RESUMO
Cyclooxygenases (particularily Cox-2) are involved in carcinogenesis and metastatic cancer progression. The expression profiles of the cyclooxygenases and the roles they play in established tumours of similar stage remains unclear. We report that Cox-1 and Cox-2 expression is highly variable in Dukes' C tumours, and changes in Cox-1 expression may be of importance.
Assuntos
Neoplasias Colorretais/genética , Isoenzimas/genética , Prostaglandina-Endoperóxido Sintases/genética , RNA Neoplásico/genética , Sequência de Bases , Neoplasias Colorretais/enzimologia , Neoplasias Colorretais/mortalidade , Neoplasias Colorretais/patologia , Ciclo-Oxigenase 1 , Ciclo-Oxigenase 2 , Primers do DNA , Humanos , Mucosa Intestinal/enzimologia , Proteínas de Membrana , Estadiamento de Neoplasias , Reação em Cadeia da Polimerase/métodos , Valores de Referência , Ribotipagem/métodos , Análise de Sobrevida , Fatores de Tempo , Transcrição Gênica/genéticaRESUMO
BACKGROUND: Cyclo-oxygenase inhibition for the treatment of colorectal neoplasia has been studied with renewed interest since the discovery of cyclo-oxygenase (Cox) 2 and the introduction of specific Cox-2 inhibitors. These drugs have implications for both the prevention of colorectal carcinoma and the potential treatment of the disease. METHODS AND RESULTS: A Medline database search was performed for articles using the keywords "colonic, colon or rectal and neoplasia or cancer" and "cyclo-oxygenase or Cox-2." Cross-references of relevant historical papers were also included. There is substantial evidence that Cox-2 plays a role in the development and progression of colorectal cancer. The specific inhibition of this enzyme has been shown to inhibit cancer growth in in vitro and in vivo models. The mechanisms of action for these effects are poorly understood and potential clinical applications at present remain under investigation. CONCLUSION: Cox-2 inhibitors have great promise as useful additions to current cancer treatments. There is a need for randomized clinical trials to define a role for these drugs in chemoprevention, recurrence prophylaxis, and adjuvant therapy for colorectal and other solid tumours.
Assuntos
Neoplasias Colorretais/tratamento farmacológico , Isoenzimas/antagonistas & inibidores , Inibidores da Angiogênese/uso terapêutico , Apoptose/efeitos dos fármacos , Quimioterapia Adjuvante , Neoplasias Colorretais/patologia , Neoplasias Colorretais/prevenção & controle , Ciclo-Oxigenase 2 , Humanos , Inibidores de Metaloproteinases de Matriz , Proteínas de Membrana , Recidiva Local de Neoplasia/prevenção & controle , Prostaglandina-Endoperóxido SintasesRESUMO
Obtaining information from the Internet can be fun. As the Internet is unregulated, the quality of this information can vary enormously and time can be wasted searching poor quality websites. Despite this, use of the Internet for postgraduate medical education is increasing.