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PLoS Negl Trop Dis ; 5(12): e1415, 2011 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-22180796

RESUMO

BACKGROUND: Over the last 15 years, visceral leishmaniasis (VL) has emerged as a public health concern in Tbilisi, the capital of Georgia. METHODOLOGY/PRINCIPAL FINDINGS: Seroepidemiological surveys were conducted to determine the prevalence and incidence of infection in children and dogs within the main focus of VL, and to identify risk factors associated with human infection. Of 4,250 children investigated, 7.3% were positive by direct agglutination test in a baseline survey; an apparent incidence rate of 6.0% was estimated by one year follow-up. None of the seropositive children progressed to VL during the survey. Increased seropositivity at one year was predicted by presence at baseline of clustered flying insects (OR = 1.49; P = 0.001), perceived satisfactory sanitation (OR = 1.65; P<0.001), stray dogs (OR = 1.33; P = 0.023), and by persistent fever during the 6 months prior to baseline survey (OR = 14.2; P<0.001). Overall, 18.2% (107/588) of domestic and 15.3% (110/718) of stray dogs were seropositive by the rk39 dipstick test. Clinical VL signs were found in 1.3% of domestic and 2.9% of stray, seropositive dogs. Parasites isolated from human and dog samples were identified by PCR and phylogenetic analysis of the Leishmania 70 kDa heat-shock protein (HSP70) gene as Leishmania infantum. CONCLUSIONS/SIGNIFICANCE: There is an active focus of L. infantum transmission in Tbilisi with a high prevalence of human and canine infections.


Assuntos
Doenças Transmissíveis Emergentes/epidemiologia , Leishmania infantum/isolamento & purificação , Leishmaniose Visceral/epidemiologia , Adolescente , Animais , Criança , Pré-Escolar , Doenças Transmissíveis Emergentes/parasitologia , Doenças Transmissíveis Emergentes/veterinária , Cães , Características da Família , República da Geórgia/epidemiologia , Humanos , Incidência , Lactente , Leishmania infantum/classificação , Leishmania infantum/genética , Leishmaniose Visceral/parasitologia , Leishmaniose Visceral/veterinária , Razão de Chances , Filogenia , Reação em Cadeia da Polimerase , Estudos Soroepidemiológicos
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