Deep brain stimulation of the subthalamic nucleus to improve symptoms and cognitive functions in patients with refractory obsessive-compulsive disorder: a longitudinal study.

There are conflicting results regarding the effect of deep brain stimulation (DBS) of different regions on the cognitive functions of patients with severe refractory obsessive-compulsive disorder (OCD). Moreover, it is not yet clear whether the rate of improvement in obsession-compulsion symptoms and cognitive functions following DBS is interrelated. We investigated the effect of the subthalamic nucleus (STN)-DBS on both the severity of symptoms and cognitive functions of patients and also investigated the possible interrelationship between the two. Twelve patients (10 males and two females; 56.17 ± 4.52 years old) were assessed before and 1 month and 3 months after the DBS surgery using the Yale-Brown Obsessive-Compulsive Scale (Y-BOCS), the N-Back, the selective and divided attention (SDA), the Tower of London (TOL), and the Wisconsin Card Sorting (WCS) tests. We found that the severity of symptoms and cognitive functions improved significantly after DBS and this effect lasted at least up to 3 months. Furthermore, it was revealed that the severity of symptoms and cognitive profiles of patients were significantly correlated. Compulsion severity had the highest correlation with perseveration errors, while obsession severity was most correlated with the number of n-back errors. Based on our findings, it seems that the STN acts at least to some extent as a common functional/anatomical ground for the severity of symptoms and cognitive functions of patients with severe refractory OCD, and it can probably be considered as the region of interest for DBS in this group of patients.

Correlations of Accelerometer-Measured Physical Activity with Body Image and Quality of Life among Young and Older Adults: A Pilot Study.

Significant evidence suggests that regular physical activity (PA) is correlated with numerous psychological benefits in adults such as improving body image and quality of life. However, this issue has not been differentiated between young and older adults. In addition, most previous studies used a self-reported questionnaire for measuring PA, the objectivity of which is limited in several ways. Hence, by using accelerometer technology for monitoring PA, this study was designed to examine the correlations of PA with body image and quality of life in young and older adults. In this cross-sectional study, we used objective actigraphy and survey data from 147 young and older adults, including 77 young and 70 older adults from Tehran, Iran. To examine our variables and hypothesis, the following instruments were implemented: the Persian version of the Multidimensional Body-Self Relations Questionnaire (MBSRQ), the Persian version of the Quality-of-Life Questionnaire (WHOQOL-BREF), and the ActiGraph wGT3X-BT for measuring PA. An independent t-test and a multivariate regression analysis were used to analyze the data. The weekly PA of both young and older adults was found to be lower than the recommended amount. Young adults engaged in significantly more weekly PA than older adults. For young adults, PA (including MPA, VPA, and MVPA) was generally found to be significantly correlated with body image and quality of life. For older adults, however, we found only significant correlations between VPA and quality of life. These findings indicated that PA is a critical concern in adults, particularly older adults. Accordingly, it is necessary to adopt appropriate strategies to promote an active lifestyle among adults.

Associations between Physical Activity and Mental Health in Iranian Adolescents during the COVID-19 Pandemic: An Accelerometer-Based Study.

Using self-reported questionnaires, several studies found that social isolation during the COVID-19 pandemic has significantly changed the level of physical activity (PA) in children and adolescents. Since the objectivity of self-reported PA is limited in several ways, we used modern accelerometers in this study to assess the PA levels of male and female adolescents during the pandemic-related lockdown. Moreover, the association of PA with mental health of the adolescents were analyzed. A total of 136 students (76 girls, mean age of 16.28 ± 0.97 years) from various schools in Iran wore the accelerometer (ActiGraph GT3X-BT) for seven consecutive days. Mental health was measured through the Depression, Anxiety, Stress Scale-21 of Lovibond and Lovibond (1995). Descriptive statistics and independent t-tests were used to analyze the PA levels of male and female students, and linear regressions were computed to examine whether PA predicts mental health status. On average, the daily time spent in moderate-to-vigorous PA (MVPA) was 18.47 min, which is clearly below the WHO guideline of at least 60 min of MVPA per day. Only 4% of adolescents showed MVPA for more than 30 min per day. Male students were significantly more active than their female peers (p = 0.015). As expected, MVPA was negatively associated with mental health issues such as depression, anxiety, and stress. However, the majority of adolescents reported symptoms of mild-to-moderate mental health disorders. These results emphasize the need for targeted strategies and offerings geared to young people's needs and preferences to promote an adequate level of PA and good mental health during and after the ongoing pandemic.

The relationship between attention and static balance disturbance in patients with Parkinson's disease.

OBJECTIVE: Balance disturbance is one of the main complications of the Parkinson's disease (PD). As studies have shown that impairments in some cognitive processes can lead to balance problems, we investigated the relationship between focused and divided attention and static balance in patients with PD and a healthy control group. METHODS: We included 111 patients with PD (M age = 49.41, SD = 6.33 years) and 142 healthy individuals (M age = 50.62, SD = 6.07 years). All participants were evaluated with the Trails Making Test A and B (TMT), and all participants' balance was evaluated with a Wii Balance Board, from which we measured the antero-posterior (AP), medio-lateral (ML), and total center of pressure (COP) velocity. We compared the two groups in terms of TMT-A, TMT-B, and COP velocity tests in both eyes-open and eyes-closed conditions with independent t-tests, and we calculated Pearson's correlation coefficients between the balance board-derived outcomes and the TMT scores. RESULTS: The two groups differed significantly on TMT-A and TMT-B scores, in total and ML COP velocity in both eyes-closed and eyes-open conditions, and in AP COP velocity only in eyes-open condition. Among patients with PD, TMT-A and TMT-B scores were positively correlated with total, ML, and AP COP velocity, in both eyes-open and eyes-closed conditions. CONCLUSIONS: Associated attention deficits may be among the causes of balance disturbances in patients with PD, though both attention and balance may have a common root in brain circuitry.

Motor reaction time and accuracy in patients with multiple sclerosis: effects of an active computerized training program.

In this study, we aimed to determine the difference of motor reaction time and accuracy between the patients with moderate multiple sclerosis (MS) and healthy subjects and to determine whether a specified cognitive-motor training can improve the speed and accuracy of information processing in patients with MS. A total of 205 patients (30% males) and 276 age-/gender-matched healthy subjects (31% males) were included in the study. Furthermore, using a stratified randomization method, patients with MS were randomly assigned to one of two groups: active information processing training (AIPT) (n = 49) or post-control (n = 55). The AIPT group was asked to complete a computerized visual-manual training program and the post-control group asked to complete the same task without an increase in difficulty. Before and after the intervention phase, the simple, choice, and semantic reaction times and accuracies of all participants were evaluated using the VLS measurement battery. Our results demonstrated that the case and control group were significantly different in terms of the simple, choice, and semantic motor reaction times and accuracies. Compared with the pre-intervention phase, the AIPT and control group's performances in the post-intervention phase were considerably improved in simple, choice, and semantic motor reaction times and choice and semantic motor reaction accuracies. The results also showed that the AIPT group performed significantly better than the post-control group in terms of simple and choice motor reaction times. We showed the positive effects of training on the performance of patients with MS in motor reaction time and accuracy.

Mechanisms of beneficial effects of exercise training on non-alcoholic fatty liver disease (NAFLD): Roles of oxidative stress and inflammation.

Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver disorder which is associated with accumulation of fats in the liver. It causes a wide variety of pathological effects such as non-alcoholic steatohepatitis (NASH) and cirrhosis, insulin resistance, obesity, hypertension, dyslipidaemia, diabetes and cardiovascular disease. The molecular mechanisms that cause the initiation and progression of NAFLD are not fully understood. Oxidative stress (OS) induced by reactive oxygen species (ROS) and inflammation are likely a significant mechanism which can lead to hepatic cell death and tissue injury. Mitochondrial abnormalities, down-regulation of several antioxidant enzymes, glutathione (GSH) depletion and decreased activity of GSH-dependent antioxidants, accumulation of leukocytes and hepatic inflammation are the major sources of ROS overproduction in NAFLD. Excessive production of ROS suppresses the capacity of other antioxidant defence systems in NAFLD and causes further oxidative damage. Regular exercise can be considered as an effective strategy for treatment of NAFLD. It improves NAFLD by reducing intrahepatic fat content, increasing ß-oxidation of fatty acids, inducing hepato-protective autophagy, overexpressing peroxisome proliferator-activated receptor- γ (PPAR-γ), as well as attenuating hepatocyte apoptosis and increasing insulin sensitivity. Exercise training also suppresses ROS overproduction and OS in NAFLD via up-regulation of several antioxidant enzymes and anti-inflammatory mediators. Therefore, an understanding of these molecules and signalling pathways gives us valuable information about NAFLD progression and a method for developing a suitable clinical treatment. This review aimed to evaluate sources of ROS and OS in NAFLD and the molecular mechanisms involved in the beneficial effects of exercises on NAFLD.

Internal and External Imagery Effects on Tennis Skills Among Novices.

The purpose of this study was to determine the effects of internal and external visual imagery perspectives on performance accuracy of open and closed tennis skills (i.e., serve, forehand, and backhand) among novices. Thirty-six young male novices, aged 15-18 years, from a summer tennis program participated. Following initial skill acquisition (12 sessions), baseline assessments of imagery ability and imagery perspective preference were used to assign participants to one of three groups: internal imagery ( n = 12), external imagery ( n = 12), or a no-imagery (mental math exercise) control group ( n = 12). The experimental interventions of 15 minutes of mental imagery (internal or external) or mental math exercises followed by 15 minutes of physical practice were held three times a week for six weeks. The performance accuracy of the groups on the serve, forehand, and backhand strokes was measured at pre- and post-test using videotaping. Results showed significant increases in the performance accuracy of all three tennis strokes in all three groups, but serve accuracy in the internal imagery group and forehand accuracy in the external imagery group showed greater improvements, while backhand accuracy was similarly improved in all three groups. These findings highlight differential efficacy of internal and external visual imagery for performance improvement on complex sport skills in early stage motor learning.