Model of charge transfer collisions between C60 and slow ions.

A semiclassical model describing the charge transfer collisions of C60 fullerene with different slow ions has been developed to analyze available observations. These data reveal multiple Breit-Wigner-like peaks in the cross sections, with subsequent peaks of reactive cross sections decreasing in magnitude. Calculations of charge transfer probabilities, quasi-resonant cross sections, and cross sections for reactive collisions have been performed using semiempirical interaction potentials between fullerenes and ion projectiles. All computations have been carried out with realistic wave functions for C60's valence electrons derived from the simplified jellium model. The quality of these electron wave functions has been successfully verified by comparing theoretical calculations and experimental data on the small angle cross sections of resonant C60+C60 + collisions. Using the semiempirical potentials to describe resonant scattering phenomena in C60 collisions with ions and Landau-Zener charge transfer theory, we calculated theoretical cross sections for various C60 charge transfer and fragmentation reactions which agree with experiments.

Solid-state culture of Azospirillum brasilense: a reliable technology for biofertilizer production from laboratory to pilot scale.

A biofertilizer of Azospirillum brasilense was produced in solid-state culture (SSC) from laboratory to pilot scale. Similar operation conditions (continuous aeration and mild intermittent mixing) and two dimensionless numbers with similar L/D ratio and a similar working volume were applied to reach a scale-up factor of 75. An innovative bioreactor with rotating helical ribbons (15 kg wet matter) was used at pilot scale. A mathematical model was proposed and validated to evaluate the respirometry trends at laboratory and pilot scale exhibiting similar behavior. The cell viability was (1.3 ± 0.4) × 109 and (1.3 ± 0.3) × 109 colony-forming units per gram of initial dry mass at laboratory and pilot scale, at 36 and 43 h, respectively. A. brasilense maintains its viability twelve months of storage at 4 and 30 °C. This is the first report of A. brasilense being cultivated in SSC under controlled conditions. SSC processes involving unicellular microorganisms with tolerance to agitation are a promising technology to produce biofertilizers.

Rydberg Electrons in a Bose-Einstein Condensate.

We investigate a hybrid system composed of ultracold Rydberg atoms immersed in an atomic Bose-Einstein condensate (BEC). The coupling between Rydberg electrons and BEC atoms leads to excitations of phonons, the exchange of which induces a Yukawa interaction between Rydberg atoms. Because of the small electron mass, the effective charge associated with this quasiparticle-mediated interaction can be large. Its range, equal to the BEC healing length, is tunable using Feshbach resonances to adjust the scattering length between BEC atoms. We find that for small healing lengths, the distortion of the BEC can "image" the Rydberg electron wave function, while for large healing lengths the induced attractive Yukawa potentials between Rydberg atoms are strong enough to bind them.

Tuning ultracold chemical reactions via Rydberg-dressed interactions.

We show that ultracold chemical reactions with an activation barrier can be tuned using Rydberg-dressed interactions. Scattering in the ultracold regime is sensitive to long-range interactions, especially when weakly bound (or quasibound) states exist near the collision threshold. We investigate how, by Rydberg dressing a reactant, one enhances its polarizability and modifies the long-range van der Waals collision complex, which can alter chemical reaction rates by shifting the position of near-threshold bound states. We carry out a full quantum mechanical scattering calculation for the benchmark system H(2)+D, and show that resonances can be moved substantially and that rate coefficients at cold and ultracold temperatures can be increased by several orders of magnitude.

Quantum Hall to charge-density-wave phase transitions in ABC-trilayer graphene.

ABC-stacked trilayer graphene's chiral band structure results in three (n=0, 1, 2) Landau level orbitals with zero kinetic energy. This unique feature has important consequences on the interaction-driven states of the 12-fold degenerate (including spin and valley) N=0 Landau level. In particular, at many filling factors ν(T) = ±5, ±4, ±2, ±1 a quantum phase transition from a quantum Hall liquid state to a triangular charge-density wave occurs as a function of the single particle-induced Landau level orbital splitting Δ(LL). Experimental signatures of this phase transition are also discussed.

Care and outcomes in patients with ischemic stroke with and without preexisting dementia.

OBJECTIVE: To describe clinical characteristics and evaluate processes of care and outcomes at discharge in patients with ischemic stroke with and without preexisting dementia. METHODS: Retrospective cohort study using the Registry of the Canadian Stroke Network including patients presenting with an acute ischemic stroke between 2003 and 2008. Preexisting dementia was defined as any type of dementia that was present prior to the index stroke case. Palliative patients were excluded. Demographic information, clinical presentation, selected process measures (e.g., thrombolysis, admission to stroke unit, carotid imaging, stroke prevention), pneumonia, death, disability, and disposition at discharge were analyzed. RESULTS: Among 9,304 eligible patients with an acute ischemic stroke, 702 (9.1%) had a history of dementia. Patients with dementia were older (mean age 81 vs 70 years; p < 0.001), had more severe strokes (Canadian Neurological Scale score <4, 20.7% vs 10.5%; p < 0.001), and were more likely to have atrial fibrillation (22.8% vs 15.3%; p < 0.001) than those without dementia. Patients with dementia were slightly less likely to be admitted to a stroke unit (63% vs 67.6%; odds ratio [OR] 0.82, 95% confidence interval [CI] 0.70-0.96) or to receive thrombolysis (10.5% vs 15.7%; OR 0.63, 95% CI 0.49-0.81). There were no differences in other performance measures. Patients with preexisting dementia had higher disability at discharge (OR 3.20, 95% CI 2.64-3.87) and were less likely to be discharged to their prestroke place of residence (24% vs 45%; p < 0.001). CONCLUSIONS: In patients with stroke, preexisting dementia is associated with high rates of disability and institutionalization, representing an increasing challenge for the health care system.

Anomalous exciton condensation in graphene bilayers.

In ordinary semiconductor bilayers, exciton condensates appear at total Landau-level filling factor nu{T}=1. We predict that similar states will occur in Bernal stacked graphene bilayers at many nonzero integer filling factors. For nu{T}=-3, 1 we find that the superfluid density of the exciton condensate vanishes and that a finite-temperature fluctuation-induced first order isotropic-smectic phase transition occurs when the layer densities are not balanced. These anomalous properties of bilayer graphene exciton condensates are due to the degeneracy of Landau levels with n=0 and n=1 orbital character.

Set-up and routine use of a database of 10,555 genotyped blood donors to facilitate the screening of compatible blood components for alloimmunized patients.

BACKGROUND AND OBJECTIVES: Large-scale genotyping of blood donors for red blood cell and platelet antigens has been predicted to replace phenotyping assays in the screening of compatible blood components for alloimmunized patients. Although several genotyping platforms have been described, novel procedures and processes are needed to perform genotyping efficiently and to maximize its benefits for blood banks. MATERIALS AND METHODS: Here we describe the processes and procedures developed to introduce large-scale genotyping in our routine operations. RESULTS: Preliminary cost-benefit analysis indicated that genotyping must target frequent blood donors (> 3 donations/year) to be efficiently used. A custom-designed computer application was developed to manage the whole project. It selects frequent donors among recent donations, prints coded labels to identify blood samples sent to the external genotyping laboratory, and stores genotyping results. It can search for donors compatible for any combination of the 22 genotyped antigens as well as consult the current inventory for the presence of the corresponding blood components. The phenotype of recovered components is confirmed by standard serology techniques prior to shipment to hospitals. CONCLUSION: Since October 2007, 10 555 blood donors have been genotyped. The database is used on a regular basis to find compatible blood components with a genotype-phenotype concordance of 99.6%.

FiberWire is superior in strength to stainless steel wire for tension band fixation of transverse patellar fractures.

BACKGROUND: The metal implants used to achieve fixation of displaced transverse patellar fractures are associated with implant failure, postoperative pain and a significant re-operation rate. Recent studies have examined braided suture as a possible alternative to stainless steel wire to increase patient satisfaction and decrease re-operation rates, but suture has not demonstrated clearly superior fixation strength. FiberWire is a reinforced braided polyblend suture that has demonstrated superior characteristics to the previous sutures studied and has not to our knowledge been examined as a material for tension band fixation of transverse patellar fractures. METHODS: Materials testing was performed on repeated samples of No. 5 FiberWire suture and 18-gauge stainless steel wire. The strength and stiffness of each material was measured. The two materials were then used for tension band fixation on a novel transverse patellar fracture model and tested to failure by three-point bending. The constructs included a single stainless steel wire, a single-strand FiberWire tied with a sliding knot, double-strand FiberWire tied with sliding knots and double-strand FiberWire tied with a Wagoner's Hitch. The fixation strength and stiffness of the constructs were measured. FINDINGS: Unlike stainless steel, FiberWire maintained its initial stiffness until failure. Furthermore, during three-point-bend testing, double-strand FiberWire was found to have a significantly higher failure load than stainless steel wire when the suture was tied and locked under the tension produced by a modified Wagoner's Hitch. INTERPRETATION: FiberWire is a potentially superior alternative to stainless steel wire in tension band fixation of transverse patellar fractures.

Intra-Landau-level cyclotron resonance in bilayer graphene.

Interaction driven integer quantum-Hall effects are anticipated in graphene bilayers because of the near degeneracy of the eight Landau levels which appear near the neutral system Fermi level. We predict that an intra-Landau-level cyclotron resonance signal will appear at some odd-integer filling factors, accompanied by collective modes which are nearly gapless and have approximate k3/2 dispersion. We speculate on the possibility of unusual localization physics associated with these modes.

Anisotropic states of two-dimensional electrons in high magnetic fields.

We study the collective states formed by two-dimensional electrons in Landau levels of index n > or = near half filling. By numerically solving the self-consistent Hartree-Fock (HF) equations for a set of oblique two-dimensional lattices, we find that the stripe state is an anisotropic Wigner crystal (AWC), and determine its precise structure for varying values of the filling factor. Calculating the elastic energy, we find that the shear modulus of the AWC is small but finite (nonzero) within the HF approximation. This implies, in particular, that the long-wavelength magnetophonon mode in the stripe state vanishes q(3/2) like as in an ordinary Wigner crystal, and not like q(5/2) as was found in previous studies where the energy of shear deformations was neglected.

Spectroscopic determination of the s-wave scattering lengths of 86Sr and 88Sr.

We report the use of photoassociative spectroscopy to determine the ground-state s-wave scattering lengths for the main bosonic isotopes of strontium, 86Sr and 88Sr. Photoassociative transitions are driven with a laser red detuned by up to 1400 GHz from the 1S0-1P1 atomic resonance at 461 nm. A minimum in the transition amplitude for 86Sr at -494 +/- 5 GHz allows us to determine the scattering lengths 610a0 < a86 < 2300a0 for 86Sr and a much smaller value of -1a0 < a88 < 13a0 for 88Sr.

Evanescent-wave mirror for ultracold diatomic polar molecules.

We describe the interaction of an ultracold diatomic polar molecule with an evanescent-wave mirror. Several features of this system are explored, such as the coupling between internal rovibrational states of the molecule and the laser field. Numerical simulations show quantum reflection and state selection under attainable physical conditions. Such molecular optics components will facilitate the manipulation and trapping of ultracold molecules, and might serve in future applications in several fields, e.g., as devices to filter and select a state for ultracold chemistry, to measure extremely low temperatures of molecules, or to manipulate states for quantum information processing.

Carotid endarterectomy--an evidence-based review: report of the Therapeutics and Technology Assessment Subcommittee of the American Academy of Neurology.

OBJECTIVE: To assess the efficacy of carotid endarterectomy for stroke prevention in asymptomatic and symptomatic patients with internal carotid artery stenosis. Additional clinical scenarios, such as use of endarterectomy combined with cardiac surgery, are also reviewed. METHODS: The authors selected nine important clinical questions. A systematic search was performed for articles from 1990 (the year of the last statement) until 2001. Additional articles from 2002 through 2004 were included using prespecified criteria. Two reviewers also screened for other relevant articles from 2002 to 2004. Case reports, review articles, technical studies, and single surgeon case series were excluded. RESULTS: For several questions, high quality randomized clinical trials had been completed. Carotid endarterectomy reduces the stroke risk compared to medical therapy alone for patients with 70 to 99% symptomatic stenosis (16% absolute risk reduction at 5 years). There is a smaller benefit for patients with 50 to 69% symptomatic stenosis (absolute risk reduction 4.6% at 5 years). There is a small benefit for asymptomatic patients with 60 to 99% stenosis if the perioperative complication rate is low. Aspirin in a dose of 81 to 325 mg per day is preferred vs higher doses (650 to 1,300 mg per day) in patients undergoing endarterectomy. CONCLUSIONS: Evidence supports carotid endarterectomy for severe (70 to 99%) symptomatic stenosis (Level A). Endarterectomy is moderately useful for symptomatic patients with 50 to 69% stenosis (Level B) and not indicated for symptomatic patients with <50% stenosis (Level A). For asymptomatic patients with 60 to 99% stenosis, the benefit/risk ratio is smaller compared to symptomatic patients and individual decisions must be made. Endarterectomy can reduce the future stroke rate if the perioperative stroke/death rate is kept low (<3%) (Level A). Low dose aspirin (81 to 325 mg) is preferred for patients before and after carotid endarterectomy to reduce the rate of stroke, myocardial infarction, and death (Level A).

Photoassociative spectroscopy at long range in ultracold strontium.

We report photoassociative spectroscopy of 88Sr(2) in a magneto-optical trap operating on the 1S0-->3P1 intercombination line at 689 nm. Photoassociative transitions are driven with a laser red detuned by 600-2400 MHz from the 1S0-->1P1 atomic resonance at 461 nm. Photoassociation takes place at extremely large internuclear separation, and the photoassociative spectrum is strongly affected by relativistic retardation. A fit of the transition frequencies determines the 1P1 atomic lifetime (tau=5.22+/-0.03 ns) and resolves a discrepancy between experiment and recent theoretical calculations.

Local blockade of Rydberg excitation in an ultracold gas.

In the laser excitation of ultracold atoms to Rydberg states, we observe a dramatic suppression caused by van der Waals interactions. This behavior is interpreted as a local excitation blockade: Rydberg atoms strongly inhibit excitation of their neighbors. We measure suppression, relative to isolated atom excitation, by up to a factor of 6.4. The dependences of this suppression on both laser irradiance and atomic density are in good agreement with a mean-field model. These results are an important step towards using ultracold Rydberg atoms in quantum information processing.

A task-orientated intervention enhances walking distance and speed in the first year post stroke: a randomized controlled trial.

OBJECTIVE: To evaluate the efficacy of a task-orientated intervention in enhancing competence in walking in people with stroke. DESIGN: Two-centre observer-blinded stratified block-randomized controlled trial. SETTING: General community. SUBJECTS: Between May 2000 and February 2003, 91 individuals with a residual walking deficit within one year of a first or recurrent stroke consented to participate. INTERVENTIONS: The experimental intervention comprised 10 functional tasks designed to strengthen the lower extremities and enhance walking balance, speed and distance. The control intervention involved the practice of upper extremity activities. Subjects in both groups attended sessions three times a week for six weeks. MAIN MEASURES: Six-minute walk test (SMWT), 5-m walk (comfortable and maximum pace), Berg Balance Scale, timed 'up and go'. RESULTS: At baseline, subjects in the experimental (n = 44) and control (n = 47) groups walked an average distance of 209 m (SD = 126) and 204 m (SD =131), respectively, on the SMWT. Mean improvements of 40 m (SD =72), and 5 m (SD =66) were observed following the experimental and control interventions, respectively. The between-group difference was 35 m (95% confidence interval (CI) 7, 64). Significant between-group effects of 0.21 m/s (95% CI 0.12, 0.30) and of 0.11 m/s (95% CI 0.03, 0.19) in maximum and comfortable walking speed, respectively, were observed. People with a mild, moderate or severe walking deficit at baseline improved an average of 36 (SD =96), 55 (SD = 56) and 18 m (SD = 23), respectively, in SMWT performance following the experimental intervention. CONCLUSIONS: Study findings support the efficacy of a task-orientated intervention in enhancing walking distance and speed in the first year post stroke, particularly in people with moderate walking deficits.

Quantum depinning transition of quantum Hall stripes.

We examine the effect of disorder on the electromagnetic response of quantum Hall stripes using an effective elastic theory to describe their low-energy dynamics, and replicas and the Gaussian variational method to handle disorder effects. Within our model we demonstrate the existence of a depinning transition at a critical partial Landau level filling factor Deltanu(c). For DeltanuDeltanu(c). For Deltanu> or =Deltanu(c), we find a partial RSB solution in which there is free sliding only along the stripe direction. The transition is analogous to the Kosterlitz-Thouless phase transition.

Characteristics of photoreceptor PDE (PDE6): similarities and differences to PDE5.

Phosphodiesterase 6 (PDE6) is highly concentrated in the retina. It is most abundant in the internal membranes of retinal photoreceptors, where it reduces cytoplasmic levels of cyclic guanosine monophosphate (cGMP) in rod and cone outer segments in response to light. The rod PDE6 holoenzyme comprises alpha and beta catalytic subunits and two identical inhibitory gamma subunits. Each catalytic subunit contains three distinct globular domains corresponding to the catalytic domain and two GAF domains (responsible for allosteric cGMP binding). The PDE6 catalytic subunits resemble PDE5 in amino-acid sequence as well as in three-dimensional structure of the catalytic dimer; preference for cGMP over cyclic adenosine monophosphate (cAMP) as a substrate; and the ability to bind cGMP at the regulatory GAF domains. Most PDE5 inhibitors inhibit PDE6 with similar potency, and electroretinogram studies show modest effects of PDE5 inhibitors on visual function-an observation potentially important in designing PDE5-specific therapeutic agents.