Making Leaps and Hitting Boundaries in Reconsolidation: Overcoming Boundary Conditions to Increase Clinical Translatability of Reconsolidation-based Therapies.

Reconsolidation results in the restabilisation, and thus persistence, of a memory made labile by retrieval, and interfering with this process is thought to enable modification or weakening of the original trace. As such, reconsolidation-blockade has been a focus of research aiming to target the maladaptive memories underlying mental health disorders, including post-traumatic stress disorder and drug addiction. Current first-line therapies are not effective for all patients, and a substantial proportion of those for whom therapies are effective later relapse. A reconsolidation-based intervention would be invaluable as an alternative treatment for these conditions. However, the translation of reconsolidation-based therapies to the clinic presents a number of challenges, with arguably the greatest being the overcoming of the boundary conditions governing the opening of the reconsolidation window. These include factors such as the age and strength of memory, and can broadly be divided into two categories: intrinsic features of the targeted memory itself, and parameters of the reactivation procedure used. With maladaptive memory characteristics inevitably varying amongst individuals, manipulation of the other limitations imposed by procedural variables have been explored to circumvent the boundary conditions on reconsolidation. Although several apparently discrepant results remain to be reconciled and these limitations yet to be truly defined, many studies have produced successful results which encouragingly demonstrate that boundary conditions may be overcome using various proposed strategies to enable translation of a reconsolidation-based intervention to clinical use.

Modification of Lignocellulosic Materials with a Mixture of m-DMDHEU/Choline Chloride to Remove CrO4 2-, NO3 -, and H2AsO4 - in Aqueous Solution.

A new denaturation agent is the mixture of 4,5-dihydroxy-1,3-bis(methoxymethyl)imidazolidin-2-one (m-DMDHEU)/choline chloride (CC) introduced to modify three kinds of lignocellulosic materials containing different lignin contents in the following order: cotton used in medicine < sawdust from acacia auriculiformis wood < powder from the coconut shell. The modification process is carried out through two main steps: 0.2 N NaOH solution with 70% v/v ethanol and 30% v/v water was applied to remove lignin and activate the initial raw materials, and then delignified materials were modified with m-DMDHEU/CC by using a parched heat supply method after chemical impregnation. Structural characterictics and physicochemical properties of modified materials were tested and dissected by scanning electron microscopy, Fourier transform infrared spectroscopy, solid-state 13C nuclear magnetic resonance spectroscopy (solid-state 13C CP-MAS NMR), specific surface area, and pH at the point of zero charge (pHPZC). The ability to adsorb and exchange anions of modified materials was referred and examined by using aqueous solutions containing CrO4 2-, NO3 -, and H2AsO4 - anions in different conditions. The results revealed that anionite lignocellulosic materials could separate these anions with very good efficiency and better than strong anion exchange resin (GA-13) in the same conditions; outlet water could meet the permissible drinking and living water standards; and the m-DMDHEU cross-link bridge also was a good bridge to connect CC to cellulose chain beside other common urea cross-link bridges.