Cost-effectiveness uncertainty may bias the decision of coal power transitions in China.

A transition away from coal power always maintains a high level of complexity as there are several overlapping considerations such as technical feasibility, economic costs, and environmental and health impacts. Here, we explore the cost-effectiveness uncertainty brought by policy implementation disturbances of different coal power phaseout and new-built strategies (i.e., the disruption of phaseout priority) in China based on a developed unit-level uncertainty assessment framework. We reveal the opportunity and risk of coal transition decisions by employing preference analysis. We find that, the uncertainty of a policy implementation might lead to potential delays in yielding the initial positive annual net benefits. For example, a delay of six years might occur when implementing the prior phaseout practice. A certain level of risk remains in the implementation of the phaseout policy, as not all strategies can guarantee the cumulative positive net benefits from 2018-2060. Since the unit-level heterogeneities shape diverse orientation of the phaseout, the decision-making preferences would remarkably alter the selection of a coal power transition strategy. More strikingly, the cost-effectiveness uncertainty might lead to missed opportunities in identifying an optimal strategy. Our results highlight the importance of minimizing the policy implementation disturbance, which helps mitigate the risk of negative benefits and strengthen the practicality of phaseout decisions.

Tracing Organophosphate Ester Pollutants in Hadal Trenches─Distribution, Possible Origins, and Transport Mechanisms.

Unraveling the mysterious pathways of pollutants to the deepest oceanic realms holds critical importance for assessing the integrity of remote marine ecosystems. This study tracks the transport of pollutants into the depths of the oceans, a key step in protecting the sanctity of these least explored ecosystems. By analyzing hadal trench samples from the Mariana, Mussau, and New Britain trenches, we found the widespread distribution of organophosphate ester (OPE) flame retardants but a complex transport pattern for the OPE in these regions. In the Mariana Trench seawater column, OPE concentrations range between 17.4 and 102 ng L-1, with peaks at depths of 500 and 4000 m, which may be linked to Equatorial Undercurrent and topographic Rossby waves, respectively. Sediments, particularly in Mariana (422 ng g-1 dw), showed high OPE affinity, likely due to organic matter serving as a transport medium, influenced by "solvent switching", "solvent depletion", and "filtering processes". Amphipods in the three trenches had consistent OPE levels (29.1-215 ng g-1 lipid weight), independent of the sediment pollution patterns. The OPEs in these amphipods appeared more linked to surface-dwelling organisms, suggesting the influence of "solvent depletion". This study highlights the need for an improved understanding of deep-sea pollutant sources and transport, urging the establishment of protective measures for these remote marine habitats.

Hidden dangers: High levels of organic pollutants in hadal trenches.

The "V"-shaped structure of hadal trenches acts as a natural collector of organic pollutants, drawing attention to the need for extensive research in these areas. Our review identifies significant concentrations of organic pollutants, including persistent organic pollutants, black carbon, antibiotic-resistant genes, and plastics, which often match those in industrialized regions. They may trace back to both human activities and natural sources, underscoring the trenches' critical role in ocean biogeochemical cycles. We highlight the complex lateral and vertical transport mechanisms within these zones. Advanced methodologies, including stable isotope analysis, biomarker identification, and chiral analysis within isotope-based mixing models, are crucial for discerning the origins and pathways of these pollutants. In forthcoming studies, we aim to explore advanced methods for precise pollutant tracing, develop predictive models to forecast the future distribution and impacts of pollutants in hadal zones and on the Earth's larger ecological systems.

Mechanically strong, hydrostable, and biodegradable all-biobased transparent wood films with UV-blocking performance.

Petroleum-based plastics are useful but they pose a great threat to the environment and human health. It is highly desirable yet challenging to develop sustainable structural materials with excellent mechanical and optical properties for plastic replacement. Here, we report a simple and efficient method to manufacture high-performance all-biobased structural materials from cellulosic wood skeleton (WS) and gelatin via oxidation and densification. Specifically, gelatin was grafted to the oxidized cellulose wood skeletons (DAWS) and then physically crosslinked via Tannic acid (TA), resulting in a significant enhancement of the material properties. Notably, only a mild pressure was applied during the drying process to form a densified TA/Gelatin/transparent wood film(TWF). The developed TA/Gelatin/TWF (thickness:100 ± 12 µm) exhibited a desirable combination of high strength (∼154.59 MPa), light transmittance (86.2 % at 600 nm), low haze (16.7 %), high water stability (wet strength: ∼130.13 MPa) and ultraviolet blocking efficacy which surpass most of the petroleum-based plastics. In addition, due to the all bio-based origins (wood and gelatin), TA/Gelatin/TWF are easily biodegradable under natural conditions, leading to less impact on the environment. These findings would hold promises for exploring high-quality all bio-based wood composites as eco-friendly alternatives to substitute plastics with wide applications, e.g. anti-counterfeiting, UV protection, and flexible electricals.

Co-drivers of Air Pollutant and CO2 Emissions from On-Road Transportation in China 2010-2020.

Co-controlling the emissions of air pollutants and CO2 from automobiles is crucial for addressing the intertwined challenges of air pollution and climate change in China. Here, we analyze the synergetic characteristics of air pollutant and CO2 emissions from China's on-road transportation and identify the co-drivers influencing these trends. Using detailed emission inventories and employing index decomposition analysis, we found that despite notable progress in pollution control, minimizing on-road CO2 emissions remains a formidable task. Over 2010-2020, the estimated sectoral emissions of VOCs, NOx, PM2.5, and CO declined by 49.9%, 25.9%, 75.2%, and 63.5%, respectively, while CO2 emissions increased by 46.1%. Light-duty passenger vehicles and heavy-duty trucks have been identified as the primary contributors to carbon-pollution co-emissions, highlighting the need for tailored policies. The driver analysis indicates that socioeconomic changes are primary drivers of emission growth, while policy controls, particularly advances in emission efficiency, can facilitate co-reductions. Regional disparities emphasize the need for policy refinement, including reducing dependency on fuel vehicles in the passenger subsector and prioritizing co-reduction strategies in high-emission provinces in the freight subsector. Overall, our study confirms the effectiveness of China's on-road control policies and provides valuable insights for future policy makers in China and other similarly positioned developing countries.

Trophodynamics of halogenated organic pollutants (HOPs) in aquatic food webs.

Halogenated organic pollutants (HOPs) represent hazardous and persistent compounds characterized by their capacity to accumulate within organisms and endure in the environment. These substances are frequently transmitted through aquatic food webs, engendering potential hazards to ecosystems and human well-being. The trophodynamics of HOPs in aquatic food webs has garnered worldwide attention within the scientific community. Despite comprehensive research endeavors, the prevailing trajectory of HOPs, whether inclined toward biomagnification or biodilution within global aquatic food webs, remains unresolved. Furthermore, while numerous studies have probed the variables influencing the trophic magnification factor (TMF), the paramount determinant remains elusive. Collating a compendium of pertinent literature encompassing TMFs from the Web of Science between 1994 and 2023, our analysis underscores the disparities in attention accorded to legacy HOPs compared to emerging counterparts. A discernible pattern of biomagnification characterizes the behavior of HOPs within aquatic food webs. Geographically, the northern hemisphere, including Asia, Europe, and North America, has demonstrated greater biomagnification than its southern hemisphere counterparts. Utilizing a boosted regression tree (BRT) approach, we reveal that the food web length and type emerge as pivotal determinants influencing TMFs. This review provides a valuable basis for gauging ecological and health risks, thereby facilitating the formulation of robust standards for managing aquatic environments.

Efficient ultraviolet blocking film on the lignin-rich lignocellulosic nanofibril from bamboo.

The ultraviolet (UV) blocking performance of current bio-based devices is always limited by delignification and exploited chemical treatment. Lignocellulosic nanofibril (LCNF) is a promising green alternative that could efficiently impede UV radiation. Herein, we proposed a robust LCNF film that achieved 99.8 ± 0.19 % UVB blocking, 96.1 ± 0.23 % UVA blocking, and was highly transparent without complex chemical modification. Compared to conventional lignin composites, this LCNF method involves 29.5 ± 2.31 % lignin content directly extracted from bamboo as a broad-spectrum sun blocker. This bamboo-based LCNF film revealed an excellent tensile strength of 94.9 ± 3.6 MPa and outstanding stability, adapting to the natural environment's variability. The residual hemicellulose could also embed the link between lignin and cellulose, confirming high lignin content in the network. The connection between lignin and hemicelluloses in the cellulose network was explored and described for the fibrillation of lignocellulosic nanofibrils. This research highlights the promising development of LCNFs for UV protection and bio-based solar absorption materials.

Muscle-inspired anisotropic carboxymethyl cellulose-based double-network conductive hydrogels for flexible strain sensors.

Conductive hydrogels are considered one of the most promising materials for preparing flexible sensors due to their flexible and extensible properties. However, conventional hydrogels' weak mechanical and isotropic properties are greatly limited in practical applications. Here, the internal structure of the hydrogel was regulated by pre-stretching synergistic ion crosslinking to construct a carboxymethyl cellulose-based double network-oriented hydrogel similar to muscle. The introduction of pre-stretching increased the tensile strength of the double-network hydrogel from 1.45 MPa to 4.32 MPa, and its light transmittance increased from 67.3 % to 84.5 %. In addition, the hydrogel's thermal stability and electrical conductivity were improved to a certain extent. Its good mechanical properties and conductive properties can be converted into stable electrical signal output during deformation. The carboxymethyl cellulose-based double network oriented hydrogels were further assembled as flexible substrates into flexible sensor devices. The hydrogel sensors can monitor simple joint movements as well as complex spatial movements, which makes them have potential application value in the research field of intelligent response electronic devices such as flexible wearables, intelligent strain sensing, and soft robots.

Insulative Biobased Glaze from Wood Laminates Obtained by Self-Adhesion.

The combination of optical transparency and mechanical strength is a highly desirable attribute of wood-based glazing materials. However, such properties are typically obtained by impregnation of the highly anisotropic wood with index-matching fossil-based polymers. In addition, the presence of hydrophilic cellulose leads to a limited water resistance. Herein, this work reports on an adhesive-free lamination that uses oxidation and densification to produce transparent all-biobased glazes. The latter are produced from multilayered structures, free of adhesives or filling polymers, simultaneously displaying high optical clarity and mechanical strength, in both dry and wet conditions. Specifically, high values of optical transmittance (≈85.4%), clarity (≈20% with low haze) at a thickness of ≈0.3 mm, and highly isotropic mechanical strength and water resistance (wet strength of ≈128.25 MPa) are obtained for insulative glazes exhibiting low thermal conductivity (0.27 W m-1 K-1 , almost four times lower than glass). The proposed strategy results in materials that are systematically tested, with the leading effects of self-adhesion induced by oxidation rationalized by ab initio molecular dynamics simulation. Overall, this work demonstrates wood-derived materials as promising solutions for energy-efficient and sustainable glazing applications.

Construction of strong and tough carboxymethyl cellulose-based oriented hydrogels by phase separation.

Anisotropic hydrogels have attracted extensive attention because they are similar to natural hydrogel-like materials and exhibit superiority and new functions that isotropic hydrogels cannot. Here, we fabricated strong and tough carboxymethyl cellulose-based conductive hydrogels with oriented hierarchical structures through pre-stretching, solvent displacement induced phase separation, and subsequent ionic crosslinking immobilization. Solvent displacement made the pre-stretched carboxymethyl cellulose-based polymer network more dense and linear, while the toughness of the hydrogel was further improved under the effect of phase separation. Strong and tough hydrogels were prepared by combining pre-stretching and phase separation; the variation range (tensile strength of 2.24-6.19 MPa and toughness of 19.41-22.92 MJ/m3) can be adjusted by the stretching ratio. Compared with traditional carboxymethyl cellulose-based hydrogels, the tensile strength and toughness were increased by 49 times and 15 times, respectively. In addition, the hydrogels had good underwater stability, ion cross-linking made the hydrogels have good conductivity, and the directional stratification structure gave the hydrogels conductive anisotropy. These characteristics give hydrogel sensors broad application prospects in flexible wearable devices, anisotropic sensors, and intelligent underwater devices.

Preparation of antifouling and highly hydrophobic cellulose nanofibers/alginate aerogels by bidirectional freeze-drying for water-oil separation in the ocean environment.

Oil spills frequently occur in the ocean, and adsorption is one of the effective ways to deal with oil spills. Compared with other adsorbent materials, biomass aerogel has superior selective adsorption capacity. CNF/SA aerogels with good mechanical properties (340 kPa at 90 % strain) and high adsorption capacity (88.91 g/g) were prepared by mixing cellulose nanofibers (CNF) with sodium alginate (SA) through bidirectional freeze-drying, ionic crosslinking, and surface modification to effectively solve the ocean oil spill problem. The bidirectional freeze-drying technology is a green and efficient technique for preparing layered microstructured composite aerogels. The prepared aerogels have a three-dimensional interpenetrating lamellar structure, low density (24.2 mg/cm3), high porosity (97.85 %), and high hydrophobicity (WCA = 144.5°), can be calibrated and used repeatedly. It has potential applications in water-oil separation and can be used as an absorbent for effectively treating oil spills in the ocean environment.

Mechanically strong all-chitin filaments: Wet-spinning of ß-chitin nanofibers in aqueous NaOH.

Herein, a facile wet-spinning strategy was used for the fabrication of mechanically strong all-chitin filaments from an aqueous NaOH solution using ß-chitin nanofibers (ß-ChNFs). It is hypothesized that to reach high mechanical performance it is important to preserve the crystalline structure of chitin during fabrication. To explore this possibility, ß-ChNFs were disintegrated from squid pens by a mild procedure and showed a uniform diameter of 10-25 nm, length of a few microns, and a high aspect ratio of more than 200. An interesting finding was that gel-like ß-ChNF filaments were directly formed in aqueous NaOH without using any organic or ionic agents. The gelation of ß-ChNFS under alkali treatments contributed to the construction of strong nanonetworks and thus facilitated the formation of high-strength filaments. The resulting all-chitin filaments showed a high tensile strength and Young's modulus of 251.3 ± 12.45 MPa and 12.1 ± 0.72 GPa, respectively, which were further investigated for utilization as flexible sensors. The advantages of this strategy included the lack of use of any toxic solvents and the achievement of high mechanical performance for the all-chitin filaments. We believe that this wet-spinning approach may promote the functional utilization of chitin to develop high-strength filaments in smart textiles, biosensors, and structural reinforcements.

A non-mitogenic FGF4 analog alleviates non-alcoholic steatohepatitis through an AMPK-dependent pathway.

BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) has emerged as a major liver disease increasingly in association with non-alcoholic steatohepatitis (NASH), cirrhosis and hepatocellular carcinoma (HCC). However, there are currently no approved therapies for treating NAFLD and NASH. Fibroblast growth factor 4 (FGF4) has recently been shown as a promising drug candidate for several metabolic diseases. METHODS: Mice fed a high-fat diet with high fructose/glucose drinking water (HF/HFG, Western-like diet) for 21 weeks were intraperitoneally injected with non-mitogenic recombinant FGF4△NT (rFGF4△NT, 1.0 mg/kg body weight) every other day for 8 weeks. Primary mouse hepatocytes cultured in medium containing high glucose/palmitic acid (HG/PA) or TNFα/cyclohexane (TNFα/CHX) were treated with 1.0 µg/ml rFGF4△NT. Changes in parameters for histopathology, lipid metabolism, inflammation, hepatocellular apoptosis and fibrosis were determined. The Caspase6 activity and AMPK pathway were assessed. RESULTS: Administration of rFGF4△NT significantly attenuated the Western-like diet-induced hepatic steatosis, inflammation, liver injury and fibrosis in mice. rFGF4△NT treatment reduced fatty acid-induced lipid accumulation and lipotoxicity-induced hepatocyte apoptosis, which were associated with inhibition of Caspase6 cleavage and activation. Inhibition of AMP-activated protein kinase (AMPK) by Compound C or deficiency of Ampk abrogated rFGF4△NT-induced hepatoprotection in primary hepatocytes and in mice with NASH. CONCLUSION: rFGF4△NT exerts significant protective effects on NASH via an AMPK-dependent signaling pathway. Our study indicates that FGF4 analogs may have therapeutic potential for the Western-like diet induced NASH.

Strong, Water-Resistant, and Ionic Conductive All-Chitosan Film with a Self-Locking Structure.

Renewable and biodegradable natural polymeric materials are attractive candidates for replacing nonbiodegradable plastics. However, it is challenging to fabricate polysaccharide-based materials (such as cellulose and chitin) that can be used in humid or even watery environments due to their inferior stability against water. Here, a self-locking structure is constructed to develop a strong, water-resistant, and ionic conductive all-chitosan film without other additives. The densely packed self-locking structure introduces strong interactions between chitosan nanofibers, preventing the fibers from disentangling even in watery environments. The resulting film exhibits outstanding tensile strength of ∼144 MPa, superior wet strength of ∼54.3 MPa, and high ionic conductivity of 0.0012 S/cm at 10-4 M KCl, which are significantly higher than those of conventional polysaccharide-based materials and many commercially used plastics. Additionally, it also possesses outstanding flexibility, excellent thermal stability, good antimicrobial ability, and biodegradability, which make it a promising eco-friendly alternative to plastics for many potential applications, such as packaging bags, drinking straws, and ion regulation membranes.

FGF4 protects the liver from nonalcoholic fatty liver disease by activating the AMP-activated protein kinase-Caspase 6 signal axis.

BACKGROUND AND AIMS: NAFLD represents an increasing health problem in association with obesity and diabetes with no effective pharmacotherapies. Growing evidence suggests that several FGFs play important roles in diverse aspects of liver pathophysiology. Here, we report a previously unappreciated role of FGF4 in the liver. APPROACH AND RESULTS: Expression of hepatic FGF4 is inversely associated with NAFLD pathological grades in both human patients and mouse models. Loss of hepatic Fgf4 aggravates hepatic steatosis and liver damage resulted from an obesogenic high-fat diet. By contrast, pharmacological administration of recombinant FGF4 mitigates hepatic steatosis, inflammation, liver damage, and fibrogenic markers in mouse livers induced to develop NAFLD and NASH under dietary challenges. Such beneficial effects of FGF4 are mediated predominantly by activating hepatic FGF receptor (FGFR) 4, which activates a downstream Ca2+ -Ca2+ /calmodulin-dependent protein kinase kinase beta-dependent AMP-activated protein kinase (AMPK)-Caspase 6 signal axis, leading to enhanced fatty acid oxidation, reduced hepatocellular apoptosis, and mitigation of liver damage. CONCLUSIONS: Our study identifies FGF4 as a stress-responsive regulator of liver pathophysiology that acts through an FGFR4-AMPK-Caspase 6 signal pathway, shedding light on strategies for treating NAFLD and associated liver pathologies.

Paracrine FGFs target skeletal muscle to exert potent anti-hyperglycemic effects.

Several members of the FGF family have been identified as potential regulators of glucose homeostasis. We previously reported that a low threshold of FGF-induced FGF receptor 1c (FGFR1c) dimerization and activity is sufficient to evoke a glucose lowering activity. We therefore reasoned that ligand identity may not matter, and that besides paracrine FGF1 and endocrine FGF21, other cognate paracrine FGFs of FGFR1c might possess such activity. Indeed, via a side-by-side testing of multiple cognate FGFs of FGFR1c in diabetic mice we identified the paracrine FGF4 as a potent anti-hyperglycemic FGF. Importantly, we found that like FGF1, the paracrine FGF4 is also more efficacious than endocrine FGF21 in lowering blood glucose. We show that paracrine FGF4 and FGF1 exert their superior glycemic control by targeting skeletal muscle, which expresses copious FGFR1c but lacks ß-klotho (KLB), an obligatory FGF21 co-receptor. Mechanistically, both FGF4 and FGF1 upregulate GLUT4 cell surface abundance in skeletal muscle in an AMPKα-dependent but insulin-independent manner. Chronic treatment with rFGF4 improves insulin resistance and suppresses adipose macrophage infiltration and inflammation. Notably, unlike FGF1 (a pan-FGFR ligand), FGF4, which has more restricted FGFR1c binding specificity, has no apparent effect on food intake. The potent anti-hyperglycemic and anti-inflammatory properties of FGF4 testify to its promising potential for use in the treatment of T2D and related metabolic disorders.

Gradient Diffusion Anisotropic Carboxymethyl Cellulose Hydrogels for Strain Sensors.

Recently, because of the unique properties of anisotropic and isotropic structures, there are more research studies on anisotropic hydrogels. We prepared a gradient anisotropic carboxymethyl cellulose hydrogel (CMC-Al3+) by directionally diffusing aluminum chloride solution. The orientation of carboxymethyl cellulose (CMC) chains is perpendicular to the direction of aluminum ion diffusion. The degree of cross-linking and orientation gradually decrease along the direction of aluminum ion diffusion. Compared with anisotropic hydrogels prepared by other methods, the hydrogels prepared by directionally diffusing aluminum ion solution have a gradient lamellar structure. Because of the large amount of aluminum ions in CMC-Al3+, the hydrogel shows good sensing performance. CMC-Al3+ is packaged with PVC electrical flame retardant tape to produce a strain sensor used to detect human tiny movements, which can accurately and stably monitor tiny movements. Hydrogel-based strain sensors can be widely used in the fields of human-computer intelligence, human-computer interaction, and wearable devices in the future.

Toward Strong and Tough Wood-Based Hydrogels for Sensors.

The purpose of this research is to develop strong and tough wood-based hydrogels, which are reinforced by an aligned cellulosic wood skeleton. The hypothesis is that improved interfacial interaction between the wood cell wall and a polymer is of great importance for improving the mechanical performance. To this end, a facile and green approach, called ultraviolet (UV) grafting, was performed on the polyacrylamide (PAM)-infiltrated wood skeleton without using initiators. An important finding was that PAM-grafted cellulose nanofiber (CNF) architectures formed in the obtained hydrogels under UV irradiation, where CNFs themselves serve as both initiators and cross-linkers. Moreover, an alkali swelling treatment was utilized to improve the accessibility of the wood cell wall before UV irradiation and thus facilitate grafting efficiency. The resulting alkali-treated Wood-g-PAM hydrogels exhibited significantly higher tensile properties than those of the Wood/PAM hydrogel and were further assembled into conductive devices for sensor applications. We believe that this UV grafting strategy may facilitate the development of strong wood-based composites with interesting features.

Surface and Interface Engineering for Nanocellulosic Advanced Materials.

How do trees support their upright massive bodies? The support comes from the incredibly strong and stiff, and highly crystalline nanoscale fibrils of extended cellulose chains, called cellulose nanofibers. Cellulose nanofibers and their crystalline parts-cellulose nanocrystals, collectively nanocelluloses, are therefore the recent hot materials to incorporate in man-made sustainable, environmentally sound, and mechanically strong materials. Nanocelluloses are generally obtained through a top-down process, during or after which the original surface chemistry and interface interactions can be dramatically changed. Therefore, surface and interface engineering are extremely important when nanocellulosic materials with a bottom-up process are fabricated. Herein, the main focus is on promising chemical modification and nonmodification approaches, aiming to prospect this hot topic from novel aspects, including nanocellulose-, chemistry-, and process-oriented surface and interface engineering for advanced nanocellulosic materials. The reinforcement of nanocelluloses in some functional materials, such as structural materials, films, filaments, aerogels, and foams, is discussed, relating to tailored surface and/or interface engineering. Although some of the nanocellulosic products have already reached the industrial arena, it is hoped that more and more nanocellulose-based products will become available in everyday life in the next few years.