The Double Burden of Malnutrition is Associated with Continued Breastfeeding and Early Consumption of Ultra-Processed Drinks in Socially Vulnerable Brazilian Children.

This study aimed to assess the association between the double burden of malnutrition (DBM) with continued breastfeeding and the early introduction of ultra-processed drinks in children living in situations of social vulnerability. This cross-sectional population-based study was carried out in a capital city in the Northeast of Brazil, which included 561 children. It was observed that introducing soft drinks into the child's diet during the first year of life was directly associated with DBM but indirectly with continuous breastfeeding for 12 or more months. These results indicate paths that can be followed to reverse the current scenario.

Perceptual representations mediate effects of stimulus properties on liking for music.

Perceptual pleasure and its concomitant hedonic value play an essential role in everyday life, motivating behavior and thus influencing how individuals choose to spend their time and resources. However, how pleasure arises from perception of sensory information remains relatively poorly understood. In particular, research has neglected the question of how perceptual representations mediate the relationships between stimulus properties and liking (e.g., stimulus symmetry can only affect liking if it is perceived). The present research addresses this gap for the first time, analyzing perceptual and liking ratings of 96 nonmusicians (power of 0.99) and finding that perceptual representations mediate effects of feature-based and information-based stimulus properties on liking for a novel set of melodies varying in balance, contour, symmetry, or complexity. Moreover, variability due to individual differences and stimuli accounts for most of the variance in liking. These results have broad implications for psychological research on sensory valuation, advocating a more explicit account of random variability and the mediating role of perceptual representations of stimulus properties.

Factors Associated with Continued Breastfeeding Practice in Children Under 2 Years of Age Assisted by the Brazilian Conditional Cash Transfer Program, Bolsa Família.

Breastfeeding is the first guarantee of the human right to adequate food and the benefits of continued breastfeeding up to 2 years of age are well established. This cross-sectional study sought to explore the association between socioeconomic, demographic, and nutritional factors and the practice of continued breastfeeding in children aged 6 to 24 months assisted by the Brazilian conditional cash transfer program, Bolsa Família. Our findings emphasize the role of unfavorable socioeconomic conditions in diminishing the practice of continued breastfeeding. They also suggest the importance of policy-level actions to promote and support breastfeeding and to combat early ultra-processed foods consumption.

Relations between perceived affect and liking for melodies and visual designs.

Sensory valuation is a fundamental aspect of cognition. It involves assigning hedonic value to a stimulus based on its sensory information considering personal and contextual factors. Hedonic values (e.g., liking) can be deemed affective states that motivate behavior, but the relations between hedonic and affective judgments have yet to be established. To fill this gap, we investigated the relations between stimulus features, perceived affect, and liking across domains and with potentially relevant individual traits. Fifty-eight participants untrained in music and visual art rated their liking and perceived valence and arousal for visual designs and short melodies varying in balance, contour, symmetry, or complexity and filled out several questionnaires. First, we examined group-level relations between perceived affect and liking across domains. Second, we inspected the relations between the individual use of musical and visual properties in judgments of liking and perceived affect-that is, between aesthetic and perceived-affect sensitivities. Third, we inquired into the influence of information-related (need for cognition, or NFC) and affect-related (need for emotion) traits on individual sensitivities. We found domain-specific effects of the stimulus features on liking, a linear association between valence and liking, the inverted-U model of arousal and liking, a binary profile of musical aesthetic sensitivities, and a modulatory effect of NFC on how people use stimulus properties in their hedonic and affective judgments. In summary, the results suggest that hedonic value is primarily computed from domain-specific sensory information partially moderated by NFC. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Social and Racial Disparities in Food Consumption Among Brazilian College Students: a Nationwide Study.

This study aims to assess the association between economic class, race/skin color, and food consumption among Brazilian college students. A cross-sectional web-based survey was conducted with college students from all over Brazil. Demographic data, economic class, self-reported race/skin color, anthropometry, and food consumption markers from the Brazilian Food and Nutrition Surveillance System were collected. The final sample comprised 5843 participants with a mean age of 24.1 (SD: 6.3) years, 4292 (73.5%) were female, and 810 (13.9%) in the highest economic stratum. We observed a progressive decrease in the frequency of fresh fruits and vegetables consumption from higher to lower economic classes (p < 0.01 for both). Contrarily, there was a progressive increase in the frequency of consumption of beans from higher to lower economic classes (p < 0.01). The frequency consumption of vegetables was also associated with race/skin color (p < 0.01), being lower in brown (PR: 0.94; CI 95%: 0.90; 0.98), and black (PR: 0.91; 95% CI: 0.85; 0.98) individuals, compared to white individuals. Brown individuals showed higher frequency consumption of beans (PR: 1.10; 95% CI: 1.05; 1.15) than whites. When compared to individuals of white race/skin color, brown (PR: 1.07; 95% CI: 1.01; 1.13) and black (PR: 1.15; 95% CI: 1.07; 1.23) individuals showed higher frequency consumption of sweetened beverages. Economic class and race/skin color were independent factors associated with the food consumption of Brazilian college students.

Social network of malnourished children and its association with family's food and nutritional security / Rede social de crianças desnutridas e sua relação com a segurança alimentar e nutricional da família

Abstract Objectives: evaluate the relationship between family's food and nutrition insecurity (FNI) and the social network of malnourished children. Methods: cross-sectional study with 92 children, included in the economic class D-E. For the analysis of the children's social network, the mothers answered four simple questions. To investigate the FNI, the Brazilian Scale of Food Insecurity was used. The association between variables was analyzed by Poisson regression with robust analysis of variances. Results: 56.5% of the children had a weak social network (<10 individuals), and the prevalence of FNI was 72.8%. An inverse association was observed between children of the daily social network and FNI family (OR=0.94; CI95%=0.89-0.99], p=0.03). The number of individuals in the children's daily social network was negatively associated with the likelihood of FNI. The mother's educational level was also related to FNI (OR=2.20 [CI95%=1.11-4.34]; p=0.02), being the child up to 2.2 times more likely to be in FNI when the mother has less than four years of study. Conclusion: these results suggest that social network is associated with the FNI of malnourished children. Interventions designed to strengthen instrumental and other forms of support among small social networks can improve the health/nutrition of malnourished children with FNI.

Resumo Objetivos: avaliar a relação entre a insegurança alimentar e nutricional (IAN) da família e a rede social de crianças desnutridas. Métodos: estudo transversal com 92 crianças, inseridas na classe econômica D-E. Para a análise da rede social das crianças, as mães responderam quatro perguntas simples. Para investigar a IAN foi utilizada a Escala Brasileira de Insegurança Alimentar. A associação entre as variáveis foi analisada por regressão de Poisson com análise robusta das variâncias. Resultados: 56,5% das crianças apresentaram rede social fraca (<10 indivíduos), e a prevalência de IAN foi de 72,8%. Foi observada uma associação inversa entre rede social diária das crianças e IAN da família (RP=0,94, [IC95%=0,89-0,99]; p=0,03). O número de indivíduos na rede social diária das crianças se associou negativamente com a probabilidade de IAN. O nível de escolaridade materno também estava relacionado com a IAN (RP=2,20 [IC95%=1,11-4,34]; p=0,02), tendo a criança até 2,2 vezes mais probabilidade de estar em IAN quando a mãe apresenta menos de quatro anos de estudo. Conclusão: esses resultados sugerem que a rede social está associada à IAN de crianças desnutridas. Intervenções destinadas a fortalecer maneiras instrumentais e outras formas de apoio entre pequenas redes sociais podem melhorar a saúde/nutrição de crianças desnutridas com IAN.

The relationship between total energy expenditure and physical activity level in women living in an impoverished Brazilian urban area.

OBJECTIVE: This study aimed to describe how strong is the relationship between TEE and PAL in women living in an impoverished Brazilian urban area. METHODS: Anthropometric, hormonal (insulin, TSH, FT4 , and FT3 ), body composition (deuterium), TEE (doubly labeled water) and PAL (metabolic equivalent task [MET]-7-day triaxial accelerometer, ActivPAL®) data were collected from 55 women (mean age: 31y, mean BMI: 27.4 kg/m2 ). Adjusted-TEE models were calculated incorporating the residuals of anthropometric, hormonal, and body composition variables in the TEE, to assess the relation between MET and adjusted-TEE, through three different analyzes: linear regression, nonlinear regression and change-point regression. RESULTS: Most participants (89.1%, n = 49) were classified as low-active. There was no association between crude TEE and MET.h/d (R2  = 0.05; p = 0.09). There was a positive, although weak, linear relationship between adjusted-TEE and MET.h/d (ß = 2705.26 kcal; 95% CI: 436.25; 4974.27; adj-R2  = 0.08). A change point of this relationship was identified in the MET.h/d value of 1.53 (SD = 0.02; adj-R2 = 0.13). The association between adjusted-TEE and MET.h/d before the change point (ß = 5101.46 kcal; 95%CI: 978.84; 9224.08; adj-R2  = 0.11) was stronger than the association in the full linear model, nevertheless, it was still weak. This association stop existing when it is assessed in individuals after the change point (ß = -6609.92 kcal; 95%CI: -16773.24; 3553.40; adj-R2  = 0.08). CONCLUSIONS: These results suggest that the relationship between TEE and PAL is weak and it is not completely linear in women living in an impoverished Brazilian urban area.

Clinical, histological and molecular profiling of different stages of alcohol-related liver disease.

OBJECTIVE: Alcohol-related liver disease (ALD) ranges from never-decompensated ALD (ndALD) to the life-threatening decompensated phenotype, known as alcohol-related hepatitis (AH). A multidimensional study of the clinical, histological and molecular features of these subtypes is lacking. DESIGN: Two large cohorts of patients were recruited in an international, observational multicentre study: a retrospective cohort of patients with ndALD (n=110) and a prospective cohort of patients with AH (n=225). Clinical, analytical, immunohistochemistry and hepatic RNA microarray analysis of both disease phenotypes were performed. RESULTS: Age and mean alcohol intake were similar in both groups. AH patients had greater aspartate amino transferase/alanine amino transferase ratio and lower gamma-glutamyl transferase levels than in ndALD patients. Patients with AH demonstrated profound liver failure and increased mortality. One-year mortality was 10% in ndALD and 50% in AH. Histologically, steatosis grade, ballooning and pericellular fibrosis were similar in both groups, while advanced fibrosis, Mallory-Denk bodies, bilirubinostasis, severe neutrophil infiltration and ductular reaction were more frequent among AH patients. Transcriptome analysis revealed a profound gene dysregulation within both phenotypes when compare to controls. While ndALD was characterised by deregulated expression of genes involved in matrisome and immune response, the development of AH resulted in a marked deregulation of genes involved in hepatocyte reprogramming and bile acid metabolism. CONCLUSIONS: Despite comparable alcohol intake, AH patients presented with worse liver function compared with ndALD patients. Bilirubinostasis, severe fibrosis and ductular reaction were prominent features of AH. AH patients exhibited a more profound deregulation of gene expression compared with ndALD patients.

Dietary patterns of children aged 6-24 months assisted by the Bolsa Família Program.

OBJECTIVE: This study aimed to verify the association between socio-economic and demographic characteristics and dietary patterns (DP) of children assisted by the Conditional Cash Transfer Program, Bolsa Família Program (BFP). DESIGN: This is a cross-sectional study. DP were defined using a principal component analysis. The association of the predictive variables and DP was modelled using multilevel linear regression analysis. SETTING: This study was conducted in six municipalities from the State of Alagoas, Brazil. PARTICIPANTS: The participants were children aged 6-24 months who were assisted by the BFP. RESULTS: A total of 1604 children were evaluated. Four DP were identified (DP1, DP2, DP3 and DP4). DP1 is composed of traditional Brazilian food. DP2 is formed mostly from ultra-processed foods (UPF). DP3 consists of milk (non-breast) with added sugar, while DP4 consists of fresh and minimally processed foods. Caregivers with higher age and education (ß = -0·008; (95 % CI -0·017, -0·000); ß = -0·037; (95 % CI -0·056, -0·018), respectively) were negatively associated with DP2. We observed a negative association between households with food insecurity (ß = -0·204; (95 % CI -0·331, -0·078)) and DP4 and a positive association between caregivers with higher age and education (ß = 0·011; (95 % CI (0·003; 0·019); ß = 0·043; (95 % CI 0·025, 0·061), respectively) and DP4. CONCLUSION: This study identified the association between socio-economic inequities and DP early in life, with an early introduction of UPF, in children assisted by BFP in the State of Alagoas.

Feasibility of a Mobile-Based System for Unsupervised Monitoring in Parkinson's Disease.

Mobile health (mHealth) has emerged as a potential solution to providing valuable ecological information about the severity and burden of Parkinson's disease (PD) symptoms in real-life conditions. Objective: The objective of our study was to explore the feasibility and usability of an mHealth system for continuous and objective real-life measures of patients' health and functional mobility, in unsupervised settings. Methods: Patients with a clinical diagnosis of PD, who were able to walk unassisted, and had an Android smartphone were included. Patients were asked to answer a daily survey, to perform three weekly active tests, and to perform a monthly in-person clinical assessment. Feasibility and usability were explored as primary and secondary outcomes. An exploratory analysis was performed to investigate the correlation between data from the mKinetikos app and clinical assessments. Results: Seventeen participants (85%) completed the study. Sixteen participants (94.1%) showed a medium-to-high level of compliance with the mKinetikos system. A 6-point drop in the total score of the Post-Study System Usability Questionnaire was observed. Conclusions: Our results support the feasibility of the mKinetikos system for continuous and objective real-life measures of a patient's health and functional mobility. The observed correlations of mKinetikos metrics with clinical data seem to suggest that this mHealth solution is a promising tool to support clinical decisions.

HCV eradication in recurrent hepatitis C after liver transplantation normalizes enhanced endothelial activation.

The increased risk of cardiovascular disease (CVD) conferred by hepatitis C virus (HCV) is especially relevant after liver transplantation (LT), but its mechanism is still not well defined. This study aimed to evaluate the influence of HCV eradication in inflammatory and endothelial activation markers after LT. We evaluated inflammatory (TNF-alfa, IL-6, IL-8, and MCP-1) and endothelial activation (E-selectin, ICAM-1, VCAM-1, and MMP-9) markers before and after eradication in 45 LT recipients with HCV infection (LT+/HCV+) and 44 non-transplanted HCV-infected patients (LT-/HCV+). We also considered an additional group of 40 LT recipients without HCV infection (LT+/HCV-). LT+/HCV+ patients presented a higher endothelial activation status before eradication compared with LT+/HCV- patients. However, levels of E-selectin, ICAM-1, VCAM-1, and MMP-9 were comparable between LT+/HCV+ and LT-/HCV+ patients before eradication. HCV eradication decreased ICAM-1 (5466.55 pg/ml vs. 3354.88 pg/ml, P < 0.001) and VCAM-1 (10456.52 pg/ml vs. 6658.85 pg/ml, P < 0.001) levels in LT+/HCV+ and LT-/HCV+ patients. Remarkably, HCV eradication restored levels of endothelial activation markers of LT+/HCV+ patients compared with that of LT+/HCV- patients. HCV plays a major role in endothelial dysfunction after LT. Furthermore, HCV eradication restores endothelial activation despite the exposure to immunosuppressive therapy.

Trend of the nutritional status of pregnant adolescent beneficiaries of the Brazilian Bolsa Família conditional cash transfer program in the 2008-2018 period. / Tendência do estado nutricional de gestantes adolescentes beneficiárias do programa de transferência condicionada de renda brasileiro Bolsa Família no período 2008-2018.

This ecological study aimed to analyze the trend of the nutritional status of pregnant adolescent beneficiaries of the Brazilian Bolsa Família conditional cash transfer program in the 2008-2018 period. We evaluated secondary data of pregnant adolescent beneficiaries of the Bolsa Família Program from January 2008 to December 2018, extracted from the public reports of the WEB Food and Nutrition Surveillance System. We accessed the monitoring reports on the consolidated public-access health conditionalities of the Bolsa Família Program, always considering the second validity. An annual variation of -1.2% (95%CI: [-1.6; -0.8] p<0.01) was observed in the prevalence of underweight in Brazil in the studied sample. The prevalence of overweight and obesity in the country had annual variations of 2.9% (95%CI: [2.0; 3.7] p<0.01) and 7.5% (95%CI: [5.7; 9.3] p<0.01), respectively. We conclude by saying, that, in the evaluated period, the prevalence of underweight among pregnant adolescent beneficiaries of the Bolsa Família Program showed a decreasing trend, while the prevalence of overweight and obesity increased throughout Brazil.

Trata-se de um estudo ecológico que objetivou analisar a tendência do estado nutricional de gestantes adolescentes beneficiárias do programa brasileiro de transferência condicionada de renda, Bolsa Família, no período 2008-2018. Foram avaliados dados secundários de gestantes adolescentes beneficiárias do Programa Bolsa Família no período de janeiro de 2008 a dezembro de 2018, extraídos dos relatórios públicos do Sistema de Vigilância Alimentar e Nutricional WEB. Foram consultados os relatórios de acompanhamento das condicionalidades de saúde consolidados de acesso público do Programa Bolsa Família, sempre considerando a 2ª vigência. Observou-se uma variação anual de -1,2% (IC95%: [-1,6; -0,8] p<0,01) na prevalência de baixo peso na amostra estudada. Com relação as prevalências de sobrepeso e obesidade no país, observou-se variações anuais de 2,9% (IC95%: [2,0; 3,7] p<0,01) e 7,5% (IC95%: [5,7; 9,3] p<0,01), respectivamente. Conclui-se que, no período avaliado, a prevalência de baixo peso entre as gestantes adolescentes beneficiárias do Programa Bolsa Família apresentou uma tendência decrescente, ao passo que as prevalências de sobrepeso e obesidade apresentam uma tendência crescente em todo o Brasil.

Tendência do estado nutricional de gestantes adolescentes beneficiárias do programa de transferência condicionada de renda brasileiro Bolsa Família no período 2008-2018 / Trend of the nutritional status of pregnant adolescent beneficiaries of the Brazilian Bolsa Família conditional cash transfer program in the 2008-2018 period

Resumo Trata-se de um estudo ecológico que objetivou analisar a tendência do estado nutricional de gestantes adolescentes beneficiárias do programa brasileiro de transferência condicionada de renda, Bolsa Família, no período 2008-2018. Foram avaliados dados secundários de gestantes adolescentes beneficiárias do Programa Bolsa Família no período de janeiro de 2008 a dezembro de 2018, extraídos dos relatórios públicos do Sistema de Vigilância Alimentar e Nutricional WEB. Foram consultados os relatórios de acompanhamento das condicionalidades de saúde consolidados de acesso público do Programa Bolsa Família, sempre considerando a 2ª vigência. Observou-se uma variação anual de -1,2% (IC95%: [-1,6; -0,8] p<0,01) na prevalência de baixo peso na amostra estudada. Com relação as prevalências de sobrepeso e obesidade no país, observou-se variações anuais de 2,9% (IC95%: [2,0; 3,7] p<0,01) e 7,5% (IC95%: [5,7; 9,3] p<0,01), respectivamente. Conclui-se que, no período avaliado, a prevalência de baixo peso entre as gestantes adolescentes beneficiárias do Programa Bolsa Família apresentou uma tendência decrescente, ao passo que as prevalências de sobrepeso e obesidade apresentam uma tendência crescente em todo o Brasil.

Abstract This ecological study aimed to analyze the trend of the nutritional status of pregnant adolescent beneficiaries of the Brazilian Bolsa Família conditional cash transfer program in the 2008-2018 period. We evaluated secondary data of pregnant adolescent beneficiaries of the Bolsa Família Program from January 2008 to December 2018, extracted from the public reports of the WEB Food and Nutrition Surveillance System. We accessed the monitoring reports on the consolidated public-access health conditionalities of the Bolsa Família Program, always considering the second validity. An annual variation of -1.2% (95%CI: [-1.6; -0.8] p<0.01) was observed in the prevalence of underweight in Brazil in the studied sample. The prevalence of overweight and obesity in the country had annual variations of 2.9% (95%CI: [2.0; 3.7] p<0.01) and 7.5% (95%CI: [5.7; 9.3] p<0.01), respectively. We conclude by saying, that, in the evaluated period, the prevalence of underweight among pregnant adolescent beneficiaries of the Bolsa Família Program showed a decreasing trend, while the prevalence of overweight and obesity increased throughout Brazil.

Evaluative judgment across domains: Liking balance, contour, symmetry and complexity in melodies and visual designs.

Evaluative judgment-i.e., assessing to what degree a stimulus is liked or disliked-is a fundamental aspect of cognition, facilitating comparison and choosing among alternatives, deciding, and prioritizing actions. Neuroimaging studies have shown that evaluative judgment involves the projection of sensory information to the reward circuit. To investigate whether evaluative judgments are based on modality-specific or modality-general attributes, we compared the extent to which balance, contour, symmetry, and complexity affect liking responses in the auditory and visual modalities. We found no significant correlation for any of the four attributes across sensory modalities, except for contour. This suggests that evaluative judgments primarily rely on modality-specific sensory representations elaborated in the brain's sensory cortices and relayed to the reward circuit, rather than abstract modality-general representations. The individual traits art experience, openness to experience, and desire for aesthetics were associated with the extent to which design or compositional attributes influenced liking, but inconsistently across sensory modalities and attributes, also suggesting modality-specific influences.

Association between the consumption of ultra-processed foods and the practice of breast-feeding in children under 2 years of age who are beneficiaries of the conditional cash transfer programme, Bolsa Família.

OBJECTIVE: To evaluate the association between the consumption of ultra-processed foods (UPF) and the practice of breast-feeding in children under 2 years of age assisted by the conditional cash transfer programme, Bolsa Família Programme (PBF). DESIGN: A cross-sectional study. The consumption of UPF and the practice of breast-feeding were assessed using a structured 24-h recall. Associations were calculated using hierarchical Poisson regression, adjusted at the last level by socio-economic, demographic and environmental variables from previous hierarchical levels. SETTING: Six counties from the state of Alagoas, Brazil. PARTICIPANTS: Children aged 6-24 months, assisted by PBF. RESULTS: A total of 1604 children were evaluated, 11·7% of whom were overweight, and most had consumed UPF (90·6%) in the last 24 h. The most consumed UPF were biscuits, chocolate milk and baby food with 74·8, 66·8 and 24·9%, respectively. Through multivariable analysis, an association was found between lower consumption of UPF in the continuation of breast-feeding until the second year of life (prevalence ratio (PR) 0·91, 95 % CI 0·86, 0·96) and in the first year of life (PR 0·93, 95 % CI 0·88, 0·99). CONCLUSIONS: It was found that the studied population had a high consumption of UPF, which harmed continued breast-feeding. We highlight the importance of strengthening public policies aimed at the promotion, protection and support of breast-feeding and healthy complementary feeding aimed at populations that have difficulties in physical and economic access to a healthy and adequate diet.

Association between iron deficiency anaemia and complementary feeding in children under 2 years assisted by a Conditional Cash Transfer programme.

OBJECTIVE: To evaluate the association between Fe deficiency anaemia (IDA) and complementary feeding in children under 2 years old assisted by the Conditional Cash Transfer programme, Bolsa Família (BFP). DESIGN: Cross-sectional study. Data were obtained through a standardised form, questionnaire to assess the eating habits of children under 2 years of age, capillary Hb (HemoCue®) and the Brazilian Household Food Insecurity Measurement Scale. Associations were calculated using hierarchical Poisson regression, adjusted at the last level by socio-economic, demographic and environmental variables from previous hierarchical levels. SETTING: Six municipalities from the State of Alagoas, Brazil. PARTICIPANTS: Children aged 6-24 months assisted by BFP. RESULTS: A total of 1604 children were evaluated, among whom 58·1 % had anaemia. A higher number of food groups consumed (prevalence ratio (PR) = 0·97; 95 % CI 0·95, 0·99; P = 0·009), the consumption of dairy (PR = 0·86; 95 % CI 0·79, 0·84; P = 0·001) and meat (PR = 0·90; 95 % CI 0·83, 0·99; P = 0·030) in addition to bottle feeding (PR = 0·88; 95 % CI 0·82, 0·96; P = 0·004) were associated with a lower prevalence of IDA. CONCLUSIONS: IDA is still a serious public health problem in children under 2 years old assisted by BFP in Alagoas. We highlight the importance of promoting complementary feeding based on a diversified dietary intake, as well strengthening prophylactic supplementation programmes to increase children's adherence in conjunction with the implementation of food and nutrition education to help reduce the prevalence of this condition.

Association between COVID-19 diagnosis and economic class, race/skin color and social distancing in Brazilian university students / Associação entre o diagnóstico de COVID-19 e a classe econômica, raça/cor da pele e distanciamento social em universitários brasileiros

ABSTRACT: Purpose: To determine the association between diagnosis of COVID-19 and the economic class, race/skin color, and adherence to social distancing in Brazilian university students. Methods: This is a nationwide cross-sectional study carried out with online questionnaires applied to Brazilian university students, at 94 universities in the public and private education network. Self-reported age, sex, economic class data, race/skin color, COVID-19 diagnosis, and adherence to social distancing measures were collected. Results: 5,984 individuals were evaluated. No significant association was found between the diagnosis of COVID-19 and economic class and race/skin color in the multivariable analysis. However, we observed that there were significant associations between the diagnosis of COVID-19 and partial adherence to social distancing, with leaving home only for going to work (PR: 1.35; 95% CI: 1.10­1.66; p < 0.01) and with non-adherence to social distancing (PR: 1.96; 95% CI: 1.29­2.97; p <0.01). Conclusion: The diagnosis of COVID-19 was associated with age, non-adherence and partial adherence to social distancing measures in Brazilian university students, but was not associated with race/skin color and economic class.

Objetivo: Verificar a associação entre o diagnóstico de COVID-19 e a classe econômica, raça/cor da pele e adesão às medidas ao distanciamento social em universitários brasileiros. Métodos: Estudo transversal, de abrangência nacional, realizado com universitários brasileiros. Foram coletados dados autorreferidos de idade, sexo, classe econômica, raça/cor, diagnóstico do COVID-19 e adesão às medidas de distanciamento social. Resultados: 5.984 indivíduos foram avaliados. Não foi encontrada associação significativa entre o diagnóstico de COVID-19, a classe econômica e raça/cor na análise multivariável. Observamos que houve associações significativas entre o diagnóstico de COVID-19 e adesão parcial ao distanciamento social (RP: 1,35; IC 95%: 1.10­1.66; p < 0,01) e com a não adesão ao distanciamento social (RP: 1,96; IC95%: 1.29­2.97; p < 0,01). Conclusão: O diagnóstico de COVID-19 foi associado à idade, não adesão e adesão parcial às medidas de distanciamento social em universitários brasileiros, mas não se associou à raça/cor e classe econômica. (AU)

Lazer doméstico em tempos de pandemia da covid-19 / Domestic leisure in covid 19 pandemic times

O presente artigo tem como objetivo apresentar as vivências de lazer mais presentes em tempos de pandemia da Covid-19 e suas relações com os conceitos e as barreiras socioculturais do lazer. Considerando as políticas de quarentena e isolamento social, as vivências de lazer se restringiram ao espaço do lar, surgindo assim novas possibilidades ligadas ao ambiente virtual e também ao ambiente doméstico, como lives musicais, crescimento do uso de plataformas de streaming para filmes, séries, música, jogos, assim como atividades físicas, gastronômicas, jardinagem e roteiros turísticos virtuais. Embora encontradas vivências adaptadas ao espaço do lar, houve também a intensificação de barreiras socioculturais relativas ao nível econômico, grau de instrução, acesso a espaços e equipamentos de lazer, acesso à internet, entre outras. A metodologia foi composta por pesquisa bibliográfica e documental em livros, artigos acadêmicos, publicações e conteúdo jornalísticos ligado a lazer, entretenimento, consumo e lazer doméstico, assim como de órgãos e instituições relacionados a lazer, cultura e turismo em conjunto com alguns levantamentos sobre o novo coronavírus. Como resultado está a existência de novas vivências de lazer e a transformação de algumas que até então eram desenvolvidas em ambientes externos à casa.

This article aims to present the leisure experiences most present in pandemic times of Covid-19 and their relationship with the concepts and socio-cultural barriers of leisure. Considering the quarantine and social distancing policies, leisure experiences were restricted to the home space, thus emerging new possibilities related to the virtual environment and also the domestic environment, such as musical "lives", use of streaming platforms for films, series, music, games, as well as physical exercises, cooking and gardening activities and virtual tours. Although it was possible to find experiences adapted to the home space, there was also the intensification of socio-cultural barriers related to the economic development level, education level, access to leisure spaces and equipment, internet access, among others. The methodology consisted of bibliographic and documentary research in books, articles, publications, news and jornalistic content related to leisure, entertainment, consumption and domestic leisure, as well as organs and institutions related to leisure, culture and tourism in line with some surveys related to the new coronavirus. As a result, there is the existence of new leisure experiences and the transformation of some that until then were developed outside their houses.

Adnexal Involvement in Endometrial Cancer: Prognostic Factors and Implications for Ovarian Preservation.

PURPOSE: To determine the risk factors related to adnexal involvement in endometrial cancer (EC) and its implications for ovarian preservation in young women. METHODS: We analyzed a series of 802 patients who were treated at AC Camargo Cancer Center from July 1991 to July 2017. Patients who had peritoneal or systemic dissemination (stage IV) were excluded. Chi square and Fisher's exact tests were used to analyze the correlations between categories and clinicopathological variables. Multivariate analysis was performed by logistic regression. RESULTS: Forty-nine (6.2%) patients had adnexal involvement-43 (5.4%) ovarian and 24 (2.9%) tubal. After excluding the 14 (28%) cases with suspicious findings, 788 subjects were analyzed and adnexal involvement found in 35 (4.4%) cases. Adnexal involvement was statistically related to non-endometrioid histologies (12.6% vs. 3.1%; p < 0.001), lymph node metastasis (17% vs. 2.6%; p < 0.001), histological grade 3 tumors (9.4% vs. 2.1%; p < 0.001), presence of LVSI (14.2% vs. 2.4%; p < 0.001), and deep myometrial invasion (≥ 50%) (10.8% vs. 3.5%; p < 0.001). Although age younger than 45 years had higher risk of adnexal involvement, it was not statistically significant (8.9% vs. 4.2%; p = 0.13). Seven (14.2%) patients with adnexal involvement were aged < 45 years, 3 of whom (42.8%) had suspicious adnexal masses that were detected before surgery. Notably, all patients aged < 45 years and with adnexal involvement had at least 1 risk factor, such as presence of LVSI, grade 3 disease, node metastasis, or deep myometrial invasion. No patient with clinically normal ovaries and aged under 45 years, with endometrioid grades 1 and 2, superficial myometrial invasion, or node negativity had adnexal involvement. CONCLUSIONS: Ovarian preservation may be considered for patients younger than 45 years old with low-risk EC (grades 1 and 2 tumors, absence of LVSI, and myometrial invasion < 50%).