Rare adrenal incidentaloma: ganglioneuroma.

Ganglioneuroma (GN) is a rare, benign neurogenic tumor that develops from sympathetic ganglion cells. It occurs mainly in the retroperitoneal region. Adrenal localization is rare. We report a case of adrenal ganglioneuroma in a 22-year-old woman with no previous history of the disease. The tumor was discovered incidentally on an entero scan ordered as part of the etiological assessment for chronic diarrhea. The diagnosis was confirmed by pathological examination.

A case of extremely rare pathology: Renal malakoplakia.

Malakoplakia is a granulomatous tissue inflammation with a characteristic histological appearance, mainly affecting the urogenital system and morphologically reflecting a macrophage disease. If bladder involvement is the most common, renal involvement is very rare and may be responsible for a differential diagnosis problem with renal cell carcinoma. We present a clinical case of renal malacoplakia mimicking malignant renal cell carcinoma diagnosed after partial nephrectomy in a 58-year-old woman with no history of recurrent urinary infections.

What may an adrenal mass conceal? Adrenal gastrointestinal stromal tumor: a case report.

Extraintestinal gastrointestinal stromal tumors (GISTs) are extremely rare, and adrenal GISTs are even exceptional. Only three cases have been reported in the literature thus far, the current case being the fourth. This case demonstrates the need of including extraintestinal GIST in the differential diagnosis when investigating adrenal tumors. Herein, we present a case of adrenal GIST diagnosed in a 60-year-old female patient who had a left adrenal GIST surgically removed as an adrenal tumor.

Oleanolic acid: an antimycobacterial component of Syzygium aromaticum L. and inhibitor of efflux mediated drug resistance.

Oleanolic acid (OA) was isolated from Syzygium aromaticum L. buds, and structurally characterised using different spectroscopic techniques; MS, IR,1H/13C-NMR and 2D NMR experiments. The antimycobacterial activity according to a resazurin microtiter assay (REMA) showed important inhibitory effect of OA on the virulent H37Rv strain, with the lowest minimum concentration of 50 µg/mL, compared to other fractions. Molecular docking of OA with BacA drug efflux pump resulted in good binding affinity of hydrophobic interaction type. Therefore, OA could contribute to the antimycobacterial action of clove buds, and has potential as an efflux pump inhibitor. Further studies are required on its use to combat multidrug resistant strains.

A rare complication in percutaneous nephrolithotomy: clinical case and implications.

Percutaneous nephrolithotomy has become the standard procedure for the management of large kidney stones. Compared with other endo-urological techniques, it has a better fragmentation rate in a single session for kidney stones over 20 mm. It is therefore the recommended first-line treatment modality for large kidney stones. Bleeding is a well-known complication of this procedure, often requiring transfusion. In 0.8% of cases, bleeding can be severe, requiring surgical intervention to control hemostasis. Damage to the lumbar artery is a very rare event, and a potential complication. To our knowledge, this is the first report of lumbar artery involvement during percutaneous nephrolithotomy, complicated by severe bleeding and hemodynamic instability, necessitating conversion. Surgical exploration revealed a severed and bleeding lumbar artery. After hemostasis control by coagulation and ligation, the patient became stable. The patient was discharged on D3, where ureteroscopic lithotripsy was planned after collegial discussion with the patient. Based on this experience, it is important for the surgeon to have in mind certain principles and a thorough knowledge of the classic lateral lumbotomy approach to the kidney.

Chemical composition and toxicity of Moroccan mentha spicata and Artemisia absinthium essential oils against Pthorimaea operculella, the potato moth.

The current methods employed to mitigate losses caused by Phthorimaea operculella primarily rely on the application of synthetic insecticides. We have utilised essential oils of Mentha spicata L. and Artemisia absinthium against Phthorimaea operculella. The essential oils were obtained using hydrodistillation and analysed via gas chromatography-mass spectrometry. Mentha spicata essential oil contained D-limonene (25.12%) and D-carvone (7.47%) while the essential oil of Artemisia absinthium was rich of 3,3,5-trimethylcyclohexene (27.93%) and camphor (22.50%). Five concentrations (0, 1, 2, 4, and 8 µL/L of air) were applied to the four phases of P. operculella, neonate larvae, nymphs, eggs and adults. The results of the biological tests showed that spearmint oil was more toxic than wormwood oil, particularly at the adult and Chrysalide stages. Essential oils could be considered good alternatives to chemical pesticides for the protection of potato crops.

Improvement of humic acid (HA) removal using a new inorganic-organic composite coagulant: α-costic acid as a modifier of polyaluminum chloride properties.

In this work, α-costic acid (αCA), a plant sesquiterpenoid from Dittrichia viscosa, was grafted into polyaluminum chloride (PAC), forming a new eco-sustainable composite coagulant PAC-αCA with improved functionality. The α-costic acid fraction grafted into the PAC and the distribution of aluminum forms in the composite coagulant were evaluated for their effectiveness in removing bentonite and humic acid from synthetic water. The interaction mechanism between PAC and α-CA was examined by the Al-Ferron time spectrophotometric method, density functional theory (DFT), and FTIR analysis. By monitoring the aluminum speciation in the composite coagulant PAC-αCA, it was discovered that the introduction of α-CA impacted the distribution of various aluminum forms, including mononuclear Ala, highly polymeric Alb, colloidal, and medium polymeric Alc. The theoretical analysis identified the Alb species as particularly sensitive to reacting with α-CA. Furthermore, coagulation performance tests demonstrated that increasing the percentage of α-CA and promoting the prevalence of Alb and Alc species over Ala species in PAC-αCA led to improved removal of turbidity and UV254. This study provides an attractive and practical option for water treatment plants to remove colloidal suspensions in raw water effectively.

Clove Buds Volatile Compounds: Inhibitory Activity on Mycobacterium Growth and Molecular Docking on Mmr Efflux Pump Drug Resistance.

Syzygium aromaticum is used in traditional and modern medicine for its various and outstanding pharmacological properties. Here, we studied the chemical composition of hexane extract and non-polar fractions (NPF) obtained from the maceration and fractionation of clove buds, in order to evaluate their in vitro antimycobacterial activity, as well as their contribution against efflux pump (EP) resistance through molecular docking experiments. The gas chromatography-mass spectrometry (GC-MS) analysis of the volatile profiles revealed the presence of eugenol, followed by eugenyl acetate, and ß-caryophyllene as common major compounds. According to Resazurin microtiter assay (REMA), Mycobacterium tuberculosis H37 Rv strain was sensitive to all volatile samples at concentration range between 10 and 100 µg/mL. The NPF of ethanol extract was the best inhibitor with a MIC=10 µg/mL. The in silico study revealed a strong binding affinity between eugenol and Mmr EP protein (-8.1 Kcal/mol), involving two binding modes of hydrogen bond and π-alkyl interactions. The non-polarity character of clove volatile constituents, and their potential additive or synergistic effects could be responsible for the antimycobacterial activity. In addition, these findings suggest the benefic effect of eugenol in the management of mycobacterium drug resistance, whether as potential inhibitor of Mmr drug EP, or modulator during combination therapy.

Hematuria complicated by urinary retention revealing post-radiotherapy gangrenous cystitis with peritoneal involvement: an exceptional case in current urological practice.

Gangrenous cystitis is a pathology that is rarely encountered in current urological practice. It is due to necrosis of the bladder wall, which may be superficial or involve the entire wall. Its exact pathogenesis is unknown, but several factors make its diagnosis based on cystoscopy or imaging. Its surgical treatment depends on the operative finding. In this report, the authors report a case of gangrenous cystitis in a 73-year-old patient with a history of prostatectomy and radiotherapy whose main manifestation was urinary retention. The diagnosis was made by computed tomography scan. Surgical exploration confirmed the diagnosis, thus imposing a partial cystectomy with an omentum base plasty. Despite a good postoperative clinical and biological evolution, the patient died in the intensive care unit following respiratory distress and ventricular tachycardia. This case reminds once again the high mortality associated with this pathology.

A large dedifferentiated retroperitoneal liposarcoma extended to the testis: a rare case report.

Liposarcomas are neoplasms of mesodermal origin representing less than 1% of all malignant tumors and 1 to 2% of urogenital lesions. Primary retroperitoneal liposarcomas extending into the inguinal canal are rare. We present the case of a large retroperitoneal liposarcoma invading the left testicle and its spermatic cord. It was diagnosed by imaging as a large mass that compresses surrounding abdominal structures and communicating with the inguinal canal. A surgical intervention consisting of en bloc resection of the tumor and the left testicle with its cord was performed by 2 routes, intercostal and inguinal. Histology showed a dedifferentiated liposarcoma, which is a rare entity with a high rate of malignancy and a poor prognosis. The treatment of choice is wide surgical resection with clear margins; chemotherapy and radiotherapy are less sensitive. The patient did not manifest any particular complaints during the first six months after surgery.

Synthesis of eugenol derivative by the ring opening of epoxide eugenol and its analysis through chemical reactivity: a DFT approach.

Eugenol, a plant bioactive component, is frequently found in a variety of medicinal plants with well-defined functional attributes. Essential oils containing eugenol were extracted from buds of Eugenia caryophyllata commonly named clove using hydrodistillation. Afterwards, the analysis of the essential oils using gas chromatography/mass spectrometry (GC/MS) shows that eugenol is the major constituent with 70.14% of it. The alkene group in eugenol was epoxidised using m-chloroperbenzoic acid leading to the synthesis of epoxide eugenol. The epoxide ring was cleaved to vanillyl glycol by mixed the epoxide eugenol with aluminum chloride hydrate in an ethanolic medium. A Density Functional Theory (DFT) study was investigated to understand the reactivity of the epoxide eugenol with the aluminum chloride hydrate. The results obtained from DFT based reactivity descriptors were in good agreement with the experiment results.

Primary renal lymphoma in an immunocompetent patient.

Renal lymphoma is rarely primary, but its diagnosis is critical because it requires specialized medical treatment. We present the case of a 59-year-old man who was admitted to the hospital for a painful left renal mass revealed by isolated chronic low back pain. A clinical examination revealed left lumbar tenderness. A non-lymphoma Hodgkin's type B was discovered during a renal biopsy. As part of the extension workup, a PET scan was performed, which revealed no secondary location, and the patient underwent chemotherapy. Following the start of chemotherapy, a complete remission was observed, as well as a reduction in the size of the kidney.

Performance Evaluation of New Chalcone Oxime Functionalized Graphene Oxide as a Corrosion Inhibitor for Carbon Steel in a Hydrochloric Acid Solution.

This study aims to synthesize new chalcone oxime functionalized graphene oxide (CO-GO) and investigate the enhancement in corrosion protection. The morphology and structure of the synthesized CO-GO have been characterized by elemental analysis: Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), thermal gravimetric analysis (TGA), and scanning electron microscopy (SEM). Moreover, the effectiveness of corrosion inhibition was investigated by utilizing electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization (PDP). The results of the above analyses demonstrate that CO-GO has an outstanding corrosion inhibitor performance of up to 94% and acts as a mixed-type inhibitor with a primarily anodic action. The effect of temperature on a carbon steel surface indicates that the tested composites are chemisorbed. A few techniques were able to provide surface characterization such as scanning electron microscopy and ultraviolet (UV)-visible spectroscopy to confirm inhibitor adsorption on the carbon steel surface.

Acute renal failure and bladder tumors, about 106 cases.

OBJECTIVES: The overall objective of the study was to determine the prevalence of acute renal failure due to bladder tumors by describing the clinical, paraclinical, therapeutic, histological and clinical evolution parameters. MATERIALS AND METHODS: Retrospective study over a period of 2 years dating from the first of September 2017 to the 31 of October 2019 on a number of patients with acute renal failure due to bladder tumors treated at the department of urology in the Ibn Roch teaching Hospital in Casablanca. RESULTS: In a series of 597 cases of bladder tumors, the prevalence of acute renal failure was 17.8%. The mean age was 69.5 years [51-88], with a male predominance (97%). The main clinical signs were hematuria (87%), lower back pain (62%), oligo-anuria (31%) and acute urine retention (12%). The mean serum creatinine on admission was 1316µmol/L (extremes: 155-2477) and The mean serum urea was 2.4g/L (0.8-4). Renal ultrasound showed hydronephrosis in 96% of cases, which was bilateral in 69% of cases. Hemodialysis was indicated in 23.6% of the cases, due to hyperkalemia (14.1%), metabolic acidosis (6.6%) and acute pulmonary oedema in (2.8%). Percutaneous nephrostomy was performed in 77% of cases, bladder catheterization in 21% of cases and double J-stenting in 2% of cases. As to the treatment of bladder tumors, endoscopic trans-urethral bladder resection was the main treatment and was performed in (71%) of cases. Meanwhile, 21% of the patients benefited from a cystoprostatectomy and combined radio-chemotherapy was indicated in 9% of cases. The main histological finding was transitional cell carcinoma (98%). The evolution of renal function was favorable in 87% of cases. CONCLUSION: Acute renal failure is a frequent and severe complication of bladder tumors that can be life-threatening and makes it difficult to treat bladder tumors requiring multidisciplinary management.

Isolation, characterization, and antimicrobial activity of communic acid from Juniperus phoenicea.

OBJECTIVES: A mixture of Z and E communic acid is isolated for the first time from the cones of Juniperus phoenicea. Its biological activity was studied. METHODS: The plant material was extracted in a Soxhlet apparatus with n-hexane, the resulting extract was subjected to column chromatography (CC) on silica gel. The structure elucidation of the constituents of the isolated fraction was identified by comparison of its spectroscopic properties 1H and 13C NMR data with those reported in the literature. The antimicrobial assay of hexanic extract and isolated compounds was carried out by the disc diffusion and micro-dilution methods. RESULTS: A mixture of two diterpene acids isomers was isolated, with a high yield (68%). Their chemical structures were confirmed after comparing their spectral data with published reports. These natural products exhibited a significant antibacterial and antifungal activity against the tested strains. Indeed, for Bacillus cereus, Staphylococcus aureus, and Pseudomonas aeruginosa, the inhibition zone diameters (36-37 mm) was better than penicillin, novobiocin, and amoxicillin. For Candida albicans activity, it show that the mixture possess an activity similar to that of Metrazol. Against Escherichia coli, the inhibitory activity was found less than Amoxicillin. This is the first report of isolation of communic acid from J. phoenicea. CONCLUSIONS: These results showed that the cones of J. phoenicea were an important source of communic acid, and its hexanic extract had the greatest potential antibacterial activity against both Gram-negative and Gram-positive bacteria and C. albicans.

Spontaneous rupture of the fornix due to a ureteral lithiasis of 3 mm causing a urinoma: report of an original case.

Rupture of the pyelocalyceal cavities or fornix is a rare and potential urological emergency. It is most often secondary to obstructive uropathy. It can lead to extravasation of urine at the perirenal or retro-peritoneal level, which can have serious consequences. The clinic reported the case of a 37-year-old patient who presented to the emergency department with hyperalgesic (right) renal colic. Intense right lumbar tenderness was found on clinical examination, renal function was preserved. The radiological examination, CT scan mainly, revealed a significant ureteralhydronephrosis by urinary meatus calculus measuring 3 mm with a density of 271 HU and a perirenal effusion and extravasation of the PDC at a late time. The emergency therapeutic management consisted of a bypass with a double J stent. The evolution was marked by a clinico-biological improvement.

Isolated rupture of the superficial dorsal vein of the penis during intercourse: A rare cause of false penile fracture.

Superficial dorsal vein rupture is a rare penile emergency, it presentation could suggest penile fracture instead. While penile fractures are a true emergency, superficial dorsal vein rupture is not as the consequences for the patient are different and loss of erectile function is rare. Herein we report the case of a 49 years old man who presented with acute ecchymosis and swollen appearing after sexual intercourse and suggesting penile fracture, and whom surgical exploration found a tear of the superficial dorsal vein. For which a ligation was accomplished. The prognosis was excellent. The patient reported maintained erectile function.

Retroperitoneal Schwannoma: Case report.

Schwannoma is a rare benign tumor that comes from the SCHWANN cells that sheath the peripheral nerves. Retroperitoneal location is even rarer than the frequency of this neoplasia. The diagnosis is immuno-histochemical and the treatment is surgical. We report the case of a 36-year-old patient with abdominal pain and transit disorders for 4 months. An abdominal CT scan was found a rounded tissue mass of 10 cm long with well-defined borders. The patient was prepared for surgical removal. Per-operatively, a mass was found in the sub hepatic area, pushing the right kidney backwards. Anatomo-pathological examination was in favor of Schwannoma.

Spontaneous renal forniceal rupture due to a bladder tumor.

Extravasation of urine following rupture of the renal fornix is a rare complication mostly caused by obstruction secondary to distal ureteric stones. We report the case of a rupture of FORNIX secondary to a bladder tumor.

[Left inferior vena cava and kidney transplantation]. / La veine cave inférieure gauche et la greffe rénale.

Congenital anomalies of the large vessels are rare. Left inferior vena cava is the second most common anomaly after duplication. They are a challenge that some Departments of Urology and Vascular Disease face. We report the case of a patient admitted for kidney transplantation in whom left inferior vena cava was detected on radiological evaluation performed in the preoperative period.