RESUMO
Time- and concentration-related actions of lipopolysaccharide (LPS) on the synthesis of prostaglandin E(2) (PGE(2)) were investigated in cartilage explants and synoviocytes harvested from 3 age groups of horses, all with clinically normal joint function: group A <10 years; group B 11-20 years and group C >20 years. Cartilage explants from group A horses were least and those from group C were most sensitive to LPS. Significant increases in PGE(2) concentration (P Assuntos
Cartilagem Articular/citologia
, Dinoprostona/biossíntese
, Líquido Sinovial/citologia
, Envelhecimento/metabolismo
, Animais
, Cartilagem Articular/efeitos dos fármacos
, Cartilagem Articular/metabolismo
, Células Cultivadas
, DNA/metabolismo
, Dinoprostona/fisiologia
, Cavalos
, Lipopolissacarídeos/farmacologia
, Proteoglicanas/metabolismo
, Líquido Sinovial/efeitos dos fármacos
, Líquido Sinovial/metabolismo