Hierarchically structured passive radiative cooling ceramic with high solar reflectivity.

Passive radiative cooling using nanophotonic structures is limited by its high cost and poor compatibility with existing end uses, whereas polymeric photonic alternatives lack weather resistance and effective solar reflection. We developed a cellular ceramic that can achieve highly efficient light scattering and a near-perfect solar reflectivity of 99.6%. These qualities, coupled with high thermal emissivity, allow the ceramic to provide continuous subambient cooling in an outdoor setting with a cooling power of >130 watts per square meter at noon, demonstrating energy-saving potential on a worldwide scale. The color, weather resistance, mechanical robustness, and ability to depress the Leidenfrost effect are key features ensuring the durable and versatile nature of the cooling ceramic, thereby facilitating its commercialization in various applications, particularly building construction.

Empirical mode decomposition of the atmospheric flows and pollutant transport over real urban morphology.

The momentum transport and pollutant dispersion in the atmospheric surface layer (ASL) are governed by a broad spectrum of turbulence structures. Whereas, their contributions have not been explicitly investigated in the context of real urban morphology. This paper aims to elucidate the contributions from different types of eddies in the ASL over a dense city to provide the reference of urban planning, realizing more favorable ventilation and pollutant dispersion. The building-resolved large-eddy simulation dataset of winds and pollutants over the Kowloon downtown, Hong Kong, is decomposed into a few intrinsic mode functions (IMFs) via empirical mode decomposition (EMD). EMD is a data-driven algorithm that has been successfully implemented in many research fields. The results show that four IMFs are generally enough to capture most of the turbulence structures in real urban ASL. In particular, the first two IMFs, which are initiated by individual buildings, capture the small-scale vortex packets that populate within the irregular building clusters. On the other hand, the third and fourth IMFs capture the large-scale motions (LSMs) detached to the ground surface that are highly efficient in transport. They collectively contribute to nearly 40% of vertical momentum transport even with relatively low vertical turbulence kinetic energy (TKE). LSMs are long, streaky structures that mainly consist of streamwise TKE components. It is found that the open areas and regular streets promote the portion of streamwise TKE in LSMs, improving the vertical momentum transport and pollutant dispersion. In addition, these streaky LSMs are found to play a crucial role in pollutant dilution in the near field after the pollutant source, while the small-scale vortex packets are more efficient in transport in the mid-field and far-field.

Wavelet analysis of the atmospheric flows over real urban morphology.

Winds are the basic forces for atmospheric transport such as pollutant removal and pedestrian thermal comfort. The transport capability is commonly measured in terms of length and velocity scales. In this connection, the flows in the atmospheric surface layer (ASL) over the Kowloon Peninsula, Hong Kong (HK) are scrutinized by the large-eddy simulation (LES) to characterize the motion scales over real urban morphology. Apart from statistical analysis, the streamwise fluctuating velocity u' is examined by both wavelet and energy spectrum in which a primary peak is consistently shown at streamwise wavelength 70 m ≤ λx ≤ 300 m. A secondary peak at a longer wavelength 800 m ≤ λx ≤ 3000 m, however, is unveiled by wavelet only. It denotes the existence of intermittent turbulence structures whose sizes are much larger than those of buildings. Further wavelet analysis reveals that majority energy-carrying eddies are enlarging (tens to hundreds of meters) from the roughness sublayer (RSL) to the inertial sublayer (ISL). Analogous to its smooth-wall and schematic rough-wall counterparts, the turbulence kinetic energy (TKE) over urban areas is peaked in the ISL which is carried by eddies of size 50 m ≤ λx ≤ 1000 m. The (horizontal) spatial distribution of energy-carrying eddies is further visualized to compare the crucial motion scales in the RSL and ISL. Finally, conditional sampling is used to demystify the contribution to vertical momentum flux u'w' in terms of streamwise wavelength and quadrants. The results advance our fundamental understanding of ASL transport processes, fostering sustainable environmental policy.

Localized Characteristics of the First Three Typical Condensation Frosting Stages in the Edge Region of a Horizontal Cold Plate.

Condensation frosting usually causes a negative influence on heat exchangers employed in engineering fields. As the relationships among the first three typical condensation frosting stages in the edge regions of cold plates are still unclear, an experimental study on the localized condensation frosting characteristics in the edge region of a cold plate was conducted. The edge effects on the water droplet condensation (WDC), water droplet frozen (WDF) and frost layer growth characteristics were quantitatively investigated. The results showed that the number of droplets coalescing in the edge-affected regions was around 50% greater than in the unaffected regions. At the end of the WDC stages, the area-average equivalent contact diameter and coverage area ratio of water droplets in the edge-affected regions were 2.69 times and 11.6% greater than those in the unaffected regions under natural convection, and the corresponding values were 2.24 times and 9.9% under forced convection. Compared with the unaffected regions, the WDF stage duration in the edge-affected regions decreased by 63.6% and 95.3% under natural and forced convection, respectively. Additionally, plate-type and feather-type frost crystals were, respectively, observed in natural and forced convection. The results of this study can help in the better understanding of the condensation frosting mechanism on a cold plate, which provides guidelines for optimizing the design of heat exchanger structures and system control strategies facing frosting problems.

Small Molecule Inhibitors of TET Dioxygenases: Bobcat339 Activity Is Mediated by Contaminating Copper(II).

Ten eleven translocation (TET) dioxygenases 1-3 are non-heme Fe(II) and α-ketoglutarate dependent enzymes that catalyze oxidation of 5-methylcytosine (5mC) in DNA to hydroxymethyl-C, formyl-C, and carboxy-C. This typically leads to gene activation and epigenetic remodeling. Most known inhibitors of TET are α-ketoglutarate mimics that may interfere with other α-ketoglutarate dependent enzymes. Recently, a novel cytosine-based inhibitor of TET, Bobcat339, was reported to have mid-µM inhibitory activity against TET1 and TET2. The molecule is now sold as a TET inhibitor by several vendors. We independently prepared Bobcat339 in our laboratory and observed that it had minimal inhibitory activity against human TET1 and TET2 via a quantitative LC-ESI-MS/MS assay. Furthermore, the inhibitory activity of commercial Bobcat339 preparations was directly correlated with Cu(II) content. We therefore conclude that Bobcat339 alone is not capable of inhibiting TET enzymes at the reported concentrations, and that its activity is enhanced by contaminating Cu(II).

All-weather thermochromic windows for synchronous solar and thermal radiation regulation.

Adaptive control of solar and thermal radiation through windows is of pivotal importance for building energy saving. However, such synchronous passive regulations are challenging to be integrated into one thermochromic window. Here, we develop a solar and thermal regulatory (STR) window by integrating poly(N-isopropylacrylamide) (pNIPAm) and silver nanowires (AgNWs) into pNIPAm/AgNW composites. A hitherto unexplored mechanism, originating from the temperature-triggered water capture and release due to pNIPAm phase transition, is exploited to achieve simultaneous regulations of solar transmission and thermal emission. The STR window shows excellent solar modulation (58.4%) and thermal modulation (57.1%) and demonstrates effective regulation of indoor temperatures during both daytime and nighttime. Compared to other thermochromic technologies, the STR window reduces heat loss in cold environment while promotes heat dissipation in hot conditions, achieving efficient energy saving in all weathers. This dual solar and thermal regulation mechanism may provide unidentified insights into the advancement of smart window technology.

Infection control measures for public transportation derived from the flow dynamics of obstructed cough jet.

During the COVID-19 pandemic, WHO and CDC suggest people stay 1 m and 1.8 m away from others, respectively. Keeping social distance can avoid close contact and mitigate infection spread. Many researchers suspect that suggested distances are not enough because aerosols can spread up to 7-8 m away. Despite the debate on social distance, these social distances rely on unobstructed respiratory activities such as coughing and sneezing. Differently, in this work, we focused on the most common but less studied aerosol spread from an obstructed cough. The flow dynamics of a cough jet blocked by the backrest and gasper jet in a cabin environment was characterized by the particle image velocimetry (PIV) technique. It was proved that the backrest and the gasper jet can prevent the front passenger from droplet spray in public transportation where maintaining social distance was difficult. A model was developed to describe the cough jet trajectory due to the gasper jet, which matched well with PIV results. It was found that buoyancy and inside droplets almost do not affect the short-range cough jet trajectory. Infection control measures were suggested for public transportation, including using backrest/gasper jet, installing localized exhaust, and surface cleaning of the backrest.

Airborne infection risk of nearby passengers in a cabin environment and implications for infection control.

BACKGROUND: Expiratory droplets cause high infection risk to nearby passengers via airborne route. METHODS: We built a two-row four-seat setup to simulate a public transport cabin. A cough generator and a nebulizer were used to simulate the cough and talk processes respectively. Exposure and infection risk of nearby passengers was studied. The effect of gasper jet and backrest on risk mitigation was investigated. RESULTS: For the activity of coughing, the front passenger has much higher infection risk, which was around four times of that of other passengers, because of the concentration surge in the inhalation zone. For talking, the nearby passengers have similar infection risk because nearby passengers were all exposed to concentration surges with similar peak value. Gasper jet of the infected passenger and higher backrest can extinguish or reduce the concentration surge of front passengers and reduce the infection risk due to coughing and talking droplets. CONCLUSION: The passengers near the infected passenger have very high infection risk. The overhead gasper and a higher backrest can reduce the exposure and mitigate the risk of infection. It is believed that the control measures to protect nearby passengers are urgently needed in public transport cabins.

A Solution-Processed Inorganic Emitter with High Spectral Selectivity for Efficient Subambient Radiative Cooling in Hot Humid Climates.

Daytime radiative cooling provides an eco-friendly solution to space cooling with zero energy consumption. Despite significant advances, most state-of-the-art radiative coolers show broadband infrared emission with low spectral selectivity, which limits their cooling temperatures, especially in hot humid regions. Here, an all-inorganic narrowband emitter comprising a solution-derived SiOx Ny layer sandwiched between a reflective substrate and a self-assembly monolayer of SiO2 microspheres is reported. It shows a high and diffusive solar reflectance (96.4%) and strong infrared-selective emittance (94.6%) with superior spectral selectivity (1.46). Remarkable subambient cooling of up to 5 °C in autumn and 2.5 °C in summer are achieved under high humidity without any solar shading or convection cover at noontime in a subtropical coastal city, Hong Kong. Owing to the all-inorganic hydrophobic structure, the emitter shows outstanding resistance to ultraviolet and water in long-term durability tests. The scalable-solution-based fabrication renders this stable high-performance emitter promising for large-scale deployment in various climates.

DEB-FAPy-dG Adducts of 1,3-Butadiene: Synthesis, Structural Characterization, and Formation in 1,2,3,4-Diepoxybutane Treated DNA.

Metabolic activation of the human carcinogen 1,3-butadiene (BD) by cytochrome 450 monooxygenases gives rise to a genotoxic diepoxide, 1,2,3,4-diepoxybutane (DEB). This reactive electrophile alkylates guanine bases in DNA to produce N7-(2-hydroxy-3,4-epoxy-1-yl)-dG (N7-DE-dG) adducts. Because of the positive charge at the N7 position of the purine heterocycle, N7-DEB-dG adducts are inherently unstable and can undergo spontaneous depurination or base-catalyzed imidazole ring opening to give N6 -[2-deoxy-D-erythro-pentofuranosyl]-2,6-diamino-3,4-dihydro-4-oxo-5-N-1-(oxiran-2-yl)propan-1-ol-formamidopyrimidine (DEB-FAPy-dG) adducts. Here we report the first synthesis and structural characterization of DEB-FAPy-dG adducts. Authentic standards of DEB-FAPy-dG and its 15 N3 -labeled analogue were used for the development of a quantitative nanoLC-ESI+ -HRMS/MS method, allowing for adduct detection in DEB-treated calf thymus DNA. DEB-FAPy-dG formation in DNA was dependent on DEB concentration and pH, with higher numbers observed under alkaline conditions.

The effect of head orientation and personalized ventilation on bioaerosol deposition from a cough.

Head orientations directly determine movement directions of exhaled pathogen-laden droplets, while there is a lack of research about the effect of the infected person's head orientations on respiratory disease transmission during close contact. This work experimentally investigated the effect of different head orientations of an infected person (IP) on the bioaerosol deposition on a healthy person (HP) during close contact. Also, the effectiveness of PV flow in reducing bioaerosol deposition on the HP under the IP's different head orientations was investigated. Bacteriophage T3 was employed to represent viruses inside the cough-generated aerosols. The bioaerosol depositions on different locations of the HP's upper body (chest, shoulder, and neck) and face (chin, mucous membranes, cheek, and forehead) were characterized by a cultivation method. Results showed that the IP's different head orientations resulted in significantly different deposition density on the HP. PV flow could reduce the bioaerosol deposition remarkably for most cases investigated. The effectiveness of PV flow in reducing deposition on the HP was significantly affected by the IP's head orientations. Findings suggest that changing head orientations can be a control measure to reduce the bioaerosol deposition. Personalized ventilation can be a potential method to reduce the bioaerosol deposition on the HP.

Site-Specific 5-Formyl Cytosine Mediated DNA-Histone Cross-Links: Synthesis and Polymerase Bypass by Human DNA Polymerase η.

DNA-protein cross-links (DPCs) between DNA epigenetic mark 5-formylC and lysine residues of histone proteins spontaneously form in human cells. Such conjugates are likely to influence chromatin structure and mediate DNA replication, transcription, and repair, but are challenging to study due to their reversible nature. Here we report the construction of site specific, hydrolytically stable DPCs between 5fdC in DNA and K4 of histone H3 and an investigation of their effects on DNA replication. Our approach employs oxime ligation, allowing for site-specific conjugation of histones to DNA under physiological conditions. Primer extension experiments revealed that histone H3-DNA crosslinks blocked DNA synthesis by hPol η polymerase, but were bypassed following proteolytic processing.

Biotechnology of Plastic Waste Degradation, Recycling, and Valorization: Current Advances and Future Perspectives.

Invited for this month's cover is the collaborative group of Dr. Carol Sze Ki Lin and Dr. Xiang Wang. The image illustrates the biodegradation of plastics and the potential for plastic waste recycling and valorization to address the plastic waste dilemma. The Minireview itself is available at 10.1002/cssc.202100752.

Respiratory bioaerosol deposition from a cough and recovery of viable viruses on nearby seats in a cabin environment.

Respiratory bioaerosol deposition in public transport cabins is critical for risk analysis and control of contact transmission. In this work, we built a two-row four-seat setup and an air duct system to simulate a cabin environment. A thermal manikin on the rear left-hand seat was taken as the infected passenger (IP) and "coughed" three times through a cough generator. The deposited viruses and droplets on nearby seats were measured by a cultivation method and microscope, respectively. The effects of seat backrest and overhead gasper jet were studied. Results showed that the number of deposited virus on the front seat was one order of magnitude higher than that on other seats which only contained droplets smaller than 10 µm in diameter. When the backrest was 15 cm higher than the cough, the deposited number of viruses was reduced to 5% of that with the backrest at the same height with the cough. The gasper jet above the IP with a velocity of 1.5 m/s can reduce the deposited viruses to 4% of that with gasper off. It indicates that both the gasper jet and backrest can work as mitigation measures to block the cough jet and protect the nearby passengers.

Biotechnology of Plastic Waste Degradation, Recycling, and Valorization: Current Advances and Future Perspectives.

Although fossil-based plastic products have many attractive characteristics, their production has led to severe environmental burdens that require immediate solutions. Despite these plastics being non-natural chemical compounds, they can be degraded and metabolized by some microorganisms, which suggests the potential application of biotechnologies based on the mechanism of plastic biodegradation. In this context, microbe-based strategies for the degradation, recycling, and valorization of plastic waste offer a feasible approach for alleviating environmental challenges created by the accumulation of plastic waste. This Minireview highlights recent advances in the biotechnology-based biodegradation of both traditional polymers and bio-based plastics, focusing on the mechanisms of biodegradation. From an application perspective, this Minireview also summarizes recent progress in the recycling and valorization of plastic waste, which are feasible solutions for tackling the plastic waste dilemma.

Effects of GSTT1 Genotype on the Detoxification of 1,3-Butadiene Derived Diepoxide and Formation of Promutagenic DNA-DNA Cross-Links in Human Hapmap Cell Lines.

Smoking is a leading cause of lung cancer, accounting for 81% of lung cancer cases. Tobacco smoke contains over 5000 compounds, of which more than 70 have been classified as human carcinogens. Of the many tobacco smoke constituents, 1,3-butadiene (BD) has a high cancer risk index due to its tumorigenic potency and its abundance in cigarette smoke. The carcinogenicity of BD has been attributed to the formation of several epoxide metabolites, of which 1,2,3,4-diepoxybutane (DEB) is the most toxic and mutagenic. DEB is formed by two oxidation reactions carried out by cytochrome P450 monooxygenases, mainly CYP2E1. Glutathione-S-transferase theta 1 (GSTT1) facilitates the conjugation of DEB to glutathione as the first step of its detoxification and subsequent elimination via the mercapturic acid pathway. Human biomonitoring studies have revealed a strong association between GSTT1 copy number and urinary concentrations of BD-mercapturic acids, suggesting that it plays an important role in the metabolism of BD. To determine the extent that GSTT1 genotype affects the susceptibility of individuals to the toxic and genotoxic properties of DEB, GSTT1 negative and GSTT1 positive HapMap lymphoblastoid cell lines were treated with DEB, and the extent of apoptosis and micronuclei (MN) formation was assessed. These toxicological end points were compared to the formation of DEB-GSH conjugates and 1,4-bis-(guan-7-yl)-2,3-butanediol (bis-N7G-BD) DNA-DNA cross-links. GSTT1 negative cell lines were more sensitive to DEB-induced apoptosis as compared to GSTT1 positive cell lines. Consistent with the protective effect of GSH conjugation against DEB-derived apoptosis, GSTT1 positive cell lines formed significantly more DEB-GSH conjugate than GSTT1 negative cell lines. However, GSTT1 genotype did not affect formation of MN or bis-N7G-BD cross-links. These results indicate that GSTT1 genotype significantly influences BD metabolism and acute toxicity.

Holey aligned electrodes through in-situ ZIF-8-assisted-etching for high-performance aqueous redox flow batteries.

Fabricating electrodes with large specific surface area (SSA) and high permeability has been the long-standing target in redox flow batteries (RFBs). In this work, we propose a novel ZIF-8-assisted etching approach to form holey fibers in the electrospinning process of aligned electrode structures. The etching approach allows the formation of holey fibers with small pores of ~50 nm, offering large active surface areas for redox reactions, while the aligned macrostructure with the holey fibers of 3-5 µm in diameter ensures a high permeability along the fiber direction. The application of the prepared electrodes to a vanadium redox flow battery (VRFB) enables an energy efficiency (EE) of 87.2% at the current density of 200 mA cm-2, which is 13.3% higher than that with conventional electrospun carbon electrodes. Even at high current densities of 300 and 400 mA cm-2, the battery still maintains energy efficiencies of 83.3% and 79.3%. More excitingly, the prepared electrode yields a high limiting current density of 4500 mA cm-2 and a peak power density of 1.6 W cm-2. It is anticipated that the present electrospinning method combining the ZIF-8-assisted etching approach with a way to form ordered fiber structures will allow even more high-performance electrodes for RFBs in the future.

Solution-Processed All-Ceramic Plasmonic Metamaterials for Efficient Solar-Thermal Conversion over 100-727 °C.

Low-cost and large-area solar-thermal absorbers with superior spectral selectivity and excellent thermal stability are vital for efficient and large-scale solar-thermal conversion applications, such as space heating, desalination, ice mitigation, photothermal catalysis, and concentrating solar power. Few state-of-the-art selective absorbers are qualified for both low- (<200 °C) and high-temperature (>600 °C) applications due to insufficient spectral selectivity or thermal stability over a wide temperature range. Here, a high-performance plasmonic metamaterial selective absorber is developed by facile solution-based processes via assembling an ultrathin (≈120 nm) titanium nitride (TiN) nanoparticle film on a TiN mirror. Enabled by the synergetic in-plane plasmon and out-of-plane Fabry-Pérot resonances, the all-ceramic plasmonic metamaterial simultaneously achieves high, full-spectrum solar absorption (95%), low mid-IR emission (3% at 100 °C), and excellent stability over a temperature range of 100-727 °C, even outperforming most vacuum-deposited absorbers at their specific operating temperatures. The competitive performance of the solution-processed absorber is accompanied by a significant cost reduction compared with vacuum-deposited absorbers. All these merits render it a cost-effective, universal solution to offering high efficiency (89-93%) for both low- and high-temperature solar-thermal applications.

Bio-inspired TiO2 nano-cone antireflection layer for the optical performance improvement of VO2 thermochromic smart windows.

Vanadium dioxide (VO2) is a promising material for thermochromic glazing. However, VO2 thermochromic smart windows suffer from several problems that prevent commercialization: low luminous transmittance (Tlum) and low solar modulation ability (ΔTsol). The solution to these problems can be sought from nature where the evolution of various species has enabled them to survive. Investigations into the morphology of moths eyes has shown that their unique nanostructures provide an excellent antireflection optical layer that helps moths sharply capture the light in each wavelength from a wide angle. Inspired by this mechanism, a VO2 thermochromic smart window coated with a TiO2 antireflection layer with a novel nano-cone structure, is presented in this study to achieve high Tlum and ΔTsol. Optimization for the key structure parameters is summarized based on the FDTD numerical simulations. The optimized structure exhibits a Tlum of 55.4% with ΔTsol of 11.3%, an improvement of about 39% and 72% respectively compared to the VO2 window without an antireflection layer. Furthermore, wide-angle antireflection and polarization independence are also demonstrated by this nano-cone coating. This work provides an alternative method to enhance the optical performance of VO2 smart windows.

Interindividual Differences in DNA Adduct Formation and Detoxification of 1,3-Butadiene-Derived Epoxide in Human HapMap Cell Lines.

Smoking-induced lung cancer is a major cause of cancer mortality in the US and worldwide. While 11-24% of smokers will develop lung cancer, risk varies among individuals and ethnic/racial groups. Specifically, African American and Native Hawaiian cigarette smokers are more likely to get lung cancer as compared to Caucasians, Japanese Americans, and Latinos. It is important to identify smokers who are at the greatest risk of developing lung cancer as they should be candidates for smoking cessation and chemopreventive intervention programs. Among 60+ tobacco smoke carcinogens, 1,3-butadiene (BD) is one of the most potent and abundant (20-75 µg per cigarette in mainstream smoke and 205-361 µg per cigarette in side stream smoke). BD is metabolically activated to 3,4-epoxy-1-butene (EB), which can be detoxified by glutathione S-transferase theta 1 (GSTT1)-mediated conjugation with glutathione, or can react with DNA to form 7-(1-hydroxy-3-buten-2-yl)guanine (EB-GII) adducts. In the present study, we employed EBV-transformed human lymphoblastoid cell lines (HapMap cells) with known GSTT1 genotypes to examine the influence of the GSTT1 gene on interindividual variability in butadiene metabolism, DNA adduct formation/repair, and biological outcomes (apoptosis). We found that GSTT1- HapMap cells treated with EB in culture produced lower levels of glutathione conjugates and were more susceptible to apoptosis but had similar numbers of EB-GII adducts as GSTT1+ cells. Our results suggest that GSTT1 can influence an individual's susceptibility to butadiene-derived epoxides.