1.
J Mol Cell Cardiol
; 12(10): 939-54, 1980 Oct.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6257913
Assuntos
Contração Miocárdica/efeitos dos fármacos , Miocárdio/metabolismo , Nucleotídeos Cíclicos/metabolismo , Inibidores de Fosfodiesterase/farmacologia , Proteínas Quinases/metabolismo , Animais , AMP Cíclico/metabolismo , AMP Cíclico/farmacologia , GMP Cíclico/metabolismo , Papaverina/farmacologia , Pentoxifilina/farmacologia , Ratos , Teofilina/farmacologia
2.
Experientia
; 36(9): 1088-90, 1980 Sep 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-6252042
RESUMO
Perfusion of the isolated rat heart at constant heart rate and coronary flow with the inhibitor of cyclic nucleotide phosphodiesterase, pentoxifylline (10(-4) moles/l), produced no significant effect on the maximum rate and the peak of contraction, but increased the maximum rate of relaxation. cAMP level and cAMP-dependent protein kinase activity were increased in the absence of changes in cGMP. The results were identical in hearts of reserpinized rats.
