INFLUENCE OF PHYTOCOMPOSITIONS ON DYNAMICS OF CHANGES IN BASAL GLYCEMIA AND GLYCEMIA IN ORAL GLUCOSE TOLERANCE TEST IN RATS WITH STREPTOZOTOCIN-NICOTINAMIDE-INDUCED DIABETES MELLITUS TYPE 2.

Diabetes mellitus is one of the global medical, social and economic problems of today.Therefore, it is important to develop a new mechanism of action with fewer side effects that can reduce glycemia and insulin resistance. The aim of the study was to determine the effect of phytocompositions on the basis of Galega officinalis L. and Galevit in the conditions of therapeutic and prophylactic use in experimental type 2 diabetes mellitus contribute to the recovery of carbohydrate metabolism.on the dynamics of changes in basal glycemia and glycemia after oral glucose tolerance test in animals under conditions of experimental streptozotocin diabetes. The composition of the maturing phytocomposition and its lipocomposite form includes dry extract Galega officinalis L. - 50.0 mg, dry extract of Vaccinium myrtillus L. leaf - 50.0 mg, taurine - 1.4 mg. Type 2 diabetes mellitus was modeled on the method of Islam S., Choi H. 50 nonlinear white rats-males body weighing 180-220 g were used for the experimental studies.All animals were randomized into 5 groups of 10 rats: 1 - control group; 2 - animals with with T2DM; 3 - animals with diabetes mellitus, which received reference drugs (Arfa combi); 4 - STZ+N and substances received phytocomposition; 5 - STZ+N and Galevit. The investigated phytocompositions were administered intragastrically once a day for 28 days, starting 24 h after induction of type 2 diabetes mellitus. Phytocompositionson the basis of Galega officinalis L. and Galevit in the conditions of therapeutic and prophylactic use in experimental type 2 diabetes mellitus contribute to the recovery of carbohydrate metabolism. At the effectiveness of correction of metabolic changes, in experimental diabetes mellitus, phytocomposition based on Galega officinalis L. is not inferior, and liposomal form of dry extract Galevit is dominated by the reference phyto-agent Arfa combi. The spectrum of metabolic activity and the effectiveness of the therapeutic and prophylactic action of the application of the liposomal form of this phytocomposition under the conditional name Galevit is more justified on the basis of pathological changes, and the develo-pment of a new antidiabetic herbal remedy is more expedient.

[83-year-old patient with salmonella bacteremia and infection-associated Sweet's syndrome]. / 83-jähriger Patient mit Salmonellenbakteriämie und Infekt-getriggertem Sweet-Syndrom.

HISTORY AND PHYSICAL EXAMINATION: An 83 year-old man presented with watery diarrhea and a rash. He was hypotensive, febrile and dehydrated. The rash was maculopapular and most pronounced on the dorsal trunk. INVESTIGATIONS: The lab tests showed an acute renal failure with hypokalemia and hyponatremia. Salmonella typhimurium was isolated from the aerobic blood culture, stool cultures were negative. The rash was consistent with an infection-associated Sweet's syndrome. THERAPY AND COURSE OF DISEASE: The patient was admitted and received iv fluids and potassium. An empiric antibiotic treatment with i. v. ciprofloxacin was started and changed to p. o. after 8 days. Antibiotic therapy was given 11 days total. After the administration of steroids the skin rash resolved. CONCLUSION: It is important to draw blood cultures in patients presenting with diarrhea if fever is present. Complications associated with non-typhoidal salmonella bacteremia occur most frequently in elderly patients and include pneumonia, infected aneurysms and bone/soft part infections. In rare cases patients can also present with a skin rash.