RESUMO
Staphylococcal scalded-skin syndrome (SSSS) is an exfoliative dermatitis resultant from the infection with exfoliative-toxin-producing (ET) Staphylococcus aureus. This syndrome usually occurs in children, while adult cases are generally linked to renal-deficiency or immunossupresion. A case of a 74 years old woman presenting SSSS after hospital admission due to cardiovascular disorders is presented and discussed. Cytokines (TNF-a, IFN-g, IL-6, IL-13 and IL-10) and nitric oxide (NO) production in vitro by whole blood leukocytes (WBL) were investigated. Leukocytes stimulated by lipopolysaccharide or phytohemagglutinin produced increased IFN-g, TNF-a, IL-13 and NO levels after treatment. Based on these results, immunological aspects of the disease are discussed
El síndrome de la piel escaldada estafilocócica (SSSS) es una dermatitis exfoliante resultante de la infección por Staphylococcus aureus productores de toxinas exfoliantes. Este síndrome ocurre generalmente en niños, mientras que su manifestación en adultos está generalmente relacionada con deficiencia renal o inmunosupresión. Se presenta y discute el caso de una mujer de 74 años de edad con SSSS luego de su admisión en el hospital por complicaciones cardiovasculares. Fue evaluada la producción in vitro de citocinas (TNF-a, IFN-g, IL-6, IL-13, IL-10) y óxido nítrico (NO) por células de sangre total (WBL). Los leucocitos estimulados por lipopolisacarideos y fitohemaglutinina produjeron elevados niveles de IFN-g, TNF-a, IL-13 y NO en el final del tratamiento. Basados en estos resultados, se discuten los aspectos inmunológicos de la enfermedad
Assuntos
Humanos , Masculino , Citocinas , Óxido Nítrico/uso terapêutico , Síndrome da Pele Escaldada EstafilocócicaRESUMO
Staphylococcal scalded-skin syndrome (SSSS) is an exfoliative dermatitis resultant from the infection with exfoliative-toxin-producing (ET) Staphylococcus aureus. This syndrome usually occurs in children, while adult cases are generally linked to renal-deficiency or immunossupresion. A case of a 74 year old woman presenting SSSS after hospital admission due to cardiovascular disorders is presented and discussed. Cytokines (TNF-alpha, IFN-gamma, IL-6, IL-13 and IL-10) and nitric oxide (NO) production in vitro by whole blood leukocytes (WBL) were investigated. Leukocytes stimulated by lipopolysaccharide or phytohemagglutinin produced increased IFN-gamma, TNF-alpha, IL-13 and NO levels after treatment. Based on these results, immunological aspects of the disease are discussed.