Trends in the prevalence of obesity, overweight, and thinness among schoolchildren aged 7-14 years from southern Brazil (2002-2019).

OBJECTIVE: To analyze the obesity, overweight, and thinness trends among Brazilian schoolchildren by sex, age group, and type of school according to World Health Organization (WHO) and International Obesity Task Force (IOTF) criteria. METHODS: We conducted four surveys between 2002 and 2018/19 involving schoolchildren aged 7-14 years from a state capital in southern Brazil. Weight status was classified using both WHO and IOTF criteria. RESULTS: In the total sample, obesity prevalence based on the IOTF and the WHO criteria were 72% and 44% higher in 2018/19 compared with 2002, respectively. Over the whole period, the obesity prevalence increased among children (WHO: 10.1% vs. 14.1%; IOTF: 5.0% vs. 8.3%), and those from public schools (WHO: 10.5% vs. 16.4%; IOTF: 5.6% vs. 10.1%). There was no significant reduction in thinness prevalence over the analyzed period. CONCLUSION: Obesity prevalence remains on an upward trend in a state capital in southern Brazil, especially among children from public schools. A higher prevalence of overweight and obesity was observed using the WHO criteria compared with IOTF criteria.

Mal control y elevado riesgo cardiovascular en hipertensos de una universidad

Introducción: La hipertensión arterial es una enfermedad de alta prevalencia y complicaciones mortales. Debido a ello, se necesitan un adecuado manejo en la atención primaria y estrategias preventivas y de intervención, como la iniciativa HEARTS en las Américas. Se sabe también que entre los trabajadores de la Universidad de Ciencias Médicas de Matanzas existe una elevada prevalencia de hipertensos. Objetivo: Identificar el comportamiento del control de la enfermedad y la estratificación de riesgo cardiovascular global. Materiales y métodos: Estudio descriptivo transversal en el que se incluyeron los primeros 80 pacientes hipertensos valorados en la consulta de la mencionada institución. Los métodos empleados fueron el analítico-sintético, el inductivo-deductivo, el histórico-lógico y los estadísticos. Resultados: De 808 trabajadores, 276 eran hipertensos, para una prevalencia de 34,1 %. Dentro de los inadecuados estilos de vida, predominó el sedentarismo, con 59 pacientes (73,7 %); 40 de los 80 pacientes estudiados tenían un riesgo cardiovascular cuantitativo igual o mayor del 10 %, mientras que el riesgo cardiovascular cualitativo mostró que 68 (85 %) tenían un riesgo medio o alto. Dentro del daño en órganos diana predominaron las enfermedades cardiovasculares, con un 16,2 %. Conclusiones: La hipertensión arterial sigue siendo uno de los factores de riesgo más importantes de enfermedad cardiovascular y cerebrovascular. Su pesquisa, control y estimación del riesgo constituyen una prioridad de la atención médica a nivel primario.

Introduction: Arterial hypertension is a disease of high prevalence and fatal complications. Due to this, an adequate management is needed in the primary care, and also preventive and intervention strategies, as the HEARTS initiative in the Americas. It is also known that there is a high prevalence of hypertensive patients among the working staff of the Matanzas University of Medical Sciences. Objective: To identify the behavior of disease control and global cardiovascular risk stratification. Materials and methods: Cross-sectional descriptive study in which the first 80 hypertensive patients evaluated in the consultation of the aforementioned institution were included. The methods used were analytical-synthetic, inductive-deductive, historical-logical and statistical. Results: Of 808 workers, 276 were hypertensive, for a prevalence of 34.1%. Among the inadequate lifestyles, sedentary lifestyle predominated, with 59 patients (73.7%); 40 of the 80 patients studied had a quantitative cardiovascular risk equal to or greater than 10%, while qualitative cardiovascular risk showed that 68 (85%) had a medium or high risk. Cardiovascular diseases predominated within target organ damage, with 16.2%. Conclusions: Arterial hypertension continuous to be one of the most important risk factors for cardiovascular and cerebrovascular diseases. Its screening, control and risk assessment are a priority of the medical care at the primary level.

Neighborhood Availability and Use of Food, Physical Activity, and Social Services Facilities in Relation to Overweight and Obesity in Children and Adolescents.

OBJECTIVE: To evaluate the association of a combined measure of availability and use of facilities from the food environment and overweight (including obesity) among schoolchildren, while taking into account the physical activity and social-assistance environments. METHODS: Cross-sectional study with a probabilistic sample of schoolchildren aged 7 to 14 years living in a southern Brazilian city (n = 2026). Multilevel analyses were performed with overweight as outcome and the food environment as main exposure. Models were adjusted for the physical activity and social-assistance environments, as well as individual and other residential neighborhood characteristics. RESULTS: Greater availability of restaurants around the home was associated with higher odds of overweight (odds ratio [OR] = 1.40; 95% CI = 1.06-1.85). Stronger associations were found for schoolchildren reporting to use restaurants (OR = 1.48; 95% CI = 1.15-1.90). This association remained significant after adjusting for the presence of other food retailers. Schoolchildren who had social-assistance facilities around their homes, but reported not to use them, showed consistently higher odds of being overweight (OR = 1.34; 95% CI = 1.01-1.78) as compared to schoolchildren who had these facilities near home and used them. The physical activity environment was not associated with the outcome. CONCLUSIONS: Availability and use of the food and social-assistance environments were significantly associated with overweight (including obesity) among the schoolchildren. Future research should consider the use of environmental facilities in combination to their geographical availability. Our results highlight the need for policies that limit the access to obesogenic food outlets by children and adolescents.

Methodological aspects and characteristics of participants in the study on the prevalence of obesity in children and adolescents in Florianópolis, Southern Brazil, 2018-2019: EPOCA study.

PURPOSE: To describe the methodological aspects and characteristics of the participants of the EPOCA survey. METHODS: The study was conducted with schoolchildren aged between seven to 14 years old from 30 schools in Florianópolis, Southern Brazil. Body mass, height, girths, and skinfold thicknesses were measured. Food consumption and physical activity from the previous day were self-reported using the validated Web-CAAFE questionnaire. Adolescents completed a specific questionnaire about physical activity, meal consumption, and weight control behaviors. Parents/guardians responded to a sociodemographic and habits questionnaire. RESULTS: A total of 1671 schoolchildren participated in the study (response rate: 27.2%). About 63% of schoolchildren were enrolled in public schools. Most studied in the morning shift (54.2%), were female (53.1%) and aged between seven and 10 years (58.1%). The prevalence of overweight was 33.7% and obesity was 11.3%. CONCLUSIONS: The data obtained will allow us to assess the trend in the prevalence of overweight and obesity and associated factors when compared to other surveys performed. Descriptions of the logistics and protocols can help in the development and improvement of similar studies. It is hoped that the results of EPOCA 2018/2019 may help in the design of obesity prevention policies and programs for this population.

Presença de desertos alimentares em um distrito sanitário de uma capital brasileira: um estudo descritivo e exploratório sobre a distribuição espacial de estabelecimentos comerciais de alimentos / Food deserts in a health district of a Brazilian capital: a descriptive and exploratory study on the spatial distribution of commercial food establishments

Introdução: O ambiente alimentar que a comunidade está inserida pode influenciar, positiva ou negativamente no acesso à alimentação de qualidade e consequentemente na sua saúde. Objetivo: Identificar a presença de desertos alimentares em um distrito sanitário de uma capital brasileira. Métodos: Estudo descritivo, transversal e exploratório, utilizando dados secundários de diferentes fontes institucionais para mapear a distribuição espacial de estabelecimentos de comercialização de alimentos: restaurantes, padarias, supermercados, minimercados/mercearias, hortifrutigranjeiros, vendedores ambulantes e lanchonetes/fastfood. Os estabelecimentos foram agrupados nas categorias in natura, ultraprocessados e mistos, de acordo com a predominância do tipo de alimentos comercializados. Para a análise, a densidade de estabelecimentos in natura juntamente com os mistos por mil habitantes (usuários cadastrados nos centros de saúde) foram calculadas.  Resultados: Foram investigados 111 estabelecimentos, sendo 20% que comercializavam alimentos in natura (saudáveis), 27% alimentos ultraprocessados (não saudáveis) e 53% considerados mistos. Conclusões: Foram observadas áreas que podem ser consideradas desertos alimentares, locais onde há pouca (ou ausência) de oferta de alimentos in natura, e por consequência dificultando o acesso a alimentos saudáveis.

Introduction: The communities' food environment can positively or negatively influence access to quality food and consequently, people's health. Objective: Identify the presence of food deserts in a health district of a Brazilian capital. Methods: Descriptive, cross-sectional and exploratory study, using secondary data from different institutional sources to map the spatial distribution of food establishments such as restaurants, bakeries, supermarkets, minimarkets/grocery stores, fruit and vegetable stores, street vendors and cafeterias/fast food. The establishments were grouped into fresh, ultra-processed and mixed food categories, according to the predominance of the type of food offered. For the purpose of analysis, the density of fresh food establishments together with mixed food establishments per thousand inhabitants (as registered in the health centers) was calculated.  Results: A total of 111 establishments were investigated, 20% selling fresh foods (healthy), 27% ultra-processed foods (unhealthy) and 53% considered mixed food sellers. Conclusions: Areas that can be considered food deserts were found, i.e. places where there is little (or absence) of fresh food supply, and consequently making access to healthy foods difficult.

Cytokine levels as predictors of mortality in critically ill patients with severe COVID-19 pneumonia: Case-control study nested within a cohort in Colombia.

Background: High levels of different cytokines have been associated in COVID-19 as predictors of mortality; however, not all studies have found this association and its role to cause multi-organ failure and death has not been fully defined. This study aimed to investigate the association of the levels of 10 cytokines with mortality in patients with COVID-19 admitted to the intensive care unit (ICU). Materials and methods: This is a case-control study nested within a cohort of patients with COVID-19 who were on mechanical ventilation and were not hospitalized for more than 48 h across nine ICUs in Medellín, Colombia. Serum samples were collected upon admission to the ICU and 7 days later and used to measure cytokine levels. Results: Upon admission, no differences in mortality between the cytokine levels were observed when comparisons were made quantitatively. However, in the multivariate analysis, patients with median IL-1ß levels <1.365 pg/ml showed an increase in mortality (OR = 3.1; 1.24<7.71; p = 0.015). On day 7 in the ICU, IL-1ß median levels were lower (0.34 vs. 2.41 pg/ml, p = 0.042) and IL-10 higher (2.08 vs. 1.05 pg/ml, p = 0.009) in patients who died. However, in the multivariate analysis, only IL-12p70 was associated with mortality (OR = 0.23; 0.07<0.73; p = 0.012). The mean difference in the levels between day 1 and day 7 decreased in both IFN-γ (3.939 pg/ml, p < 0.039) and in IL-18 (16.312 pg/ml, p < 0.014) in the patients who died. A low IL-1ß/IL-10 ratio was associated with mortality on both day 1 and day 7, while an IL-1ß/IL-10 ratio below the cut-off on day 7 was associated with decreased survival. The lowest TNFα/IL-10 ratio was associated with mortality only on day 7. Conclusion: At the time of admission, patients with median IL-1ß levels lower than 1.365 pg/ml had increased mortality. An IL-1ß/IL-10 ratio <2 at day 7 and IL-12p70 levels >1.666 pg/ml was associated with decreased survival.

Evaluation of the Effects of Genistein In Vitro as a Chemopreventive Agent for Colorectal Cancer-Strategy to Improve Its Efficiency When Administered Orally.

Colorectal Cancer (CRC) ranks third in terms of incidence and second in terms of mortality and prevalence worldwide. In relation to chemotherapy treatment, the most used drug is 5-fluorouracil (5-FU); however, the use of this drug generates various toxic effects at the systemic level. For this reason, new therapeutic strategies are currently being sought that can be used as neoadjuvant or adjuvant treatments. Recent research has shown that natural compounds, such as genistein, have chemotherapeutic and anticancer effects, but the mechanisms of action of genistein and its molecular targets in human colon cells have not been fully elucidated. The results reported in relation to non-malignant cell lines are also unclear, which does not allow evidence of the selectivity that this compound may have. Therefore, in this work, genistein was evaluated in vitro in both cancer cell lines SW480 and SW620 and in the non-malignant cell line HaCaT. The results obtained show that genistein has selectivity for the SW480 and SW620 cell lines. In addition, it inhibits cell viability and has an antiproliferative effect in a dose-dependent manner. Increased production of reactive oxygen species (ROS) was also found, suggesting an association with the cell death process through various mechanisms. Finally, the encapsulation strategy that was proposed made it possible to demonstrate that bacterial nanocellulose (BNC) is capable of protecting genistein from the acidic conditions of gastric fluid and also allows the release of the compound in the colonic fluid. This would allow genistein to act locally in the mucosa of the colon where the first stages of CRC occur.

Chemopreventive Effect on Human Colon Adenocarcinoma Cells of Styrylquinolines: Synthesis, Cytotoxicity, Proapoptotic Effect and Molecular Docking Analysis.

Seven styrylquinolines were synthesized in this study. Two of these styrylquinolines are new and were elucidated by spectroscopic analysis. The chemopreventive potential of these compounds was evaluated against SW480 human colon adenocarcinoma cells, its metastatic derivative SW620, and normal cells (HaCaT). According to the results, compounds 3a and 3d showed antiproliferative activity in SW480 and SW620 cells, but their effect seemed to be caused by different mechanisms of action. Compound 3a induced apoptosis independent of ROS production, as evidenced by increased levels of caspase 3, and had an immunomodulatory effect, positively regulating the production of different immunological markers in malignant cell lines. In contrast, compound 3d generated a pro-oxidant response and inhibited the growth of cancer cells, probably by another type of cell death other than apoptosis. Molecular docking studies indicated that the most active compound, 3a, could efficiently bind to the proapoptotic human caspases-3 protein, a result that could provide valuable information on the biochemical mechanism for the in vitro cytotoxic response of this compound in SW620 colon carcinoma cell lines. The obtained results suggest that these compounds have chemopreventive potential against CRC, but more studies should be carried out to elucidate the molecular mechanisms of action of each of them in depth.

Territorios hidrosociales: historia ambiental de la apropiación social y sostenibilidad en la cuenca del Río Dagua, Colombia en el siglo XX / Hydrosocial territories: Environmental history of social appropriation and sustainability in the Dagua River Basin, Colombia in the twentieth century

RESUMEN Reconocer el carácter híbrido, complejo y sistémico del agua desde los estudios hidrosociales, implicó entender que esta circula en un proceso continuo entre los diversos actores en diferentes periodos históricos. En la cuenca del río Dagua, las profundas transformaciones que han alterado o modificado naturalmente la dinámica ecológica de la cuenca, están estrechamente vinculadas a la forma de apropiación social que cada uno de los actores que allí confluyen realizan, no solo del agua sino del territorio, creando y recreando territorios hidrosociales. Con una metodología interdisciplinaria y descriptiva, a través del análisis documental y del trabajo etnográfico con talleres, entrevistas semiestructuras y trabajo de campo, se reconoció que la apropiación social del agua está determinada por la cultura, es flexible y depende de cada contexto ontológico, geográfico e histórico, en el que se suscribe. El documento abarca desde el periodo precolombino hasta la actualidad y permitió mostrar que la apropiación social del agua no es excluyente ni en tiempo ni espacio. Puede darse simultáneamente, lo que sugiere que, en algunos momentos históricos, coexiste y puede estar inscrita a sociedades diferentes, con modos de vida y diferentes visiones-nociones y acciones de construir territorios hidrosociales, a lo largo del tiempo.

ABSTRACT Recognizing the hybrid, the complex and systemic character of water from hydrosocial studies implied understanding that it circulates in a continuous process between the various actors in different historical periods. In the Dagua river basin, the profound transformations that have naturally altered or modified the ecological dynamics of the basin are closely linked to the form of social appropriation that each of the actors that converge there carries out, not only of water but also of the territory, thus creating and recreating hydrosocial territories. With an interdisciplinary and descriptive methodology, through documentary analysis, and ethnographic work with workshops, semi-structural interviews and fieldwork, it recognized that the social appropriation of water determined by culture is flexible and depends on each ontological and geographical context and history subscribed. The document ranges from the pre-Columbian period to the present and shows that the social appropriation of water is not exclusive in time or space. It can occur simultaneously, which suggests that, in some historical moments, it coexists and may be inscribed in different societies, with different ways of life and different visions-notions and actions of building hydrosocial territories over time.

Association between healthy food environment and metabolic syndrome, waist circumference, and systolic blood pressure in older adults in Southern Brazil.

The aim of this study was to investigate the association between healthy food outlet proximity, metabolic syndrome (MS), and two of its components, waist circumference (WC) and systolic blood pressure (SBP), in older adults (63-107 years old, median age 73 years) living in Florianópolis, South Brazil in 2013-2014. This is a cross-sectional analysis of the second wave of the EpiFloripa Aging Cohort Study. Individual-level data on MS, WC, SBP, and socio-demographic and health-related characteristics were collected from face to face interviews. The healthy food environment was assessed via the number and types of establishments present. The residences of older adult participants were georeferenced using Geographical Information System (GIS) software. The number of each type of food establishment in a 500 m buffer around the each residence was determined. Multivariate linear regression was used to test association between food outlet proximity and continuous outcomes (SBP and WC), and multiple logistic regression was used to examine the relations between the predictor variables and the dichotomous outcome of MS (yes/no). The study revealed that greater frequency of supermarkets and restaurants in the neighborhood was associated with a lower likelihood of having MS. WC was lower in individuals living in places with greater availability of greengrocers' shops and restaurants. The results demonstrated that the number of establishments in a neighborhood is associated with cardiometabolic outcomes, and the likelihood of MS and increased WC is lower for older adults who live in neighborhoods with more access to establishments that sell foundational components of a healthy diet.

Autopercepção do tamanho corporal em escolares: um estudo transversal / Self-perception of body size in schoolchildren: a cross-sectional study

Introdução: A identificação precoce de imprecisões nas estimativas do tamanho corporal pode ser fundamental para planejar e realizar ações de prevenção e tratamento mais eficazes relacionadas à percepção e distúrbios da imagem corporal. Objetivo: Estimar a prevalência de superestimação e subestimação do tamanho corporal em escolares com magreza, peso normal e obesidade e os fatores associados. Métodos: Estudo transversal e de base escolar realizado em Florianópolis, Santa Catarina, Brasil. O estudo foi realizado com uma amostra de 1.530 escolares de sete a dez anos matriculados em escolas públicas e privadas de Florianópolis. Foram analisados dados sociodemográficos e antropométricos, bem como suas percepções sobre a imagem corporal. As percepções do tamanho corporal foram avaliadas utilizando-se as Escalas de Silhuetas para Crianças Brasileiras. Foi utilizada regressão logística para análise das associações. Resultados: A prevalência de magreza ou de peso normal em escolares que se consideravam com obesidade foi de 10%. Nenhum dos escolares com obesidade se consideraram magros ou com peso normal. Nos escolares magros, a imagem corporal desejada referente à obesidade manteve-se associada à percepção de considerar-se obeso (odds ratio = 2,64, p < 0,05). O sobrepeso, no sexo feminino, se manteve associado à condição de considerar-se magro (odds ratio = 3,07, p < 0,05). Conclusões: A superestimação e subestimação do tamanho corporal foram observadas entre crianças de 7 a 10 anos, particularmente do sexo feminino. Outros estudos utilizando diferentes variáveis e abordagens metodológicas são necessários para identificar, em profundidade, as causas da distorção da imagem corporal.

Introduction: Early identification of inaccuracies in body size estimations can be fundamental to plan and accomplish more effective prevention and treatment actions related to body image perception and disorders. Objective: To assess the prevalence of overestimation and underestimation of body size in thin, normal-weight, and obese schoolchildren and the factors associated. Methods: Cross-sectional and school-based study conducted in Florianópolis, Santa Catarina, Brazil. The study was conducted with a sample of 1,530 schoolchildren from seven to ten years old enrolled at public and private schools in Florianópolis-SC, Brazil. Sociodemographic and anthropometric data, as well as their perceptions on body image, were analyzed. Perceptions of body size were evaluated using the Figure Rating Scales for Brazilian Children. Logistic regression was used to analyze associations. Results: The prevalence of thinness or normal-weight schoolchildren who considered themselves with obesity was 10%. None of the schoolchildren with obesity considered themselves thin or normal-weighted. Considering thin and normal-weight schoolchildren, a desired body image equivalent to obesity was associated with an overestimation of their own obesity (odds ratio = 2.64, P < 0.05). Overweight in female schoolchildren was associated with an underestimation of self-thinness (odds ratio = 3.07, P < 0.05). Conclusions: Self-overestimation and underestimation of body sizes were observed among 7-10 year-old schoolchildren, particularly females. Further studies using different variables and methodological approaches are needed to know in depth the causes of distorted body image.

School feeding in Covid-19 times: mapping of public policy execution strategies by state administration / Alimentação escolar em tempos de Covid-19: mapeamento das estratégias de execução da política pública pelos gestores estaduais

Abstract Objective Identify and discuss strategies for execution the National School Feeding Program by state administrations during the coronavirus disease pandemic 2019. Methods This is a descriptive cross-sectional investigation. An exploratory review of the official publication of state governments and the Federal District to find out the strategies for the execution of the National School Feeding Program, after school closures due to the Covid-19 pandemic. Information on the form of execution and the public served by the action were reviewed in a descriptive manner. Results Out of the 27 federative units, 55% distributed food kits, 26% supplied food cards/vouchers and 19% provided food kits and food cards/vouchers. As to the scope, 37% maintained general service, 30% attended schoolchildren from families registered in the Brazilian cash transfer program (Bolsa Família) and 26% attended schoolchildren from families registered in the Underprivileged Families Registry. Conclusion The National School Feeding Program was weak in terms of assuring the Human Right to Adequate Food and Food and Nutrition Security. The slowness of the federal administration and the gaps in the regulations issued may explain the changes in the reported strategies, which, in their majority, violate the principle of universality.

RESUMO Objetivo Identificar e discutir estratégias de execução do Programa Nacional de Alimentação Escolar adotadas pelas gestões estaduais durante a pandemia de coronavírus 2019. Métodos Trata-se de pesquisa transversal descritiva. Foram realizadas visitas exploratórias nas páginas oficiais dos governos estaduais e do Distrito Federal para obtenção de informações a respeito das estratégias de execução do Programa Nacional de Alimentação Escolar após a suspensão das aulas pela pandemia por de COVID-19. As informações sobre a forma de execução e o público atendido pela ação foram analisadas de modo descritivo. Resultados Das 27 unidades federativas, 55% distribuíram kits de alimentos, 26% entregaram cartão/vale alimentação e 19% forneceram kits de alimentos e cartão/vale alimentação. Com relação à abrangência, 37% mantiveram atendimento universal, 30% atenderam escolares de famílias cadastradas no Programa Bolsa Família e 26% atenderam escolares de famílias registradas no Cadastro Único. Conclusão Verificou-se a fragilidade do Programa Nacional de Alimentação Escolar quanto à garantia do Direito Humano à Alimentação Adequada e da Segurança Alimentar e Nutricional. A morosidade do gestor federal e lacunas das normativas expedidas podem explicar as modificações nas estratégias relatadas e que, em sua maioria, ferem o princípio da universalidade.

Enfermedades hepáticas y embarazo / Liver diseases and pregnancy

Resumen La prevalencia de las enfermedades hepáticas en el embarazo no es despreciable, ya que estas se presentan en 3%-5% de todas las gestaciones. Entre las múltiples causas se encuentran cambios fisiológicos del embarazo; enfermedad hepática preexistente, siendo las más comunes las enfermedades colestásicas (colangitis biliar primaria y colangitis esclerosante primaria), hepatitis autoinmune, enfermedad de Wilson, hepatitis virales crónicas, cirrosis establecida de cualquier etiología y paciente con historia de trasplante hepático; enfermedad hepática adquirida durante el embarazo, siendo las principales las hepatitis virales, la toxicidad inducida por medicamentos y la hepatolitiasis; hepatopatía relacionada con el embarazo, en la cual se encuentran 5 entidades principales: hiperémesis gravídica, colestasis intrahepática del embarazo, preeclampsia, síndrome HELLP e hígado graso del embarazo. La severidad de estas entidades tiene una amplia gama de presentaciones, desde la paciente que es completamente asintomática, hasta la falla hepática aguda e incluso la muerte. La gravedad del cuadro se asocia con una morbilidad y mortalidad significativas tanto para la madre como para el feto, lo cual hace que una evaluación rápida, diagnóstico certero y manejo apropiado por un equipo multidisciplinario (incluida obstetricia de alto riesgo, hepatología, gastroenterología y radiología intervencionista), en un servicio que tenga la posibilidad de ofrecer trasplante hepático, sean fundamentales para obtener buenos desenlaces.

Abstract Liver diseases develop in 3% to 5% of all gestations. Among the causes are: 1. Physiological changes of pregnancy. 2. Pre-existing liver diseases and conditions. The most common are cholestatic diseases such as primary biliary cholangitis and primary sclerosing cholangitis. Others include autoimmune hepatitis, Wilson's disease, chronic viral hepatitis, cirrhosis of any etiology and histories of liver transplantation. 3. Liver disease acquired during pregnancy, especially viral hepatitis, drug-induced toxicity and hepatolithiasis. 4. Pregnancy-related liver diseases including hyperemesis gravidarum, intrahepatic cholestasis of pregnancy, preeclampsia, HELLP syndrome and fatty liver of pregnancy. Severity ranges from absence of symptoms to acute liver failure and even death. Severe cases have significant morbidity and mortality for both mother and fetus. These cases require rapid evaluation, accurate diagnosis and appropriate management by a multidisciplinary team including high-risk obstetrics, hepatology, gastroenterology and interventional radiology. Availability of liver transplantation is also important for obtaining good outcomes.

Parental Perceived Travel Time to and Reported Use of Food Retailers in Association with School Children's Dietary Patterns.

Considering the association between the neighborhood food environment and individual eating behaviors, this study aimed to assess the association between parents' reported use of food facilities by their children, and parental perceived travel time to food facilities, with their children's dietary patterns. Parents reported the use of supermarkets, full-service and fast-food restaurants, and perceived travel time to these food retailers. To assess school children's food consumption, a previous day dietary recall was applied. Factor analysis was conducted to identify dietary patterns. To test the association between reported use and perceived travel time to food retailers and school children's dietary patterns, we performed multilevel linear regression analyses. Parents' reported use of supermarkets was associated with children's higher score in the "Morning/Evening Meal" pattern. The use of full-service and fast-food restaurants was associated with children's higher score in the "Fast Food" pattern. Higher parental perceived travel time to full-service and fast-food restaurants was associated with children's lower score in the "Fast Food" pattern. Although the use of full-service and fast-food restaurants was associated with a less healthy dietary pattern, the perception of living further away from these food retailers may pose a barrier for the use of these facilities.

Association between food, physical activity, and social assistance environments and the body mass index of schoolchildren from different socioeconomic strata.

The aim of this article was to evaluate associations between body mass index (BMI) and use of and distance from subjects homes of elements of the food and physical activity environments and use of social assistance environment, in schoolchildren from 7 to 14 years living in Florianópolis (South Brazil), stratified by monthly family income. A cross-sectional study was conducted with a probabilistic sample of 2152 schoolchildren. Univariate and multivariate linear regression analyses were conducted to test for associations between BMI and the use of and distance from supermarkets, bakeries and farmers' markets; use of and distance from parks/playgrounds and football pitches; and use of health centers, Reference Centers for Social Assistance, instructional facilities, residents associations, religious groups and a Brazilian program for cash transfer. Overweight and obesity rates were 21.5 and 12.7%, respectively. Among schoolchildren from low-income families, living more than 11 min' walk from parks/playgrounds was associated with higher BMI (ß = 0.53; 95% CI = 0.33-0.73). In the high-income strata, a longer distance from home to football pitches was associated with lower BMI (ß = -0.49; 95% CI = -0.69; -0.29). Neither food nor social assistance environments were associated with BMI of schoolchildren, even when analyzed by income strata.

Evidences of the association between individual attributes and bullying: a cross-sectional study with adolescents from Florianópolis, Santa Catarina State, Brazil.

This study aimed to estimate the prevalence of bullying and to verify the association between nutritional status, demographic and socioeconomic factors, and individual attributes among schoolchildren aged from 11 to 14 years. This is cross-sectional study with a probabilistic sample of 975 adolescents attending public and private schools in Florianópolis, Santa Catarina State, Brazil. Bullying was investigated with a self-administered questionnaire by applying Item Response Theory and dichotomized according to victimization or not. Body mass index (BMI) was classified according to the World Health Organization criteria. Data such as age, school type and location, household income, as well as the education background of the parents were collected by a questionnaire given to the parents. Crude and adjusted analyses were performed using logistic regression. The prevalence of victims of bullying and of overweight/obese adolescents was 13.2% and 29%, respectively. No association was found between bullying and age, sex, school type, mother's education, household income, and overweight/obesity. The crude analysis model indicated that overweight/obese adolescents and those with individual attributes (fat, thin, tall, short, good-looking, ugly, from a different ethnic background, rich, poor, with a disability and/or other) had a greater chance of being bullied. In the analysis model adjusted by household income and stratified by sex, boys were discriminated for being fat, good-looking, ugly, or for having a disability, while girls were discriminated for being fat, tall, short, ugly, rich, poor, among other individual attributes.

Body mass index and association with use of and distance from places for physical activity and active leisure among schoolchildren in Brazil. Cross-sectional study.

BACKGROUND: We evaluated associations between use of public places for physical activity and active leisure (PAAL) and their distances from subjects' homes and indicators of overweight and obesity, among schoolchildren from different socioeconomic levels, in the city of Florianópolis, Brazil. DESIGN AND SETTING: Cross-sectional study conducted on a sample of 2,152 schoolchildren aged 7 to 14 years, enrolled at 30 public and private schools. METHODS: The exposure variables were the use of public places for PAAL in the neighborhood and their distance from schoolchildren's homes. The outcomes were body mass index (BMI) and waist circumference (WC). Univariate and multivariate linear regression analyses were conducted according to income strata. RESULTS: Among the schoolchildren from low-income families, living closer to parks/playgrounds was associated with lower BMI (ß = -2.15; 95% confidence interval, CI = -2.53; -1.77) and lower WC (ß = -0.11 95% CI = -0.17; -0.05), while living at these distances from football pitches was associated with higher BMI (ß = 1.73; 95% CI = 0.31; 3.15) and larger WC measurements (ß = 0.03; 95% CI = 0.005; 0.14). Among the schoolchildren in low-income groups, living at an intermediate distance from beaches was associated with lower BMI (ß = -1.10; 95% CI = -1.61; -0.59). CONCLUSION: Living closer to parks/playgrounds was associated with lower BMI and WC among schoolchildren from low-income families. Living closer to football pitches was associated with higher BMI and WC among these schoolchildren. Living at intermediate distances from beaches was associated with lower BMI among these schoolchildren.

Niveles de glucemia intraoperatoria y su relación con la morbimortalidad a corto y largo plazo en pacientes con trasplante de hígado en un hospital de alta complejidad / Levels of intraoperative glycemia and their relations to short and long term morbidity and mortality in liver transplant patients at a highly complex hospital

Resumen Objetivo: se realizó un estudio en pacientes sometidos a trasplante de hígado (TH) con el objetivo de determinar los valores de glucemia en cada una de las fases de la cirugía del TH y su relación con la morbimortalidad postoperatoria. Materiales y métodos: se identificaron los trasplantes hepáticos entre 2013 y 2015 en los registros institucionales. La información se tomó de la nota operatoria, registros de laboratorio y evoluciones de historia clínica. Se buscaron diferencias en la glucemia en las 3 fases del trasplante entre diabéticos y no diabéticos, la presencia de infección y rechazo. Resultados: en total, se estudiaron 73 pacientes trasplantados, 54,8% (n = 40) de sexo masculino, con una mediana en la edad de 59 años (rango intercuartílico [RIQ] = 52-53). El 32,9% (n = 24) tenía antecedente de diabetes mellitus (DM). Se encontraron diferencias en la glucemia inicial y final (127 mg/dL frente a 212 mg/dL) en diabéticos (p = 0,001), así como en los no diabéticos (glucemia inicial: 105 mg/dL frente a la final: 190 mg/dL) (p <0,000). La proporción de rechazo fue mayor en diabéticos (14,3%, n = 7). No se encontraron diferencias significativas en la presencia de infecciones entre diabéticos y no diabéticos. Se confirmó el diagnóstico de diabetes postrasplante en el 15,1%. Conclusiones: un adecuado control glucémico en los diferentes períodos del transoperatorio en el TH logra igualar la tasa de complicaciones a nivel infeccioso en pacientes diabéticos y no diabéticos; el rechazo continúa siendo más frecuente en pacientes diabéticos. Es necesaria una búsqueda activa de la diabetes postrasplante en cada uno de nuestros pacientes.

Abstract Objective: This study was of patients who underwent liver transplantation has the objective of determining glycemia values ​​in each phase of liver transplant surgery and their relationships with post-operative morbidity and mortality. Materials and Methods: Liver transplant patients were identified in institutional records from 2013 to 2015. The information was taken from operative notes, laboratory records and clinical histories. We searched for differences in blood glucose levels during the three phases of transplantation and compared the incidences of infections and rejections for diabetics and non-diabetics. Results: A total of 73 transplant patients were studied: 54.8% (n = 40) were male, the median age was 59 years (RIQ = 52-53), and 32.9% (n = 24) had histories of Diabetes Mellitus. Differences were found between initial and final serum glucose levels of diabetics (127 mg/dl vs. 212 mg/dl, p = 0.001) as well as in non-diabetics (105 mg/dl vs. 190 mg/dl, p < 0.000). The proportion of rejection was highest among diabetics (14.3%, n = 7). No significant differences were found in the proportions of diabetic and non-diabetic patients who developed infections. Diagnosis of post-transplant diabetes was confirmed in 15.1% of the sample. Conclusions: Adequate monitoring of blood glucose levels during all trans-operative periods of liver transplantation can equalize the rate of infectious complications in diabetic and non-diabetic patients. Rejection continues to be more frequent among diabetic patients. An active search for post-transplant diabetes is necessary for every patient.

Body mass index and association with use of and distance from places for physical activity and active leisure among schoolchildren in Brazil. Cross-sectional study

ABSTRACT BACKGROUND: We evaluated associations between use of public places for physical activity and active leisure (PAAL) and their distances from subjects' homes and indicators of overweight and obesity, among schoolchildren from different socioeconomic levels, in the city of Florianópolis, Brazil. DESIGN AND SETTING: Cross-sectional study conducted on a sample of 2,152 schoolchildren aged 7 to 14 years, enrolled at 30 public and private schools. METHODS: The exposure variables were the use of public places for PAAL in the neighborhood and their distance from schoolchildren's homes. The outcomes were body mass index (BMI) and waist circumference (WC). Univariate and multivariate linear regression analyses were conducted according to income strata. RESULTS: Among the schoolchildren from low-income families, living closer to parks/playgrounds was associated with lower BMI (β = -2.15; 95% confidence interval, CI = -2.53; -1.77) and lower WC (β = -0.11 95% CI = -0.17; -0.05), while living at these distances from football pitches was associated with higher BMI (β = 1.73; 95% CI = 0.31; 3.15) and larger WC measurements (β = 0.03; 95% CI = 0.005; 0.14). Among the schoolchildren in low-income groups, living at an intermediate distance from beaches was associated with lower BMI (β = -1.10; 95% CI = -1.61; -0.59). CONCLUSION: Living closer to parks/playgrounds was associated with lower BMI and WC among schoolchildren from low-income families. Living closer to football pitches was associated with higher BMI and WC among these schoolchildren. Living at intermediate distances from beaches was associated with lower BMI among these schoolchildren.

Utilization of food outlets and intake of minimally processed and ultra-processed foods among 7 to 14-year-old schoolchildren. A cross-sectional study

ABSTRACT BACKGROUND: Access to food retailers is an environmental determinant that influences what people consume. This study aimed to test the association between the use of food outlets and schoolchildren's intake of minimally processed and ultra-processed foods. DESIGN AND SETTING: This was a cross-sectional study conducted in public and private schools in Florianópolis, state of Santa Catarina, southern Brazil, from September 2012 to June 2013. METHODS: The sample consisted of randomly selected clusters of schoolchildren aged 7 to 14 years, who were attending 30 schools. Parents or guardians provided socioeconomic and demographic data and answered questions about use of food outlets. Dietary intake was surveyed using a dietary recall questionnaire based on the previous day's intake. The foods or food groups were classified according to the level of processing. Negative binomial regression was used for data analysis. RESULTS: We included 2,195 schoolchildren in the study. We found that buying foods from snack bars or fast-food outlets was associated with the intake frequency of ultra-processed foods among 11-14 years old in an adjusted model (incidence rate ratio, IRR: 1.11; 95% confidence interval, CI: 1.01;1.23). Use of butchers was associated with the intake frequency of unprocessed/minimally processed foods among children 11-14 years old in the crude model (IRR: 1.11; 95% CI: 1.01;1.22) and in the adjusted model (IRR: 1.11; 95% CI: 1.06;1.17). CONCLUSIONS: Use of butchers was associated with higher intake of unprocessed/minimally processed foods while use of snack bars or fast-food outlets may have a negative impact on schoolchildren's dietary habits.