluation time: initial, ceramic veneer and spark erosion. Finally, all prostheses were subjected to 106 mechanical cycles (2 Hz/150 N), and screw-loosening was re-evaluated. Data were subjected to two-way ANOVA for repeated measures, and the Bonferroni test as a post hoc technique (α = 0.05). At the initial time, the milling group presented the lowest marginal misfit (p < 0.001). Ceramic veneer did not alter marginal misfit for all groups (p > 0.05); spark erosion decreased the misfit values for the SLM and EBM groups (p < 0.05). Evaluation time did not alter screw-loosening values for all groups (p = 0.191), although the milling group presented the highest screw-loosening values (p < 0.05). Ceramic veneer and spark erosion reduced strain in the components regardless of the manufacturing technology used (p < 0.05). The milling group presented the lowest stress values regardless of evaluation time (p = 0.001), and lower stress values were found after spark erosion regardless of the manufacturing group (p = 0.016). In conclusion, although milled frameworks exhibited the best biomechanical behavior, frameworks manufactured by additive technologies presented acceptable values of screw-loosening torque, strain and stress. Ceramic veneer did not negatively interfere in the biomechanical tests of the study, and clinically acceptable marginal misfit was achieved after spark erosion. Therefore, such 3D printing technologies seem to be feasible for the manufacturing of full-arch implant-supported frameworks.

Biomechanical behavior of CAD/CAM cobalt-chromium and zirconia full-arch fixed prostheses.

PURPOSE: To verify the influence of computer-aided design/computer-aided manufacturing (CAD/CAM) implant-supported prostheses manufactured with cobalt-chromium (Co-Cr) and zirconia (Zr), and whether ceramic application, spark erosion, and simulation of masticatory cycles modify biomechanical parameters (marginal fit, screw-loosening torque, and strain) on the implant-supported system. MATERIALS AND METHODS: Ten full-arch fixed frameworks were manufactured by a CAD/CAM milling system with Co-Cr and Zr (n=5/group). The marginal fit between the abutment and frameworks was measured as stated by single-screw test. Screw-loosening torque evaluated screw stability, and strain analysis was explored on the implant-supported system. All analyses were performed at 3 distinct times: after framework manufacturing; after ceramic application in both materials' frameworks; and after the spark erosion in Co-Cr frameworks. Afterward, stability analysis was re-evaluated after 106 mechanical cycles (2 Hz/150-N) for both materials. Statistical analyses were performed by Kruskal-Wallis and Dunn tests (α=.05). RESULTS: No difference between the two materials was found for marginal fit, screw-loosening torque, and strain after framework manufacturing (P>.05). Ceramic application did not affect the variables (P>.05). Spark erosion optimized marginal fit and strain medians for Co-Cr frameworks (P<.05). Screw-loosening torque was significantly reduced by masticatory simulation (P<.05) regardless of the framework materials. CONCLUSION: Co-Cr and Zr frameworks presented similar biomechanical behavior. Ceramic application had no effect on the biomechanical behavior of either material. Spark erosion was an effective technique to improve Co-Cr biomechanical behavior on the implant-supported system. Screw-loosening torque was reduced for both materials after masticatory simulation.

Biomechanical behavior of overdentures supported by different implant position and angulation using Micro ERA® system: a finite element analysis study

Aim: The aim of this study was to investigate the biomechanical behavior of implant-retained mandibular overdentures using Micro ERA® system with different implant position and angulation by finite element analysis (FEA). Methods: Four 3D finite element models of simplified mandibular overdentures were constructed, using one Bränemark implant with a Micro ERA® attachment. The implant was positioned on the canine or lateral incisor area with an angulation of either 0º (C-0º; LI-0º) or 17º (C-17º, LI-17º) to the vertical axis. A 100 N axial load was applied in one side simultaneously, from first premolar to second molar. In all models it was analyzed the overdenture displacement, compressive/tensile stress in the bone-implant interface, and also the von Mises equivalent stress for the nylon component of the housing. The stresses were obtained (numerically and color-coded) for further comparison among all the groups. Results: The displacement on the overdenture was higher at the posterior surface for all groups, especially in the C-17º group. When comparing the compressive/tensile stress in the bone-implant interface, the lateral-incisor groups (LI-0º and LI-17º) had the highest compressive and lowest tensile stress compared to the canine groups (C-0º and C-17º). The von Mises stress on the nylon component generated higher stress value for the LI-0º among all groups. Conclusions: The inclination and positioning of the implant in mandibular overdenture interferes directly in the stress distribution. The results showed that angulated implants had the highest displacement. While the implants placed in the lateral incisor position presented lower compressive and higher tensile stress respectively. For the attachment the canine groups had the lowest stress

Inserção do Conteúdo Fitoterapia em Cursos da Área de Saúde / Inclusion of Phytotherapy Content in Health Training Courses

RESUMO Este trabalho verificou a opinião de acadêmicos da Saúde sobre a inserção do conteúdo fitoterapia nos cursos de graduação. Trata-se de estudo transversal e analítico, realizado com aplicação de questionário a alunos de Enfermagem, Medicina e Odontologia em 2011. Participaram 248 acadêmicos, a maioria do sexo feminino (69,8%), com idade entre 17 e45 anos. Os estudantes (70,8%) mostraram interesse pela inclusão da fitoterapia, sem diferença entre os sexos (p= 0,757), sendo 83,1% da Enfermagem, 68,2% da Medicina e 63,0% da Odontologia (p=0,019). Entre as motivações destacam-se: ampliação do conhecimento (35,7%) e constatação da evidência científica (16,5%). O desconhecimento da Política Nacional de Práticas Integrativas e Complementares foi de 84,7% na Enfermagem, 84,6% na Medicina e 74,7% na Odontologia (p=0,166), sem diferença significativa entre os sexos (p= 0,333). Conclui-se que os estudantes são favoráveis à inserção do conteúdo fitoterápico no currículo, embora desconheçam a Política Nacional de Práticas Integrativas e Complementares, regulamentada para o sistema de saúde brasileiro.

ABSTRACT This study examined the views of health academics about the inclusion of herbal medicine content in undergraduate courses. It is cross-sectional analytical study, with a questionnaire applied tonursing, medical and dentistry students in 2011. The study involved248 students, mostly women (69.8%), aged 17-45 years. The students (70.8%) showedinterest in the inclusion of herbal medicine, with no difference between genders (p = 0.757) and 83.1% of nursing, 68.2% and 63.0% of medical and dentistry students (p = 0.019), respectively. The reasons given for this include: expansion of knowledge (35.7%) and finding scientific evidence (16.5%). 84.7% of the nursing students, 84.6% ofthe medical students and 74.7% of the dentistry students (p = 0.166) did not know about the National Policy on Integrative and Complementary Practices, with no significant difference between genders (p = 0.333). In conclusion, students favor the inclusion of herbal medicine content in the curriculum, despite being unaware of the National Policy on Integrative and Complementary Practices, regulated forthe Brazilian health system.