Effect of pupil dilation on IOLMaster® measurements in Pakistani Eyes.

Objectives: To analyse the effect of pupil dilation on intraocular lens instrument IOLMaster 500 biometric measurements, and to determine the effect of these measurements on intraocular lens power calculations in Asian eyes. METHODS: The prospective study was conducted at the Aga Khan University Hospital, Karachi, between January and April 2017, and comprised all patients scheduled for cataract surgery who underwent scanning with IOLMaster 500. For each patient, pre-dilation and post-dilation measurements were taken. The intraocular lens power was determined through Sanders/Retzlaff/Kraff Theoretical, Holladay, and Hoffer Q formulae. Data was analysed using SPSS 24. RESULTS: There were 276 eyes of 138 participants who had a mean age of 59.7±11.1 years. Anterior chamber depth changed significantly with pupil dilation (p=0.001). No significant changes were observed in the axial length (p=0.410), keratometry measurements (p=0.931), and intraocular lens power calculations (p>0.05). CONCLUSIONS: The change in anterior chamber depth, though significant, was perhaps clinically non-significant.

Incidence of endophthalmitis after intravitreal injections at a tertiary care hospital.

OBJECTIVE: To report the incidence of endophthalmitis after the use of intravitreal injection for anti-vascular endothelial growth factor therapy. METHODS: This was a single-centre retrospective study conducted at the Aga Khan University Hospital, Pakistan. A total of 11 128 injections were administered to 2054 patients between January 2013 and December 2015. All procedures were performed in an operating room setting, and postinjection antibiotics were prescribed. RESULTS: Three cases of endophthalmitis occurred during the study period, with the per-injection risk of endophthalmitis being 0.027%. CONCLUSION: The results highlight the benefit of administering intravitreal injections in a surgical setting in addition to enforcing quality protocols. We also recommend further investigation to scrutinize the role of antibiotics prescribed after deploying intravitreal injections so that unnecessary use of such may be curtailed.