RESUMO
Large animal models are important tools for hepatocellular carcinoma (HCC) research, especially in studies of hepatic vasculature, interventional techniques, and radiofrequency or microwave hyperthermia. Currently, diethylnitrosamine (DENA)-induced HCC in pigs is the only large animal model for in situ HCC with a tumor latency of 10-26 months. While phenobarbital (PB) is often used to accelerate DENA-induced HCC in rodents, it has not been previously studied in the porcine model. Therefore, we hypothesize that the addition of PB in the DENA-induced HCC porcine model will accelerate tumor latency compared to DENA alone. HCC and benign lesions were seen on serial MRI and confirmed on histopathology. Liver and tumors were further characterized by CT angiography, vascular corrosion casting, and permittivity measurements.
Assuntos
Dietilnitrosamina/administração & dosagem , Modelos Animais de Doenças , Neoplasias Hepáticas Experimentais/induzido quimicamente , Fenobarbital/administração & dosagem , Animais , Carcinógenos , Sinergismo Farmacológico , Feminino , Injeções Intraperitoneais , Neoplasias Hepáticas Experimentais/sangue , Neoplasias Hepáticas Experimentais/diagnóstico por imagem , Neoplasias Hepáticas Experimentais/patologia , Suínos , Porco MiniaturaRESUMO
En el estudio sobre la prevalencia de enteroparasitosis en Coroico, realizado con los alumnos de 2do. año de la carrera de medicina, se encontro un grado de parasitacion de 94.4% en dicha poblacion, que es mayor que en la poblacion encuestada de Caranavi y de la ciudad de La Paz; ademas los parametros de talla y peso estan, en efecto, con relacion a la normalidad y son 54.38 en la talla y 66.25 en el peso. Una comparacion de la frecuencia de enteroparasitosis en las poblaciones citadas, muestra diferencias en algunos parasitos, especialmente en los Cestodes
