[The characteristics of the pharmacotherapy for patients with ischemic heart disease and hypertension in relation to age]. / Osobennosti farmakoterapii bol'nykh ishemicheskoi bolezn'iu serdtsa i gipertonicheskoi bolezn'iu v zavisimosti ot vozrasta.

On the basis of literary and own findings the authors discuss disputable problems of the pharmacotherapy of ischemic heart disease and hypertensive disease in the age aspect including patients over 60 years of age. Approaches are analyzed to individual choice of adequate pharmacotherapy, criteria of selection and dosages with special emphasis of adreno-beta-blockaders and calcium antagonists as well as criteria of evaluation of pharmacotherapy.

[Beta-adrenoblockaders and calcium antagonists in the treatment of patients with ischemic heart disease combined with hypertension]. / Beta-adrenoblokatory i antagonisty kal'tsiia v lechenii bol'nykh ishemicheskoi bolezn'iu serdtsa v sochetanii s gipertonicheskoi bolezn'iu.

The authors studied 67 patients with ischemic heart disease associated with hypertensive disease and revealed that the use of beta-adrenoblockaders and calcium antagonists resulted in a reduction of the manifestations of the disease, increase of physical load tolerance, optimization of its hemodynamic and oxygen provision. In patients under 60 years of age of beta-adrenoblockaders resulted in an increase of the myocardial contractility. This was not observed in those over 60 years of age. It is concluded that in patients combining IHD with hypertensive disease under 60 it is more preferable to use beta-adrenoblockers, in those over 60--calcium antagonists.

[Mathematical analysis of the interrelations of the indicators of lipid metabolism and parameters of the oxygen transport system in patients with ischemic heart disease]. / Matematicheskii analiz vzaimosviazei mezhdu pokazateliami lipidnogo obmena i parametrami kislorodtransportnoi sistemy u bol'nykh ishemicheskoi bolezn'iu serdtsa.

Mathematical processing of research results (correlation, multifactorial and cluster analyses) has demonstrated intricate relationships between blood lipid composition and parameters of hemodynamic and oxygen support of exercise, undetectable by routine statistical procedures, in coronary patients. Coronary patients with hyperlipoproteinemia (HLP) showed inadequately strained and uneconomical cardio-respiratory operation in the course of exercise. The pattern of hemodynamic and oxygen support of exercise was similar in HLP patients with cardialgia and coronary HLP patients whose coronary reserve was mildly limited. The control of lipid metabolic disorders is of preventive as well as direct therapeutic value, as it aims to eliminate hypoxia, normalize hemodynamic and oxygen support of exercise and, consequently, improve working capacity.

[Effectiveness of physical training in patients who have had a myocardial infarct]. / Effektivnost' fizicheskikh trenirovok u bol'nykh, perenesshikh infarkt miokarda.

A study of the effects of exercise on cardiovascular function of myocardial infarction survivors showed their physical stress tolerance to increase as a result of improved myocardial contractility and the optimum adjustment of hemodynamic and oxygen support of exercise. Therefore, exercise should be used more extensively as part of the rehabilitation effort following myocardial infarction.

[Catecholamines and the oxygen transport system during the physical loading of patients with a history of myocardial infarct]. / Katekholaminy i kislorodnotransportnaia sistema pri fizicheskoi nagruzke u bol'nykh, perenesshikh infarkt miokarda.

A study of the time course of hemodynamic and oxygen load and catecholamine content in 74 patients after myocardial infarction showed that cardiac output as a pump was less effective in the persons with a higher load tolerance (over 50 W) in a high concentration of noradrenaline in the blood; a higher oxygen debt was revealed after equal exercise. The data obtained can be important for recommendation of beta-adrenoblockers to patients after myocardial infarction.