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Autoimmun Rev ; 15(4): 375-8, 2016 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-26777307

RESUMO

Behçet's disease (BD) is a systemic inflammatory disorder of unknown aetiology. Pulmonary haemorrhage from ruptured pulmonary artery aneurysms (PAA) in this condition carries a high mortality but treatment has largely been empiric with use of glucocorticoids and cyclophosphamide. Tumour necrosis factor α (TNF-α) was recently recognised as a mediator in the pathogenesis of BD inflammatory lesions. TNFα inhibitors have been shown in various case reports/series to have beneficial effects in uveoretinitis, entero-Behçet's, neuro-Behçet's and BD arthritis. We describe the efficacy and tolerability of infliximab in 2 patients with Behçet's disease complicated by pulmonary vasculitis admitted to our unit during the years 2004-2015, and discuss the previously published data in this area.


Assuntos
Aneurisma/etiologia , Anticorpos/uso terapêutico , Síndrome de Behçet/tratamento farmacológico , Artéria Pulmonar , Fator de Necrose Tumoral alfa/imunologia , Adulto , Síndrome de Behçet/imunologia , Síndrome de Behçet/patologia , Humanos , Masculino
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