Antenatal size, early childhood growth, and asthma within a cohort created by data linkage.

INTRODUCTION: The gestation when small for gestational age (SGA) is first associated with asthma is not well understood. Here, we use routinely acquired data from 10 weeks gestation to up to 28 years of age to test the hypothesis that SGA before birth is associated with an increased risk for asthma in a large population born between 1987 and 2015. METHODS: Databases were linked to produce a single database that held antenatal fetal ultrasound measurements; maternal characteristics; birth measurements; childhood anthropometric measurements at age 5 years; hospital admission data (1987-2015); and family doctor prescribing (2009-2015). Asthma admission and receipt of any asthma medications were the outcomes. Analyses related single and then multiple anthropometric measurements to asthma outcomes. RESULTS: Outcome data were available for 63,930 individuals. Increased length in the first-trimester size was associated with a reduced odds ratio (OR) for asthma admission of 0.991 [0.983, 0.998] per mm increase and also a shorter time to first admission, with a hazard ratio risk of 0.987 [0.980, 0.994] per mm increase. Independent of all earlier measurements, increased height at 5 years (available in a subset of 15,760) was associated with reduced OR for an asthma admission, with OR of 0.874 [0.790, 0.967] per z score. Longitudinal measurements of weight were not related to asthma outcomes. CONCLUSIONS: Longer first-trimester length is associated with more favorable asthma outcomes, and subsequently, increased height in childhood is also independently associated with more favorable asthma outcomes. Interventions that reduce SGA and encourage healthy postnatal growth might improve asthma outcomes.

Antenatal Fetal Size and Obesity in Five-Year-Old Children in a Large Cohort Created by Data Linkage.

Background: What is not well understood is the gestational age at which the fetal size deviates from normal for children who develop obesity. Here we test the hypothesis that large-for-gestational age before birth is associated with increased risk for obesity in early childhood. Methods: In this retrospective study, routinely acquired antenatal ultrasound assessments in the first, second, and third trimester were linked to anthropometric measurements at 5.5 years. Results: There were 15,760 individuals, including 678 with obesity, 1955 overweight, and 1254 thin. Compared with children of healthy weight, children who had obesity were shorter in the first trimester [mean difference 0.19 z scores (0.10, 0.28)] and heavier in the second [mean difference z scores 0.15 (0.03, 0.27)] and third trimester [mean difference z scores 0.18 (0.05, 0.32)]. Children in the thin category were lighter compared with children of healthy weight in the third trimester and those in the overweight category were heavier compared with children of healthy weight in the third trimester. All associations were independent of birth weight. Conclusions: The difference in growth trajectories between children who have obesity compared with overweight or thin suggests different underlying mechanisms.

Replacing barium enema with CT colonography in patients older than 70 years: the importance of detecting extracolonic abnormalities.

OBJECTIVE: The objective of our study was to evaluate the significance of extracolonic abnormalities in patients older than 70 years referred for CT colonography (CTC). MATERIALS AND METHODS: We performed a retrospective analysis of 400 consecutive patients older than 70 years undergoing CTC over a 14-month period. All patients presented with weight loss, alteration of bowel habits, rectal blood loss, abdominal pain, or anemia; these symptoms led to clinical suspicion of lower gastrointestinal abnormalities. RESULTS: Five hundred five separate extracolonic abnormalities were detected in 268 of 400 patients (67%). One hundred thirty-nine pathologic processes were deemed significant in 116 patients. Of these, 110 lesions (79%) were previously unknown in 96 of the 400 patients (24.0%). Forty-nine of the 400 patients (12.3%) had at least one malignancy, including 23 extracolonic malignancies and 29 colorectal malignancies. Thirteen patients had early cancers (T1N0M0 or T2N0M0). Twenty of the colon cancer patients had significant previously unknown extracolonic abnormalities, half of which were related to the primary tumor and half of which were unrelated extracolonic abnormalities. CONCLUSION: In patients older than 70 years being examined because of lower gastrointestinal symptoms, CTC findings yield a high number of new significant extracolonic abnormalities. This finding makes a compelling case for targeting this group of patients for a CTC service.

Inguinofemoral hernia: accuracy of sonography in patients with indeterminate clinical features.

OBJECTIVE: The objective of our study was to investigate the accuracy of sonography in patients with symptoms suggestive of a hernia and normal or equivocal clinical examination findings. SUBJECTS AND METHODS: Fifty-nine consecutive patients (47 men, 12 women; median age, 51 years; range, 19-82 years) were enrolled in a prospective study of sonography and herniography for investigation of inguinofemoral pain. All patients were referred with a history suggestive of hernia but with equivocal clinical features by three experienced surgeons. All patients underwent sonography and herniography examinations performed by experienced radiologists blinded to clinical details. The imaging variables recorded for each side were normal (including posterior inguinal wall bulging), hernia (indirect, direct, femoral, and abdominal wall), or nondiagnostic. The percentage of exact agreement, sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for sonography and herniography and were compared with surgery when performed; then all sides for sonography were compared with herniography. RESULTS: Surgery was performed in 18 patients (31%) on 21 sides and found hernia (n = 20) and patulous posterior inguinal wall (with no hernia) (n = 1). Compared with surgery, the results of sonography versus herniography, respectively, were exact agreement (91% vs 71%), sensitivity (95% vs 70%), specificity (100% vs 100%), PPV (100% vs 100%), and NPV (50% vs 14%). The sensitivity of sonography was significantly higher than that of herniography (McNemar test, p = 0.025). Both techniques had one false-negative in the same patient. Herniography had five additional false-negatives identified as hernias at sonography and surgery. Compared with herniography as the reference, the sonography findings were in exact agreement in 91% (107/118) of the cases; and sensitivity was 90% (19/21); specificity, 91% (88/97); PPV, 68% (19/28); and NPV, 98% (88/90). CONCLUSION: Sonography is an accurate technique for the detection of inguinofemoral hernias in patients with clinically equivocal findings.