RESUMO
Dietary administration of the fungicide folpet, N-(trichloromethylthio) phthalimide, to B6C3F1 mice at dose levels of 1,000, 5,000 and 10,000 ppm induced a dose-related appearance of duodenal atypical hyperplasia, adenomas and adenocarcinomas. The appearance in some of these animals of gastric papillomas and gastric squamous cell carcinomas was correlated in many instances to the presence of duodenal obstructions. It is suggested that the gastric lesions appeared subsequent to, and as an indirect result of, these partial lumenal duodenal obstructions. We suggest that the presence of duodenal obstructions is consistent with the notion that reflux of folpet, bile acids and pancreatic enzymes into the stomach may have acted to irritate and consequently stimulate local neoplastic proliferation. In addition, the duodenal obstructions may have resulted in delayed emptying time of the stomach contents with consequential stagnation. This would cause high concentrations of folpet to act locally on the gastric mucosa.
Assuntos
Fungicidas Industriais/toxicidade , Neoplasias Gastrointestinais/induzido quimicamente , Ftalimidas/toxicidade , Adenocarcinoma/induzido quimicamente , Adenoma/induzido quimicamente , Carcinoma de Células Escamosas/induzido quimicamente , Relação Dose-Resposta a Droga , Feminino , Humanos , Hiperplasia , Lactente , Neoplasias Intestinais/induzido quimicamente , Obstrução Intestinal/induzido quimicamente , Intestinos/patologia , Masculino , Pigmentação da Pele/efeitos dos fármacos , Neoplasias Gástricas/induzido quimicamenteRESUMO
Three groups of Fischer 344 rats were fed Merpafol (Makhteshim, Israel), an agricultural fungicide, in increasing concentrations for a period of 2 years. A control group was maintained under identical conditions, but without the addition of the fungicide in the diet. A range of nonneoplastic and neoplastic lesions were observed in the kidneys of rats fed Merpafol. The histogenesis of the renal tumors is discussed in relation to chemical-induced epithelial hyperplasia and cystic tubular dilation. Comparative aspects of renal cyst development and carcinoma in humans are also discussed.
Assuntos
Captana/análogos & derivados , Carcinógenos , Fungicidas Industriais/toxicidade , Neoplasias Renais/induzido quimicamente , Adenoma/induzido quimicamente , Adenoma/patologia , Adenoma/secundário , Animais , Captana/toxicidade , Carcinoma/induzido quimicamente , Carcinoma/patologia , Carcinoma/secundário , Cicloexenos , Relação Dose-Resposta a Droga , Feminino , Neoplasias Renais/patologia , Masculino , Ratos , Ratos Endogâmicos F344RESUMO
The clinical course following endosulfan ingestion in a suicidal attempt is described. The clinical picture comprised three stages: the acute cardiac and convulsive stage followed by subacute pulmonary and convulsive stage and finally the slow recovery stage. This is the first known survivor of endosulfan ingestion.