RESUMO
BACKGROUND: The Solitaire AB stent is one of many assistant stents used for treating wide-necked cerebral aneurysm, and has been used since 2003. However, large sample studies on its safety and effectiveness are lacking. The objective of this study was to evaluate the effectiveness and safety of the Solitaire AB stent in the coil embolization of wide-necked cerebral aneurysms. METHODS: Retrospective review of the clinical and image data of 116 patients with wide-necked cerebral aneurysms who had been enrolled at six interventional neuroradiology centers from February 2010 to February 2014 and had been treated by coil embolization; in total, 120 Solitaire AB stents were used. The degree of aneurysm occlusion was examined using digital subtraction angiography (DSA) immediately after the procedure and during follow-up, and was graded using the modified Raymond classification. We also observed complications to evaluate the safety and effectiveness of this therapy. RESULTS: The 120 Solitaire AB stents (4 mm × 15 mm, four stents; 4 mm × 20 mm, 16 stents; 6 mm × 20 mm, 36 stents; 6 mm × 30 mm, 64 stents) were inserted to treat 120 wide-necked cerebral aneurysms. All stents were inserted successfully. DSA immediately post-surgery revealed 55 cases of complete occlusion, 59 cases of neck remnant, and six cases of aneurysm remnant. Perioperatively, there were four cases of hemorrhage and four cases of stent thrombosis. The follow-up spanned 3-37 months; of 92 patients examined by DSA at the 6-month follow up, 12 had disease recurrence. CONCLUSIONS: The Solitaire AB stent is effective with a good technical success rate and short-term effect for assisting coil embolization of wide-necked cerebral aneurysms.
Assuntos
Prótese Vascular , Embolização Terapêutica , Aneurisma Intracraniano/cirurgia , Procedimentos Neurocirúrgicos/instrumentação , Procedimentos Neurocirúrgicos/métodos , Stents/estatística & dados numéricos , Angiografia Cerebral , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Estudos Retrospectivos , Resultado do TratamentoRESUMO
Febrile seizures (FS) are common in children, and the incidence is 2-5% before the age of 5 years. A four-generation Chinese family with autosomal dominant febrile seizure and epilepsy was studied by genome-wide linkage analysis. Significant linkage was identified with markers on chromosome 3q26.2-26.33 with a maximum pairwise LOD score of >3.00. Fine mapping defined the new genetic locus within a 10.7-Mb region between markers D3S3656 and D3S1232. A maximum multipoint LOD score of 5.27 was detected at marker D3S1565. A previously reported CLCN2 gene for epilepsy was excluded as the disease-causing gene in the family by mutational analysis of all exons and exon-intron boundaries of CLCN2 and by haplotype analysis. Mutation analysis of KCNMB2 and KCNMB3, which were two potassium-channel genes in this linkage region, did not reveal a disease causing mutation. Our results identified another novel locus on chromosome 3q26.2-26.33, and future studies of the candidate genes at the locus will identify a new gene for combined FS and idiopathic epilepsies.
Assuntos
Cromossomos Humanos Par 3/genética , Epilepsia/genética , Convulsões Febris/genética , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Criança , Pré-Escolar , China/epidemiologia , Mapeamento Cromossômico , Epilepsia/epidemiologia , Feminino , Genes Dominantes , Ligação Genética , Genoma Humano , Haplótipos , Humanos , Lactente , Escore Lod , Masculino , Pessoa de Meia-Idade , Linhagem , Penetrância , Convulsões Febris/epidemiologiaRESUMO
A new method for the determination of trace beryllium in geological samples by oxygen-air-acetylene flame atomic absorption spectrometry is reported in the present paper. The optimum determination conditions were selected. When suitable amounts of 8-hydroxyquinoline are added, the interference effect from the coexisting elements can be minimized and the sensitivity for the determination of beryllium can be increased. The detection limit (k = 3) is 0.006 microg x mL(-1) for beryllium. The method has been applied to the determination of trace beryllium in geological standard samples, and the results are in good agreement with the certified values with a precision of 4.69% RSD( n = 8).
Assuntos
Berílio/análise , Sedimentos Geológicos/análise , Espectrofotometria Atômica/métodos , Acetileno/química , Ácidos/química , Ar , Berílio/química , Sedimentos Geológicos/química , Oxigênio/química , Oxiquinolina/química , Reprodutibilidade dos Testes , Espectrofotometria Atômica/instrumentaçãoRESUMO
Non-ion surface active agent can be separated from its solution of water by heating to its cloud point. A new method for the determination of zinc in mineral samples by flame atomic absorption spectrophotometer after phase separation and extraction making use of its cloud point was studied in this paper. The conditions of phase separation and extraction such as using Triton X-100 as phase separation agent, and octanol to drop the cloud point, and the influence of acidity and the number of times for oscillating were discussed. The detection limit was 0.005 microg x mL(-1). This method has been applied to the determination of zinc in ores with satisfactory results.