45 años de la Sociedad Cubana de Ciencias Morfológicas: recuento histórico

RESUMEN En 2018 se cumplieron 45 años de labor de la Sociedad Cubana de Ciencias Morfológicas -asociación no gubernamental perteneciente al Consejo Nacional de Sociedades Científicas de la Salud en Cuba-, creada en 1973 con un nombre representativo de las especialidades que en sus inicios la componían mayormente: la Anatomía, la Histología y la Embriología. En el propio 2018, por decisión de la dirección del Consejo Nacional de Sociedades Científicas y la Dirección de Asociaciones del Ministerio de Justicia, esta desaparece. El presente artículo expone una síntesis histórica de la Sociedad Cubana de Ciencias Morfológicas.

ABSTRACT In 2018, the Cuban Society of Morphological Sciences-a non-governmental association belonging to the National Council of the Scientific Societies of Health in Cuba-completed 45 years of work; it was created in 1973 with a representative name of the specialties that at the beginning composed it mostly: Anatomy, Histology and Embryology. In 2018 itself, by decision of the board of the national Council of Scientific Societies and the Directorate of Associations of the Ministry of Justice, it disappears. The current article presents a historical synthesis of the Cuban Society of Morphological Sciences.

Epidermal growth factor and growth hormone-releasing peptide-6: combined therapeutic approach in experimental stroke.

PURPOSE: Stroke is the second cause of mortality worldwide, with a high incidence of disability in survivors. Promising candidate drugs have failed in stroke trials. Combined therapies are attractive strategies that simultaneously target different points of stroke pathophysiology. The aim of this work is to determine whether the combined effects of epidermal growth factor (EGF) and growth hormone-releasing peptide-6 (GHRP6) can attenuate clinical signs and pathology in an experimental stroke model. METHODS: Brain global ischemia was generated in Mongolian gerbils by 15 minutes of carotid occlusion. After reperfusion, EGF, GHRP6 or EGF+GHRP6 were intraperitoneally administered. Clinical manifestations were monitored daily. Three days after reperfusion, animals were anesthetized and perfused with an ink solution. The anatomy of the Circle of Willis was characterized. Infarct volume and neuronal density were analyzed. RESULTS: EGF+GHRP6 co-administration reduced clinical manifestations and infarct volume and preserved neuronal density. No correlation was observed between the grade of anastomosis of the Circle of Willis and clinical manifestations in the animals receiving EGF+GHRP6, as opposed to the vehicle-treated gerbils. CONCLUSIONS: Co-treatment with EGF and GHRP6 affects both the clinical and pathological outcomes in a global brain ischemia model, suggesting a suitable therapeutic approach for the acute management of stroke.

Alteraciones morfométricas de los hepatocitos de ratas albinas que ingieren alcohol desde la adolescencia / Morphometric alterations of the hepatocytes of albinic rats ingesting alcohol since adolescence

Se estudió el hígado, se midieron las variables: área núcleo, área citoplasma, y relación núcleo citoplasma de los hepatocitos de las zonas periportal, intermedia y perivenosa. Se utilizaron 40 ratas de uno y otro sexos, conformándose 2 grupos: alcohólicas y controles. A las alcohólicas se le suministró etanol 40 por ciento diluido en agua desde los 28 hasta los 90 d de nacidas, por vía oral y mediante una cánula intraesofágica. Las variables morfométricas área núcleo y la relación núcleo citoplasma resultaron estadísticamente diferentes y mayores en las ratas alcohólicas