RESUMO
This paper is an attempt to convey in a lucid way how to go about writing a scientific article for publication in an appropriate journal. Topics covered are: a) reasons to write a paper b) types of papers c) asking a question and formulating an hypothesis d) the complex series of steps necessary before you begin your study e) additional considerations once your study is complete f) the process of writing the paper and g) writing skills. In the concluding remarks I comment on the possibility of rejection of your submission which should not be taken personally. If this does occur it should not deter you from contributing to medical science.
Assuntos
Pesquisa Biomédica/métodos , Editoração , Redação , HumanosRESUMO
The Division of Lung Diseases of the National Heart, Lung and Blood Institute (NHLBI) recently held a workshop to identify gaps in our understanding and treatment of childhood lung diseases and to define strategies to enhance translational research in this field. Leading experts with diverse experience in both laboratory and patient-oriented research reviewed selected areas of pediatric lung diseases, including perinatal programming and epigenetic influences; mechanisms of lung injury, repair, and regeneration; pulmonary vascular disease (PVD); sleep and control of breathing; and the application of novel translational methods to enhance personalized medicine. This report summarizes the proceedings of this workshop and provides recommendations for emphasis on targeted areas for future investigation. The priority areas identified for research in pediatric pulmonary diseases included: (1) epigenetic and environmental influences on lung development that program pediatric lung diseases, (2) injury, regeneration, and repair in the developing lung, (3) PVD in children, (4) development and adaptation of ventilatory responses to postnatal life, (5) nonatopic wheezing: aberrant large airway development or injury? (6) strategies to improve assessment, diagnosis, and treatment of pediatric respiratory diseases, and (7) predictive and personalized medicine for children.
Assuntos
Pesquisa Biomédica , Doenças Respiratórias , Criança , Humanos , National Heart, Lung, and Blood Institute (U.S.) , Estados UnidosRESUMO
This paper focuses on the main problems that authors of rejected papers have had in their submissions to Pediatric Pulmonology over the past 5 years or so. It is intended as a teaching tool for residents, fellows, allied health personnel, practicing physicians and even some academic physicians who need a refresher on what goes wrong and how they may avoid rejection of their labor. The approach is somewhat lighthearted but nevertheless the message is quite serious.
Assuntos
Manuscritos como Assunto , Revisão da Pesquisa por Pares , Tomada de Decisões , Humanos , Publicações Periódicas como Assunto , Projetos de Pesquisa , RedaçãoAssuntos
Pneumopatias , Vasculite , Criança , Diagnóstico Diferencial , Humanos , Imunossupressores/uso terapêutico , Incidência , Pneumopatias/diagnóstico , Pneumopatias/epidemiologia , Pneumopatias/terapia , Plasmaferese , Prognóstico , Vasculite/diagnóstico , Vasculite/epidemiologia , Vasculite/terapiaAssuntos
Genes Bacterianos/genética , Complexo Mycobacterium avium/classificação , Mycobacterium tuberculosis/classificação , Animais , Técnicas de Tipagem Bacteriana , Bovinos , Evolução Molecular , Genoma , Humanos , Complexo Mycobacterium avium/genética , Mycobacterium tuberculosis/genética , Sensibilidade e EspecificidadeRESUMO
We describe the development of pediatric pulmonology in North America, from its rudimentary beginning in the early part of the 20th century. Milestones in the history of lung diseases affecting children, such as tuberculosis, cystic fibrosis, asthma, and neonatal lung disease, are discussed. Finally, maturation into a subspecialty recognized by the American Board of Pediatrics is described.
Assuntos
Pediatria/história , Pneumologia/história , História do Século XIX , História do Século XX , História do Século XXI , Pneumopatias/classificação , Pneumopatias/epidemiologia , Pneumopatias/terapia , América do Norte/epidemiologiaRESUMO
El tiempo inspiratorio previo a la realización de una maniobra espiratoria forzada máxima (FEM) es una variable que no ha sido completamente estudiada en Fibrosis Quística (FQ). El objetivo de este estudio fue evaluar la hipótesis que niños con FQ tendrían mayores volúmenes y flujos espiratorios forzados al disminuir la duracion del tiempo inspiratorio. Se estudiaron 16 niños con FQ, en etapa estable, sin haber presentado una exacerbación respiratoria en los ultimos dos meses, (10 hombres), de edad 11,9 ñ 0,7 años (promedio ñ ES), con un FEV1 de 62,8 ñ 6,4 porciento predicho. Las pruebas de función pulmonar consistieron en la medición de volúmenes pulmonares estáticos y resistencia de la vía aérea, seguido de evaluación dinámica de la función pulmonar. Esta última medición fue precedida de 3 maniobras inspiratorias diferentes en forma aleatoria[inspiración y detención de 0 segundos (M0), 2 segundos (M2) o 5 segundos (M5)]. El grupo se dividió en pacientes con hiperinsuflación pulmonar detectada por VR/CPT > 30 porciento, (n=9) y sin hiperinsuflación pulmonar RV/CPT menor o igual 30 porciento (n=7). Los resultados demostraron que, en los pacientes con hiperinsuflación, VEF1 y CVF fueron 8,9 ñ 3,4 porciento (p<0,02) y 9,3 ñ 2,1 porciento (p > 0,001) mayores respectivamente, después de M0 en comparación a después de M2 y 2,4 ñ 2,8 porciento (p = ns) menor respectivamente después de M5 en relación a después de M2 (M0 vs M5:p<0,01 para ambos, VEF1 y CVF). En resumen, en pacientes portadores de fibrosis quística e hiperinsuflación, VEF1 y CVF son significativamente mayores luego de realizar una espiración sin detención de inspiración de 2 ó 5 segundos. Sugerimos que los mecanismos de relajación de la musculatura lisa del árbol bronquial pueden ser los responsables de este hallazgo