Prototype System for Measuring and Analyzing Movements of the Upper Limb for the Detection of Occupational Hazards.

In the work environment, there are usually different pathologies that are related to Repetitive Efforts and Movements (REM) that tend to predominantly affect the upper limbs. To determine whether a worker is at risk of suffering some type of pathology, observation techniques are usually used by qualified technical personnel. In order to define from quantitative data if there is a risk of suffering a pathology due to movements and repetitive efforts in the upper limb, a prototype of a movement measurement system has been designed and manufactured. This system interferes minimally with the activity studied, maintaining a reduced cost of manufacture and use. The system allows the study of the movements made by the subject in the work environment by determining the origin of the Musculoskeletal Disorder (MSD) from the movements of the elbow and wrist, collecting data on the position and accelerations of the arm, forearm and hand, and taking into account the risk factors established for suffering from an MSD: high repetition of movements, the use of a high force in a repetitive manner, or the adoption of forced positions. The data obtained with this system can be analyzed by qualified personnel from tables, graphs, and 3D animations at the time of execution, or stored for later analysis.

Morphogeometric analysis for characterization of keratoconus considering the spatial localization and projection of apex and minimum corneal thickness point.

This work evaluates changes in new morphogeometric indices developed considering the position of anterior and posterior corneal apex and minimum corneal thickness (MCT) point in keratoconus. This prospective comparative study included 440 eyes of 440 patients (age, 7-99 years): control (124 eyes) and keratoconus (KC) groups (316 eyes). Tomographic information (Sirius®, Costruzione Strumenti Oftalmici, Italy) was treated with SolidWorks v2013, creating the following morphogeometric parameters: geometric axis-apex line angle (GA-AP), geometric axis-MCT line angle (GA-MCT, apex line-MCT line angle (AP-MCT), and distances between apex and MCT points on the anterior (anterior AP-MCTd) and posterior corneal surface (posterior AP-MCTd). Statistically significant higher values of GA-AP, GA-MCT, AP-MCT and anterior AP-MCTd were found in the keratoconus group (p ≤ 0.001). Moderate significant correlations of corneal aberrations (r ≥ 0.587, p < 0.001) and corneal thickness parameters (r ≤ -0.414, p < 0.001) with GA-AP and AP-MCT were found. Anterior asphericity was found to be significantly correlated with anterior and posterior AP-MCTd (r ≥ 0.430, p < 0.001). Likewise, GA-AP and AP-MCT showed a good diagnostic ability for the detection of keratoconus, with optimal cutoff values of 9.61° (sensitivity 85.5%, specificity 80.3%) and 18.08° (sensitivity 80.5%, specificity 78.7%), respectively. These new morphogeometric indices allow a clinical characterization of the 3-D structural alteration occurring in keratoconus, with less coincidence in the spatial projection of the apex and MCT points of both corneal surfaces. Future studies should confirm the potential impact on the precision of these indices of the variability of posterior corneal surface measurements obtained with Scheimpflug imaging technology.

An agent-based approach for the application of nature's forms to product conceptual design.

Given current high market competitiveness, it is necessary to differentiate between products that perform the same function. For this objective, designer can recur to various sources of inspiration in the searching of the more attractive form during the conceptual design stage. One of these sources can be nature, which offers a large number of geometries and textures that can be used from a shape point of view to help the designer in the creative process. This work presents an agent-based approach for a design-aided tool to provide users with some ideas, beginning with simple parts/concepts, and then increasing the complexity level according to the answers offered by designer. The proposed paradigm was implemented using the JADE agent-based platform. In order to validate the platform, several product categories were offered to fifteen different users and a total of sixty design proposals were obtained with the aid of the platform. After evaluating all the proposals, twelve of the sixty designs were finally selected and modelled by a Computer-Aided Design software. The obtained results demonstrate the feasibility of using an agent-based approach to obtain an adaptive intelligent solution to the product conceptual design problem.

Study and characterization of morphogeometric parameters to assist diagnosis of keratoconus.

BACKGROUND: In case of significant imperfections on the cornea, data acquisition is difficult and a significant level of missing data could require the interpolation of important areas of the cornea, resulting in a very ambiguous model. The development of methods to define in vivo customised geometric properties of the cornea based only on real raw data is extremely useful to diagnose and assess the progression of diseases directly related to the corneal architecture. The present work tries to improve the prognostic of corneal ectasia creating a 3D customised model of the cornea and analysing different geometric variables from this model to determine which variables or combination of them could be defined as an indicator of susceptibility to develop keratoconus. METHODS: A corneal geometric reconstruction was performed using zonal functions and retrospective Scheimpflug tomography data from 187 eyes of 187 patients. Morphology of healthy and keratoconic corneas was characterized by means of geometric variables. The performance of these variables as predictors of a new geometric marker was assessed and their correlations were analysed. RESULTS: The more representative variable to classify the corneal anomalies related to keratoconus was posterior apex deviation (area under receiver operating characteristic curve > 0.899; p < 0.0001). However, the strongest correlations in both healthy and pathological corneas were provided by the metrics directly related to the thickness, as deviations of the anterior/posterior minimum thickness points. CONCLUSIONS: The presented morphogeometric approach based on the analysis and custom geometric modelling of the cornea demonstrates to be useful for the characterization and diagnosis of keratoconus disease, stating that geometrical deformation is an effective marker of the ectatic disease's progression.

Keratoconus Detection Based on a New Corneal Volumetric Analysis.

There are numerous tomographic indices for the detection of keratoconus risk. When the indexes based on corneal volume are analyzed, two problems are presented: on the one hand, they are not very sensitive to the detection of incipient cases of keratoconus because they are not locally defined in the primary developmental region of the structural abnormalities; and on the other hand, they do not register the geometric decompensation driven by the asymmetry present during the disease progression. This work performed a morphogeometric modeling of the cornea by the aid of CAD tools and using raw topographic data (Sirius system, CSO, Firenze). For this method, four singular points present on the corneal surfaces were located and the following parameters based on corneal volume were calculated: VOLmct, defined by the points of minimal thickness; VOLaap, defined by the anterior corneal apex, and VOLpap, defined by the posterior corneal apex. The results demonstrate that a further reduction of corneal volume in keratoconus happens and significantly progresses along the disease severity level. The combination of optical and volumetric data, that collect the sensitivity of the asymmetry generated by the disease, allows an accurate detection of incipient cases and follow up of the disease progression.

A new approach to keratoconus detection based on corneal morphogeometric analysis.

PURPOSE: To characterize corneal structural changes in keratoconus using a new morphogeometric approach and to evaluate its potential diagnostic ability. METHODS: Comparative study including 464 eyes of 464 patients (age, 16 and 72 years) divided into two groups: control group (143 healthy eyes) and keratoconus group (321 keratoconus eyes). Topographic information (Sirius, CSO, Italy) was processed with SolidWorks v2012 and a solid model representing the geometry of each cornea was generated. The following parameters were defined: anterior (Aant) and posterior (Apost) corneal surface areas, area of the cornea within the sagittal plane passing through the Z axis and the apex (Aapexant, Aapexpost) and minimum thickness points (Amctant, Amctpost) of the anterior and posterior corneal surfaces, and average distance from the Z axis to the apex (Dapexant, Dapexpost) and minimum thickness points (Dmctant, Dmctpost) of both corneal surfaces. RESULTS: Significant differences among control and keratoconus group were found in Aapexant, Aapexpost, Amctant, Amctpost, Dapexant, Dapexpost (all p<0.001), Apost (p = 0.014), and Dmctpost (p = 0.035). Significant correlations in keratoconus group were found between Aant and Apost (r = 0.836), Amctant and Amctpost (r = 0.983), and Dmctant and Dmctpost (r = 0.954, all p<0.001). A logistic regression analysis revealed that the detection of keratoconus grade I (Amsler Krumeich) was related to Apost, Atot, Aapexant, Amctant, Amctpost, Dapexpost, Dmctant and Dmctpost (Hosmer-Lemeshow: p>0.05, R2 Nagelkerke: 0.926). The overall percentage of cases correctly classified by the model was 97.30%. CONCLUSIONS: Our morphogeometric approach based on the analysis of the cornea as a solid is useful for the characterization and detection of keratoconus.