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1.
Parasitol Res ; 92(3): 211-4, 2004 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-14652741

RESUMO

The efficacy of 5-chloro-2-methylthio-6-(1-naphthyloxy)- 1H-benzimidazole, called "alpha", was tested against Fasciola hepatica. Fluke-free calves ( n=32) were divided into 8 groups and infected with 150 metacercariae per animal. All animals subsequently received a second infection with another 150 metacercariae, given at different time intervals aimed to produce flukes of differing ages within the experimental animals. When the flukes reached the required age in the animals, four groups were treated with a single oral dose of 12 mg/kg of compound alpha and the remaining ones served as non-treated controls. Two weeks after treatment the animals of all groups were sacrificed and the livers were removed to determine the numbers of parasites present in the treated and untreated controls. In the treated groups the fluke reduction for the 3 day/2 week group was 100%, for the 3 week/4 week group it was 96.4%, for the 6 week/8 week group it was 99.2% and for the 10 week/12 week group it was 100%.


Assuntos
Anti-Helmínticos/uso terapêutico , Fasciola hepatica/patogenicidade , Fasciolíase/tratamento farmacológico , Animais , Benzimidazóis/uso terapêutico , Bovinos , Modelos Animais de Doenças , Ensaio de Imunoadsorção Enzimática , Fasciola hepatica/crescimento & desenvolvimento
2.
Rev Latinoam Microbiol ; 37(2): 171-8, 1995.
Artigo em Espanhol | MEDLINE | ID: mdl-8552877

RESUMO

The aim of the present study was to evaluate the flukicide efficacy of the 2-amino-5(6)-chloro-1-methoxycarbonylbenzimidazole (II), named Fasciolinip-1, against eight and twelve-week old flukes in sheep. In a first experiment 35 young sheep were infected each with 300 metacercariae of Fasciola hepatica. Eight weeks postinfection five groups of seven animals each were treated as follows: Groups 1, 2 and 3 were given 2.5, 5 and 10 mg/kg of Fasciolinip-1. Groups 4 and 5 remained as non-treated and vehicle controls, respectively. In a second study, 32 sheep were infected each with 150 metacercariae. Twelve weeks postinfection, the animals were divided into 4 groups of 8 sheep each. Groups 1, 2 and 3 were treated orally with 5, 10 and 15 mg/kg of Fasciolinip-1, respectively. Group 4 remained as non-treated control. Fifteen days after treatment, all sheep from both experiments were killed to collect the flukes present in liver. Results indicated efficacies of 19.1%, 49.6% and 65.2% for groups 1, 2 and 3 of the first study and 48.3%, 64.8 and 90.6% for sheep of the second experiment, respectively. It was concluded that Fasciolinip-1 removed 8-week old flukes in limited numbers and 12-week old flukes in 90.6% when used at 15 mg/kg body weight.


Assuntos
Anti-Helmínticos/uso terapêutico , Benzimidazóis/uso terapêutico , Fasciola hepatica/efeitos dos fármacos , Fasciolíase/veterinária , Doenças dos Ovinos/tratamento farmacológico , Animais , Anti-Helmínticos/farmacologia , Benzimidazóis/farmacologia , Ductos Biliares/parasitologia , Avaliação Pré-Clínica de Medicamentos/veterinária , Fasciola hepatica/isolamento & purificação , Fasciolíase/tratamento farmacológico , Feminino , Fígado/parasitologia , Masculino , Contagem de Ovos de Parasitas , Ovinos , Doenças dos Ovinos/parasitologia , Resultado do Tratamento
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