Differences in Fecal Short-Chain Fatty Acids between Alcoholic Fatty Liver-Induced Cirrhosis and Non-alcoholic (Metabolic-Associated) Fatty Liver-Induced Cirrhosis.

The objective of this study was to investigate the metabolic activity of the gut microbiota in cirrhosis due to different variants of fatty liver disease (alcoholic vs. non-alcoholic [metabolic-associated] one [AFLD and MAFLD]). The present study included 24 patients with alcoholic liver cirrhosis, 16 patients with MAFLD-related cirrhosis, and 20 healthy controls. The level and spectrum of short-chain fatty acids (SCFAs) were determined via gas-liquid chromatography. All patients with cirrhosis showed a decrease in the total content of SCFAs (p < 0.001) and absolute content of acetate (p < 0.001), propionate (p < 0.001), butyrate (p < 0.001), and isovalerate (p < 0.001). In MAFLD cirrhosis, the metabolic activity of the microbiota was significantly altered compared to patients with alcoholic cirrhosis, as evidenced by a lower total SCFA content (p < 0.001) and absolute content of acetate (p < 0.001), propionate (p < 0.001), and butyrate (p < 0.001); a higher relative content of isovalerate (p < 0.001); and a higher IsoCn/Cn ratio (p < 0.001). Various clinical and laboratory parameters correlate differently with fecal SCFAs and their fractions in cirrhosis due to AFLD and MAFLD. SCFA-producing metabolic activity is reduced more in MAFLD cirrhosis than in alcoholic cirrhosis. According to the etiological factors of cirrhosis, disorders of this metabolic activity may be involved in different pathogenetic pathways.

To Share or Not to Share? The Role of Retailer's Information Sharing in a Closed-Loop Supply Chain.

Retailers are faced with a dilemma of whether to share demand information with other supply chain members, and if so, how to share it. Our research interest is motivated by the grounds that the value of downstream retailers' sales information to upstream manufacturers is to improve the accuracy of manufacturers' order forecasting. This problem is particularly important in the remanufacturing of closed-loop supply chains (CLSCs). In this study, we consider a retailer (she) as the demand information holder, who sells new and remanufactured products in wholesale to a manufacturer (he) and, simultaneously, she and the manufacturer competitively collect used products from the customers. We explicitly characterize the role of information sharing in a CLSC. We contributed to the information-sharing literature by integrating the existing information-sharing model with dual recycling channels and channel power structure. Previous literature suggests that retailers prefer to share demand information with other firms when the market demand is high. However, surprisingly, we find that when the manufacturer does not play a leading role, the retailer shares her forecast demand information with the manufacturer if the market demand is low. We also show that information sharing reduces the overall profit of the supply chain when the manufacturer dominates the market. In addition, our results also illustrate that information sharing affects the performance of the supply chain mainly by affecting the wholesale price.