Assuntos
Protocolos de Quimioterapia Combinada Antineoplásica/química , Etoposídeo/química , Protocolos de Quimioterapia Combinada Antineoplásica/análise , Protocolos de Quimioterapia Combinada Antineoplásica/normas , Cromatografia em Camada Fina , Etoposídeo/análise , Etoposídeo/normas , Humanos , Garantia da Qualidade dos Cuidados de Saúde/normasRESUMO
Twenty one cases of proven subarachnoid hemorrhage (S.A.H.) have been analysed in a protocol especially including transcranial doppler (T.C.D.) and 88mTc-H.M.P.A.O. single photon emission tomography (H.M.P.A.O.-S.P.E.C.T.). Seventeen patients were intraoperatively studied. All data were compared with clinical grading, computerized tomography (C.T.) and angiography. S.P.E.C.T. is a quite recent method of measuring and three-dimensional imaging of brain perfusion. It provides important information for the diagnosis of ischemic syndromes in S.A.H. Sixty-two S.P.E.C.T.-scans were performed in twenty one patients. Fifty-eight were abnormal and showed significant abnormalities of brain perfusion varying in extent and severity. In this preliminary study, we set out to validate the clinical use of H.M.P.A.O.-S.P.E.C.T. for the diagnosis of "vapospasm" comparing S.P.E.C.T. data with classical criteria. We propose a classification which allowed us to quantify the ischemic risk in an attempt to adapt the global therapeutic management to hemodynamic data. This method appears to be very sensitive and reliable in this field. It will introduce, if these first results are confirmed, important criteria for the evaluation of patients presenting with S.A.H. as far as prognosis and treatment are concerned, especially in regard to timing of surgery and institution of medical hemodynamic therapy.
Assuntos
Aneurisma Roto/complicações , Circulação Cerebrovascular , Aneurisma Intracraniano/complicações , Ataque Isquêmico Transitório/diagnóstico por imagem , Compostos de Organotecnécio , Oximas , Hemorragia Subaracnóidea/diagnóstico por imagem , Tomografia Computadorizada de Emissão de Fóton Único , Ecoencefalografia , Feminino , Humanos , Período Intraoperatório , Masculino , Pessoa de Meia-Idade , Período Pós-Operatório , Cuidados Pré-Operatórios , Hemorragia Subaracnóidea/etiologia , Hemorragia Subaracnóidea/fisiopatologia , Tecnécio Tc 99m ExametazimaAssuntos
Compostos de Benzilideno/farmacologia , Furanos/farmacologia , Hipolipemiantes , Animais , Compostos de Benzilideno/síntese química , Avaliação Pré-Clínica de Medicamentos , Furanos/síntese química , Hiperlipidemias/tratamento farmacológico , Hipolipemiantes/síntese química , Ratos , Ratos EndogâmicosRESUMO
A series of 35 new derivatives of 3-benzylidene benzopyran-4-one carboxylic acid was synthesized; their antiinflammatory and analgesic activities were investigated and compared with those of acetylsalicylic acid, phenylbutazone, ketoprofene and glafenine. Among these compounds, four were found to be more potent than the references compounds in tests of antiinflammatory and analgesic activity. Seven compounds were tested on rat blood platelet aggregation induced by ADP. From these tests, HD-039, HD-041, HD-044 and HD-049 appear to be promising antiinflammatory, analgesic and anticlotting agents, although this original series shows little structural analogy with classical non-steroidal antiinflammatory agents.