RESUMO
BACKGROUND: The classification of digestive neuroendocrine tumors is difficult due to their heterogeneity and rareness. AIMS: Reclassify the digestive neuroendocrine tumors according to the WHO-2010 classification . Methods: A retrospective study included 26 patients having digestive neuroendocrine tumors , is achieved in our Pathology Laboratory of the Military Hospital of Tunis between 2000 and 2013. RESULTS: The mean age of patients was 49.64 years. The Sex ratio was 1.36. It was 6 gastric tumors, 5 small intestine tumors , 5 pancreatic tumors, 5 appendix tumors , one hypatic tumor, one gall bladder tumor , one rectal tumor and one colon tumor. According to the WHO -2000 classification, tumors are categorised into 11 well differentiated endocrine tumors, 13 well differentiated endocrine carcinoma and 2 poorly differentiated carcinoma . According to the WHO -2010 classification, tumors were re-evaluated as 16 neuroendocrine tumors grade 1, 6 neuroendocrine tumors grade 2 and 4 neuroendocrine carcinoma . CONCLUSION: There was a concordance between the two classifications in 93% of cases. The WHO -2010 classification may allow a better classification for the digestive neuroendocrine tumors, however there are some histological categories that remained difficult to classify.
Assuntos
Neoplasias do Sistema Digestório/classificação , Tumores Neuroendócrinos/classificação , Neoplasias do Apêndice/classificação , Carcinoma Neuroendócrino/classificação , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Neoplasias Pancreáticas/classificação , Estudos Retrospectivos , Neoplasias Gástricas/classificação , Organização Mundial da SaúdeRESUMO
BACKGROUND: The classification of digestive neuroendocrine tumors is difficult due to their heterogeneity and rareness. AIMS: Reclassify the digestive neuroendocrine tumors according to the WHO-2010 classification . Methods: A retrospective study included 26 patients having digestive neuroendocrine tumors , is achieved in our Pathology Laboratory of the Military Hospital of Tunis between 2000 and 2013. RESULTS: The mean age of patients was 49.64 years. The Sex ratio was 1.36. It was 6 gastric tumors, 5 small intestine tumors , 5 pancreatic tumors, 5 appendix tumors , one hypatic tumor, one gall bladder tumor , one rectal tumor and one colon tumor. According to the WHO -2000 classification, tumors are categorised into 11 well differentiated endocrine tumors, 13 well differentiated endocrine carcinoma and 2 poorly differentiated carcinoma . According to the WHO -2010 classification, tumors were re-evaluated as 16 neuroendocrine tumors grade 1, 6 neuroendocrine tumors grade 2 and 4 neuroendocrine carcinoma . CONCLUSION: There was a concordance between the two classifications in 93% of cases. The WHO -2010 classification may allow a better classification for the digestive neuroendocrine tumors, however there are some histological categories that remained difficult to classify.
Assuntos
Neoplasias do Sistema Digestório/classificação , Tumores Neuroendócrinos/classificação , Neoplasias do Apêndice/classificação , Neoplasias do Apêndice/patologia , Neoplasias do Sistema Digestório/patologia , Feminino , Humanos , Neoplasias Intestinais/classificação , Neoplasias Intestinais/patologia , Intestino Delgado , Masculino , Pessoa de Meia-Idade , Tumores Neuroendócrinos/patologia , Neoplasias Pancreáticas/classificação , Neoplasias Pancreáticas/patologia , Estudos Retrospectivos , Neoplasias Gástricas/classificação , Neoplasias Gástricas/patologia , Tunísia , Organização Mundial da SaúdeRESUMO
Pyoderma gangrenosum (PG) and Sweet's Syndrome (SS) are inflammatory skin diseases caused by the accumulation of neutrophils in the skin and, rarely, in internal organs. These neutrophilic dermatosis (NDs) are distinguished by the existence of forms of transition or overlap. They are frequently associated to systemic diseases especially hematologic and gastrointestinal ones. We report a case of a patient with ulcerative colitis (UC) who successively developed two types of NDs: PG then SS. A 66 years old patient with a history of UC consulted in July 2012 for an erythematous swelling of the back of the right hand treated with antibiotics without improvement. At that time, bacteriological samples were negative. In October 2012, he was hospitalized for polyarthralgia and impaired general condition. In physical examination, he had vesiculobullous plaque of 10 cm long of the right hand and wrist, infiltrated erythematous plaque on the right leg and another topped with a large pustule at the left ankle. Skin biopsy showed at the back of the right hand an aspect of PG and at the infiltrated plaques of the ankle an aspect of SS. Prednisone was started with improvement of the skin lesions and a recovery condition. The combination of PG and SS has already been described in cases of hematologic malignancy and rarely in UC. There is also the notion of passage from a neutrophilic dermatosis to another. Indeed, a typical lesion initially of SS can evolve to a future PG. This case demonstrates that neutrophilic dermatoses form a continous spectrum of entities that may occur in UC.
Assuntos
Colite Ulcerativa/complicações , Pioderma Gangrenoso/etiologia , Síndrome de Sweet/etiologia , Idoso , Biópsia , Colite Ulcerativa/fisiopatologia , Glucocorticoides/uso terapêutico , Humanos , Masculino , Prednisona/uso terapêutico , Pioderma Gangrenoso/diagnóstico , Pioderma Gangrenoso/patologia , Síndrome de Sweet/diagnóstico , Síndrome de Sweet/patologiaRESUMO
BACKGROUND: Gastrointestinal stromal tumors - commonly called GISTs - are rare; yet, they represent an important type of mensenchymal tumors arising within the gastrointestinal tract. The acronym GIST was introduced in 1998 to define a well established pathological entity which bears a highly specific marker called KIT (CD117). Scientific interest for these tumors in recent years is mainly due to the progress in identification by immunohistochemistry and the advent of targeted molecular therapy. AIM: To reclassify mesenchymal tumors of the digestive tract using advanced immunophenotyping. METHODS: We examined the digestive tissue tumors operated at the Principal Military Hospital of Instruction of Tunis over a 19-year period from 1992 to 2011. RESULTS: We collected 22 cases of benign mesenchymal tumors of the digestive tract. Tumors were initially diagnosed as leiomyomas (4 cases), schwannomas (2 cases), gastrointestinal stromal tumors (14 cases), a leiomyoblastoma and a mesenchymal tumor with fusiform cells. The immunohistochemical study has allowed to correct some diagnoses and, in one case, the block has been exhausted. In total, we selected 18 cases of gastrointestinal stromal tumor, a tumors. The final diagnosis of GIST was confirmed by the positivity of C-kit or DOG1. CONCLUSIONS: The combined use of C-kit and DOG1 ensures accurate diagnosis of GIST. The DOG1 has allowed us to detect the 3 stromal tumors negative for C-kit. This antibody has achieved a diagnostic gain of 15 %. The rate of GIST tumors labeled increased from 71 % to 86 % among mesenchymal tumors.
Assuntos
Doenças Renais Císticas/diagnóstico , Neoplasias Renais/diagnóstico , Nefroma Mesoblástico/diagnóstico , Fatores Etários , Feminino , Humanos , Doenças Renais Císticas/complicações , Doenças Renais Císticas/patologia , Doenças Renais Císticas/cirurgia , Neoplasias Renais/complicações , Neoplasias Renais/patologia , Neoplasias Renais/cirurgia , Pessoa de Meia-Idade , Nefroma Mesoblástico/complicações , Nefroma Mesoblástico/patologia , Nefroma Mesoblástico/cirurgiaRESUMO
The sarcoma of the penis is a very rare tumor more exceptional is the Leiomyosarcoma of the penis for which the diagnosis required an immunohistochemical study. The prognosis for this tumor is poor. We report a case, which arise to a 53 year-old-man in this instance we did a review of the medical literature.