Changing Patterns of the Prevalence of Helicobacter Pylori Among Patients at a Corporate Hospital in Ghana.

INTRODUCTION: Helicobacter pylori (H. pylori) discovered in 1982, has strongly been associated with multiple clinical disorders of the gastrointestinal tract. This study described the prevalence of H. pylori among large numbers of patients over two different time periods in Accra, Ghana. METHODS: It was a retrospective records review on patients attending a quasi-government hospital in Accra, Ghana, during two time periods, 1999 and 2012. A total of 2401 records were reviewed, 1128 in first period and 1273 in second period. Biopsy was taken from the gastric antrum for Rapid Urease Test (RUT) in identifying H. Pylori. Data on patient characteristics, clinical diagnosis and findings upon endoscopy were analyzed by simple descriptive statistics. Associations between categorical outcome variables were determined by Chi square test at 95% significance level. RESULTS: H. pylori infection was high in patients with upper gastrointestinal symptoms 69.7% (1999) and 45.2% (2012), and was even higher in patients with gastritis and duodenal ulcer. H. pylori infection however, decreased among patients over the period, 69.7% in 1999 to 45.2% in 2012. Sex differences in H. pylori infection was identified (higher among males) and young adults (21-40 years). Commonest symptom in all patients was non-ulcer dyspepsia, 86.9% in 1999 and 84.2% in 2012, while gastritis and duodenal ulcer were the commonest endoscopic finding in the two periods. CONCLUSION: Appropriate management guidelines in West Africa considering the high background H. pylori infection and other co-infections requiring particular antibiotic combination therapy is required.

Post-operative surgical-site infection from skin bleaching: a case report.

BACKGROUND: Prolonged application of steroid containing cream can pose a serious challenge to users. Apart from making the skin lighter it creates a spectrum of diseases in those that use them as the adrenal glands are suppressed and are unable to secrete more steroids when required. OBJECTIVE: The objective is to report on a patient who presented with severe sepsis after a long period of application of steroids to the skin. METHODS: A patient who has applied steroids to the skin over a prolonged period was followed up during treatment to ascertain the complications that the patient sustained during the period of treatment. CONCLUSION: The patient was found to have developed a pelvic induration without abscess. She also had a large anterior abdominal wall abscess superficial to the external oblique muscle extending towards the left flank.

The health of adult women in Accra, Ghana: self-reporting and objective assessments 2008-2009.

OBJECTIVES: The study provides a full description of the state of women's health in Accra, Ghana using self-reported as well as objective health measures. Using data from the Women's Health Survey of Accra, Wave 2 (WHSA-2), the authors a) examine the consistency of the objective measures of health status (anthropometry and blood pressures) with self-report measures, including the Short Form 36 indices for 8 separate domains of health; and b) describe the main socio-economic differentials in morbidity. METHODS: Cross-sectional household survey with field measurements. 2814 women aged 18 and over were interviewed and measured in their homes in late 2008 and early 2009. The physical measurements included height, weight, waist and hip measurement and 3 or more measures of resting blood pressure. RESULTS: Using the 8 domains of self-reported health captured by the Short Form 36 instrument, we find that physical health worsens more sharply with age than mental health. Social class differentials are narrow in the younger cohorts but widen amongst the elderly. The physical measurements reveal unhealthy levels of obesity and hypertension, worsening steadily with rising age. Age and the wealth of the household influence women's health more than their individual characteristics such as education. CONCLUSIONS: Younger women appear to be in good health with steady declines in physical and mental health with age. The major threat to women's health appears to be the rising levels of obesity and hypertension with mean BMIs for all women over age 45 in excess of 30, producing elevated blood pressures and associated high risks of heart attacks and stroke rising sharply amongst the elderly.

Clinic visits and cervical cancer screening in accra.

OBJECTIVE: To determine the factors that increase the chances of a woman in Accra having a Pap smear and whether women who have recently visited clinics have higher chances of having had Pap smears. DESIGN: A cross-sectional study METHODS: A representative sample of women in Accra, Ghana was interviewed and the clinical and demographic factors influencing cervical cancer screening was assessed. RESULTS: Out of 1193 women with complete data, only 25 (2.1%) had ever had a Pap smear performed though 171 (14.3%) had their last outpatient clinic visit for either a gynaecological consultation or a regular check up. Simple logistic regression showed that a high educational level, high socioeconomic status and a history over the past month of postmenopausal or intermenstrual bleeding significantly increased the odds of ever having a pap smear. Neither monthly income nor last clinic visit for a gynaecological consultation or regular check up increased the odds of having a pap smear. Multiple logistic regression showed that a high educational level and experiencing postmenopausal or intermenstrual bleeding were the most important determinants of ever having a Pap smear. CONCLUSION: While we wait for a national program for cervical cancer screening, there is a need for clinicians to put more individual effort into ensuring that asymptomatic women are screened for cervical cancer.

Surgically correctable adrenal-dependent hypertension: a report of five cases.

SummaryAlthough endocrine causes of secondary hypertension are relatively uncommon, medical practitioners must maintain a high index of suspicion for them in certain categories of patients. Such patients include young individuals, those with difficult-to-treat hypertension and those presenting with symptoms, clinical signs and/or laboratory parameters well-known to be associated with Cushing's syndrome, Conn's syndrome or phaeochromocytoma.This paper reports on 5 patients identified over a 2-year period with various hormonally-active adrenal adenomas causing hypertension in an environment where, hitherto, the occurrence of these conditions was generally thought to be rare. Aspects of the patients' histories, examination and laboratory findings that drew attention to the possibility of the diagnosis in each case are highlighted, as are the confirmatory investigations and management methods used by a multidisciplinary team of medical practitioners. The clinical outcome with appropriate treatment of adrenal-related hypertension is good and can result in significant cost savings in the long term.

Upper gastrointestinal endoscopy at the korle bu teaching hospital, accra, ghana.

SUMMARY OBJECTIVES: To study the indications for endoscopy, the endoscopic diagnosis and other lessons learnt. METHODS: A retrospective and prospective audit of all upper gastrointestinal endoscopies performed in the Endoscopy Unit of the Korle-Bu Teaching Hospital from January 1995 to December 2002 was performed. RESULTS: A total of 6977 patients, 3777 males and 3200 females with age range 1 year 8 months to 93 years were endoscoped. The mean age of males was 43.5 +/- 0.5 and females 43.7 +/- 0.6 years. Epigastric pain (42.5%), dyspepsia (32.8%) and haematemesis and melaena (14.2%) were the commonest reasons for endoscopy. Chronic duodenal ulcer (19.6%), acute gastritis (12.7%), duodenitis (10.2%), oesophagitis (7.5%) were the commonest diagnoses. Normal endoscopy was reported in 41.1% patients, and was higher in the younger age group compared to the older (R = 0.973, P<0.001). Nine hundred and ninety (14.2%) patients were endoscoped for haematemesis and melaena of which chronic duodenal ulcer (32.1%), gastritis/gastric erosions (12.8%), oesophageal varices (9.8%), carcinoma of the stomach (6.4%), and duodenitis (4.2%), were the commonest causes. No lesion was found in 20.6% of these patients. Urease test was positive in 75% of all biopsy specimen and 85% in chronic duodenal ulcer, gastritis and duodenitis. CONCLUSION: The normal endoscopy rate is high and needs to be reduced in order to help prolong the lives of the endoscopes. Chronic duodenal ulcer is usually associated with H. pylori infection and is the commonest cause of upper gastrointestinal bleeding.

Deep venous thrombosis of the lower limb in young ambulant ghanaians.

SUMMARY BACKGROUND: Deep venous thrombosis (DVT) usually affects patients who are over 40 years old, obese, bed ridden or have had major operations or have hypercoagulable states. Healthy and ambulant young people are usually not affected. OBJECTIVES: To report the observation of DVT in young patients below the age of 40 years METHODS: A study of all healthy and ambulatory patients below the age of forty years with a diagnosis of DVT seen on one surgical unit at the Korle Bu Teaching Hospital, Accra was performed from 1(st) January 2000 to 30(th) June 2003. RESULTS: Eleven patients, eight (8) females and three (3) males aged between 20 and 40 years with a median age of 32 years were treated. All the patients had deep venous thrombosis of the lower limb confirmed with Doppler studies and duplex scan of the lower limb. Swollen lower limb was the commonest presenting symptom and sign. Prolonged sitting was the main factor in 9 out of eleven patients. CONCLUSIONS: Deep venous thrombosis may not be a rare condition in the young ambulant Ghanaian and may be related mainly to a sedentary life style. Diagnosis should be suspected in patients who present with unilateral swollen and oedematous leg. There is the need to study the ailment in greater detail.

Health of urban Ghanaian women as identified by the Women's Health Study of Accra.

OBJECTIVE: The purpose of the Women's Health Study of Accra was to provide an assessment of the prevalence of communicable and non-communicable illnesses. METHOD: This was a prospective, community-based study that included an interview for medical illnesses, a comprehensive physical examination, and laboratory testing. A total of 1328 women were examined at Korle Bu Teaching Hospital, University of Ghana. RESULTS: Prevalent conditions included poor vision (66.8%), malaria (48.7%), pain (42.8%), poor dentition (41.6%), hypertension (40.2%), obesity (34.7%), arthritis (27.1%), chronic back pain (19.4%), abnormal rectal (16.0%) and pelvic examinations (12.7%), HIV in women age 24-29 (8.3%), and hypercholesterolemia (22.7%). Increasing age, lack of formal education, and low-income adversely affected health conditions. CONCLUSION: The high prevalence of preventable illnesses in this expanding urban population indicates that the health care services are obligated to develop and provide screening, preventive strategies and treatment for both general health and gynecologic health conditions.

Secular trends in menarcheal age among Ghanaian women in Accra.

The Women's Health Study of Accra is a population-based cross-sectional survey that was conducted between March and September 2003 to assess the burden of disease in women in Accra. In addition to data relating to general health and living conditions, data on age at first menstruation was collected during the survey. A retrospective cohort analysis of the reported age at menarche was conducted using data from 2,644 women aged between 18 and 100 years. The median age of first menstruation of the entire cohort was 15.5 years and the median age of first menstruation among those aged <20 was 14.5 years. There was a statistically significant difference in median age at menstruation among the different age and socioeconomic groups. Multiple linear regression showed a significant decline of 0.2 years per decade in the mean age at menarche among Ghanaian women.

Gallstones in Ghanaian children with sickle cell disease.

OBJECTIVE: This prospective, cross-sectional study was done to define the prevalence and age of onset of gallstones in Ghanaina children with Sickle Cell Disease (SCD) in steady state, using ultrasonography. MATERIALS AND METHOD: The study was conducted at the Paediatric SCD clinic, Korle Bu Teaching Hospital, Accra, Ghana. Three hundred and fifteen (315) children comprising 162 males and 153 females aged 2 to 13 years with a confirmed diagnosis of SCD of haemoglobin SS, (HbSS), Haemoglobin SC, (HbSC) or Haemoglobin S-betathalassemia (SbetaThal) genotype whose parents/guardians gave informed conset, were recruited consecutively. The main outcome measure was the detection of gallstones in the gall bladder or common bile duct by ultrasonography. RESULTS: Thirteen children, 12 males and 1 female had gallstone, giving an overall prevalence of 4%. The youngest was aged 6. Four children had sludge only. Peak age of prevalence was 12 years. All patients under 12 years with gallstone were males (92.3%). The very high male: female ratio in these sickle cell disease children is at variance with the normal male: female ratio of 1:4.6. Although twenty percent of all the patients were genotype SC, only one SC patient had gallstones, giving a prevalence rate of 0.3%, and a prevalence ratio of stone in SS: SC of 12:1. Twenty patients had no spleen detectable clinically or on ultrasoound examination and none of them had gallstones. CONCLUSION: Gallstones occur at an early age in children with sickle cell disease in Ghana.

Faecal pancreatic elastase--1 a non invasive measure of exocrine pancreatic function.

BACKGROUND: Faecal pancreatic elastase-1 is a laboratory based test used for the diagnosis or exclusion of exocrine pancreatic insufficiencies. Pancreatic elastase-1, is released into blood circulation during inflammation of the pancreas, but unlike most pancreatic enzymes it is stable during intestinal passage and not degraded. OBJECTIVES: The major objective of this work was to establish the assay of faecal pancreatic elastase-1 in spot stool samples as an exocrine pancreatic function test at Korle-Bu (a referral) hospital in Ghana, for the diagnosis of pancreatic diseases. METHOD: Twenty-five apparently healthy persons; mean age of 43.4 years and thirty-two patients with various pancreatic diseases, mean age 51.4 years were referred for the test based on clinical presentation, imaging studies and biopsy findings. The male to female ratio was 6.4:3.6 and 8.1:1.9 respectively. An ELISA technique which recognizes human pancreatic elastase-1 from spot stool samples was employed for the test and read photometrically at 405nm. RESULTS: Elastase-1 activity in spot stool samples from apparently healthy group ranged from 165 to 870mg/g with a mean of 379 (SE 41)mg/g, and a range of 20 to 285mg/g with a mean of 112.9 (SE 11.6)mg/g obtained for the pancreatic disease group. Disease severity was classified as mild to moderate with elastase-1 concentration between 100 and 200mg/g stool and the severe pancreatic insufficiency group with elastase-1 concentration of less than 100mg/g stool. The pancreatic elastase-1 was found to be stable in faeces for several weeks when stored frozen, hence the convenience for batch determinations. CONCLUSION: The test is non invasive and can assist with the diagnosis of inflammatory conditions of the pancreas where imaging results are equivocal.

Women with painful breasts without palpable masses: do they really need a mammogram?

This prospective study was carried out over a period of 36 months, and the study population was, all the women (726) referred for mammograms on account of painful breast(s) without palpable masses. They were matched with the same number of asymptomatic women in a control group. The mammographic findings in the women with painful breast(s) and no palpable masses were normal in 639 (88%), benign in 80 (11%), suspicious in 2 (0.3%) and malignant in 5 (0.7%). In the control group mammograms showed normal breasts in 625 (86.1%), benign and suspicious lesions in 87 (12%) and 7 (1.0%) respectively. Malignant lesions were recorded in 7 (0.9%) women. The prevalence of breast cancer was similar in women with painful breast(s) and the control asymptomatic cases. Our reports show that inspite of the pain experienced by the women in this study mammography had a low diagnostic yield of malignant lesions, just as it was found in the control group. Mammography therefore, in these patients will only provide reassurance.

How often are Ghananian gallbladder stones cholesterol-rich.

BACKGROUND: Although the prevalence of symptomatic gallbladder stone disease in Ghana increased almost four-fold between 1966 and 1991, little is known about the composition of and aetiopathogenesis of these stones, nor about their suitability for non-surgical (dissolution) treatments. METHODS: To study this, gallstones from 67 out of 90 patients coming to cholecystectomy were retrieved and, based on their external appearance, classified provisionally as cholesterol(chol) (n = 8), black pigment (n = 28) and brown pigment (n = 31) stones. The gallstones were then homogenised, their cholesterol(chol) content measured chemically and the stones re-classified as cholesterol-poor (< 10% chol by weight), intermediate (10-75% chol) and cholesterol-rich (> 75% chol). The relationship between the initial and the definitive classifications was then examined and the biliary bacteriology (carried out on fresh samples of gallbladder(GB) bile obtained by fine needle aspiration) on gallstone composition, analysed. RESULTS: The external appearance correctly predicted stone composition in the 28 thought, initially, to have black pigment stones (all of whom had stones containing < 10% chol by weight, on chemical analysis) and the eight believed, originally to have "cholesterol" stones (all of whom had stones with > 75% chol) but it proved unreliable in the 31 considered, at the time of surgery, to have brown pigment stones (mean chol content 58+ SEM 35%; range 0-98%. By chemical analysis, more than half the patients 35 of 67 or 52% had cholesterol-poor stones, nine (13% of the total) had intermediate stones, while 23 (34%) had cholesterol-rich stones. Cholesterol-rich gallstones were also more frequent in women than in men (p < 0.03). Only nine of 43 patients (21%) whose GB bile was aspirated, had positive bacterial cultures. There was no obvious difference in stone composition between those with positive, and those with negative, cultures. CONCLUSION: Since the majority of Ghanaian patients with cholecystolithiasis have gallbladder stones with < 75% chol by weight, when active treatment is indicated surgery is more appropriate than dissolution therapy. However contrary to common belief, cholesterol-rich gallstones do occur in West Africa: 34% of the present series had stones with > 70% chol by weight.

Changing pattern of intestinal obstruction in Accra, Ghana.

BACKGROUND/AIMS: Over the past 50 years acute intestinal obstruction has remained among the commonest causes of the acute abdomen, along with peritonitis, appendicitis and gastrointestinal perforations. However several observers have noticed over the past 2 decades a shift in the etiological spectrum. The study aims at ascertaining the precise nature of the change. METHODOLOGY: Published data on intestinal obstruction from the Korle Bu Teaching Hospital over the past 50 years were reviewed, as the consistent report format permitted ready comparison of the series. Emphasis was placed on clinical features, established cause and resulting complications. RESULTS: The case load of intestinal obstruction has dwindled over the past 3 decades, accounting for 0.7% of all hospital admissions compared with 1.4% 30 years earlier. External hernias together with adhesive bands still constitute the bulk of presenting cases, but the proportions have changed with strangulated hernias accounting for 59.8% instead of 77.6%. The change has paralleled a rise in elective hernia day case surgery. The incidence of intussusception has almost doubled (7.4% from 4.0%) and it still afflicts the very young. Colonic neoplasms have been commoner over the past 2 decades although the incidence (3.3%) falls short of Western figures. Overall mortality has remained unchanged at 9.4% and this has been associated with a rise in resection rates to 18.3%. CONCLUSIONS: The patterns of intestinal obstruction have been much influenced by changing attitudes regarding elective hernia surgery and evolving financial policies.

Incidence of Helicobacter pylori infection in Ghanaian patients with dyspeptic symptoms referred for upper gastrointestinal endoscopy.

Helicobacter pylori has been linked with peptic ulcer disease, non-autoimmune gastritis, non peptic ulcer dyspepsia and gastric carcinoma and lymphoma. This study looked at the incidence of H. pylori infection in Ghanaian patients with dyspeptic symptoms referred for upper gastro-intestinal endoscopy and its relationship to various pathologies. Detection was by the CLO urease test. A hundred and thirty (130) patients were studied. 75.4% tested positive for H. pylori infection and the incidence peaks in the 5th decades. While 23.5% H. pylori positive patients had active duodenal or gastric ulcer, 18.8% of H. pylori negative patients also had the ulcer. Out of 43 patients with normal oesophago-gastro-duodenoscopy, 74.4% were H. pylori positive, 66.6% of gastric malignancies tested positive for H. pylori infection. It remains to be confirmed that eradication of H. pylori will relieve the peptic symptoms in affected patients with no ulcer disease.

Day surgery at Korle Bu Teaching Hospital: a six year review.

Day surgery is not simply a matter of economics for the health institution or the individual patient, or improved utilization of scarce and dwindling resources, or even a matter of increasing access to health care, fundamental as this is to us in the developing world. The ultimate question is to what extent does it satisfy the true needs of the patient and meet the requirements of his care as a whole. To address this day surgery in a general surgical unit has been reviewed over a 6 year period. This covered a total of 1547 cases consisting of hernias, hydroceles, excision biopsies, varicose veins etc. Infiltrative local anaesthesia using lignocaine (4 mg/kg) mostly with 1 in 200,000 adrenaline added proved effective in 98 percent of cases; there were no deaths. For the institutions day surgery has proven cost effective, lowering cost of operative treatment and improving utilization of scarce resources. It has also proven eminently acceptable to patients and their families, enhancing access to care and significantly reducing the personal cost of treatment. To demonstrate enhanced health economics future studies should ideally show a parallel diminution of in-patient bed facilities with increasing load of day surgery.

The changing pattern of cholelithiasis in Accra.

One hundred and sixty-five cholecystectomies were performed in the 12 year period 1980-1991 Only 67 were performed in the first 10 year period but in the last 2 years (1990-1991), 98 patients underwent cholecystectomy. While patients with biliary tract disease occupied 0.4% of General Surgical beds in 1966-68 patients for cholecystectomy now occupy 1.5% of all General Surgical beds. The rising incidence of gall stone disease is the result of a genuine increase in the incidence as well as better diagnosis supported by the use of ultrasonography.

The microflora of bile in Ghanaians.

Bile was obtained from the gall bladder of 104 patients undergoing cholecystectomy for gall stone disease. Bile was also obtained from the common bile duct and T-tube of 17 patients who also had exploration of common bile duct. During the same period, 148 cholecystectomies were performed. The specimens were sent for culture and sensitivity and 32.7% of the specimens grew bacteria. The factors that were associated with positive culture were emergency cholecystectomy for acute cholecystitis and empyema of gall bladder, carcinoma of gall bladder and obstructive jaundice. The commonest organisms were E. Coli (28.2%) and Klebsiella (17.9%). Pseudomonas surprisingly formed 10.2% of the cultured organisms. Salmonella that causes typhoid, which is an endemic disease in Ghana, formed only 7.7% of the isolates. Most of the organisms were resistant to Ampicillin and tetracyclines. The antibiotics that most were sensitive to were Gentamicin and Cefuroxime. Therefore the antibiotics that are recommended for use as prophylaxis in biliary tract surgery are Gentamicin or Cefuroxime.