RESUMO
Cardiovascular disease (CVD) is a leading cause of morbidity and mortality, especially among the aging population. The "response-to-injury" model proposed by Dr. Russell Ross in 1999 emphasizes inflammation as a critical factor in atherosclerosis development, with atherosclerotic plaques forming due to endothelial cell (EC) injury, followed by myeloid cell adhesion and invasion into the blood vessel walls. Recent evidence indicates that cancer and its treatments can lead to long-term complications, including CVD. Cellular senescence, a hallmark of aging, is implicated in CVD pathogenesis, particularly in cancer survivors. However, the precise mechanisms linking premature senescence to CVD in cancer survivors remain poorly understood. This article aims to provide mechanistic insights into this association and propose future directions to better comprehend this complex interplay.
RESUMO
The aim of this study was to improve the quality of the micropropagated A. angustifolia Haw. plants cultured in temporary immersion bioreactors (TIS) comparing them with those produced through conventional semisolid-solid tissue culture system (SS). The Recipient for Automated Temporary Immersion (RITA®) bioreactor was used as TIS in this work. The effect of different culture conditions, such as explants density, genotype, and duration of the incubation stages, were analyzed. The growth and morphological parameters measured for the in vitro cultured plants were: plant height, number of new leaves, number of shoots/explants, growth index (GI), dry mass content, and water content. In all experiments, it was observed that plantlets cultivated in the TIS grew larger than those cultivated in SS. Analyzing all the parameters used in this study, the results showed that RITA bioreactor generates a better shoot production and a better GI when using 20 plantlets per container. The number of shoots increased with time of culture (60 days) in both systems. However, the shoots and plantlets cultivated in TIS grew bigger and showed better quality (did not present necrosis in the leaves) than the ones cultured in SS. This study provides experimental evidence that the application of TIS for micropropagation of A. angustifolia is a viable option for the production of high-quality shoots for reforestation purposes.
RESUMO
Piper crassinervium, P. aduncum, P. hostmannianum, and P. gaudichaudianum contain the new benzoic acid derivatives crassinervic acid (1), aduncumene (8), hostmaniane (18), and gaudichaudianic acid (20), respectively, as major secondary metabolites. Additionally, 19 known compounds such as benzoic acids, chromenes, and flavonoids were isolated and identified. The antifungal activity of these compounds was evaluated by bioautographic TLC assay against Cladosporium cladosporioides and C. sphaerospermum.