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1.
Zhonghua Yi Xue Za Zhi ; 96(48): 3866-3869, 2016 Dec 27.
Artigo em Chinês | MEDLINE | ID: mdl-28057154

RESUMO

Objective: To explore the diagnostic value of progesterone in 21-hydroxylase deficiency (21-OHD). Methods: One hundred and ninety-three patients (female: 127, male: 66) with 21-OHD were recruited at Peking Union Medical College Hospital between January and December 2015. At the same time, 253 patients (female: 162, male: 91) with other disease were included as control, and their sex hormone and 17-OHP were measured simultaneously. The correlation between 17-alpha-hydroxyprogesterone (17-OHP) and progesterone was analyzed and the probability of progesterone as the diagnostic biomarker of 21-OHD was determined. Results: There was obvious positive correlation between progesterone and 17-OHP levels in subjects with different age and gender, and the correlation coefficient was from 0.775 to 0.878 (all P<0.001). Receiver operating characteristic curve (ROC) analysis showed that the area under curve was from 0.930 to 1.000 (all P<0.001) when using progesterone as the diagnostic biomarker. Conclusions: Obvious positive correlation exists between progesterone and 17-OHP in patients with 21-OHD. The measurement of progesterone can be an assistant method for the diagnosis of 21-OHD.


Assuntos
17-alfa-Hidroxiprogesterona , Hiperplasia Suprarrenal Congênita/diagnóstico , Progesterona , Biomarcadores , Feminino , Humanos , Masculino
2.
Zhonghua Fu Chan Ke Za Zhi ; 29(10): 586-8, 635, 1994 Oct.
Artigo em Chinês | MEDLINE | ID: mdl-7712869

RESUMO

Sixty one samples of colostrum from mothers with positive serum Hepatitis B virus (HBV) test were collected and determined for serial HBV markers along with HBV DNA. Results showed that HBsAg, HBeAg and anti-HBc were most likely transferred by milk, while anti-HBs and anti-HBe had less possibility to enter the colostrum (P < 0.01). The overall HBV DNA positive rate was 42.6% in the 61 samples. The various HBV markers detected in mothers' serum presented a high consistency with those discovered in the corresponding milk samples. There were significantly higher rate of milk HBV transmission from mothers with serum positive HBsAg, HBeAg and anti-HBc or either one of them than those with positive for anti-HBs and/or anti-HBe.


Assuntos
Aleitamento Materno , Portador Sadio/transmissão , Colostro/virologia , Hepatite B/transmissão , Transmissão Vertical de Doenças Infecciosas , DNA Viral/análise , Feminino , Anticorpos Anti-Hepatite B/análise , Antígenos de Superfície da Hepatite B/análise , Antígenos E da Hepatite B/análise , Humanos , Gravidez
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