Advanced non-squamous NSCLC with no actionable oncogenic driver in Spain: a cross-sectional descriptive analysis of data from the Thoracic Tumor Registry.

BACKGROUND: Non-small cell lung cancer (NSCLC) accounts for the vast majority of all diagnosed lung cancers. According to their histology, most NSCLCs are considered non-squamous cell carcinoma (NSCC), and up to 85% of the latter may lack either one of the two main actionable oncogenic drivers (i.e., EGFR mutations and ALK rearrangements). OBJECTIVE: Our analysis aimed to describe the clinical and epidemiological characteristics of Spanish patients suffering from NSCC with no actionable oncogenic driver in daily clinical practice. DESIGN: A retrospective, cross-sectional, descriptive analysis. METHODS: We analyzed the records of all Spanish patients with advanced NSCC diagnosed between January 2011 and January 2020 and included in the Spanish Thoracic Tumor Registry database. We evaluated the presence of metastasis and molecular profiling at the time of diagnosis and treatments received. We also assessed overall survival (OS) and progression-free survival (PFS) according to first-line treatment. RESULTS: One thousand seven hundred ninety-seven Spanish patients with NSCC were included. They were mainly men (73.2%), smokers (current [44.4%] and former [44.4%]) and presented adenocarcinoma histology (97.6%). Most patients had at least one comorbidity (80.4%) and one metastatic site (96.8%), and a non-negligible number of those tested were PD-L1 positive (35.2%). Notably, the presence of liver metastasis indicated a shorter median OS and PFS than metastasis in other locations (p < 0.001). Chemotherapy was more often prescribed than immunotherapy as first-, second-, and third-line treatment in that period. In first-line, the OS rates were similar in patients receiving either regimen, but PFS rates significantly better in patients treated with immunotherapy (p = 0.026). Also, a high number of patients did not reach second- and third-line treatment, suggesting the failure of current early diagnostic measures and therapies. CONCLUSIONS: This analysis of the most lethal tumor in Spain could highlight the strengths and the weaknesses of its clinical management and set the ground for further advances and research.

The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis.

Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.

The role of IFN-γ production during retroviral infections: an important cytokine involved in chronic inflammation and pathogenesis

ABSTRACT Interferon-gamma (IFN-γ) plays a crucial role in viral infections by preventing viral replication and in the promotion of innate and adaptive immune responses. However, IFN-gamma can exert distinct effects in different persistent viral infections. The long-term overproduction of IFN-γ in retroviral infections, such as the human immunodeficiency virus (HIV), human T-lymphotropic virus type 1 (HTLV-1), and human endogenous retroviruses (HERVs), resulting in inflammation, may cause neuronal damage. This review is provocative about the role of IFN-γ during persistent retroviral infections and its relationship with the causation of some neurological disorders that are important for public health.

Polymorphisms in COMT, ADRB2 and HTR1A genes are associated with temporomandibular disorders in individuals with other arthralgias.

Objective: To evaluate the association between polymorphisms in genes and comorbid presence of arthralgias and TMD.Methods: This is a case-control study. The groups formed were individuals with chronic arthralgia and 1) myofascial pain (n = 42); 2) articular (n = 16); 3) multiple diagnoses (n = 69); 4) with TMD and without some other arthralgia (n = 16); 5) without TMD but with pain in other joints (n = 82); and 6) a control group (n = 72). SNPs in COMT, ADRB2, and HTR1A genes were investigated.Results: The CT genotype for the COMT (rs9332377) gene was associated with the absence of myofascial pain (p = .05). In the ADRB2 (rs1042713) gene, the AA genotype was associated with the absence of myofascial pain (p = .03).Discussion: This study supports the hypothesis that alterations in the COMT, ADRB2, and HTR1A genes influence the presence of chronic pain and TMD.

Especiação de bactérias encontradas no gelo através do método MALDI-TOF-MS / Specification of bacteria found in the through the MALDI-TOF-MS method

Objetivo ­ Determinar a especiação de bactérias gram-negativas em quatro diferentes marcas de gelo através do método MALDI-TOFMS e avaliar sua potabilidade. Metodos ­ Com o equipamento multiparâmetros, da marca Hanna®, foram avaliados: pH, condutividade elétrica, oxigênio dissolvido e temperatura. Preparou-se meio Agar Mac Conkey para observação do crescimento bacteriano de Gramnegativas, sua morfologia através da coloração de Gram e a sua especiação pelo método MALD-TOF-MS. Resultados ­ Houve crescimento na amostra 4 e como método MALDI-TOF-MS foi identificada a espécie Pseudomonas monteilli. Conclusão ­ Os parâmetros físico-químicos estão de acordo com a Resolução 357/05 do CONAMA e a portaria 2.914/11 do MS. A espécie P. monteilli foi detectada em 15 minutos, podendo substituir o método tradicional que levaria dias para identificação, tornando um método revolucionário e de importância à saúde pública.

Objective ­ To determine the speciation of gram-negative bacteria in four different ice brands using the MALDI-TOF-MS method and to evaluate their potability. Methods - With the Hanna® multiparameter equipment, the following parameters were evaluated: pH, electrical conductivity, dissolved oxygen and temperature. Mac Conkey Agar medium was prepared for observation of Gram-negative bacterial growth, its morphology by Gram staining and its speciation by the MALD-TOF-MS method. Results ­ There was growth in sample 4 and as the MALDI-TOF-MS method was identified the species Pseudomonas monteilli. Conclusion ­ The physicochemical parameters are in accordance with CONAMA Resolution 357/05 and MS Ordinance 2.914 / 11. P. monteilli was detected within 15 minutes and could replace the traditional method that would take days to identify, making it a revolutionary method of public health importance.

Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing.

Biopolymeric films with silver sulfadiazine (AgSD) are proposed as an alternative to the occlusive AgSD-containing creams and gauzes, which are commonly used in the treatment of conventional burns. While the recognized cytotoxicity of AgSD has been reported to compromise its use as an antimicrobial drug in pharmaceuticals, this limitation can be overcome by developing sustained-release formulations. Microporous materials as zeolites can be used as drug delivery systems for sustained release of AgSD. The purpose of this work was the development and characterization of chitosan/zeolite composite films to be used as wound dressings. Zeolite was impregnated with AgSD before the production of the composite films. The physicochemical properties of zeolites and the films were evaluated, as well as the antimicrobial activity of the polymeric films and the cytotoxicity of the films in fibroblasts Balb 3T3/c. Impregnated zeolite exhibited changes in FTIR spectra and XRD diffraction patterns, in comparison to non-impregnated composites, which corroborate the results obtained with EDX-SEM. The pure chitosan film was compact and without noticeable defects and macropores, while the film with zeolite was opaquer, more rigid, and efficient against Candida albicans and some gram-negative bacteria. The safety evaluation showed that although the AgSD films present cytotoxicity, they could be used in a concentration-dependent fashion.

Mammospheres of hormonal receptor positive breast cancer diverge to triple-negative phenotype.

OBJECTIVES: This study aimed to characterize mammospheres from hormonal receptor (HR) positive and triple-negative breast cancer (TNBC), hypothesizing a differential profile of CSC and differentiation markers, and a stemness enrichment when successive sphere forming-protocols are performed. METHODS: Breast cancer cells MCF-7 and HCC1806 were submitted to sphere-forming protocols. The first sphere generation (MS1) was cultured in adherent conditions (G1). This procedure was repeated and generations of mammospheres (MS1, MS2, and MS3) and sphere-derived cells in adherent conditions (G1, G2, and G3) were obtained. The mammosphere forming capacity, self-renewal, area and doubling time were evaluated. Flow cytometry regarding CD133, CD24, and CD44 and western-blot regarding aldehyde dehydrogenase (ALDH), hormonal receptors and P53 expression was performed. RESULTS: Breast cancer cell lines harboured the capacity to form spheres, which originated derived adherent populations. The sphere-forming capacity was enhanced in HCC1806-MS3 compared to MS1. Self-renewal was higher in MCF-7 mammospheres, which also had an increased area. The putative CSC markers CD133 showed tendency to be enhanced in mammospheres but the CD44+/CD24-/low phenotype was not identified. The expression of ALDH was greater in mammospheres from MCF-7 and HCC1806 than in the respectively derived adherent cells. The expression of oestrogen receptor (ER)-α, progesterone receptor (PR) and P53 decreased in MCF-7 spheres. ER-ß expression was lower in mammospheres from both cell lines compared with parental and derived adherent populations. CONCLUSIONS: Loss of HR and P53 expression in HR-positive mammospheres evidences the minor population of CSC which shares characteristics with the TNBC phenotype.

Temporomandibular joint involvement in rheumatoid arthritis patients: association between clinical and tomographic data.

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and synovial hyperplasia, which usually affects multiple joints. The temporomandibular joint (TMJ) becomes susceptible to the development of changes resulting from RA. The aim of this study was to evaluate the presence of TMD and degenerative bone changes in TMJ in patients diagnosed with RA (rheumatoid arthritis). The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/ TMD) questionnaire was used for clinical evaluation of the TMJ and for TMD classification of 49 patients of both sexes and all ages. Individuals who had already undergone prior treatment for TMD and/or with a history of craniofacial trauma were excluded. The participants underwent cone beam computed tomography (CBCT) exams to assess possible degenerative changes in the mandibular condyle and the articular eminence. The frequencies of the changes found are presented and the possible associations between clinical and CT findings analyzed using the chisquare test. It was found that 75% of the patients had complaints of pain in the orofacial region, including arthralgia, myalgia or both. As for the diagnoses, 100% of the sample was diagnosed as RDC/TMD Group III (arthralgia, osteoarthritis or osteoarthrosis). The presence of degenerative bone changes was found in 90% of the subjects, the most prevalent being flattening (78.7%) and osteophytes (39.3%). The association test suggested a greater tendency to develop degenerative changes in asymptomatic individuals (p = 0.01). The asymptomatic nature of the involvement of the TMJ in RA can hide structural damage seen in imaging. Thus, the importance of early diagnosis and treatment to reduce structural and functional damage is emphasized.

A artrite reumatoide (AR) é uma doença sistêmica, autoimune, caracterizada por inflamação crônica e hiperplasia sinovial, que usualmente afeta múltiplas articulações. Dentre estas, a articulação temporomandibular (ATM), tornase susceptível ao desenvolvimento de alterações. O estudo objetiva avaliar a presença de desordem temporomandibular (DTM) e altera ções ósseas degenerativas da ATM (articulação temporo man di bu lar) de pacientes diagnosticados com AR (artrite reumatóide). Como metodologia, aplicouse o questionário Research Diagnostic Criteria for Temporomandibular Disorder (RDC/ TDM) em para avaliação clínica da ATM e classificação da desordem temporomandibular em 49 pacientes de ambos os sexos e idade variável. Foram excluídos os indivíduos que já haviam realizado tratamento prévio para DTM e/ou com histórico de traumatismo crâniofacial. Posteriormente os participantes foram submetidos a exames de tomografia computadorizada de feixe cônico (TCFC) para avaliação de possíveis alterações degenerativas no côndilo mandibular e na eminência articular. Foram apresentadas as frequências das alterações encontradas e verificouse a associação entre os achados clínicotomográficos por meio do teste do Quiquadrado. Após a avaliação clínica verificouse que 75% dos pacientes possuíam queixas de dor na região orofacial, variando entre a presença de artralgia, mialgia ou ambas. Quanto aos diagnósticos, 100% da amostra apresentou diagnóstico do Grupo III do RDC/TMD (artralgia, osteoartrite ou osteoartrose). A presença de alterações ósseas degenera tivas foi encontrada em 90% dos indivíduos avaliados, sendo que as mais prevalentes foram aplainamento (78,7%) e osteófito (39,3%). O teste de associação sugeriu uma maior tendência de desenvolvimento de alterações degenerativas nos indivíduos assintomáticos (p = 0.01). O caráter assintomático do envolvimento da ATM na AR pode ocultar danos estruturais vistos em imagem. Assim, ressaltase a importância do diagnóstico e tratamento precoces para redução de danos estruturais e funcionais.

Temporomandibular joint involvement in rheumatoid arthritis patients: association between clinical and tomographic data / Envolvimento da articulação temporomandibular em pacientes com artrite reumatoide - associação entre dados clínicos e tomográficos

Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by chronic inflammation and synovial hyperplasia, which usually affects multiple joints. The temporomandibular joint (TMJ) becomes susceptible to the development of changes resulting from RA. The aim of this study was to evaluate the presence of TMD and degenerative bone changes in TMJ in patients diagnosed with RA (rheumatoid arthritis). The Research Diagnostic Criteria for Temporomandibular Disorders (RDC/ TMD) questionnaire was used for clinical evaluation of the TMJ and for TMD classification of 49 patients of both sexes and all ages. Individuals who had already undergone prior treatment for TMD and/or with a history of craniofacial trauma were excluded. The participants underwent cone beam computed tomography (CBCT) exams to assess possible degenerative changes in the mandibular condyle and the articular eminence. The frequencies of the changes found are presented and the possible associations between clinical and CT findings analyzed using the chisquare test. It was found that 75% of the patients had complaints of pain in the orofacial region, including arthralgia, myalgia or both. As for the diagnoses, 100% of the sample was diagnosed as RDC/TMD Group III (arthralgia, osteoarthritis or osteoarthrosis). The presence of degenerative bone changes was found in 90% of the subjects, the most prevalent being flattening (78.7%) and osteophytes (39.3%).

A artrite reumatoide (AR) é uma doença sistêmica, autoimune, caracterizada por inflamação crônica e hiperplasia sinovial, que usualmente afeta múltiplas articulações. Dentre estas, a articulação temporomandibular (ATM), tornase susceptível ao desenvolvimento de alterações. O estudo objetiva avaliar a presença de desordem temporomandibular (DTM) e altera ções ósseas degenerativas da ATM (articulação temporo man di bu lar) de pacientes diagnosticados com AR (artrite reumatóide). Como metodologia, aplicouse o questionário Research Diagnostic Criteria for Temporomandibular Disorder (RDC/ TDM) em para avaliação clínica da ATM e classificação da desordem temporomandibular em 49 pacientes de ambos os sexos e idade variável. Foram excluídos os indivíduos que já haviam realizado tratamento prévio para DTM e/ou com histórico de traumatismo crâniofacial. Posteriormente os participantes foram submetidos a exames de tomografia computadorizada de feixe cônico (TCFC) para avaliação de possíveis alterações degenerativas no côndilo mandibular e na eminência articular. Foram apresentadas as frequências das alterações encontradas e verificouse a associação entre os achados clínicotomográficos por meio do teste do Quiquadrado. Após a avaliação clínica verificouse que 75% dos pacientes possuíam queixas de dor na região orofacial, variando entre a presença de artralgia, mialgia ou ambas. Quanto aos diagnósticos, 100% da amostra apresentou diagnóstico do Grupo III do RDC/TMD (artralgia, osteoartrite ou osteoartrose). A presença de alterações ósseas degenera tivas foi encontrada em 90% dos indivíduos avaliados, sendo que as mais prevalentes foram aplainamento (78,7%) e osteófito (39,3%).

O polimorfismo no gene da interleucina-10 tem associação com a doença peri-implantar? / Is polymorphism in interleukin 10 gene associated with peri-implant disease?

Diversos estudos têm demonstrado que indivíduos com susceptibilidade genética à doença peri-implantar podem apresentar maior risco de perda do implante dentário. Objetivo: O objetivo deste estudo foi correlacionar os aspectos clínicos e radiográficos no tecido peri-implantar, apresentando condições saudáveis e doentes, com o polimorfismo genético da interleucina-10 (IL-10). Material e métodos: 109 pacientes foram divididos em três grupos. O grupo controle foi caracterizado pela saúde peri-implantar (n=51). Os grupos teste foram divididos em mucosite (n=21; indivíduos com inflamação da mucosa peri-implantar) e peri-implantite (n = 37; perda óssea patológica peri-implantar). Os tecidos peri-implantares foram examinados clinicamente considerando o sangramento à sondagem, a cor da mucosa e a mobilidade do implante. Amostras de saliva foram coletadas para análise do polimorfismo genético da IL-10, na região promotora 592, utilizando a enzima de restrição Rsal. Resultados: Clinicamente, as regiões do grupo mucosite foram caracterizadas pela cor vermelha da mucosa e presença de sangramento à sondagem em todos os pacientes. O grupo peri-implantite mostrou mucosa avermelhada em 15 pacientes (40,5%), mas sangramento à sondagem em 9 pacientes (24,3%). Mobilidade do implante foi observada em quatro regiões (10,8%). A média de perda óssea patológica radiográfica foi de 3,8 ± 1,5 exposições de roscas. Análise do polimorfismo genético para IL-10-592, por meio do teste qui-quadrado, não apresentou diferença significativa entre os grupos saudável e testes. Conclusões: Polimorfismo na IL10-592 não está associado com o desenvolvimento da doença peri-implantar. A presença de sangramento à sondagem não caracteriza a doença peri-implantar.

Several studies have shown that individuals with genetic susceptibility to peri-implant disease may be at greater risk of loss of the dental implant. Objective: The objective of this study was to correlate the clinical and radiographic findings in the peri-implant tissue, showing healthy conditions and patients with the genetic polymorphism of interleukin-10 (IL-10). Material and methods: 109 patients were divided into three groups. The control group was characterized by periimplant health (n = 51). The test groups were divided into mucositis (n = 21; patients with inflammation of the periimplant mucosa) and peri-implant (n = 37; pathological bone loss peri-implant). The peri-implant tissues were examined clinically considering bleeding on probing, the color of the mucosa and the mobility of the implant. Saliva samples were collected for analysis of genetic polymorphism of IL-10 in the promoter region 592, using the restriction enzyme RsaI. Results: Clinically, mucositis group regions were characterized by the color red and the presence of mucosal bleeding on probing in all patients. The peri-implant group showed reddish mucosa in 15 patients (40.5%), but bleeding on probing in 9 patients (24.3%). Mobility of the implant was observed in four regions (10.8%). The mean radiographic pathological bone loss was 3.8 ± 1.5 exhibition threads. Analysis of genetic polymorphism for IL-10-592, using the chi-square test showed no significant difference between the healthy group and testing. Conclusions: Polymorphism in IL10-592 is not associated with the development of peri-implant disease. The presence of bleeding on probing does not characterize the peri-implant disease.

Self-medication in patients with temporomandibular disorders / Automedicação em pacientes com desordens temporomandibulares

Objective: Temporomandibular Disorders (TMD) are a set of painful and / or functional clinical problems that affect the joints and / or muscles of the orofacial region. The practice of self-medication, defined as the consumption of unprescribed drugs, is explained in most TMD patient cases by the occurrence of constant pain, producing discomfort and fatigue, while performing essential functions such as chewing, speaking, and swallowing, causing a drop in the quality of life of patients who have this disorder. Because of this, many see medication as a quick and sufficient means of addressing the problem of pain, and do not seek help from a professional. This study therefore aimed to evaluate, through guided interviews, the practice of self-medication in patients with temporomandibular disorder. Material and Methods: The researchers interviewed 115 patients who were referred for treatment at the Diagnosis and Treatment Service for Patients with Temporomandibular Disorder (TMJ Service), School of Dentistry, Federal University of Juiz de Fora. Results: In the sample studied there was a high prevalence of self-medication among the patients interviewed, of whom 71.3% used medication without a prescription, with a majority being female (84.14%). Headache was the main complaint reported by patients who self-medicated (39.53%), analgesics the most used drug class (58.13%), and most of the pain relief drugs were acquired through old prescriptions (40.25%). Conclusion: Thus, this work emphasizes the importance of guiding the patient and the professional regarding this practice...

Objetivo: Desordem temporomandibular (DTM), é um conjunto de problemas clínicos dolorosos e/ ou funcionais, que acometem as articulações e/ ou músculos da região orofacial. A prática de automedicação, definida como o consumo de medicamentos sem prescrição médica, na maioria dos casos de pacientes com DTM, justifica-se pela ocorrência de dores constantes, que trazem desconforto e cansaço durante a realização de importantes funções como a matigação, fala e deglutição, gerando uma queda na qualidade de vida dos pacientes que apresentam esse distúrbio. Frente a isso, muitos veem a medicação como meio mais rápido e suficiente para resolver o problema da dor e não procuram ajuda de um profissional. O presente estudo teve, portanto, como objetivo, avaliar por meio de entrevistas guiadas a prática da automedicação em pacientes com desordem temporomandibular. Material e Métodos: Foram entrevistados 115 pacientes que foram encaminhados para tratamento no Serviço de Diagnóstico e Atendimento a Pacientes com Desordem temporomandibular (Serviço ATM) da Faculdade de Odontologia da Universidade Federal de Juiz de Fora. Resultados: Na amostra avaliada houve uma alta prevalência de automedicação entre os pacientes entrevistados, dos quais 71,3% utilizaram medicação sem receita médica, sendo a maioria do sexo feminino (84,14%). A cefaléia foi a principal queixa relatada pelos pacientes que se automedicaram (39,53%), os analgésicos a classe medicamentosa mais utilizada (58,13%) e a maioria das medicações para alívio da dor foram adquiridas por meio de receitas antigas (40,25%). Conclusão: Enfatiza-se desta forma, a importância de orientar o paciente e o profissional com relação a esta prática...

Evaluation of stabilizing plate therapeutic effects on different types of temporomandibular disorders - painful evolution of patients treated in a reference center / Avaliação dos efeitos terapêuticos da placa estabilizadora nos diferentes tipos de desordens temporomandibulares – evolução sintomatológica de pacientes atendidos em um centro de referência

Objective: Evaluation of the symptomatic outcome of patients of various types of TMD treated exclusively with stabilizing plate for a period of three months patients comparing painful muscle and joint symptoms , and clinical aspects , both before and after treatment periods. Material and methods: A retrospective study of medical records of 628 rescue the last ten years (2004 – 2013) of subjects treated at the Serviço de Diagnóstico e Orientação a pacientes com Desordem Temporomandibular (Serviço ATM), Faculty of Dentistry/UFJF. The sample was divided into subgroups distinct diagnoses, in which the evaluation of symptomatic progression of patients through the analysis of pain scores, measuring the amplitude of mouth opening and the presence of joint sounds was performed. Data were obtained in early stages and after treatment with stabilizing plate. Results: The group of individuals diagnosed with muscular disorder (47.45 %) and those with multiple diagnoses (3.34 %) had a higher prevalence of chronic orofacial pain (90.26 % and 95.23 %). The remission of painful symptoms was visible in groups accompanied by increased amplitude of mouth opening. Additional way, we obtained reduction joint sounds in patients with intracapsular and degenerative disorders, respectively. Conclusion: The stabilizing plate has shown efficacy in various types of temporomandibular disorders evaluated. However, in an attempt to encompass all etiological factors in therapy, emphasizes the importance of multidisciplinary therapies for the treatment of temporomandibular disorders...

Objetivo: Avaliação da evolução sintomatológica de pacientes com diagnósticos de DTM, tratados exclusivamente com a placa estabilizadora durante um período de 3 meses, comparando a sintomatologia dolorosa muscular e articular, assim como aspectos clínicos, nos períodos anterior e posterior ao tratamento. Material e métodos: Foi realizado um estudo retrospectivo com avaliação de 628 prontuários dos últimos dez anos (2004 – 2013) de pacientes atendidos no Serviço de Diagnóstico e Orientação a pacientes com Desordem Temporomandibular (Serviço ATM) da Faculdade de Odontologia/UFJF. A amostra foi dividida em subgrupos diagnósticos distintos, nos quais foi realizada a avaliação da evolução sintomatológica dos pacientes por meio da análise de escores de dor, mensuração de amplitude da abertura bucal e presença de ruídos articulares. Os dados foram obtidos em momentos iniciais e após o tratamento com placa estabilizadora. Resultados: O grupo dos indivíduos diagnosticados com desordem muscular (47,45%) e aqueles com diagnósticos múltiplos (3,34 %) apresentaram maior prevalência de dor crônica orofacial (90,26 % e 95,23 %). A remissão da sintomatologia dolorosa foi visível nos grupos estudados acompanhada de aumento de amplitude de abertura bucal. De modo adicional, obteve-se redução ruídos articulares em pacientes com DTM intracapsulares e degenerativas, respectivamente. Conclusão: A placa estabilizadora mostrou eficácia nos variados tipos de desordens temporomandibulares avaliadas. Contudo, na tentativa de englobar todos os fatores etiológicos na terapêutica, ressalta-se a importância de terapias multidisciplinares para tratamento das desordens temporomandibulares...