Zika Virus Causing Encephalomyelitis Associated With Immunoactivation.

Brazil has experienced a Zika virus (ZIKV) outbreak with increased incidence of congenital malformations and neurological manifestations. We describe a case of a 26-year-old Brazilian Caucasian man infected with ZIKV and diagnosed with encephalomyelitis. Brain and spinal cord images showed hyperintense lesions on T2 and fluid-attenuated inversion recovery (FLAIR), and levels of proinflammatory cytokines in the cerebrospinal fluid showed a remarkable increase of interleukin (IL)-6 and IL-8. The observed pattern suggests immune activation during the acute phase, along with the neurological impairment, with normalization in the recovery phase. This is the first longitudinal report of ZIKV infection causing encephalomyelitis with documented immune activation.

Degeneraçao cerebelar subaguda paraneoplásica: relato de caso / Paraneoplastic subacute cerebellar degeneration: case report

Descrevemos caso de uma paciente de 40 anos com quadro de degeneraçao cerebelar subaguda paraneoplásica associada a tumor ovariano. Apresentamos breve revisao sobre as manifestaçoes clínicas e laboratoriais desta síndrome, enfatizando a importância do seu reconhecimento, o que possibilita muitas vezes a detecçao e tratamento precoce da doença primária

Hipotensäo intracraniana espontânea: relato de caso / Spontaneous intracranial hypotension: case report

Descrevemos o caso de um paciente de 45 anos de idade com cefaléia postural secundária a hipotensao liquórica espontânea, no qual a ressonância nuclear magnética do crânio revelou impregnaçao de contraste e espessamento meníngeo.