RESUMO
Intrauterine contraceptive devices have been associated with multitude of complications including uterine perforation and migration into adjacent organs. Here we present a rare case report on 45-year-old lady in whom intrauterine copper 7 (Cu-7) migrated into the urinary bladder leading to calculus formation. The migrated Cu-7 alongwith the calculus were successfully retrieved.
Assuntos
Culex/genética , Mutação , Animais , Cruzamentos Genéticos , Culex/isolamento & purificação , Feminino , Genes Recessivos , Marcadores Genéticos , Larva , MasculinoRESUMO
The genotoxicity of ziram (zinc-dimethyl dithiocarbamate, CAS No. 137-30-4), a carbamate fungicide, is studied in the wing, eye and female germ-line mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster. First-, second- and third-instar larvae, carrying suitable recessive genetic markers on their first and third chromosomes, were exposed to ziram. Wings and eyes of adults were screened for the induction of mosaic spots and the eggs laid by adult females for germ-line mosaicism. The Basc method was used to detect sex-linked recessive lethals. Ziram is genotoxic to the somatic and germ cells of Drosophila melanogaster.
Assuntos
Drosophila melanogaster/genética , Genes Letais , Genes Recessivos , Ligação Genética , Tiocarbamatos/toxicidade , Cromossomo X , Ziram/toxicidade , Animais , Olho/efeitos dos fármacos , Feminino , Células Germinativas/efeitos dos fármacos , Masculino , Mosaicismo , Testes de Mutagenicidade , Asas de Animais/efeitos dos fármacosRESUMO
The genotoxic potential of Rogor (dimethoate), an anticholinesterase organophosphate insecticide, has been studied in the sex-linked recessive lethal test and the wing, eye and female germ-line mosaic assays in Drosophila melanogaster. Larvae of different instars carrying suitable recessive genetic markers on their first and third chromosomes were exposed to the LD50 or half of this dose for the entire larval life. The Basc technique was followed for the detection of the induction of sex-linked recessive lethals. The wings and eyes of the adult flies and the eggs laid by the heterozygous females were checked for the induction of mosaicism. It is concluded that Rogor induces sex-linked recessive lethals in immature male germ cells and is recombinogenic and/or mutagenic in both the somatic and the germ-line cells of Drosophila.
Assuntos
Dimetoato/toxicidade , Mutação/efeitos dos fármacos , Animais , Relação Dose-Resposta a Droga , Drosophila melanogaster/efeitos dos fármacos , Drosophila melanogaster/genética , Olho , Genes Letais , Genes Recessivos , Larva/efeitos dos fármacos , Mosaicismo , Testes de Mutagenicidade , Asas de AnimaisRESUMO
The genotoxicity of zineb, a carbamate fungicide, has been tested through eye, wing and female germ line mosaic assays and the sex-linked recessive-lethal test in Drosophila melanogaster. Larvae of different instars, heterozygous for appropriate recessive genetic markers, were exposed to the fungicide in food for different durations of time. The adult eyes and wings were screened for induction of mosaic spots and the eggs laid by the females were checked for induction of female germ-line mosaicism. It is concluded that zineb is genotoxic to both somatic and germ-line cells of Drosophila.
Assuntos
Mutação/efeitos dos fármacos , Tiocarbamatos/toxicidade , Zineb/toxicidade , Animais , Drosophila melanogaster/efeitos dos fármacos , Drosophila melanogaster/genética , Feminino , Genes Letais , Genes Recessivos , Larva/efeitos dos fármacos , Masculino , Mosaicismo , Testes de Mutagenicidade , Asas de Animais/efeitos dos fármacosRESUMO
The genotoxicity of dimecron, a systemic organophosphate pesticide, has been tested in the wing, eye and germ line mosaic assays and the sex-linked recessive lethal test in Drosophila melanogaster. Larvae heterozygous for recessive marker mutations were fed the compound for various periods of time. On emergence, the wings and eyes of the adults were screened for mosaic spots and the eggs laid by the females were checked for induction of female germ line mosaicism. Dimecron is mutagenic to the somatic and germ line cells of Drosophila and induces a high frequency of sex-linked recessive lethals.
Assuntos
Drosophila melanogaster/efeitos dos fármacos , Inseticidas/farmacologia , Fosfamidona/farmacologia , Animais , Drosophila melanogaster/genética , Feminino , Genes Letais/efeitos dos fármacos , Genes Recessivos/efeitos dos fármacos , Larva , Masculino , Mosaicismo , Testes de Mutagenicidade/métodos , Oócitos , Fosfamidona/toxicidade , Cromossomos Sexuais/efeitos dos fármacosRESUMO
An autosomal recessive mutant, green pupa (gp), in Culex quinquefasciatus has been isolated. The homozygous (gp/gp) females are viable whereas male homozygotes do not develop beyond the pupal stage. The behavior of this mutant character in pedigree studies has been reported.
Assuntos
Culex/genética , Genes Letais , Mutação , Animais , Cruzamentos Genéticos , Feminino , Masculino , Fenótipo , PupaRESUMO
The mutagenic potential of metacid (methyl parathion), an anticholinesterase organophosphate pesticide, has been studied in the Drosophila eye, wing and female germ line assays and the sex-linked recessive lethal tests. Larvae 24 h, 48 h and 72 h old, heterozygous for various recessive genetic markers on the first and third chromosomes, were exposed to the LD50 and half of this dose for different periods of time. The eyes and wings were checked for the presence of mosaic spots and eggs laid by the females for germ line mosaicism. The M-5 technique was used to detect the induction of sex-linked recessive lethals. It is concluded that metacid is mutagenic in somatic and germ line cells of Drosophila and induces sex-linked recessive lethals in immature male germ cells.