A path to improved pharmaceutical productivity.

The current use of metrics-driven approaches to improve the productivity of pharmaceutical drug discovery will fail. This article presents an approach to the use of performance metrics that has the potential to guide fundamental industry improvement though cooperation.

Ca binding to the human red cell membrane: characterization of membrane preparations and binding sites.

Inside out and right side out vesicles were used to study the sidedness of Ca binding to the human red cell membrane. It was shown that these vesicles exhibited only a limited permeability to Ca, enabling the independent characterization of Ca binding to the extracellular and cytoplasmic membrane surfaces...