RESUMO
Magnetic functionalized homochiral metal-organic frameworks (MOFs) were prepared and applied to efficient enantioselective fishing of chiral drug intermediates. Under optimized conditions, the enantiomeric excess (ee) value as high as 85.2% was achieved for methyl phenyl sulfoxide (MPS) within 3 min.
Assuntos
Compostos Organometálicos/química , Sulfóxidos/síntese química , Fenômenos Magnéticos , Modelos Moleculares , Estrutura Molecular , Compostos Organometálicos/síntese química , Tamanho da Partícula , Estereoisomerismo , Sulfóxidos/química , Propriedades de Superfície , Zinco/químicaRESUMO
The development of rapid screening and identification techniques is of great importance for drug discovery, doping control, forensic identification, food safety and quality control. Ambient mass spectrometry (AMS) allows rapid and direct analysis of various samples in open air with little sample preparation. Recently, its applications in high-throughput screening have been in rapid progress. During the past decade, various ambient ionization techniques have been developed and applied in high-throughput screening. This review discusses typical applications of AMS, including DESI (desorption electrospray ionization), DART (direct analysis in real time), EESI (extractive electrospray ionization), etc., in high-throughput screening (HTS).