From the mechanism of action to clinical management: A review of cardiovascular toxicity in adult treated with CAR-T therapy.

Chimeric antigen receptor T-cell therapy represents an innovative approach to immunotherapy and currently stands out, particularly for oncohematological patients refractory to traditional treatments. Ongoing trials are further expanding its clinical use for new oncological and non-oncological indications, potentially leading to newer treatment options soon. This new approach, however, also presents challenges, including cardiovascular toxicity. Little is reported in pivotal studies, and some recent retrospective observations suggest a non-negligible incidence of side effects with presentation ranging from mild adverse cardiovascular events to fatal complications in which, in most cases, there is a direct or indirect association with cytokine release syndrome. In this literature review, the hypotheses of an important interface between cytokine release syndrome and cardiotoxicity by chimeric antigen receptor T-cell therapy will be addressed, as will current knowledge about risk factors for cardiotoxicity and recommendations for pre-therapy evaluation, post-infusion monitoring and clinical management of these complications.

COVID-19 pandemic and suicidal behavior in adults: systematic review of observational studies.

OBJECTIVE: To analyze the scientific evidence on the impact of the COVID-19 pandemic on suicidal behavior in adults. METHOD: Systematic review, conducted from June to October 2022, in the following databases: MEDLINE/PubMed, Virtual Health Library, Excerpta Medica database, Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature, PsycINFO, Web of Science, Scopus, Science Direct and Google Scholar. The selection, data extraction and assessment of methodological quality were carried out using the Methodological Index for Non-randomized Studies tool. Considering that most of the studies evaluated had significant methodological differences, it was decided to carry out a qualitative synthesis of the data. RESULTS: A total of 2112 articles were found, from which eight articles were selected that analyzed the impact of the COVID-19 pandemic on suicidal behavior in adults. CONCLUSION: The COVID-19 pandemic has influenced the suicidal behavior in adults worldwide, especially when related to race, gender, age, religion, socioeconomic, family and legal issues, and pre-existing mental disorders, leading to a greater propensity for suicidal act.

Gastrotheca Fitzinger, 1843 tadpole morphology: Larval cranium description and its evolutionary implications (Amphibia: Anura: Hemiphractidae).

Hemiphractids have a singular mode of reproduction that involves maternal care. The Andean-endemic Gastrotheca marsupiata species group includes direct-developing and tadpole-bearing species, the latter trait being unique among Gastrotheca. Larval morphology has proven to be a valuable source of evidence to understand the taxonomy and evolution of frogs but remains understudied in Hemiphractids. Herein, we redescribe the larval cranium of G. espeletia, G. gracilis, G. marsupiata, G. peruana, G. pseustes, and G. riobambae, and describe those of G. aureomaculata, G. chrysosticta, G. litonedis, G. monticola and G. psychrophila. Additionally, based on the data gathered, we explore their phylogenetic significance, expanding the knowledge regarding Gastrotheca larval internal morphology. We suggest that the presence of the posterolateral process of crista parotica, the concave palatoquadrate, the quadratoorbital commissure, and the proximal commissures II and III are putative synapomorphies for Gastrotheca. Furthermore, we suggest the long pseudopterygoid process as a putative synapomorphy for Hemiphractyidae.

Piezoelectric biomaterials with embedded ionic liquids for improved orthopedic interfaces through osseointegration and antibacterial dual characteristics.

Orthopedic implant failures, primarily attributed to aseptic loosening and implant site infections, pose significant challenges to patient recovery and lead to revision surgeries. Combining piezoelectric materials with ionic liquids as interfaces for orthopedic implants presents an innovative approach to addressing both issues simultaneously. In this study, films of poly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) incorporated with 1-ethyl-3-methylimidazolium hydrogen sulfate ([Emim][HSO4]) ionic liquid were developed. These films exhibited strong antibacterial properties, effectively reducing biofilm formation, thereby addressing implant-related infections. Furthermore, stem cell-based differentiation assays exposed the potential of the composite materials to induce osteogenesis. Interestingly, our findings also revealed the upregulation of calcium channel expression as a result of electromechanical stimulation, pointing to a mechanistic basis for the observed biological effects. This work highlights the potential of piezoelectric materials with ionic liquids to improve the longevity and biocompatibility of orthopedic implants. Offering dual-functionality for infection prevention and bone integration, these advancements hold significant potential for advancing orthopedic implant technologies and improving patient outcomes.

Multifunctional piezoelectric surfaces enhanced with layer-by-layer coating for improved osseointegration and antibacterial performance.

Implant failure is primarily caused by poor osseointegration and bacterial colonization, which demands readmissions and revision surgeries to correct it. A novel approach involves engineering multifunctional interfaces using piezoelectric polyvinylidene fluoride (PVDF) materials, which mimic bone tissue's electroactive properties to promote bone integration and provide antibacterial functionality when mechanically stimulated. In this study, PVDF films were coated with antibacterial essential oil nanoparticles and antibiofilm enzymes using a layer-by-layer (LBL) approach to ensure antibacterial properties even without mechanical stimulation. The experimental results confirmed the LBL build-up and demonstrated notable antibiofilm properties against Pseudomonas aeruginosa and Staphylococcus aureus while enhancing pre-osteoblast cell proliferation under mechanical dynamic conditions in a bioreactor that replicated the real-life environment of implants within the body. The findings highlight the potential of PVDF-coated surfaces to prevent biofilm formation and boost cell proliferation through the piezoelectric effect, paving the way for advanced implantable devices with improved osseointegration and antibacterial performance.

Usability of the ROBOVID mobile app for health education about COVID-19.

OBJECTIVE: to evaluate the usability of the ROBOVID mobile application for health education about COVID-19. METHOD: methodological study with an applied quantitative approach, developed with 21 adults, using an electronic form. Usability was assessed using the System Usability Scale. The Statistical Package for the Social Sciences software was used to analyze the data. RESULTS: the overall average score on the System Usability Scale questionnaire was 87.3, which classifies the usability of the ROBOVID application as the best achievable. Furthermore, the application has high scores for ease of memorization, user satisfaction and ease of getting to know the system, as well as excellent scores for absence of errors and speed in carrying out the tasks set. CONCLUSION: the ROBOVID application complies with the principles of usability in terms of efficiency, effectiveness and satisfaction in the evaluation of end users, showing that the application meets consumer needs in terms of its functionalities, demonstrating its viability in terms of the initial objectives. (1) ROBOVID was considered better achievable on the SUS scale by the participants. (2) The ROBOVID app meets the user's needs in terms of its functions. (3) ROBOVID helps individuals to take care of themselves and prevent COVID-19. (4) The ROBOVID app was evaluated as a useful, didactic and functional tool.

A novel method to derive a human safety limit for PFOA by gene expression profiling and modelling.

Perfluorooctanoic acid (PFOA) is a persistent environmental contaminant that can accumulate in the human body due to its long half-life. This substance has been associated with liver, pancreatic, testicular and breast cancers, liver steatosis and endocrine disruption. PFOA is a member of a large group of substances also known as "forever chemicals" and the vast majority of substances of this group lack toxicological data that would enable their effective risk assessment in terms of human health hazards. This study aimed to derive a health-based guidance value for PFOA intake (ng/kg BW/day) from in vitro transcriptomics data. To this end, we developed an in silico workflow comprising five components: (i) sourcing in vitro hepatic transcriptomics concentration-response data; (ii) deriving molecular points of departure using BMDExpress3 and performing pathway analysis using gene set enrichment analysis (GSEA) to identify the most sensitive molecular pathways to PFOA exposure; (iii) estimating freely-dissolved PFOA concentrations in vitro using a mass balance model; (iv) estimating in vivo doses by reverse dosimetry using a PBK model for PFOA as part of a quantitative in vitro to in vivo extrapolation (QIVIVE) algorithm; and (v) calculating a tolerable daily intake (TDI) for PFOA. Fourteen percent of interrogated genes exhibited in vitro concentration-response relationships. GSEA pathway enrichment analysis revealed that "fatty acid metabolism" was the most sensitive pathway to PFOA exposure. In vitro free PFOA concentrations were calculated to be 2.9% of the nominal applied concentrations, and these free concentrations were input into the QIVIVE workflow. Exposure doses for a virtual population of 3,000 individuals were estimated, from which a TDI of 0.15 ng/kg BW/day for PFOA was calculated using the benchmark dose modelling software, PROAST. This TDI is comparable to previously published values of 1.16, 0.69, and 0.86 ng/kg BW/day by the European Food Safety Authority. In conclusion, this study demonstrates the combined utility of an "omics"-derived molecular point of departure and in silico QIVIVE workflow for setting health-based guidance values in anticipation of the acceptance of in vitro concentration-response molecular measurements in chemical risk assessment.

Osteogenic differentiation of human mesenchymal stem cells on electroactive substrates.

This study investigates the effect of electroactivity and electrical charge distribution on the biological response of human bone marrow stem cells (hBMSCs) cultured in monolayer on flat poly(vinylidene fluoride), PVDF, substrates. Differences in cell behaviour, including proliferation, expression of multipotency markers CD90, CD105 and CD73, and expression of genes characteristic of different mesenchymal lineages, were observed both during expansion in basal medium before reaching confluence and in confluent cultures in osteogenic induction medium. The crystallisation of PVDF in the electrically neutral α-phase or in the electroactive phase ß, both unpoled and poled, has been found to have an important influence on the biological response. In addition, the presence of a permanent positive or negative surface electrical charge distribution in phase ß substrates has also shown a significant effect on cell behaviour.

Beneficial and harmful effects of physical activity on care-seeking for low back pain: the AUTBACK study.

PURPOSE: People who seek more care for low back pain (LBP) tend to experience poorer recovery (e.g. higher pain and disability levels). Understanding the factors associated with care-seeking for LBP might improve patient outcomes and potentially alleviate the burden of LBP on global health systems. This study aimed to investigate the relationship between different intensities, volumes, and domains of physical activity and care-seeking behaviours, in people with a history of LBP. METHODS: Longitudinal data from adult twins were drawn from the AUstralian Twin BACK study. The primary outcome was the total self-reported frequency (counts) of overall utilisation of care for LBP, over 1 year. Secondary outcomes were the utilisation of health services, and the utilisation of self-management strategies, for LBP (assessed as total frequency over 1 year). Explanatory variables were device-based measures of sedentary behaviour and moderate-to-vigorous intensity physical activity, and self-reported physical workload, and work, transport, household, and leisure domain physical activity, at baseline. RESULTS: Data from 340 individuals were included. Median age was 56.4 years (IQR 44.9-62.3 years) and 73% of participants were female. Medium-to-high baseline volumes of sedentary behaviour were significantly associated with greater counts of overall care utilisation (IRR 1.60, 95%CI 1.04-2.44) and utilisation of self-management strategies (IRR 1.60, 95%CI 1.02-2.50) for LBP, over 1 year. Medium-to-high baseline volumes of household domain physical activity were significantly associated with greater counts of utilising self-management strategies for LBP over 1 year (IRR 1.62, 95%CI 1.04-2.53). No explanatory variables were associated with the utilisation of health services for LBP. CONCLUSION: People who engage in higher baseline volumes of sedentary behaviour or physical activity in the household setting (e.g. housework, gardening, yard work, general household maintenance) utilise 1.6 times more care for LBP over 1 year. Findings suggest that higher volumes of these behaviours may be harmful for LBP. No intensities, volumes, or domains of physical activity demonstrated clear benefits for LBP. Where feasible, patients and clinicians should collaborate to screen and develop strategies to reduce engagement in sedentary behaviour or physical activity in the household setting. Contextual factors (e.g. patient symptom severity, sociocultural roles, occupational demands) should be considered when devising appropriate behaviour change strategies.

Jawbone measurements of edentulous sites related to implant planning using magnetic resonance imaging compared to cone beam computed tomography: An ex vivo study.

AIM: To compare measurements on images obtained by magnetic resonance imaging (MRI) and cone beam CT (CBCT) for height, width, and area in alveolar bone sites in human jaw specimens. MATERIAL AND METHODS: Forty edentulous alveolar posterior sites in human cadaver specimens were imaged using CBCT scanners, and with zero-echo-time MRI (ZTE-MRI). Semi-automatic volume registration was performed to generate representative coronal sections of the sites related to implant planning. ZTE-MRI sections were also presented after grayscale inversion (INV MRI). Three observers measured bone height, bone width 5 mm from the alveolar crest, and bone area stretching from the width measurement to the top of the alveolar crest in the images. Interobserver agreement was assessed by intra-class correlation coefficients (ICC). The measurements were analyzed using two-way repeated measures ANOVA factoring observer and image type. RESULTS: ICC was >0.95 for bone height, width, and bone area. No significant differences among observers (p = 0.14) or image type (p = 0.60) were found for bone height. For bone width, observer (p = 0.14) was not a significant factor, while ZTE-MRI produced width estimates that were significantly different and systematically smaller than CBCT-based estimates (p ≤ 0.001). Observer (p = 0.06) was not a significant factor regarding the bone area measurements, contrary to the imaging type where ZTE-MRI led to significantly smaller area estimates than CBCT (p ≤ 0.001). CONCLUSION: Bone height measurements were essentially equivalent using CBCT and MRI. This was found regardless of grayscale choice for the MRI. However, ZTE-MRI resulted in smaller estimates of bone width and area.

Histological investigation in aging male and female gerbil prostates after prenatal exposure to pequi (Caryocar brasiliense Cambess) oil and 17α-ethinylestradiol.

The female prostate, also known as Skene's gland, is present in both humans and rodents. Prenatal exposure to ethinylestradiol (EE2), a synthetic estrogen found in oral contraceptives, induces pormotes neoplasic prostate lesions in gerbils (Meriones unguiculatus). Conversely, pequi oil (Pe), extracted from the Brazilian Cerrado fruit, has antioxidant, anti-inflammatory, and anticancer properties, mitigates risks associated with chronic diseases related to lifestyle and aging. This study evaluates the impact of prenatal exposure to Pe (300 mg/kg) on senile gerbil offspring's male and female prostates under normal conditions and EE2 exposure (15 µg/kg/day). Histological and morphometric analyses revealed that Pe reduced male body weight and prostate epithelial height, along with a thinner muscle layer. In females, EE2 exposure reduced prostatic weight, while Pe exposure lowered epithelial height and the relative stromal compartment volume, increasing the muscle layer. Pequi oil holds potential in mitigating alterations induced by exposure to the endocrine disruptor EE2.

Usability of the ROBOVID mobile app for health education about COVID-19 / Usabilidad de la aplicación móvil ROBOVID para educación en salud acerca de la covid-19 / Usabilidade do aplicativo móvel ROBOVID para educação em saúde acerca da COVID-19

Objective: to evaluate the usability of the ROBOVID mobile application for health education about COVID-19. Method: methodological study with an applied quantitative approach, developed with 21 adults, using an electronic form. Usability was assessed using the System Usability Scale. The Statistical Package for the Social Sciences software was used to analyze the data. Results: the overall average score on the System Usability Scale questionnaire was 87.3, which classifies the usability of the ROBOVID application as the best achievable. Furthermore, the application has high scores for ease of memorization, user satisfaction and ease of getting to know the system, as well as excellent scores for absence of errors and speed in carrying out the tasks set. Conclusion: the ROBOVID application complies with the principles of usability in terms of efficiency, effectiveness and satisfaction in the evaluation of end users, showing that the application meets consumer needs in terms of its functionalities, demonstrating its viability in terms of the initial objectives.

Objetivo: evaluar la usabilidad de la aplicación móvil ROBOVID para educación en salud acerca de la COVID-19. Método: estudio metodológico con enfoque cuantitativo aplicado, desarrollado con 21 adultos, mediante formulario electrónico. La evaluación de la usabilidad se llevó a cabo mediante la System Usability Scale. Para el análisis de los datos se utilizó el software Statistical Package for the Social Sciences . Resultados: la media global por el cuestionario System Usability Scale fue de 87,3, lo que clasifica la usabilidad de la aplicación ROBOVID como mejor alcanzable. Además, la aplicación presenta índices elevados para facilidad de memorización, satisfacción del usuario y facilidad de conocimiento del sistema, además de excelentes índices para ausencia de errores y rapidez en la ejecución de las tareas establecidas. Conclusión: la aplicación ROBOVID posee conformidad con los principios de usabilidad en los criterios de eficiencia, eficacia y satisfacción en la evaluación de los usuarios finales, explicando que la aplicación satisface las necesidades de consumo frente a sus funcionalidades, demostrando su viabilidad en cuanto a los objetivos iniciales.

Objetivo: avaliar a usabilidade do aplicativo móvel ROBOVID para educação em saúde acerca da COVID-19. Método: estudo metodológico com abordagem quantitativa aplicado, desenvolvido com 21 adultos, por meio de formulário eletrônico. A avaliação da usabilidade ocorreu por meio da System Usability Scale . Para análise dos dados utilizou-se o software Statistical Package for the Social Sciences . Resultados: a média global pelo questionário System Usability Scale foi de 87,3, o que classifica a usabilidade do aplicativo ROBOVID como melhor alcançável. Ademais, o aplicativo apresenta índices elevados para facilidade de memorização, satisfação do usuário e facilidade de conhecimento do sistema, além de excelentes índices para ausência de erros e rapidez na execução das tarefas estabelecidas. Conclusão: o aplicativo ROBOVID possui conformidade com os princípios de usabilidade nos critérios de eficiência, eficácia e satisfação na avaliação dos usuários-finais, explicitando que o aplicativo atende às necessidades de consumo frente a suas funcionalidades, demostrando sua viabilidade no que tange aos objetivos iniciais.

Effectiveness of educational technology in video format on home bathing of term newborns / Eficacia de la tecnología educativa en formato de video sobre el baño domiciliario del recién nacido a término / Efetividade de tecnologia educacional em formato de vídeo sobre banho domiciliar do recém-nascido a termo

ABSTRACT Objective: evaluating the effectiveness of an educational technology in video format on the knowledge of family caregivers about home bathing of term newborns. Method: a quantitative study with a quasi-experimental, single-group, before-and-after design, carried out between February and June 2023, in the Rooming-in Unit of a municipal hospital located in the coastal lowlands of Rio de Janeiro State. Data collection consisted of three stages (pre-test, intervention, and post-test). McNemar's test was used to compare the proportion of correct answers before and after the intervention. The p<0.5 was used. Results: 107 family members took part, 86 of them women (80.4%). There was a 36.5% increase in the total number of correct answers in the post-test after the use of educational technology. Most of the questions showed an increase in the number of correct answers (n=16; 88.9%), with more than half showing a statistically significant difference between the pre-test and post-test. The questions on the use of different brands of hygiene products, the use of talcum powder, care of the umbilical cord stump, and the most suitable type of bath, as well as the temperature and duration of the bath, stood out. Conclusion: The educational video "How to bathe a newborn baby at home" proved to be effective in increasing knowledge about home bathing of term newborns. Thus, the video evaluated on the subject can be used as an educational health technology with families to promote safer care for newborns.

RESUMEN Objetivo: evaluar la efectividad de una tecnología educativa en formato video en el conocimiento de los cuidadores familiares sobre el baño domiciliario de recién nacidos a término. Métodos: estudio cuantitativo con diseño cuasiexperimental, de grupo único, tipo antes y después, realizado entre febrero y junio de 2023, en la Sala de Alojamiento Conjunto de un hospital municipal del litoral del Estado de Río de Janeiro. La recolección de datos constó de tres etapas (pretest, intervención y postest), con utilización de la prueba de McNemar para comparar la proporción de respuestas correctas antes y después de la intervención. Se adoptó p<0,05. Resultados: participaron 107 familiares, de los cuales 86 eran mujeres (80,4%). Hubo un aumento del 36,5% en el número total de respuestas correctas en la prueba posterior después del uso de tecnología educativa. La mayoría de las preguntas mostraron un aumento en el número de respuestas correctas (n=16; 88,9%), y más de la mitad mostró una diferencia estadísticamente significativa entre la prueba previa y la prueba posterior. Se destacaron preguntas sobre el uso de diferentes marcas de productos de higiene, uso de talco, cuidados del muñón umbilical y el tipo de baño más recomendado, así como la temperatura y duración del baño. Conclusión: el video educativo "Cómo bañar a un recién nacido en casa" demostró ser eficaz para aumentar el conocimiento sobre el baño de recién nacidos a término en casa. Así, el video evaluado sobre el tema puede ser utilizado como tecnología educativa en salud con los familiares, para promover una atención más segura al recién nacido.

RESUMO Objetivo: avaliar a efetividade de uma tecnologia educacional em formato de vídeo no conhecimento de familiares cuidadores sobre banho domiciliar do recém-nascido a termo. Método: estudo quantitativo com delineamento quase-experimental, de grupo único, do tipo antes e depois, realizado entre fevereiro e junho de 2023, no Alojamento Conjunto de um hospital municipal da baixada litorânea do Estado do Rio de Janeiro. A coleta de dados foi composta por três etapas (pré-teste, intervenção e pós-teste) e utilizou-se para análise o teste de McNemar para comparar a proporção de acertos antes e após a intervenção. Adotou-se p<0,05. Resultados: participaram 107 familiares, sendo 86 mulheres (80,4%). Verificou-se aumento de 36,5% no total de respostas corretas no pós-teste após o uso da tecnologia educacional. A maioria das questões apresentou aumento no número de acertos (n=16; 88,9%), sendo mais da metade com diferença estaticamente significativa entre o pré-teste e o pós-teste. Destacaram-se as questões sobre utilização de marcas variadas de produtos de higiene, uso de talco, cuidados com o coto umbilical e o tipo de banho mais indicado, bem como temperatura e duração do banho. Conclusão: o vídeo educativo "Como dar o banho do recém-nascido em casa" se mostrou efetivo no aumento do conhecimento sobre o banho domiciliar do recém-nascido a termo. Assim, pode-se utilizar o vídeo avaliado sobre o tema como uma tecnologia educacional em saúde com as famílias, a fim de promover um cuidado mais seguro ao recém-nascido.

COVID-19 pandemic and suicidal behavior in adults: systematic review of observational studies / Pandemia de COVID-19 y comportamiento suicida en adultos: revisión sistemática de estudios observacionales / Pandemia de COVID-19 e comportamento suicida de pessoas adultas: revisão sistemática de estudos observacionais

ABSTRACT Objective: To analyze the scientific evidence on the impact of the COVID-19 pandemic on suicidal behavior in adults. Method: Systematic review, conducted from June to October 2022, in the following databases: MEDLINE/PubMed, Virtual Health Library, Excerpta Medica database, Cumulative Index to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature, PsycINFO, Web of Science, Scopus, Science Direct and Google Scholar. The selection, data extraction and assessment of methodological quality were carried out using the Methodological Index for Non-randomized Studies tool. Considering that most of the studies evaluated had significant methodological differences, it was decided to carry out a qualitative synthesis of the data. Results: A total of 2112 articles were found, from which eight articles were selected that analyzed the impact of the COVID-19 pandemic on suicidal behavior in adults. Conclusion: The COVID-19 pandemic has influenced the suicidal behavior in adults worldwide, especially when related to race, gender, age, religion, socioeconomic, family and legal issues, and pre-existing mental disorders, leading to a greater propensity for suicidal act.

RESUMEN Objetivo: Analizar la evidencia científica sobre el impacto de la pandemia de COVID-19 en la conducta suicida en adultos. Método: Revisión sistemática, realizada de junio a octubre de 2022, en las siguientes bases de datos: MEDLINE/PubMed, Virtual Health Library, Excerpta Medica database, CumulativeIndex to Nursing and Allied Health Literature, Latin American and Caribbean Health Sciences Literature, PsycINFO, Web of Science, Scopus, Science Direct y Google Scholar. Los datos fueron seleccionados, extraídos y la calidad metodológica evaluada utilizando la herramienta Methodological Index for Non-randomised Studies. Teniendo en cuenta que la mayoría de los estudios evaluados presentaban diferencias metodológicas significativas, se decidió realizar una síntesis cualitativa de los datos. Resultados: Se encontraron 2112 artículos, de los cuales se seleccionaron 8 artículos que analizaban el impacto de la pandemia COVID-19 sobre el comportamiento suicida en adultos. Conclusión: La pandemia del COVID-19 ha influido en el comportamiento suicida de adultos de todo el mundo, especialmente cuando se relaciona con la raza, el sexo, la edad, la religión, los problemas socioeconómicos, familiares y legales y los trastornos mentales preexistentes, lo que ha provocado una mayor propensión al suicidio.

RESUMO Objetivo: Analisar as evidências científicas sobre impacto da pandemia da COVID-19 no comportamento suicida de pessoas adultas. Método: Revisão sistemática, realizada de junho a outubro de 2022, nas bases de dados: MEDLINE/PubMed, Biblioteca Virtual em Saúde, Excerpta Medica database, Cumulative Index to Nursingand Allied Health Literature, Literatura Latino-Americana e do Caribe em Ciências da Saúde, PsycINFO, Web of Science, Scopus, Science Direct e Google Scholar. A seleção, a extração dos dados e a avaliação da qualidade metodológica, por meio da ferramenta Methodological Index for Non-randomized Studies, foram realizadas. Considerando que a maioria dos estudos avaliados apresentaram diferenças metodológicas significativas, optou-se por realizar síntese qualitativa dos dados. Resultados: Foram encontrados 2112 artigos, dos quais foram selecionados oito artigos que analisaram o impacto da pandemia da COVID-19 no comportamento suicida de pessoas adultas. Conclusão: A pandemia da COVID-19 influenciou no comportamento suicida de pessoas adultas no mundo, em especial, quando relacionada a raça, gênero, idade, religião, problemas socioeconômicos, familiares, legais e a transtornos mentais pré-existentes, o que ocasionava maior propensão ao ato.

Uso da moulage na simulação clínica de curativos entre estudantes de enfermagem: relato de experiência / Use of moulage in the clinical simulation of dressings among nursing students: an experience report / Utilización del moulage en la simulación clínica de apósitos entre estudiantes de enfermería: informe de experiencia

Objetivo: relatar o uso de moulage na simulação clínica de curativos em lesões tegumentares entre estudantes de enfermagem. Método: relato de experiência sobre o uso de moulage para representar lesões tegumentares em simulação clínica de curativos para estudantes de enfermagem. Desenvolveu-se em cinco etapas: ponto de partida, perguntas iniciais, recuperação do processo vivido, reflexão de fundo e pontos de chegada. Resultados: realizaram-se três simulações clínicas, com 28 estudantes. Na produção da lesão tegumentar, utilizaram-se látex, massinha de maquiagem, amido de milho, tinta antialérgica, pincéis, esponja, sangue artificial e algodão, com um custo de R$107,35. No cenário simulado, havia um ator que representou o papel de paciente com lesão, após acidente automobilístico. As simulações ocorreram em três etapas: briefing, cena simulada e debriefing. Conclusão: a simulação clínica com moulage é uma estratégia para o ensino de curativos em lesões tegumentares e contribui para o processo de ensino-aprendizagem de estudantes de enfermagem.

Objective: to report on the use of moulage in the clinical simulation of dressings for skin injuries among nursing students. Methodology: experience report on the use of moulage to represent skin injuries in a clinical simulation of dressings for nursing students. It was developed in five stages: starting point, initial questions, recovery of the experienced process, background reflection and end points. Results: three clinical simulations were carried out with 28 students. In order to produce the skin injury, latex, makeup paste, cornstarch, anti-allergic paint, brushes, sponge, artificial blood and cotton were used, at a cost of R$107.35. In the simulated scenario, there was an actor who played the role of a patient with injuries after a car accident. The simulations took place in three stages: briefing, simulated scene and debriefing. Conclusion: clinical simulation with moulage is a strategy for teaching dressings for skin injuries and contributes to the teaching-learning process for nursing students.

Objetivo: informar sobre la utilización del moulage en la simulación clínica de apósitos para lesiones cutáneas entre estudiantes de enfermería. Metodología: informe de experiencia sobre la utilización del moulage para representar lesiones cutáneas en una simulación clínica de apósitos para estudiantes de enfermería. Se desarrolló en cinco etapas: punto de partida, preguntas iniciales, recuperación del proceso vivido, reflexión de fondo y puntos de llegada. Resultados: se realizaron tres simulaciones clínicas con 28 estudiantes. Para producir la lesión cutánea, se utilizó látex, pasta de maquillaje, almidón de maíz, pintura antialérgica, pinceles, esponja, sangre artificial y algodón, con un coste de R$107,35. En el escenario simulado, había un actor que representaba el papel de un paciente herido tras un accidente de coche. Las simulaciones se desarrollaron en tres etapas: briefing, escena simulada y debriefing. Conclusión: la simulación clínica con moulage es una estrategia para la enseñanza sobre apósitos de lesiones cutáneas y contribuye al proceso de enseñanza-aprendizaje de los estudiantes de enfermería.

Eficácia da ivermectina e atazanavir no tempo de recuperação dos sintomas de covid-19: uma coorte prospectiva / Effectiveness of ivermectin and atazanavir on time to resolution from covid-19 symptoms: a prospective cohort / Eficacia de ivermectina y atazanavir en el tiempo hasta lá resolución de los síntomas de covid-19: una cohorte prospectiva

Objetivo: avaliar a eficácia da Ivermectina e do Atazanavir em comparação com placebo no tempo de resolução dos sintomas e no tempo de duração da doença por COVID-19. Método: estudo observacional, de coorte prospectivo, longitudinal, descritivo e analítico com pacientes sintomáticos ambulatoriais, acompanhados por 06 meses em duas Unidades Básicas de Saúde para atendimento de COVID-19 em Teresina- Piauí, Brasil, no período de novembro a abril de 2021 identificados por amostragem aleatória 1:1:1. Foram realizados exames Reverse transcription polymerase chain reaction (RT-PCR) para confirmação laboratorial da suspeita de infecção pelo novo coronavírus e avaliação sociodemográfica e clínica. Resultados: dos 87 pacientes randomizados, 62,1% (n=54) eram do sexo masculino, com média de idade de 35,1 anos, possuíam companheira (53,9%), baixa renda (50,6%), eutróficos (40,7%) e sem comorbidades de saúde (78,2%). Não houve diferença entre o tempo médio para resolução dos sintomas, que foi de 21 dias (IQR, 8-30) no grupo atazanavir, 30 dias (IQR, 5-90) no grupo ivermectina em comparação com 14 dias (IQR, 9-21) no grupo controle. No dia 180, houve resolução dos sintomas em 100% no grupo placebo, 93,9% no grupo atazanavir e 95% no grupo ivermectina. A duração mediana da doença foi de 08 dias em todos os braços do estudo. Conclusão: o tratamento com atazanavir (6 dias) e ivermectina (3 dias) não reduziu o tempo de resolução dos sintomas e nem o tempo de duração da doença entre os pacientes ambulatoriais com COVID-19 leve em comparação com o grupo placebo. Os resultados não suportam o uso de ivermectina e atazanavir para tratamento de COVID-19 leve a moderado.

Objective: to evaluate the effectiveness of Ivermectin and Atazanavir compared to placebo in the time to resolution of symptoms and duration of illness due to COVID-19. Method: observational, prospective, longitudinal, descriptive and analytical cohort study with symptomatic outpatients, followed for 06 months in two Basic Health Units for COVID-19 care in Teresina-Piauí, Brazil, from November to April 2021 identified by 1:1:1 random sampling. Reverse transcription polymerase chain reaction (RT-PCR) tests were performed for laboratory confirmation of suspected infection with the new coronavirus and sociodemographic and clinical evaluation. Results: of the 87 randomized patients, 62.1% (n=54) were male, with a mean age of 35.1 years, had a partner (53.9%), low income (50.6%), eutrophic (40.7%) and without health comorbidities (78.2%). There was no difference between the median time to resolution of symptoms, which was 21 days (IQR, 8-30) in the atazanavir group, 30 days (IQR, 5- 90) in the ivermectin group compared with 14 days (IQR, 9- 21) in the control group. At day 180, there was resolution of symptoms in 100% in the placebo group, 93.9% in the atazanavir group, and 95% in the ivermectin group. The median duration of illness was 8 days in all study arms. Conclusion: Treatment with atazanavir (6 days) and ivermectin (3 days) did not reduce the time to symptom resolution or the duration of illness among outpatients with mild COVID-19 compared to the placebo group. The results do not support the use of ivermectin and atazanavir for the treatment of mild to moderate COVID-19.

Objetivo: evaluar la efectividad de Ivermectina y Atazanavir en comparación con placebo en el tiempo de resolución de los síntomas y duración de la enfermedad por COVID-19. Método: estudio de cohorte observacional, prospectivo, longitudinal, descriptivo y analítico con pacientes ambulatorios sintomáticos, seguidos durante 06 meses en dos Unidades Básicas de Salud para atención de COVID-19 en Teresina-Piauí, Brasil, de noviembre a abril de 2021 identificados por 1:1:1 muestreo aleatorio. Se realizaron pruebas de reacción en cadena de la polimerasa con transcriptasa inversa (RT-PCR) para confirmación de laboratorio de sospecha de infección por el nuevo coronavirus y evaluación sociodemográfica y clínica. Resultados: de los 87 pacientes aleatorizados, 62,1% (n=54) eran del sexo masculino, con una edad media de 35,1 años, tenían pareja (53,9%), bajos ingresos (50,6%), eutróficos (40,7%) y sin comorbilidades de salud (78,2%). No hubo diferencia entre la mediana de tiempo hasta la resolución de los síntomas, que fue de 21 días (RIC, 8-30) en el grupo de atazanavir, 30 días (RIC, 5- 90) en el grupo de ivermectina en comparación con 14 días (RIC, 9 - 21) en el grupo control. En el día 180, hubo una resolución de los síntomas del 100 % en el grupo de placebo, del 93,9 % en el grupo de atazanavir y del 95 % en el grupo de ivermectina. La mediana de duración de la enfermedad fue de 8 días en todos los brazos del estudio. Conclusión: El tratamiento con atazanavir (6 días) e ivermectina (3 días) no redujo el tiempo de resolución de los síntomas ni la duración de la enfermedad entre los pacientes ambulatorios con COVID-19 leve en comparación con el grupo placebo. Los resultados no respaldan el uso de ivermectina y atazanavir para el tratamiento de la COVID-19 de leve a moderada.