Assuntos
Doenças dos Anexos/diagnóstico , Encefalite Límbica/diagnóstico , Teratoma/diagnóstico , Doenças dos Anexos/complicações , Doenças dos Anexos/fisiopatologia , Adolescente , Diagnóstico Diferencial , Feminino , Febre de Causa Desconhecida/etiologia , Humanos , Encefalite Límbica/complicações , Encefalite Límbica/fisiopatologia , Transtornos Mentais/etiologia , Transtornos dos Movimentos/etiologia , Obesidade/epidemiologia , Teratoma/complicações , Teratoma/fisiopatologiaRESUMO
Recommended doses of carbidopa are 75-200 mg/day. Higher doses could inhibit brain aromatic amino-acid decarboxylase and reduce clinical effects. We compared 4-week outpatient treatments with carbidopa (75 and 450 mg/day) administered with L-dopa on the subjects' normal schedule. After each treatment phase, subjects had two 2-hour L-dopa infusions. The first infusion examined the effects of carbidopa doses administered the preceding 4 weeks, and the second infusion determined the acute effects of the two dosages of carbidopa. The antiparkinsonian effects and L-dopa and carbidopa plasma concentrations were monitored during the infusions. Twelve subjects completed the study. Carbidopa concentrations were eight times higher after the high-carbidopa phase. Area under the curve (AUC) for clinical ratings did not differ for the four L-dopa infusions, although AUC for plasma L-dopa was modestly increased with 450 mg of carbidopa. Nine subjects reported that the high-carbidopa outpatient phase was associated with greater response to L-dopa. Doses of 450 mg/day of carbidopa did not reduce the responses to L-dopa infusion, extending the safe range of carbidopa to 450 mg/day.