Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 1 de 1
Filtrar
Mais filtros








Base de dados
Assunto principal
Intervalo de ano de publicação
1.
Radiother Oncol ; 159: 224-230, 2021 06.
Artigo em Inglês | MEDLINE | ID: mdl-33798611

RESUMO

PURPOSE: The purpose of this phantom study is to demonstrate that thermoacoustic range verification could be performed clinically. Thermoacoustic emissions generated in an anatomical multimodality imaging phantom during delivery of a clinical plan are compared to simulated emissions to estimate range shifts compared to the treatment plan. METHODS: A single-field 12-layerproton pencil beam scanning (PBS)treatment plancreated in Pinnacle prescribing6 Gy/fractionwas delivered by a superconducting synchrocyclotron to a triple modality (CT, MRI, and US) abdominal imaging phantom.Data was acquired by four acoustic receivers rigidly affixed to a linear ultrasound array. Receivers 1-2 were located distal to the treatment volume, whereas 3-4 were lateral. Receivers' room coordinates were computed relative to the ultrasound image plane after co-registration to the planning CT volume. For each prescribed beamlet, a set of thermoacoustic emissions corresponding to varied beam energies were computed. Simulated emissions were compared to measured emissions to estimate shifts of the Bragg peak. RESULTS: Shifts were small for high-dose beamlets that stopped in soft tissue. Signals acquired by channels 1-2 yielded shifts of -0.2±0.7mm relative to Monte Carlo simulations for high dose spots (~40 cGy) in the second layer. Additionally, for beam energy ≥125 MeV, thermoacoustic emissions qualitatively tracked lateral motion of pristine beams in a layered gelatin phantom, and time shifts induced by changing phantom layers were self-consistent within nanoseconds. CONCLUSIONS: Acoustic receivers tuned to spectra of thermoacoustic emissions may enable range verification during proton therapy.


Assuntos
Terapia com Prótons , Humanos , Método de Monte Carlo , Imagens de Fantasmas , Prótons , Dosagem Radioterapêutica , Planejamento da Radioterapia Assistida por Computador , Ultrassonografia
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA