1.
Synthesis (Stuttg)
; 55(15): 2343-2352, 2023 Aug.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38314182
RESUMO
Secondary alicyclic amines are converted to their corresponding ring-fused imidazoles in a simple procedure consisting of oxidative imine formation followed by a van Leusen reaction. Amines with an existing α-substituent undergo regioselective ring-fusion at the α'-position. This method was utilized in a synthesis of fadrozole.