Cardiac remodeling in amateur triathletes after 24 weeks of exercise training for a half-Ironman event: a brief report.

BACKGROUND: Triathletes' physiological adaptations to exercise training can have a different impact on cardiac remodeling based on the extreme exercise preparation. Moreover, cardiac remodeling might be different depending on whether triathletes have trained for many years or if they just decided to be more active. Nevertheless, data are limited in amateur endurance athletes and studies about them are key for their safety. Therefore, we investigated the effects of exercise training for a half-ironman on cardiac remodeling. METHODS: A total of 24 amateur athletes underwent a 24-week exercise program and were followed by three-dimensional echocardiography to assess its global impact on cardiac remodeling. Subanalyses were performed based on participants past-training experience (low versus high). RESULTS: We found significant group effects on the right and left ventricle, significant time effect on the right ventricle. No significant interaction effects were observed. We observed significant correlations between the right ventricle, clinical and performance characteristics where the peak power output explained 38% of the variance, while the body surface area, weight and power at the second ventilatory threshold explained 34%, 31% and 30%, respectively. CONCLUSIONS: Changes in cardiac remodeling in response to an exercise program for a half-ironman are not homogeneous across the ventricles and are influenced by participants' past-training experience. This study strengthens our knowledge of extreme exercise training for a half-ironman to further develop better training programs and medical follow-up in amateur triathletes.

Isokinetic strength of shoulder rotator muscles in powerlifters: correlation between isometric and concentric muscle actions.

BACKGROUND: Isokinetic strength has been useful to assess muscle function related to sports and prevent injuries. The present study measured the isokinetic isometric and concentric shoulder rotators strength, agonist/antagonist ratio, and examined the relationships between isometric and concentric peak torque, and agonist/antagonist ratio in powerlifters compared to a control group. METHODS: The participants were divided into two groups: powerlifters group (N.=14) and physically active group (N.=9). Participants' were evaluated on isokinetic dynamometer for isometric, and concentric (two velocities, 60°/s and 180°/s) strength of shoulder external (ER) internal rotation (IR). Isometric contractions lasted 10 seconds, and concentric modes were 5 repetitions. RESULTS: Bilateral significant differences, between dominant and non-dominant side, were found in ER peak torque at isometric mode in powerlifters group (P=0.021). Powerlifters showed higher IR peak torque at isometric mode in dominant (P=0.040) and non-dominant side (P=0.014) than physically active group. Pearson correlations between isometric peak torque and concentric velocities ranged between 0.49 and 0.89 for powerlifters group, and between 0.73 and 0.93 for physically active group. For agonist/antagonist ratio, pearson correlation ranged between 0.47 and 0.83 for powerlifters group, and between 0.48 and 0.86 for physically active group. CONCLUSIONS: The bilateral differences in ER movement at isometric mode in powerlifters suggest that exercises for shoulder rotators must be included on training for joint safety and balance between sides despite isometric shoulder rotators strength in powerlifters was higher than physically active individuals. Results presented positive correlation between both muscle actions, isometric and concentric, in peak torque and agonist/antagonist ratio.

Early administration of L-arginine in mdx neonatal mice delays the onset of muscular dystrophy in tibialis anterior (TA) muscle.

Duchenne muscular dystrophy (DMD) is a genetic disorder that results in the absence of dystrophin, a cytoskeletal protein. Individuals with this disease experience progressive muscle destruction, which leads to muscle weakness. Studies have been conducted to find solutions for the relief of individuals with this disease, several of which have shown that utrophin, a protein closely related to dystrophin, when overexpressed in mdx neonatal mice (the murine model of DMD), is able to prevent the progressive muscle destruction observed in the absence of dystrophin. Furthermore, recent studies have shown that L-arginine induces utrophin upregulation in adult mdx mice. We hypothesized that L-arginine treatment also induces utrophin upregulation to prevent the development of muscle weakness in neonatal mdx mice. Hence, L-arginine should also prevent progressive muscle destruction via utrophin upregulation in mdx neonatal mice. Mdx neonatal mice were injected intraperitoneally daily with 800 mg/kg of L-arginine for 6 weeks, whereas control mice were injected with a physiological saline. The following experiments were performed on the tibialis anterior (TA) muscle: muscle contractility and resistance to mechanical stress; central nucleation and peripheral nucleation, utrophin, and creatine kinase quantification as well as a nitric oxide (NO) assay. Our findings show that early administration of L-arginine in mdx neonatal mice prevents the destruction of the tibialis anterior (TA) muscle. However, this improvement was related to nitric oxide (NO) production rather than the expected utrophin upregulation.

Acute effects of cannabis consumption on exercise performance: a systematic and umbrella review.

INTRODUCTION: The goal of this systematic and umbrella review was to regroup all systematic reviews, non-systematic reviews and all original articles into one convenient publication that would facilitate the theoretical and applied scientific investigations directed on cannabis consumption and exercise performance, to update current findings on the matters, and assess evidence quality. EVIDENCE ACQUISITION: The systematic review was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) method. A computer-based systematic search was conducted in September 2019 through the Pubmed, Scopus and SPORTDiscus databases. The reliability of the systematic search was assured by having the article selection process entirely repeated by a second author. Strength of evidence of the selected articles was assesses using a modified version of the Downs and Black Checklist. EVIDENCE SYNTHESIS: The systematic search yielded a total of 8 peer-reviewed publications as well as 10 literature reviews. Results show that cannabis consumption prior to exercise induces decrements in performance (reduced ability to maintain effort, physical/maximal work capacity), undesired physiological responses (increased heart and breathing rate as well as myocardial oxygen demand) and neurological effects on balance (increased sway). CONCLUSIONS: Based on the articles included in this review, the authors conclude that cannabis consumption has an ergolytic effect on exercise performance and therefore does not act as a sport performance enhancing agent as raised by popular beliefs. Thus, cannabis consumption prior to exercise should be avoided in order to maximize performance in sports. Further research should mimic modern THC dosage (150 mg).

Validation of the alpine skiing 90 seconds box jump field test and prediction of power output.

BACKGROUND: The purpose of this study was to validate the alpine ski racing 90 s box jump field-test (BJ90) with the 90 s Wingate test (W90). METHODS: Fifteen elite alpine ski racers were tested on the BJ90 (0.45 m × 0.75 m × 0.9 m) and the W90 (Ergomedic 894 E Monark; Monark AB, Varberg, Sweden) test in a random order. The number of hits on the BJ90 was written down every 15 s and for the W90 the load (7.5% of body weight) was manually dropped once the subjects reached maximum RPM without resistance. Correlations and partial correlations were calculated with a 2-tailed Pearson correlation analysis. A stepwise forward regression analysis was also performed. RESULTS: Results present significant (P<0.05) correlations and partial correlations adjusted for body weight between the total number of hits on the BJ90 and W90 peak W, peak W/kg, mean W and mean W/kg as well as with the number of hits and W90 Mean W and mean W/kg between each 15 s time slot. A linear regression predictive equation for mean relative power (W/kg) generated from the BJ90 was established: mean relative power (W/kg)=0.055*total hits+1.080 (r=0.79, P<0.001; total hits with mean W/kg). A stepwise forward regression equation for mean absolute power (W) generated from the BJ90 was also established: mean absolute power (W)=2.305*number of hits+5.081*body weight in kg-1 -169.8 (R=0.964, P<0.001, SEE=23.56). CONCLUSIONS: Practitioners could use the BJ90 to assess alpine skiers lower body power as previous research showed that both are correlated with performance and are able to discriminate skier level.

Momentum During a Running Competition: A Sequential Explanatory Mixed-Methods Study.

The purpose of this study was to better understand the psychological momentum (PM) in varsity cross-country competitive runners during a 3000 m selection trials. A sequential explanatory mixed methods design was used: recruitment trial race day (quantitative) and interview day (qualitative + maximal aerobic running speed [MARS]). Sample was consisted of fifteen university distance runners (n = six women [25.9 ± 7.0 years old; 22.2 ± 1.8 BMI] and nine men [23.2 ± 2.4 years old; 22.6 ± 1.6 BMI]). During the recruitment trial race, athletes' MARS was measured and used to create a performance index (PERFI) relative to selected moments. Also, the recruitment trial race was filmed. During the interviews, the recorded film was used to support athletes in the identification of key moments of the race, as well as to discuss positive and negative PM. PM was both defined by participants and devised by three themes: psychological, physiological and psychophysiological change. A significant PERFI difference (p < 0.001) was observed between positive (97.04 ± 5.88%) and negative (108.46 ± 7.76%) moments of PM. The results of PERFI for men and women athletes were not significantly different (p = 0.118). The PERFI standard deviation for women was not correlated (r2 = 0.26, p = 0.30) with the 3000 m time trial performance, but it was significantly correlated for men (r2 = 0.94, p < 0.001). The results of the present study could help developing interventions to focus on specific elements of the momentum such as race management/strategy, the attentiveness of the runner during the race and other elements of mental and physical preparation of the athletes.

Preparation for an Half-Ironmantm Triathlon amongst Amateur Athletes: Finishing Rate and Physiological Adaptation.

Long distance triathlon has gained in popularity amongst the general population. Coaches establish training programs based upon their knowledge, personal experience and on current training principles. The goal was to observe the effect of a triathlon training program for a half Ironman event in neophyte amateur athletes. A specific triathlon training program was followed from February to June 2016 by a group preparing for their first half ironman. Out of the 32 participants (19 Males and 13 Females; mean age of 39 ± 9.9 years old; body weight of 72.7 ± 13.4 kg and a height of 171.5 ± 10.2 cm), only one did not complete the event. A mean training volume of 410 ± 201 min per week led to a mean finishing time of 6 hours 28 minutes. The training program significantly increased the maximal oxygen consumption (45.9 ± 8.2 to 48.6 ± 7.5 ml/kg/min, p =0.002) and the maximal power output (293.1 ± 63.7 to 307.8 ± 58.7 W, p < 0.001). The absolute oxygen consumption and power output at both ventilatory thresholds also significantly increased (VT1: 2.2 ± 0.4 to 2.5 ± 0.5 L, p = 0.001; 157.8 ± 41.8 to 176.7 ± 41.1 W p = 0.009 and VT2: 2.9 ± 0.4 to 3.0 ± 0.4 L, p = 0.017; 229.3 ± 62.0 to 244.8± 55.2 W, p = 0.022 ). A significant diminution of waist circumference was observed (83.2 ± 10.0 to 81.8 ± 9.5 cm, p = 0.032) with no significant changes in body weight. Thus, a 24-week specific training program appears to be safe and efficient for amateur athletes aiming to finish their first half- Ironman event.

The relationship between body composition measured by dual-energy X-ray absorptiometry and maximal strength in classic powerlifting.

BACKGROUND: The purpose of this study was to conduct a detailed body composition analysis by Dual-Energy X-Ray Absorptiometry (DEXA scan) on classic powerlifters to understand better the relationship between various body composition variables and maximal strength. METHODS: Fifteen drug-free classic powerlifters (9 males and 6 females) underwent a DEXA scan and absolute (kg) and relative (Wilks) maximal strength from all 3 powerlifting events (squat, bench and deadlift) was registered from the previous provincial championship. A 2 tailed Pearson correlation analysis was conducted in order to present the relationships between body composition variables and performance measures. RESULTS: The main outcome of the present study is that experience in resistance training (r=0.52 to 0.74), lean body tissue (r= 0.61 to 0.95), arms mass (r=0.57 to 0.86), legs mass (r=0.53 to 0.63), bone mineral content (BMC) (r=0.52 to 0.91) and bone mineral density (BMD) (r=0.53 to 91) measures were significantly correlated (P<0.05) with most absolute (kg) and relative (Wilks) maximal strength measures. CONCLUSIONS: The results of the present study could guide practitioners working with athletes aged between 22 and 35 years old practicing sports with higher risks of fractures (e.g., alpine skiing) to potentially utilize the squat, the bench press and the deadlift not only to build strength in order to increase sport performance, but also to increase BMC and BMD of their athletes trough heavy eccentric loading to help reduce the risks of fractures. Further studies should be directed towards interventions trying to reveal that some type of relationship does exist between BMC, BMD and powerlifting performance and in what direction.

Comparison Between Power Off-Ice Test and Performance On-Ice Anaerobic Testing.

Boucher, VG, Parent, AA, Miron, FSJ, Leone, M, and Comtois, AS. Comparison between power off-ice test and performance on-ice anaerobic testing. J Strength Cond Res 34(12): 3498-3505, 2020-The importance of specific testing has been shown in ice hockey performance, and the understanding and connection between them may lead to adapting training and follow-up in elite athletes. The aim of this study was to compare 2 off-ice power tests with performances on ice with National Hockey League (NHL) players. The vertical jump and broad jump tests were used for the off-ice evaluations, whereas a modified SAS-40 and a repeated-sprint skate (RSSm) test were used on-ice as performance variables. Thirty-one players (3 goalkeepers, 10 defense players, and 18 forward players) from the NHL performed before preseason training camp. Four evaluation sessions were performed with 48-hour time intervals between them. The results show that the 2 jump types were correlated (r = 0.45 p < 0.01), and there was a significant correlation between the vertical jump and the best SAS-40 time trial for defense players, but not for forward players (r = 0.76 p = 0.02; r = 0.21 p = 0.16, respectively). By contrast, there was a significant correlation between broad jump and best SAS-40 time trial for forward players but not for defensive players (r = 0.75 p < 0.01; r = 0.19 p = 0.28, respectively). In conclusion, results show that specific player ability needs to be taken into consideration when choosing off-ice tests.

Repeated Linear and Quadrangular Sprint as a Function of Anaerobic Power.

Almansba, R, Boucher, VG, Parent, AA, and Comtois, AS. Repeated linear and quadrangular sprint as a function of anaerobic power. J Strength Cond Res 33(8): 2177-2184, 2019-This investigation aims to study in U17 soccer players the relationships among performance indices of linear or quadrangular (square shape) repeated-sprint bouts (RSBs) and leg muscular power measured with the Wingate test and the squat jump. Seventeen athletes were recruited. Participants were 16 ± 0.35 years old and had a body mass of 66.5 ± 8.69 kg and a height of 175 ± 0.05 cm. All participants performed linear or quadrangular RSBs, the Wingate test, and a vertical jump test. The mean fast linear sprint time was strongly correlated (p < 0.01) with the force and power measured with the vertical jump test (r = -0.68 and -0.75, respectively), whereas the mean linear RSB was weakly correlated with the peak power and fatigue index measured by the Wingate test (r = -0.54 and -0.56, respectively). There was a correlation between quadrangular RSBs performance indices and both Wingate and vertical jump parameters. In addition, there were no correlations (p > 0.05) between indices of the linear RSBs (decrement index, average, and fastest times) and quadrangular RSBs. Moreover, physiological and perceptual responses were significantly higher (p < 0.01) with quadrangular RSBs compared with linear RSBs. These results indicate that the Wingate test and the vertical jump test can be used as a substitute for repeated-sprint performance time. Finally, however, the repeated sprints with or without direction changes are 2 different motor abilities that should be trained independently of one another.

Classic Powerlifting Performance: A Systematic Review.

Ferland, PM and Comtois, AS. Classic powerlifting performance: A systematic review. J Strength Cond Res XX(X): 000-000, 2019-The purpose of this study was to review all scientific publications related to able-body drug-tested classic powerlifting performance since January 1, 2012, and to regroup them into a brief narrative review. Three electronic databases were systematically searched in August 2018 using the wildcard: powerlift*. A manual search was performed from the reference list of all retained articles. The search and selection strategy permitted to gather a total of 16 scientific articles published in peer-reviewed journals. Results show that practitioners should prioritize a low-bar squat and a wide grip bench press because they generally contribute to moving greater loads, bring more attention to preventing injuries, since a fair amount of powerlifters seem to train injured and prioritize a hypertrophy-power-strength model when prescribing 3 times a week daily undulating periodization on nonconsecutive days for squat and bench. Practitioners could also introduce respiratory muscle training, use daily 1 repetition maximum training combined with down sets on experienced athletes and use a rate of perceived exertion scale based on repetitions in reserve combined with an individual velocity profile when prescribing intensity. Before competition, powerlifters seem to taper in this order: the deadlift, the squat, and lastly the bench press. The Slingshot does help to move more weight because it helps to generate more inertia, but it also deactivates the triceps. Finally, the present work was limited by the present literature but could serve as a reference in the field of powerlifting. Further research should include more details about the circumstances under which they were conducted.

Athletic Profile of Alpine Ski Racers: A Systematic Review.

Ferland, PM and Comtois, AS. Athletic profile of alpine ski racers: a systematic review. J Strength Cond Res 32(12): 3591-3600, 2018-The purpose of this study was to review all anthropometric and physical test results performed on alpine ski racers that were published in the scientific literature to build an athletic profile specific to the skier's sex and level. Four electronic databases were systematically searched using the following key words: alpine, skiing, and physiology. The manual search was performed through the reference list of all suitable publications, the author's personal collection, and the proceedings of the International Congresses on Science and Skiing. The search and selection strategy permitted to gather data from 28 peer-reviewed publications that were collected on a total of 1,107 skiers coming from 11 different countries. Results of this study present the athletic profile and also review the different testing protocols. Findings show that men generally present higher test results than women and that higher-level ski racers generally present higher test results than lower-level ski racers. The present review should serve as guidelines for professionals working with alpine ski racers because most of the factors presented in the athletic profile have previously been shown to be related with performance. Further research should include more details on the testing protocols used, be directed toward female athletes, and present results from groups of athletes of the same sex and clearly identified as established at a certain level. These measures could help support further theoretical investigations.

Comparison of bioenergetics of walking during a multistage incremental shuttle walk test and a 6-min walk test in active older adults.

The goal of the present research was to compare the bioenergetics variability of walking, during the 6-min walk test (6-MWT) and a multistage incremental shuttle walk test (MISWT) in an active older population. Twenty-two healthy physically active older adults with a group mean age of 70.4 ± 5.8 years completed the 6-MWT and the MISWT. Heart rate (HR), walking speed and walking [Formula: see text]O2 were measured throughout each test with a portable metabolic cart. Strong correlations were found for the [Formula: see text]O2 peak and the walking speed (r = 0.91 and r = 0.89 respectively for 6-MWT and MISWT). Differences in [Formula: see text]O2 peak values were analysed with a paired Student's t test. Repeated measures ANOVA were conducted to detect differences between tests. The Bland and Altman plot indicates that the average difference between both tests was 2.5 ml kg-1 min-1. MISWT [Formula: see text]O2 peak means were significantly greater than the 6-MWT [Formula: see text]O2 peak mean values (21.6 ± 5.3 vs. 18.9 ± 4.5 ml kg-1 min-1) which indicate bioenergetics differences between the two walking tests. Thus, the MISWT and 6-MWT elicited different walking [Formula: see text]O2 peak and HR suggesting that the MISWT field test challenge the participants to a higher level of cardiovascular and respiratory stress. The walking [Formula: see text]O2 peak recorded for the MISWT was significantly greater than the 6-MWT. Consequently, both tests seem to measure different facets of the aerobic capacity. MISWT seems to be a better indicator of maximal aerobic power whereas the 6-MWT provides more relevant information regarding aerobic endurance in aging population.

Comparison of paraspinal cutaneous temperature measurements between subjects with and without chronic low back pain.

OBJECTIVE: The purpose of this study was to evaluate the effects of chiropractic manipulative treatment on paraspinal cutaneous temperature (PCT) for subjects with chronic low back pain and compare these PCT findings to subjects without chronic low back pain. METHODS: Two groups were created, a symptomatic treatment group (subjects with chronic low back pain, n = 11, 7 males, 4 females) and an asymptomatic, nontreatment group (asymptomatic subjects, n = 10, 6 males, 4 females). Outcomes included the modified Oswestry questionnaire and PCT measurements in the prone position after an 8-minute acclimation period. The treatment group received 9 chiropractic spinal instrument-based manipulative treatments over 2 weeks. Reevaluation was done 2 weeks after the initial evaluation for both groups. RESULTS: The preintervention Oswestry results (29.8% ± 11.8%) for the treatment group were higher than the asymptomatic group (10.2% ± 10.6%). The postintervention Oswestry results for the treatment group were 14.20 % ± 11.5%. The resulting Cohen's effect size of the spinal manipulation on the Oswestry evaluation is 0.58. The preintervention PCT showed higher temperature for the nontreatment group compared with the treatment group. Comparing the levels associated with low back pain, the nontreatment group PCT was stable, varying from 0.01°C to 0.02°C, whereas the treatment group PCT varied from 0.10°C to 0.18°C. The treatment group postintervention PCT showed an increase in temperature after the 9 visits; however, this did not reach the values of the asymptomatic group. CONCLUSION: The PCT readings for subjects with chronic low back pain were lower than the asymptomatic, nontreatment group. The PCT temperature of the treatment group increased after 9 treatments.

The metabolically healthy but obese postmenopausal woman presents a favourable heart rate variability profile.

OBJECTIVE: The purpose of this study was to investigate the heart rate variability (HRV) profile in obese women displaying the metabolically healthy but obese (MHO) phenotype. DESIGN: We studied 47 obese, sedentary postmenopausal women. Subjects were classified as MHO or at risk based on insulin resistance as assessed with the homeostatic model assessment (HOMA) index. Subjects were divided into tertiles according to HOMA values. Subjects in the lower tertile were categorised as MHO while subjects in the upper 2 tertiles represented at risk subjects. Outcome measures were heart rate variability factors (RR intervals, SDNN, LF, HF, pNN50, RMSSD), body temperature, body composition (DEXA) and a lipid profile as well as glucose and insulin. RESULTS: MHO individuals had significantly lower resting heart rate, body temperature, lean body mass as well as fasting insulin and HOMA levels compared to at risk subjects (p < 0.05). In addition, RR intervals, SDNN and LF were significantly higher in MHO individuals (p < 0.05). Moreover, stepwise regression analysis showed that SDNN was an independent predictor of the variation in HOMA in our cohort. CONCLUSION: Results of the present study indicate that postmenopausal women displaying the MHO phenotype present a favourable HRV profile. Therefore, higher HRV could be associated, at least in part, in the protective profile of MHO individuals.

Effect of electrical stimulation on lipolysis of human white adipocytes.

The goal of the present study was to investigate the effect of 30 min of electrical stimulation on the activation of lipolysis in human white adipocytes. Two stimulation protocols (S1, S2) were conducted in vitro on isolated human white adipocytes. Subcutaneous adipose tissue was obtained from female subjects undergoing abdominal adipose tissue reduction. Adipose tissue of 10 female subjects (mean age, 38.7 ± 9.1 years) and 6 female subjects (mean age, 37.2 ± 11.3 years) was obtained for S1 and S2, respectively. All subjects fasted overnight before tissue removal. The control conditions were a basal and a ß-adrenergic stimulation (isoproterenol (ISO), 10(-6) mol·L(-1)) of lipolysis. For S1, the 3 electrostimulation conditions consisted of a monopolar square-wave pulse current for 30 min at intensities of 4, 8, and 20 mA, respectively. In S2, the 2 electrostimulation conditions consisted of a bipolar square-wave alternating current for 30 min at intensities of 4 and 6 mA, respectively. Fat cell lipolysis was measured by quantifying the release of glycerol from adipocytes for 3 trials in each experimental condition. For S1, 4 mA significantly increased lipolysis 1.5 times over basal values (p ≤ 0.01), 8 mA and 20 mA did not increase lipolysis significantly, and no significant difference (p > 0.05) was found between ISO and 4 mA. For S2, 4 mA (p ≤ 0.05) and 6 mA (p ≤ 0.01) significantly increased lipolysis by 1.8 and 2.3 times above basal, respectively. Our results demonstrate that both monopolar (4 mA) and bipolar (4 and 6 mA) electrical stimulations significantly activated in vitro lipolysis. Our findings suggest the existence of a new lipolytic pathway that may involve K(v) channels shown to exist in human white adipocytes.

Paraspinal cutaneous temperature modification after spinal manipulation at L5.

OBJECTIVE: The purpose of this study was to investigate local paraspinal cutaneous temperature (CT) modifications after spinal manipulative therapy at L5. METHODS: Twenty subjects with acute low back symptoms were randomly assigned to either a treatment or a sham group (n = 10 per group). Subjects underwent an 8-minute acclimatizing period. Temperature was measured bilaterally with infrared cameras at the L5 level. In the treatment group, a traditional chiropractic manipulation (lumbar roll technique with a pisiform contact on the ipsilateral mamillary of L5) was delivered, whereas with the sham group, the same technique was used, but no thrust was applied. Cutaneous temperature control measurements were taken 2 minutes before (t(-2)) and immediately after the intervention (t(0)) and at 1, 3, 5, and 10 minutes postintervention (t(1), t(3), t(5), and t(10), respectively). RESULTS: At t(0), CT in the treatment group on the treatment side (ipsilateral side) warmed up by 0.2 degrees F, whereas in the sham group, there were no significant temperature modifications on either side. At t(3) relative to t(0), CT in the treatment group on the treatment side warmed by approximately 0.6 degrees F, whereas the contralateral side (nontreatment side) cooled. In the treatment group, significant differences were noted between sides (F = 13.36, P = .002, P = .932) and sides x times (F = 2.97, P = .016, P = .838). CONCLUSION: The effects of a lumbar spine manipulation appear noticeable by changes in paraspinal CT measurements at the level of L5. However, the meaning and mechanisms of CT modifications at L5 are still being investigated.

Consistency of cutaneous thermal scanning measures using prone and standing protocols: a pilot study.

OBJECTIVE: The goal of this pilot study was to measure paraspinal cutaneous temperature (PCT) in the prone vs standing position. METHODS: Ten symptom-free participants were evaluated. Paraspinal cutaneous temperature was recorded. Subjects were acclimated to the treatment room in a prone position for 8 minutes before the PCT was measured. After the prone PCT reading, patients stood. A standing PCT measurement was then taken. RESULTS: Paraspinal cutaneous temperature was marginally warmer when subjects were standing vs prone (PCT difference, 0.25 degrees C +/- 0.64 degrees C and 0.62 degrees C +/- 0.67 degrees C for left and right sides, respectively). The right and left side differential was the same in the prone and standing positions. There was a positive Pearson correlation (0.802-0.803; P < .000) between the standing and prone positions for both left and right sides. CONCLUSION: There are no differences between the prone or standing PCT measures if symptom-free subjects are given 8 minutes to acclimate before recording PCT measures.

Inflammatory response following a short-term course of chiropractic treatment in subjects with and without chronic low back pain.

OBJECTIVE: Inflammatory markers interleukin-6 (IL-6) and C-reactive protein (CRP) have not been evaluated in response to a short course of lumbar spinal manipulation. The purpose of this study is to observe the responses of inflammatory markers (IL-6 and CRP) after a series of 9 chiropractic spinal manipulations. METHODS: Twenty-one participants were assigned to a treatment or a control group. Only the treatment group received 9 chiropractic interventions. Pre- and postintervention measures were recorded for blood samples for detection of proinflammatory cytokines IL-6 and CRP. RESULTS: Mediators of inflammation (IL-6 and high-sensitivity CRP) were modified by the intervention received in the treatment group, and the effect size demonstrated a tendency toward the control group values. CONCLUSION: A total of 9 chiropractic lower back manipulations caused the mediators of inflammation to present a normalization response in individuals suffering from chronic low back pain.

Lack of CFTR in skeletal muscle predisposes to muscle wasting and diaphragm muscle pump failure in cystic fibrosis mice.

Cystic fibrosis (CF) patients often have reduced mass and strength of skeletal muscles, including the diaphragm, the primary muscle of respiration. Here we show that lack of the CF transmembrane conductance regulator (CFTR) plays an intrinsic role in skeletal muscle atrophy and dysfunction. In normal murine and human skeletal muscle, CFTR is expressed and co-localized with sarcoplasmic reticulum-associated proteins. CFTR-deficient myotubes exhibit augmented levels of intracellular calcium after KCl-induced depolarization, and exposure to an inflammatory milieu induces excessive NF-kB translocation and cytokine/chemokine gene upregulation. To determine the effects of an inflammatory environment in vivo, sustained pulmonary infection with Pseudomonas aeruginosa was produced, and under these conditions diaphragmatic force-generating capacity is selectively reduced in Cftr(-/-) mice. This is associated with exaggerated pro-inflammatory cytokine expression as well as upregulation of the E3 ubiquitin ligases (MuRF1 and atrogin-1) involved in muscle atrophy. We conclude that an intrinsic alteration of function is linked to the absence of CFTR from skeletal muscle, leading to dysregulated calcium homeostasis, augmented inflammatory/atrophic gene expression signatures, and increased diaphragmatic weakness during pulmonary infection. These findings reveal a previously unrecognized role for CFTR in skeletal muscle function that may have major implications for the pathogenesis of cachexia and respiratory muscle pump failure in CF patients.